Vaccination progam in farm animals prof. dr Alaa Basyoni prof Hamed Attia
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Transcript of Vaccination progam in farm animals prof. dr Alaa Basyoni prof Hamed Attia
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Prof. Dr Prof. Dr AlaaaAlaaa BasionyBasiony
ProfProf. Dr . Dr hamedhamed AttiaAttiaDepartment of animal medicineDepartment of animal medicineFaculty of veterinary medicine Faculty of veterinary medicine
Zagazig universityZagazig university
VACCINATION PROGRAM IN FARM ANIMAL
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*VACCINATION PROGRAM IN FARM ANIMAL
*TYPES OF VACCINE USED
*CAUSES OF VACCINE FAULER
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INFECTIOUS VACCINES INFECTIOUS VACCINES (ANTIGENS)(ANTIGENS)
TYPES:TYPES:
–– 11--modified live vaccinesmodified live vaccinesintramuscular,intramuscular, subcutaneous, subcutaneous, intranasalintranasal
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IMMUNITY DURATIONIMMUNITY DURATION
–– lifelife--time (infection established, time (infection established, cellular and cellular and humoralhumoral immunity)immunity)
–– one dose requiredone dose required
–– annual boosters may not be requiredannual boosters may not be required
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22--NONNON--INFECTIOUS VACCINES INFECTIOUS VACCINES (ANTIGENS)(ANTIGENS)
TYPES:TYPES:
–– killed vaccines and bacterins killed vaccines and bacterins ––intramuscular, subcutaneousintramuscular, subcutaneous
–– toxoids and leukotoxoids toxoids and leukotoxoids ––intramuscular, subcutaneousintramuscular, subcutaneous
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IMMUNITY DURATION:IMMUNITY DURATION:
–– 4 4 to to 12 12 months (infection not months (infection not established, established, humoralhumoral immunity)immunity)
–– primary dose required (priming)primary dose required (priming)
–– secondary dose required secondary dose required –– 3 3 to to 6 6 weeks weeks later (within later (within 4 4 months)months)
–– Annual or semiannual boosters requiredAnnual or semiannual boosters required
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VACCINE INSTRUCTIONSVACCINE INSTRUCTIONS
FOLLOW THE LABEL:FOLLOW THE LABEL:
refrigerate in use and storagerefrigerate in use and storage
use sanitary practices in useuse sanitary practices in use
keep out of sunlight in usekeep out of sunlight in use
properly dispose of opened vials properly dispose of opened vials after useafter use
Notice expiration date of unopened Notice expiration date of unopened vialsvials
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VACCINE LABEL USE DIRECTIONSVACCINE LABEL USE DIRECTIONS
FOLLOW THE LABEL:FOLLOW THE LABEL:
–– dosedose
–– route(s)route(s)
–– withdrawal time for slaughter (withdrawal time for slaughter (21 21 to to 60 60 days)days)
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VACCINE FAILURESVACCINE FAILURES
NO RESPONSENO RESPONSE ::
EfficacyEfficacy
stressstress
malnutritionmalnutrition
IMPROPER DOSE:IMPROPER DOSE:
IMPROPER ROUTE:IMPROPER ROUTE:
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MISHANDLED MISHANDLED ::
nonnon--refrigeratedrefrigerated
Sunlight exposureSunlight exposure
UnsanitaryUnsanitary
STORED OPENED VIALSSTORED OPENED VIALS
EXPIRED VACCINEEXPIRED VACCINE
POOR QUALITY VACCINEPOOR QUALITY VACCINE
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Bacterialvaccines
Viralvaccines
8. Covexin* 8
9. Ultrabac® 8
4. Sheep pox
vaccine
Mixedvaccines
1. FMD vaccines
3. BEF Vaccine
5. PNEUMO 3
6. PNEUMO 4
2. RP Vaccine
1. BCG vaccine
2. HS Vaccines
3. Pneumo - Bac
4. Brucella Abortus
Strain 19 Vaccine
7. Brucella Melitensis
Vaccine Strain “REV. 1”
1. Entero – 3
Vaccine
7. CattleMaster4
8. Vira Shield 5
2. ScourGuard 3
6. Abortex
5. RB51 vaccine
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1-Viral Vaccine
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1-MD Vaccine
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Monovalent Inactivated FMD Vaccine
(type O1/93 locally isolated in Egypt)
Protection of cattle, buffaloes,
sheep and goats against FMD
First dose:
- Cattle & buffaloes 3 months & older 2 ml
- Sheep & goats 1 ml
- Dairy cattle revaccinated every 4 months .
- Breeding calves sheep & goats revaccinated every 4-6 months.
PACKAGE: Each bottle Contains 300 ml
Second dose:
4 wks post 1st dose.
SC
1-
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Bivalent Inactivated FMD Vaccine
(type O1/93 and type AEGY/06
locally isolated in Egypt)
Protection of cattle, buffaloes,
sheep and goats against FMD
First dose:
- Cattle & buffaloes 3 months & older 2 ml
- Sheep & goats 1 ml
- Dairy cattle revaccinated every 4 months .
- Breeding calves sheep & goats revaccinated every 4-6 months.
PACKAGE: Each bottle Contains 300 ml
Second dose:
4 wks post 1st dose.
SC
1-
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:
The vaccine contains virus of FMD type O (1/93)
and type A (EGY/06).
It is locally isolated in Egypt.
It is inactivated by 2- bromoethylamine
hydrobromide (BEI).
Adjuvanated by aluminum hydroxide gel and
purified saponin.
COMPOSITION
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INTERACTIONS:
Other vaccination programs
should be carried out at least two
weeks before or after FMD
vaccination.
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PROPAGATION SYSTEM:
Baby hamster kidney monolayer cell
line (BHK).
INSTRUCTIONS FOR USE:
Shake the bottle before use.
the vaccine is inoculated subcutaneously in the dwelap
10-15 cm in front of the sternum.
In sheep and goats subcutaneously behind the shoulder
or in the middle of the lower side of the neck.
Press on the injection site for a while then make gentle
massage for a short time. The vaccine gives immunity for
6 months.
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VACCINE REACTION
A painful swelling may be developed
within one or two days at the site of
injection .
It does not influence the general
condition of the animals.
This swelling subsides within 10 days.
No drop in milk production.
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Aftovaxpur
- 2 ml Cattle
- 1ml Sheep
- 6 m
Inactivated polyvalent vaccine
(O1, A22, SAT2, ASIA1)
Type:
Dose:
- SC
- 300 ml 3500 LE
Route:
Duration of immunity: Price:
3-
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2-Rinder PestVaccine
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Attenuated T.C. Vaccine
(" RBOK " strain)
PACKAGE:
Available in vial of 50 or 100 doses.
Protection of cattle & buffalo
against Rinderpest
1ml
SC
Solid immunity last for
5 – 6 years
Dissolve the lyophilized material in 50
or 100 ml sterile chilled physiological
saline solution. Use it within one hour
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Cell culture Rinderpest vaccine is an attenuated vaccine which
confers immunity for many years when inoculated at optimum
conditions. Vaccine is prepared according to FAO and OIE
instructions , by using the international reference
" RBOK " strain .
MODE OF USE:
-Dissolve the lyophilized material in 50 or 100 ml (according to the
dose) sterile chilled physiological saline solution. Use it within one
hour. -The dose (1ml contain at least 103 TCID50 ) is injected
subcutaneously. -Inoculate each animal with (1 ml ) of dissolved
vaccine subcutaneously using sterile syringe. -Separate, sterile
syringe is necessary for each animal.-Vaccine should be kept on
ice, away from sunlight throughout the time of use. -Don’t use
disinfectant, alcohol to sterile needles.-The vaccine is completely
safe for Pregnant animals within the previously mentioned dose.
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Inactivated Vaccine
Protective of cattle & buffalos
against BEF
2ml
PACKAGE:
Each bottle contains
20 ml (10 doses).
SC
- Second dose ( booster dose) :
2ml after 4 weeks.
- The same program repeated
annually.
Animals must be
vaccinated before
summer season
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COMPOSION:
Each dose contains at least 106.5 TCID50 of the virus.
PROPAGATION SYSTEM:
Green monkey kidney cell line ( VERO ).
VACCINATION PROGRAME:
- Animals of 6 months age vaccinated with the vaccine.
- First dose : 2ml injected (S/C ).
- Second dose ( booster dose) : 2ml injected S/C after 4 weeks.
- The same program repeated annually.
Inactivated Bovine Ephemeral Fever Vaccine
REMARKES:
- The vaccine is safe for pregnant and lactating animals.
- Animals must be vaccinated before summer season.
CONTRAINDICATION:
Animals clinically ill or those weakened should not be vaccinated.
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4- Respiratory Virus Vaccine
IBR,BVD, PI- 3
& BRS
diseases
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4-Types ofRespiratory Virus Vaccines
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1-EgypianRespiratory Virus Vaccines
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Combined Inactivated
Respiratory Virus Vaccine
Cattle & buffalo 5 ml
Sheep 3 ml
PACKAGE: bottle 100 ml (20 doses).
Protection of cattle,
buffaloe & sheep against
IBR, BVD, & PI- 3 diseases
IM
6 m
2nd dose 2 weeks apart
1
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DESCRIPTION:
A combined inactivated vaccine used for protection of cattle,
buffaloe and sheep against IBR, BVD, & PI- 3 diseases.
"PNEUMO 3"
COMPOSITION:
- Each dose contains not less than:
- IBR 106 TCID50
- BVD 106 TCID50
- PI – 3 106 TCID50
- Adjuvants : aluminum hydroxid gel.
VACCINATION PROGRAMME:
- Animals vaccinated at ( 2 – 4 ) months old, 2nd dose must be given two
weeks after the 1 st dose . Then revaccination should be done every 6
months.
- Pregnant cow dames could be vaccinated with two doses, two months
before parturition with 2 weeks interval.
- Animals from non vaccinated dames could be vaccinated at age of 3-4
weeks.
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PACKAGE:bottle of 100 ml (20 doses).
Combined Inactivated
Respiratory Virus Vaccine
Cattle & buffalo 5 ml
Sheep 3 ml
Protection of cattle, buffaloe
& sheep against IBR, BVD,
PI- 3 & BRS diseases
IM
6 m
2nd dose 2 weeks apart
2
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" Pneumo 4"
DESCRIPTION:
A combined inactivated vaccine used for protection of cattle, Buffalo
and sheep against IBR, BVD, PI- 3 & BRS diseases.
COMPOSITION:
Each dose contains not less than:
IBR 106 TCID50
BVD 106 TCID50
PI – 3 106 TCID50
BRS 106 TCID50
Adjuvants : aluminum hydroxid gel.
VACCINATION PROGRAMME:
- Animals vaccinated at 2 – 4 months old, 2nd dose must be given two
weeks after the 1 st dose . Then revaccination should
be done every 6 months.
- Pregnant dams could be vaccinated with two doses, two months
before parturition with 2 weeks interval.
- Animals from non vaccinated dames could be vaccinated at age of 3- 4
weeks.
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2-ForienRespiratory Virus Vaccines
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Indications:For vaccination of healthy cattle,
including pregnant cows, as an aid in
preventing abortion caused by
infectious bovine rhinotracheitis (IBR,
bovine herpesvirus Type 1),
persistently infected calves caused by
bovine viral diarrhea (BVD) virus Types
1 and 2, respiratory disease caused by
IBR, BVD (Types 1 and 2),
parainfluenza3 (PI3 ) and bovine
respiratory syncytial virus (BRSV) and
leptospirosis caused by Leptospira
canicola, L. grippotyphosa, L. hardjo,
L. icterohaemorrhagiae and L. pomona.
CattleMaster® GOLD™ FP® 5 L5
1
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Protection of cattle &
buffaloe against IBR,
BVD, PI- 3 & BRS
diseases
IM
2 ml
Combined vaccine
2nd dose 2 weeks apart
One year
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Dosage and Administration
General Directions: Vaccination of healthy cattle is
recommended. Aseptically rehydrate the freeze-dried
vaccine with the liquid component provided, shake well
and administer 5 mL subcutaneously. In accordance with
Beef Quality Assurance guidelines, products should be
administered in the muscular region of the neck.
Primary Vaccination: Administer an initial 5-mL dose,
followed by a second 5-mL dose 3 weeks later. As an aid in
preventing IBR-induced abortion and BVD persistently
infected calves, administer at approximately 5 and 2 weeks
prior to breeding. Calves vaccinated before the age of 6
months should be revaccinated after 6 months of age.
Revaccination: Annual revaccination with a single dose is
recommended.
Good animal husbandry and herd health management
practices should be employed.
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Protection of cattle
& buffaloe against
IBR, BVD (2 types)
, PI- 3 & BRS
diseases
IM or SC
5 ml
Combined
Inactivated
Vaccine
2nd dose 4 weeks apart
One year
2
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5-Sheep Pox Vaccine
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Protects sheep & goats against
pox disease, & cattle against LSD
I/D or S/C
0.5 ml
Live attenuated freeze dried
tissue culture vaccine
one year
PACKAGE:Each vial contains 100 dose.
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Tissue Culture Sheep Pox Vaccine
COMPOSITION:
Each dose contains at least 102.5 TCID50.
PROPAGATION SYSTEM:
Green Monkey Kidney cell line ( Vero ).
DOSAGE:
- Reconstitute the vial contents in 50 ml physiological saline.
- Each dose is 0.5 ml injected interadermally (I/D) or subcutanously (S/C).
- Vaccination repeated annually.
REMARKS:
- The reconstituted vaccine should be used within two hours.
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2-Bacterial Vaccine
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1-BCG Vaccine
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Strain called bacille Calmette &
Guerin
Developed by Albert Calmette &
Camille Guerin two french
investigors in 1920s
attenuated strain of M. bovis
0.5 cm for cow & buffalo male calves
0.1 cm for lambs
Intradermal
Once / life (solid immunity)
Freeze Dried B.C.G. Vaccine
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the BCG was not an effective cattle vaccine
1. Used to protection of human and animals against tuberculosis
2. Give non-specific immunity to another diseases by
stimulation the immune system as:
a) Caseous lymphadenitis. b) Brucellosis.
c) Haemorrhagic septicemia. d) Listeria.
d) Staph. aureus. e) Strept. pyogens.
f) Salmonellosis. g) Pox
h) Rift Valley Fever
3. When used in fed lot animals increase the food conversion rate
Used in males onlydue to vaccinated animals persist to give tuberculin
test positive (false +ve) so, it interfere with test and slaughter program.
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BCG Vaccine.COMPOSITION :
* Vial containing 5 mg of lyophilized vaccine.
* Vial containing 6 ml of diluent ( Sauton 1+ 3 )
INDICATIONS :
1) Provide non specific immunity against viral, bacterial and parasitic diseases.
2) Protect sheep from Pseudo tuberculosis, Pox and Rift Valley Fever.
3) Increase the immune efficacy and body weight gain of fattening calves.
DIRECTIONS AND DOSAGE:
The lyophilized vaccine is reconstituted with the diluent and injected I/D as follows
: AnimalDilution Dose Vacc. Conc. Site Cow - calves2.5 ml 0.5 ml1 mgUnder the tail. Buffaloe -
calf 2.5 ml0.5 ml1 mgSide of the neck Sheep 5 ml0.1 ml0.1 mgInner aspect of the thigh or under
the fatty tail.Lambs10 ml0.1 ml0.05 ml
PRECAUTIONS:
1) The vaccine should be used quickly as possible after reconstitution, and any remaining vaccine
should be discarded.
Un used diluted vaccine, empty vails and used syringes must be disposed hygienically. 2) Bulls,
cows and buffaloes never to be vaccinated .
3) Vaccination is stopped in cases of general weakness, serious skin diseases and acute illness (
fever )
STORAGE:
The vaccine should be stored in a dry place protected from direct sunlight or diffuse day light at a
temperature between 4 - 8oC, not freezer.
Validity :
Tow years from the manufacture date.
PACKAGE:
A vial containing 5 doses for calves or 50 doses for sheep.
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2- Pasteurellosis Vaccine
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Inactivated HS Oil Adjuvant
Vaccine (type B:6)
PACKAGE: bottle 300 ml. (150 dose).
Protection of cattle & sheep
against HS & pneumonic
pasteurellosis
2 ml in cattle
1 ml in sheep
IM
9 m
1
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DESCRIPTION:Haemorrhagic septicaemia oil adjuvant is an inactivated oil emulsion vaccine used for active immunization of cattle against haemorrhagic septicaemia and pneumonic pasteurellosis.
COMPOSITION:Each dose of the vaccine contains pasteurella multocida type B:6 inactivated with formalin and emulsified in oil base.
VACCINATION PROGRAM:- In areas where the disease occur seasonaly animals should be vaccinated two or three weeks before the season.- Where the incidance is not seasonal, animals should be vaccinated every nine months.- When outbreaks of the disease occur, all contact stock must be vaccinated as soon as possible.
RECOMENDATIONS:- Shake the vaccine vigoursly before and during use to ensure good mixing.- Allow the vaccine to reach room temperature before vaccination. - Intravenous injection must be avoided. - Animals to be vaccinated should be in good health and not suffering from any disease.
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Inactivated Oil Adjuvant
Polyvalent Pneumonic
Pasteurellosis Vaccine
Cattle and buffaloes:
Over 100kg 2ml
Under 100kg 1ml.
Sheep & goat : 1ml.
PACKAGE: bottles 300 ml. (150 dose for cattle, 300 dose for sheep & goat).
Protection of Cattle, Sheep & Goat
against pneumonic pasteurellosis.
2nd dose 4 weeks apart
One year
IM
2
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Protects against H.S. in
horses, mules & donkeys
S/C
1 ml at 6th month
2 ml at 1 year
3 ml at 2 years
5 ml at 3 years
Formalized killed vaccine
6 months
3
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DESCRIPTION:Pneumo - bac is an inactivated oil adjuvant polyvalent pasteurellosis vaccine used for active immunization of cattle, sheep and goat against pneumonic pasteurellosis.
COMPOSITION:The vaccine contains pasteurella multocida types A,B & D and pasteurella haemolytica types A & T inactivated with formalin and emulsified in oil base.
VACCINATION PROGRAM: - Animals vaccinated with two doses four weeks internal.- For pregnant animals, vaccination with two doses four weeks internals at 6-8 weeks before parturition.- Animals born from vaccinated dams should be vaccinated at 8 weeks of age. - Animals born from unvaccinated dams should be vaccinated at one week age.- Revaccination with one dose annually.
RECOMENDATIONS:- In areas where the disease occurs seasonally, animals should be vaccinated at 4 or 5 weeks before the season.- When outbreaks of the disease occur, all contact stock must be vaccinated as soon as possible.
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3-Brucella Vaccine
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PACKAGE:
Vials 10 ml contains 10 reduced doses of lyophilized vaccine
( 3-10 x 109 CFU / dose ( accompanied with 20 ml diluent.
Protection of cattle, buffaloes
against Brucellosis
Living attenuated smooth B.abortus strain 19 in
serous form or freeze dried (lyophilized vaccine).
SC to female calves between 4 to 8 months old
5 successive years
Full dose (standard dose): about 60 – 80 x109
microbial cells in about 2ml.
Reduced dose (1/20 of full dose): It is widely used
nowadays specially in un-affected herd and it is
characterized by rapid decline in aglutinins.
1
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* Used in female calves at 4 – 8 months (average 6
months).
* Not used before 4 months of age due to:
(1) Reticulo-endothelial system is still undeveloped
so may result in low titer of antibodies (not
protect against disease).
(2) When given at this age, the colostrums
antibodies interfere the microbial dose and so
the immunity produce is low.
* Not used after 8 months of age: Animal produces
permanent agglutinin titer (permanent +ve
serological test).
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* Disadvantage of this vaccine:
(1) Used to vaccination of female only due to it
produce orchitis in bull.
(2) Not use in adult female as it cause abortion
except it can use in adult female in case of
outbreak.
(3) Interfere with control program due to it give
serological +ve (5% of vaccinated animal give
resistant agglutinin for 2 – 3 years).
(4) Give infection and un-dutant fever to human.
(5) Not prevent complete infection from udder.
(6) It need to be refrigerated, problems of storage
and transport at 4oC.
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COMPOSITION:
Each dose of reconstituted vaccine contains 3-10 x109
CFU of Brucella abortus Strain 19.
ADVERSE REACTIONS:
These occur rarely in both calves and adults , to be more
sever in foreign breeds.
A local swelling occurs particularly in adult cattle and
there may be a sever systemic reaction manifested by
fever lasting
for 2-3 days.
Anaphylactic shock may occur and immediate treatment
with adrenaline hydrochloride ( 1m1. of 1 : 1000 diluted
solution
injected subcutaneously ) or Antihistaminic drug, is also
recommended
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Live attenuated vaccine of Brucella
abortus rough strain RB51
10 – 34 million bacteria/2ml as one
or 2 dose 30 day interval
Protection cattle, buffaloes & sheep
against brucellosis by B. abortus.
1 – 2 years and animals
vaccinated annually
SC
2
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1. Not result in measurable Ab titers to B. abortus using
standard diagnostic tests so, not interference with
eradication program of Brucellosis using such test.
2. Eliminate costs associated with resting and trace backs
of false +ve reactors as in B. abortus st. 19 vaccine.
3. Not excrete in excretion and secretion of animals.
4. Used in all ages of the animals.
5. There is no any side effect on vaccinated animals.
6. Not protect animal infected with another species of
Brucella as Brucella melitensis
- Age: Female calves of 4 – 12 months.
- Adult non-pregnant female. (Cause abortion)
Advantages:
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Brucella Melitensis Vaccine Strain “REV.
PACKAGE:
- Vials 10 ml contains 10 doses of lyophilized vaccine (1 to 2 x 109
CFU / dose ( accompanied with 20 ml diluent.
- Vials 10 ml cantains 5 doses of lyophilized vaccine ( 1- 2 x 109
CFU / dose( accompanied with 10 ml diluent.
INDICATIONS AND DOSAGE:
After reconstitution with the accompanied diluent, it should contain 1
to 2 x 109 CFU viable organisms per 2 ml dose, given
subcutaneous to lambs and kids aged between 3 to 8 months.
Vaccination is followed by the appearance of specific antibodies.
Do not vaccinate pregnant or lactating females two month prior to
meeting.
Living attenuated B. Melitensis vaccine
3
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COMPOSITION:
Each dose of reconstituted vaccine contains 1 to
2 x 109 CFU of Brucella Melitensis “Strain Rev.
1.”ADVERSE REACTIONS:
These occur rarely in both young or adult.
A local swelling may occurs .
Severe systemic reaction manifested by fever lasting
for 2-3 days.
Allergic reaction may occur .
treatment with adrenaline or antihistaminic drugs
should be done.
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3-Clostridial Vaccine
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clostridial diseasesclostridial diseases
Lamb dysentery
Struck
Pulpy kidney
Braxy & Malignant oedema
Blackleg
Tetanus
Black disease
Bacillary haemoglobin urea
Cl. perfringens type B
Cl. perfringens type C
Cl. perfringens type D
Cl. novyi type B
Cl. septicum
Cl. chauvoei
Cl. novyi type D
Cl. tetani
caused by
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ULTRABAC® 7
• ULTRABAC 7 provides effective,
protection against the following key
clostridial diseases:
• blackleg – Cl. chauvoei
• malignant edema – Cl. septicum
• black disease – Cl. novyi
• gas-gangrene – Cl. sordellii
• enterotoxemia, enteritis – Cl. perfringens
types B, C, and DPackaging:
10-, 50-, & 200-dose vials
Dosage & route:Shake well. Aseptically administer 5 mL
subcutaneously, followed by a second
dose 4–6 weeks later
Annual revaccination with a single dose is recommended
Indications:
1
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Protects cattle, sheep & goat
against 8 clostridial diseases
S/C
Polyvalent formalized
killed vaccine
6 months
2nd dose
2 ml
5 ml
6 W1st dose
2 ml
5 ml
sheepcattle
2
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Protects cattle, sheep & goat
against 8 clostridial diseases
S/C
Polyvalent formalized
killed vaccine
6 months
2nd dose
2 ml
5 ml
6 W1st dose
2 ml
5 ml
sheepcattle
3 Cubolac 8
United Biofarm
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Protects cattle, sheep & goat
against 8 clostridial diseases
S/C
Polyvalent formalized
killed vaccine
6 months
2nd dose
2 ml
5 ml
6 W1st dose
2 ml
5 ml
sheepcattle
3-Covaccin 10
10
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Protects sheep & goat against
8 clostridial diseases
S/C
1st dose
5 ml
Polyvalent formalized
killed vaccine
6 months
2nd dose
3 ml
6 W
4
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3-Mixed Vaccine
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Inactivated Bovine Rota, Corona
Viruses and E-Coli Vaccine
Protection of newly born calves
against diarrhoea caused by
Rota, Corona viruses and E-Coli
4 ml in pregnant cow or buffalo
PACKAGE:
bottles of 20, 40 and 100ml.
IM
2 doses at least two weeks apart to
pregnant cows, the second dose
given 2-3 weeks before calving.
One year
1
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COMPOSITION:Each dose contains at least 106 TCID50 of each bovine Rota and Corona viruses and 6x1010 CFU of E - Coli k99 Pili.
VACCINATION PROGRAMME: - Two I/M doses at least two weeks apart to pregnant cows, the second dose given 2-3 weeks before calving. - Revaccination with a single third dose if cows have not calved within 40 days after
receiving their last dose.
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Inactivated Bovine Rota, Corona
Viruses and E-Coli Vaccine
Protection of newly born calves
against diarrhoea caused by
Rota, Corona viruses and E-Coli
IM
2 doses at least two weeks apart to
pregnant cows, the second dose
given 2-3 weeks before calving.
2 ml in pregnant cow or buffalo
One year
2
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Inactivated Bovine Rota, Corona
Viruses and E-Coli Vaccine
Protection of newly born calves
against diarrhoea caused by
Rota, Corona viruses and E-Coli
IM
2 ml at 160 days old
One year
3 Rota-vec Vaccine
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Vaccination programmein
dairy farms
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Vaccination programmein
dairy farms
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Cow Herd VaccinesCow Herd Vaccines
Precalving Vaccination of Cows and Precalving Vaccination of Cows and HeifersHeifers
((7 7 to to 9 9 months of pregnancy or twice a year)months of pregnancy or twice a year)
1.1. 44--way Viral BRD Vaccineway Viral BRD Vaccine
2.2. Pasteurella Bacterin & LeukotoxoidPasteurella Bacterin & Leukotoxoid
3.3. Clostridia Bacterin & LeukotoxoidClostridia Bacterin & Leukotoxoid
4.4. Scour VaccineScour Vaccine
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11--Lumpy Skin Disease Lumpy Skin Disease vaccinevaccine
First injection in FebruaryFirst injection in February
The second dose every yearThe second dose every year
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22--FMD vaccineFMD vaccine
First injection in AprileFirst injection in Aprile
The second dose after The second dose after 2 2 weeksweeks
The next vaccine every The next vaccine every 4 4 monthsmonths
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33--Rift valley vaccineRift valley vaccine
First injection in AprilFirst injection in April
The second dose in OctoberThe second dose in October
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44--Respiratory virus Respiratory virus vaccinevaccine
Calves are vaccinated at Calves are vaccinated at 60 60 days @ days @ 180 180 daysdays
All animals are vaccinated annually in All animals are vaccinated annually in septemberseptember
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55--Viral and bacterial diseases Viral and bacterial diseases causing diarrhea vaccinecausing diarrhea vaccine(Rota , corona @ E coli)(Rota , corona @ E coli)
All pregnant cows are vaccinated at All pregnant cows are vaccinated at 255 255 days of pregnancy.days of pregnancy.
The second booster dose at The second booster dose at 2 2 weeks weeks before parturitionbefore parturition
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6-Brucellosisvaccine (every vaccine (every 3 3 years)years)
First injection in JanuaryFirst injection in January
The second dose every The second dose every 3 3 yearsyears
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77--Clostredial Disease Clostredial Disease vaccinevaccine
First injection in calves at First injection in calves at 14 14 and and 42 42 days olddays old
The second dose every yearThe second dose every year
All pregnant cows are vaccinated All pregnant cows are vaccinated 2 2 weeks befor parturation .weeks befor parturation .
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8-pasteurellosisvaccine (Annually)vaccine (Annually)
All pregnant cows are All pregnant cows are vaccinated at every year (in vaccinated at every year (in April month)April month)