Usually secondary to systemic or other cardiac diseases ...
Transcript of Usually secondary to systemic or other cardiac diseases ...
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Pericardial disease
Usually secondary to systemic or other cardiac diseases
• Pericardial fluid accumulations • Pericarditis
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Pericardial Anatomy
• Two major components – visceral pericardium
mesothelial monolayer facilitate fluid and ion exchange
– parietal pericardium fibrocollagenous tissue
• Pericardial Fluid – 15 - 50 ml of clear plasma ultrafiltrate
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Pericardial Physiology
• Physiologic functions – limit cardiac dilatation – maintain normal ventricular compliance – reduce friction to cardiac movement – barrier to inflammation – limit cardiac displacement
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Pericardial effusion & hemopericardium
• Pericardial effusion: ↑ fluid due to non-inflammatory causes
- slow accumulation of 1000 ml can be accomodated - rapidly developing distension 200-300 ml causes
compression of thin walled atria, ventricles→ cardiac tamponade
• Hemopericardium: blood - rupture of myocardial infarct - rupture of dissecting aneurysm - bleeding diathesis - trauma
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Pericarditis
• Acute - serous - fibrinous - purulent - hemorrhagic
• Chronic - tubercular - chronic adhesive - chronic constrictive
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Serous pericarditis
• Serous effusion- 50-200ml, ↑ protein, high sp gravity • Causes - Viral - Rh fever - Rheumatoid arthritis - SLE • M/E: infiltration by some neutro, lymhos.
- fluid usually resorbs with resolution of underlying disease
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Fibrinous pericarditis
• Most common type, mixture of serous fluid and fibrinous exudate
• Causes - MI - Uremia - Rh fever • Clinically- friction rub • Morphology: normal transparent and glistening
pericardium is turned into a dull, opaque, “sandy” sac - cardiac surface covered by dry or moist, shaggy fibrinous exudate- bread & butter appearance
• Complete resorption or healing by organisation
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Purulent pericarditis
• Causes: pyogenic bacteria • Spread
- Contiguous spread: lungs, pleura, mediastinal lymph nodes, myocardium - Hematogenous spread: septicemia, toxins, neoplasm - Lymphatic spread - Traumatic or irradiation
• Gross: thick creamy pus coating the pericardial surfaces • M/E: dense infiltration by neutrophils • Does not resolve, heals by organisation
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Acute pericarditis – diagnostic clues
• History: sudden onset of anterior chest pain – more likely to be sharp and pleuritic – with coughing, inspiration, swallowing – worse by lying supine, relieved by sitting and leaning
forward • Physical exam: presence of rub
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Tuberculous pericarditis
• Incidence of pericarditis in patients with pulmonary TB ranges from 1-8%
• Occurs by either direct extension from an adjacent focus or by lymphatic spread
• Physical findings: fever, pericardial friction rub • TB skin test usually positive • Fluid smear for TB often negative • Pericardial biopsy more definitive: granulomas in
pericardial wall • Heal by fibrosis & calcification
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Chronic adhesive pericarditis
• Stage of organisation by fibrous adhesions • Formation of granulation tissue & neovascularisation • Adhesive mediastinopericarditis • Heart function remains normal, cardiac hypertrophy &
dilatation may occur
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Constrictive pericarditis
• Rare, dense fibrous or fibrocalcific thickening of pericardium→ heart fails to dilate during diastole, decreased cardiac output
• Results from preceding causes- tubercular, purulent, hemopericardium
• Idiopathic, radiotherapy, cardiac surgery, connective tissue disorders
• Morphology: heart encased in .5- 1cm thick & dense collagenous scar - heart size normal
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Dignostic evaluation
• Chest x-ray – usually requires > 200 ml of fluid – cannot distinguish between pericardial effusion
and cardiomegly • Echocardiography
– standard for diagnosing pericardial effusion – convenient, highly reliable, cost effective
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Tumors of Heart
• Primary tumors < Secondary tumors • Benign tumors:
myxoma, lipoma, fibroelastoma, rhabdomyoma,hemangioma
• Malignant: rhabdomyosarcoma, angiosarcoma, malignantmesothelioma
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Myxoma
• M/C primary tumor of heart (50%) • Gross: 90% occur in left atrium
- usually single, may be multiple - 1-10 cms D, polypoid, pedunculated, soft, hemorrhagic, resemble organised mural thrombus Micro: abundant mucoid intercellular stroma - low cellularity with stellate shaped cells - numerous capillary sized bld vs - lymphocytes, plasma cells and foci of hemorrhages
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Clinical effects: • Ball- valve obstruction, damage to valve leaflets • Embolization • Constitutional symptoms of fever d/t IL6 release • Part of Carneys syndrome
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Secondary tumors
• Hematogenous or lymphatic spread from lung, breast, lymphoma, leukemia, melanoma
• Direct extension from intrathoracic tumor
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Pathology of CV interventions
• Balloon angioplasty: dilation of stenosis of artery by a percutaneously inserted balloon catheter e.g percutaneous transluminal coronary angioplasty (PTCA) - Causes fracture of plaque, medial dissection, stretching of media of dissected segment
• Endovascular stents- are expandable tubes of mesh to preserve lumen patency: provide larger lumen, prevent mechanical vasospasm, dissections
• Vascular replacements- synthetic or autologous grafts that replace a segment of vessel or bypass diseased arteries
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• Coronary artery bypass graft surgery - Aorto coronary bypass: autologous grafts using reversed saphenous vein or internal mammary artery - Failure due to rethrombosis, intimal fibrous hyperplasia, atherosclerosis
• Cardiac transplantation