Usman Mast Cell and Microglial Activation -...
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 1
Dr.AnjuUsmanSingh,MD,FAAFP,ABIHM,Hom-C,FMAPS
Mast Cell and Microglial Activation
Implications for ASD
©TrueHealthMedicalCenter
Disclaimer
• Informationisforeducationalpurposesonly• Nottobetakenasspecificmedicaladvice• Allmedicaldecisionsregardinghealthissuesshouldbediscussedwithyourhealthcareprovider
• Clinicaltrialshavenotbeendoneonsometreatmentapproachesdiscussed
• Ideasandconceptsdiscussedareconsideredalternativetheoriesandnotstandardofcareyet
• Dr.UsmanSinghisMedicalDirectorofTrueHealthMedicalCenterandPureCompoundingPharmacy
• TrueHealthNaturals,Familyowned.
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 2
©TrueHealthMedicalCenter
HOPEism
It is difficult to say what is impossible, for the dream of yesterday is the hope of today and the reality of tomorrow. Robert H. Goddard
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Neuroinflammation
• Neuroinflammationiswidelyregardedaschronic.• Acuteinflammationusuallyfollowsinjurytothecentralnervoussystemimmediately,andischaracterizedbyinflammatorymolecules,endothelialcellactivation,plateletdeposition,andtissueedema.
• Chronicinflammationisthesustainedactivationofglialcells,mastcellsandrecruitmentofotherimmunecellsintothebrain.
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 3
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Causes of Neuroinflammation
• Toxic metabolites • Autoimmunity • Allergens • Aging • Microbes/Infections • Viruses • Traumatic brain injury • Spinal cord injury • Air pollution • Passive smoke • Mycotoxins • Stress
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The Unresolved Inflammatory Response aka Chronic Inflammation
• TheInnateImmuneresponseisactivated• MastCellsdegranulate• Microglialactivated• Glutamateisreleased• ExcessExcitationensues• Leadingto
• Dysautonomia• Mitochondrialdysfunction• Proteinaggregation(hyper-coaguablestate)• Oxidativestress• Abnormalneuronalconnectivity(choking)
Nicolas G. Bazan, ... Ludmila Belayev, in Basic Neurochemistry 2012
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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n engl j med 373;2
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PossibleSymptomsofMastCellActivation
• AtopicorAllergicSymptoms• Hives(urticaria),Feetingrashes,Flushing
• Angioedema• Itching• NasalCongestion• ShortnessofBreath• ChestTightness• Tachycardia• HighorLowBloodPressure
• Fatigue• MusculoskeletalPain• Nausea/Vomiting• Migraine• Difficultyconcentrating• Memoryloss• Anxiety
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 5
Various triggers cause Mast Cells to degranulate And release a variety of inflammatory cells Mast Cells cause Microglial Activation
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 6
http://www.frontiersin.org/files/Articles/112233/
Microglia release proinflammatory cells, that cause Glutamate release from neurons, Glutamate binds to the NMDA receptor, Allowing Calcium to flow into cells rapidly Excess Calcium excites the cells and causes damage to neurons
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 7
The principle excitatory receptor, the N-Methyl-D-Aspartate (NMDA) receptor, and its associated calcium (Ca2+) permeable ion channel are activated by glutamate.
©TrueHealthMedicalCenter5/15/19 Copyright by Dr. TC Theoharides
Courtesy Dr. Theoharides
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 8
Histamine,
IL-6, NGF,
NT
CRH, NGF, NT, SP
IL-6, TNF Microglia
Neuron
Mast cell
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 9
©TrueHealthMedicalCenter
“IntegrativeApproachtoMastCell/MicroglialActivation”
• DietaryInterventions• Anti-inflammatoryDiet:CF/GF/grain-free,lowglutamate,avoidexcitotoxins• Considerlowlectindiet-nightshadefreeandlegumefree• FAILSAFEDiet• Antioxidant,phytonutrient,highcarotenoiddiet
• Treatpotentialunderlyingcause!!!!!!-Toxin,Infection,Allergen*AddressMastCellActivation/MicroglialActivation*AddressGlutamateExcitation(Calciumdriven)*AddressDysautonomia/VagalNerveDysfunction• Improvecirculationandhyper-coagulation/*HBOT• CellMembraneSupport-Omega3’sEPA/DHA-highdose,PC,PS*OtherAnti-inflammatoryagents
• Spices• Foods• Herbs• EssentialOils
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ConsiderMastCellActivationwiththeseConditions
• ASD• AcuteRegressions
• SeasonalRegressions• AllergicDisorders• ReactionstoFood,Chemicals,Temperature,Stress
• Asthma• Eczema(rashes)• MultipleChemicalSensitivities• EhlersDanlosSyndrome
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 10
©TrueHealthMedicalCenter
LaboratoryWorkupImmune:InfectiousTriggers
• Bacterial-Lyme,Bartonella,Babesia,Mycoplasma/Chlamydiapneumoniae,ASOTiter,AntiDNAseBAb
• Parasitic-ToxoplasmosisAb• Fungal• ViralTiters-EBV,CMV,HHV6• VaccineTiters-MMR,VZ• OrganicAcidTest(OATS)Clostridia• StoolTest-bacteria,yeast,parasites
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LaboratoryWorkupImmune:InflammatoryMarkers
• CBC• CRP,SedimentationRate,PlateletCount• Fecalcalprotectin,lactoferrin,lysozyme• OxidativeStressMarkers
• 8OHDeoxyguanosine,LipidPeroxides,Malonodialdehyde• TotalImmunoglobulinProfile
• (totalIgE,IgM,IgA,IgAandIgGsubclasses)• TLymphocytePanel-CD4/CD8• Naturalkillercell,CD57
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 11
Work - Up Inflammation
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 12
©TrueHealthMedicalCenter
LaboratoryWorkupImmune:AutoantibodiesandAllergy
• Autoantibodytests(e.g.myelinbasicproteinantibodies,antidopamineAb,antigangliosideAb)
• OtherAutoimmuneAb-NMDA,GAD65Ab• ANA• CeliacPanel• MycotoxinPanel• IgERASTorskintestingforinhalants,food,mold
• IgGELISAtestingforfoodsensitivities
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NaturalAgentstoDecreaseMicroglialActivation
• Resveratol-neuroprotective• Pycnogenol-antioxidant• Gastrodiaelata-braininjuryneuroprotective• Piperakadsura(Japanesepepper)-PGE2inhibitor• Ganodermalucidum(ReishiMushroom)-immunemodulatory
• Epimediumbrevicornum(HornyGoatWeed)-improvesbloodflow
• Fisetin-antiaging• PQQ(pyrroloquinolinequinone)-PGE2andCOX-2inhibitor
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 13
©TrueHealthMedicalCenter
NaturalAgentstoDecreaseMicroglialActivation
• Luteolin-mastcellstabilizer• PEA(palmitylethanolamide)• Resveratol-neuroprotective• Pycnogenol-antioxidant• Gastrodiaelata-braininjuryneuroprotective• Piperakadsura(Japanesepepper)-PGE2inhibitor• Ganodermalucidum(ReishiMushroom)-immunemodulatory• Epimediumbrevicornum(HornyGoatWeed)-improvesbloodflow• Stephaniatetranda-Cachannelblocker• Fisetin-antiaging• Benfotiamine/Biotin• Vinpocetine-PDEinhibitor,Caregulation• PQQ(pyrroloquinolinequinone)-PGE2andCOX-2inhibitor
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 14
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 15
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 16
©TrueHealthMedicalCenter
Natural and Pharmaceutical Agents for Mast Cell Activation
• StingingNettles• Quercetin• Luteolin-mastcellstabilizer,antiIL-6• PEA(palmitylethanolamide)• BlackCuminSeedOil• NRF2signaler/Antioxidants:sulfuraphane,DIM,EGCG• H1blockers:diphenhydramine,chlorpheniramine,cyproheptadine,hydroxyzine
• H2blockers:ranitidine,cimetidine,famotidine• MastCellStabilizers:ketotifen,rupatadine,cromolynsodium
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 17
©TrueHealthMedicalCenter
AvoidDietaryExcitotoxins
• Caffeine• MSG• NutraSweet• Red/yellowfooddyes• Nitrites• Sulfites• Glutamates• Propionates• Benzoates• Limitintakeofphenolics(apples,grapes,bananas,strawberries,…).
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 18
©TrueHealthMedicalCenter
LimitDietaryGlutamate
• Glutamate• MonosodiumGlutamate(MSG)
• HydrolyzedProtein• ModifiedFoodStarch• NaturalFlavors• Peas,Mushrooms,Tomatoes
• ParmesanCheese• ExcessProtein
©TrueHealthMedicalCenter
GlutamateModulators
• Magnesium• P5P• Lithium• Leucine• Isoleucine • Lysine• L-Theanine• Taurine• Hypotaurine• Oxaloacetate• GABA• PQQ• Memantine/NamendaRx• Dextromethorphan/NudextaRx
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 19
©TrueHealthMedicalCenter
Glutamate Modulators
CalciumModulation- VitaminD3- VitaminK2- Vinpocetine - Stephaniatetranda
Herbs- Gingkobiloba- Silymarin- Rosemary-LemonBalm- Chamomile- SkullCap- Bacopa- Pycnogenol
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Address Dysautonomia
Down-regulateSympathetic• AdaptogenicHerbs-Ginseng,Ashwaganda,Bacopa,Tulsi• BetaBlockers-Propranolol• Alpha2adenoreceptoragonists-Clonidine,Guafacine• NMDAreceptorantagonists-Memantine,Dextromethorphan• Upregulateinhibitoryneurotransmitters-GABA,L-theanine,Taurine,Glycine
• Benfotiamine
Up-regulateParasympathetic• Acetylcholine(phosphatidylcholine,phosphatidylserine)• AcetylcholinesteraseInhibitors(galantamine,huperizineA,piracetam)
• VagusNerveStimulation(TENSunit)
AddressGutIssues-especiallySIBO• NemecheckProtocol
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 20
The Polyvagal Theory: Phylogenetic Contributions to Social Behavior
Stephen W. Porges
• Vagal regulation of heart rate and heart rate variability
• Vagal brake = modulates the visceral state
• enables the individual to rapidly engage and disengage with objects and other individuals and to promote self-soothing behaviors and calm behavioral states
• The vagal brake is obviously compromised in autism.
New conceptualization of the role of Vagus
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Polyvagal Theory Cont’d
• TheVagusisinvolvedintheregulationoftheHPAaxis.
• VagalafferentsexhibitaninhibitoryinfluenceonHPAaxisandreducecortisolsecretion.
• TheafferentVagusmediatesbehavioraldepression.
• VagusnerveandAcetylcholinehelptomediategastrointestinalinflammation.
• Lossofvagaltonetotheheartcausesincreasedsympathetictoneandreleaseofcortisol.Highcortisolcausessuppressedimmunefunction.
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 21
©TrueHealthMedicalCenter
plant compounds that have a normalizing impact on the HPA axis under times of stress, help with blood sugar regulation, anxiety, immune modulation
• PanaxGinseng• SiberianGinseng• HolyBasil• Licorice/Glycyrrhizin• Rhodiolarosea• Ashwaganda• Bacopa• GotuKola• Moringaoleifera• Schisandra
Adaptogens
http://naturehacks.com/3-common-mistakes-made-when-taking-herbal-remedies/
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 22
©TrueHealthMedicalCenter
Medicinal Herbs
• Usedtraditionallybyallculturesforhealing• Complexstructures• Numerousqualities• Multiplecomponents• Availableasdriedherb,tinctures,decoction,oils• Canbeeateninfoodsorasteas• Carefulwithdrugandvitamininteractions• Carefulwithphenolandoxalateissues• Irecommendtorotateandpulsewhenusinglongterm• Manydrugstodayareoriginallyderivedfromherbs
Role of Plant Based Therapies in ASD
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 23
©TrueHealthMedicalCenter
Licorice/Glycyrrhizin
• Preventsbreakdownofcortisoltocortisone
• Increaseshalflifeofcortisol• Selectiveestrogenreceptormodulator
• Immune• Antiviral• Isoflavinoid:antimicrobial,antifungal
• Preventulcerformation• Stimulateshealingofmucosa
©TrueHealthMedicalCenter
Holy Basil (Tulsi)
• Adaptogenicherb• Antianxiety• Bloodsugarregulation• Antibacterial,antiviral• Anti-inflammatory• Helpswithheadaches• Reducesfever• GoodsourceofVitaminK• Activecompounds:eugenol,rosmarinicacid,apigenin,myretenal,luteolin,β-sitosterol,andcarnosicacid
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Ashwaganda Withania somnifera
• Anti-inflammatory• Antitumor• Antistress
• Modulatescortisol
• Exerciseintolerance• Fatigue• Antioxidant
• Brainlipidperoxidation• Immunomodulatory
• Mobilizationandactivationofperitonealmacrophages,phagocytosis,andincreasedactivityofthelysosomalenzymes
• Hemopoetic“ScientificBasisfortheTherapeuticUseofWithaniasomnifera(Ashwagandha):AReview”Lakshmi-ChandraMishra,MD(Ayur).AltMedReview2000
©TrueHealthMedicalCenter
Buhner Herbs (anti-inflammatory)
• Polygonumcuspidatum(JapaneseKnotweed)–protectstheendotheliallining
• Scutellariabaicalensis(ChineseSkullcap)-inhibitscytokinecascade
• Salviamiltiorrhiza(RedSage/Danshen)-inhibitscytokinecascade
• ImmuneModulators• Cordyceps• Reishi• Rhodiola• Scutellariabaicalensis(ChineseSkullcap)• Unicariatomentosa(Cat’sclaw)• Eleutherococcussenticosus(SiberianGinseng)• Withaniasomnifera(Ashwaganda)
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 25
©TrueHealthMedicalCenter
Effect of Propranolol on Verbal
Problem Solving in Autism Spectrum
Neurocase:TheNeuralBasisofCognition2008,Beversdorf
• DrugsdecreasingnoradrenergicactivityarebeneficialinASD.
• Beneficialfordifficultnetworkflexibility-dependentproblems.
• Benefitsperformanceforsimpleproblems.• DecreasedflexibilityofaccesstonetworksinASD.• ASDsubjectsbenefitedfrompropranololonsimpleanagrams,whereascontrolsubjectswereimpairedbypropranolol.
©TrueHealthMedicalCenter
A Prospective, Open-Label Trial of Galantamine in Autistic Disorder
Dr. Rob Nicolson, Beth Craven-Thuss, and Judy Smith. Journal of Child and Adolescent Psychopharmacology.
October 2006, 16(5): 621-629.
• Thirteenchildrenwithautism(meanage,8.8±3.5years)participatedina12-week,open-labeltrialofgalantamine
• Results:Patientsshowedasignificantreductioninparent-ratedirritabilityandsocialwithdrawalontheABC
• SignificantimprovementsinemotionallabilityandinattentionontheConners’ParentRatingScale—Revised
• Clinicianratingsshowedreductionsintheangersubscale• Eightof13participantswereratedasrespondersonthebasisoftheirimprovementscoresontheClinicalGlobalImpressionsscale
• Overall,galantaminewaswell-tolerated,withnosignificantadverseeffectsapartfromheadachesinonepatient
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Phosphadityl Serine
• Lowerscortisol• Increasescellularmetabolism• Antioxidant• Improvesmood• Improvesmotivation• Decreasesanxiety• Improvesmemoryandcognition• Preventshippocampaldamagefromhighcortisol
©TrueHealthMedicalCenter
Phosphatidyl Serine
• Supportsthefunctionofmanyvitalenzymes.• Actsasanantioxidant,andquellsinflammationinthebrain.• InEuropeandJapan,phosphatidylserineissoldasaprescriptiondrugtotreatmemoryandlearningdysfunction.
• Agedratswithcognitivedeficitshavedemonstrateddecreasedphosphatidylserineinthehippocampus.
• Helpswithstressinduceddamageinthebrain.
• UlmannL.Brainandhippocampusfattyacidcompositioninphospholipidclassesofaged-relativecognitivedeficitrats.ProstaglandinsLeukotEssentFattyAcids.2001Mar;64(3):189-95.
• LomnitskiL.DistinctalterationsinphospholipidmetabolisminbrainsofapolipoproteinE-deficientmice.JNeurosciRes.1999Nov15;58(4):586-92.
• SuzukiS.Oraladministrationofsoybeanlecithintransphosphatidylatedphosphatidylserineimprovesmemoryimpairmentinagedrats.JNutr.2001Nov;131(11):2951-6.
• CastilhoJC.Phosphatidylserine:anantidepressiveoracognitiveenhancer?ProgNeuropsychopharmacolBiolPsychiatry.2004Jul;28(4):731-8.
• PepeuG.Nootropicdrugsandbraincholinergicmechanisms.ProgNeuropsychopharmacolBiolPsychiatry.1989;13SupplS77-S88.
• SchreiberS.Anopentrialofplant-sourcederivedphosphatydilserinefortreatmentofage-relatedcognitivedecline.IsrJPsychiatryRelatSci.2000;37(4):302-7.
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Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Hyperbaric Oxygen Reduces Neuroinflammation
©TrueHealthMedicalCenter
HBOT Decreases Neuroinflammation in Rat Model of TBI
(2.8 ATA, 2 sessions for 45 min each)
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Stress and the Autonomic Nervous System
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©TrueHealthMedicalCenter
Hyperbaric treatment for children with autism: a multicenter randomized, double blind, controlled
trial
BMCPediatr.2009RossignolDA,RossignolLW,SmithS,SchneiderC,LogerquistS,UsmanA,NeubranderJ,MadrenEM,HintzG,GrushkinB,MumperEA.
Childrenwithautismwhoreceivedhyperbarictreatmentat1.3atmand24%oxygenfor40hourlysessionshadsignificantimprovementsinoverallfunctioning,receptivelanguage,socialinteraction,eyecontact,andsensory/cognitiveawarenesscomparedtochildrenwhoreceivedslightlypressurizedroomair.PMID:19284641
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Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Anti-inflammatory Herbs, Spices and Foods
DecreaseIL-6• Allspice• Apple• Basil• Bayleaves• Blackpepper• Caraway• Chilipepper• Cinnamon• Clove• Ginger• Holybasil• Licorice• Nutmeg• Paprika• Sage• Oregano• Rooibostea• Thyme
DecreaseTNF-alpha• Billberry• Caraway• ChiliPepper• Licorice• Nutmeg• Oregano• Sage• Thyme• Bayleaf• Cinnamon• BlackPepper
Increase IL-10
• Allspice• Basil• Cardomom• ChiliPepper• Ginseng• Marjoram• Oregano• Paprika• Pomegranate
Decrease COX-2
• BayLeaf• Nutmeg• BlackPepper• Basil• Thyme• Apple• Clove• Anise
Decrease iNOS
• Licorice• Sage• Fenugreek• Oregano
©TrueHealthMedicalCenter
Common Anti-inflammatory Herbs
Curcumin-Turmeric• COX-2inhibitor,anti-prostaglandin• Similartoibuprofen• Antimicrobial• Breaksdownbiofilms• Preventsbloodclots• Helpsjointpain• NRF2stimulator• Poororalabsorption• InhibitsCOMTandMAOagenes
Boswellia–Indianfrankincense• 5-LOX(lipoxygenaseinhibitor)• TNFalphainhibitor• Antibacterial• Helpswithjointpain• Improvesspatialmemory
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Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Other Anti-inflammatory Herbs
• Cat’sclaw/Samento(Unicariatomentosa)• NaturalCalciumChannelBlocker• Antiviral,Antibacterial• Immunemodulator• ProtectsDNAfromdamage
• MilkThistle(Silymarin)• IncreasesSODandincreasesglutathioneproduction• Protectsliverandkidney
• Ginger• InhibitsNO,COX-2,andPGE2• Helpswithnausea
www.2bucketscleaning.com/2017/12/5-useful-essential-oils/
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Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Essential Oils
• Usegoesbacktoancientcivilizations2000BC• Usedbyallcultures,traditionallyasperfumes,cosmeticsandformedicinalproperties
• Volatilearomaticcompounds• Changestatequicklyfromliquidtogasatroomtemperature
• Lipophilic,fatsolublecompounds,canpenetratetissueandcells
• Potent,maycauseirritationtoskinandmucosa• Extractedfromfruits,plants,herbs,flowers,stems,leaf,seed,rootorbarkbysteamdistillation
EgyptianMedicinalEssentialOilFormulas
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Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Using Essential Oils Safely
• Topical-Maybeappliedinsmallquantitieswithacarrieroil• AccupuncturePoints• ReflexologyPoints• Massage• Triggerpoints• Carefulwithcitrusoils,maycausephotosensitivity
• Aromatic-Maybeinhaled,diffusedornebulized• Internal-Someoilscanbeconsumed(teas,water)andusedincooking
• Lessismore• Rotatevariousoils• Avoidprolongeduseofthesameoil• Readlabelsregardinguse
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Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
NeuroprotectiveOils
• CholinesteraseInhibitors• Polygonumhydropiper–Marshpepperknotweed• Rumexhastatus-Arrowleafdock• Narcissuspoeticus-Daffodil• Salvialevifolia-sagefamily• Marlierearacemose-BidiLeafTree• Cistusfamily-RockRose
• SustainedAttention• Eucalyptusglobulus• Lavandulaaugustifolia• Rosemarinusofficinalis• Methapeperita• Jasmine
©TrueHealthMedicalCenter
AntioxidantOils
• Lavender–increaseGSH• Thyme• Coriander-increaseGSHinhippocampus• Clove• Eucalyptus• Cinnamon• Juniper• Basil–anticonvulsant,helpswithsleep• Chamomile• Cumin• Coriander• Thyme• Oregano• CommonYarrow• Salviamulticaulis
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Stress and the Autonomic Nervous System
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Antimicrobial,AntioxidantandAnti-InflammatoryActivityofEssentialOils
• EucalyptusOil• LemongrassOil• ThymeOil• LinderniaOil• GeraniumOil• TeaTreeOil
• Antimicrobial• E.Coli-All• Staphylococcus-All• GramNegbacteria-notgeranium• Candida-lemongrass,thyme,lindernia• Pseudomonas-none
• DecreasedTNF-alpha–notgeranium• DecreasedLOX-5• DecreasedIL-1Beta• DecreasedIL-8• DecreasedNO• Lemongrassmostpotentantimicrobial• Thymemostpotentantioxidant
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Bitters/HOPS in Beer Have an Anti-inflammatory Effect in Alzheimer’s Mice
©TrueHealthMedicalCenter
Consider incorporating more herbs and oils in your daily routine
drinking, eating, sleeping, bathing…
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Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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• ©TrueHealthMedicalCenter
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