[Insert Name of presenter][Insert Name of hospital]

Using antibiotics prudently

- Hospital Prescriber Presentation

Contents of this presentation

• Antibiotic resistance – a patient safety issue– Situation in Ireland

– Drivers of antibiotic resistance

– Consequences of antibiotic resistance

• Why inappropriate use of antibiotics contributes to antibiotic resistance – the “why”

• How prudent use of antibiotics can be promoted in hospitals – the “how”

• European Antibiotic Awareness Day – a campaign to promote prudent use of antibiotics

2

Antibiotic resistance – a patient safety issue

3

Antibiotic resistance – a problem in the present and the future

• Antibiotic resistance is an increasingly serious public health problem: resistant bacteria have become an everyday concern in Irish hospitals.

4Trends in antibiotic resistance (invasive infections) in Ireland, 2002-2009. Source: European Antimicrobial Resistance Surveillance System (EARSS) and Health Protection Surveillance Centre (HPSC).

0

10

20

30

40

2002 2003 2004 2005 2006 2007 2008 2009

Pro

port

ion

of r

esis

tant

isol

ates

(%

)

Penicillin-non susceptible S. pneumoniae Erythromycin-resistant S. pneumoniae

Fluoroquinolone-resistant E. coli Third-gen. cephalosporin-resistant E. coli

Vancomycin-resistant E. faecium (VRE)

2002 2007

Meticillin-resistant Staphylococcus aureus (MRSA) bloodstream infections in Europe

No data

<1%

1-5%

5-10%

10-25%

25-50%

>50%

Source: European Antimicrobial Resistance Surveillance System (EARSS), 2008.

5

S. aureus/MRSA bacteraemia trends by quarter, 2002-2010Q2*

* Data for 2010 provisional up to the end of Q2;Number of laboratories participating by year-end indicated above the Q4 bars

20%

25%

30%

35%

40%

45%

50%

55%

0

50

100

150

200

250

300

350

400

450

Q1

2002

Q2

2002

Q3

2002

Q4

2002

Q1

2003

Q2

2003

Q3

2003

Q4

2003

Q1

2004

Q2

2004

Q3

2004

Q4

2004

Q1

2005

Q2

2005

Q3

2005

Q4

2005

Q1

2006

Q2

2006

Q3

2006

Q4

2006

Q1

2007

Q2

2007

Q3

2007

Q4

2007

Q1

2008

Q2

2008

Q3

2008

Q4

2008

Q1

2009

Q2

2009

Q3

2009

Q4

2009

Q1

2010

Q2

2010

%M

RSA

Num

ber o

f iso

late

s

QuarterTotal S.aureus MRSA %MRSA

23 28 41 42 42 44 43 43

MRSA in Europe, 2007: often high, but decreasing in many countries

Country with a significant increase (2005–2007)

Country with a significant decrease (2005–2007)

MRSA (%)

Source: EARSS & ECDC, 2009

No.

of

coun

trie

s

7

Ireland

Antimicrobial resistance in gram-negative bacteria, EU, 2007: already high or increasing

Country with a significant increase (2005-2007) Country with a significant decrease (2005-2007)

Carbapenem-resistant Pseudomonas aeruginosa (%)

3rd-gen. ceph.-resistant Klebsiella pneumoniae (%)3rd-gen. ceph.-resistant Escherichia coli (%)

Source: EARSS & ECDC, 2009

No.

of c

ount

ries

No.

of c

ount

ries

8

Source: European Surveillance of Antimicrobial Consumption (ESAC), 2010. In: ECDC Annual Epidemiological Report 2010: in press.

Total outpatient antibiotic use in EU Member States, Iceland and Norway, 2008

9

* Total use, i.e. including inpatients (CY, GR, LT).** Reimbursement data, i.e. not including over-the-counter sales without a prescription (ES)*** Data from 2007 (MT)

Antibiotic consumption in acute hospitals in Ireland: 2007 to Q2 2010

0

10

20

30

40

50

60

70

80

9020

07Q1

2007

Q2

2007

Q3

2007

Q4

2008

Q1

2008

Q2

2008

Q3

2008

Q4

2009

Q1

2009

Q2

2009

Q3

2009

Q4

2010

Q1

2010

Q2

Antib

iotic

Usa

ge R

ate

(DDD

/100

BDU)

General Regional/Tertiary Specialist

Data source: HPSC

Fluoroquinolone consumption in acute hospitals in Ireland: 2007 to Q2 2010

11

0

2

4

6

8

10

12

2007

Q1

2007

Q2

2007

Q3

2007

Q4

2008

Q1

2008

Q2

2008

Q3

2008

Q4

2009

Q1

2009

Q2

2009

Q3

2009

Q4

2010

Q1

2010

Q2

Antib

iotic

Usa

ge R

ate

(DDD

/100

BDU)

General Regional/Tertiary Specialist

Data source: HPSC

Hospital antibiotic prevalence survey, 2009: prevalence of antibiotic use

Hospital antibiotic prevalence survey, 2009: indications for antibiotic use

13

Hospital antibiotic prevalence survey, 2009: duration of peri-operative prophylaxis

14

Antibiotic use at (insert hospital name)

Insert individual hospital antibiotic consumption data, available from hospital pharmacist or from Ajay Oza at HPSC

Antibiotic resistance – A patient safety issue for all hospitals

• The emergence, selection and spread of resistant bacteria in hospitals is a major patient safety issue. – Infections with antibiotic-resistant bacteria can result in

increased patient morbidity and mortality, as well as increased hospital length of stay.1-2

– Antibiotic resistance frequently leads to a delay in appropriate antibiotic therapy.3

– Inappropriate or delayed antibiotic therapy in patients with severe infections is associated with worse patient outcomes and sometimes death.4-6

16

1. Cosgrove SE, Carmeli Y. The impact of antimicrobial resistance on health and economic outcomes. Clin Infect Dis. 2003 Jun 1;36(11):1433-7. 2. Roberts RR, Hota B, Ahmad I, Scott RD, 2nd, Foster SD, Abbasi F, et al. Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship. Clin Infect Dis. 2009 Oct 15;49(8):1175-84. 3. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999 Feb;115(2):462-74. 4. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000 Jul;118(1):146-55. 5. Lodise TP, McKinnon PS, Swiderski L, Rybak MJ. Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia. Clin Infect Dis. 2003 Jun 1;36(11):1418-23. 6. Alvarez-Lerma F. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. ICU-Acquired neumonia Study Group. Intensive Care Med. 1996 May;22(5):387-94.

Antibiotic resistance – a daily occurrence in our hospital

• In our [country / hospital] the most frequent resistant infections are the following [insert appropriate data where available].

• These infections have resulted in [insert data on additional days of hospitalisation, morbidity, mortality, and costs where available].

17

Why inappropriate use of antibiotics contributes to antibiotic resistance

– the “why”

18

In-patients are at high risk of antibiotic-resistant infections

• Misuse of antibiotics in hospitals is one of the main factors that drive development of antibiotic resistance.7-9

• Patients in hospitals have a high probability of receiving an antibiotic10 and 50% of all antibiotic use in hospitals can be inappropriate.11-12

• In a 2009 prevalence survey of antibiotic use in Irish hospitals:

– 34% of patients were receiving antibiotics on the day of the survey

– 42% of antibiotic use did not follow evidence-based guidelines

19

7. Singh N, Yu VL. Rational empiric antibiotic prescription in the ICU. Chest. 2000 May;117(5):1496-9. 8. Lesch CA, Itokazu GS, Danziger LH, Weinstein RA. Multi-hospital analysis of antimicrobial usage and resistance trends. Diagn Microbiol Infect Dis. 2001 Nov;41(3):149-54. 9. Lepper PM, Grusa E, Reichl H, Hogel J, Trautmann M. Consumption of imipenem correlates with beta-lactam resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2002 Sep;46(9):2920-5. 10. Ansari F, Erntell M, Goossens H, Davey P. The European surveillance of antimicrobial consumption (ESAC) point-prevalence survey of antibacterial use in 20 European hospitals in 2006. Clin Infect Dis. 2009 Nov 15;49(10):1496-504.11. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD003543. 12. Willemsen I, Groenhuijzen A, Bogaers D, Stuurman A, van Keulen P, Kluytmans J. Appropriateness of antimicrobial therapy measured by repeated prevalence surveys. Antimicrob Agents Chemother. 2007 Mar;51(3):864-7.

Misuse of antibiotics drives antibiotic resistance

• Studies prove that misuse of antibiotics may cause patients to become colonised or infected with antibiotic-resistant bacteria, such as;

– Meticillin-resistant Staphylococcus aureus (MRSA)

– Vancomycin-resistant enterococci (VRE)

– Highly-resistant Gram-negative bacilli 13-14 E.g. E. coli, Klebsiella sp., Pseudomonas sp.

• Misuse of antibiotics is also associated with an increased incidence of Clostridium difficile infections.15-17

20

13. Safdar N, Maki DG. The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med. 2002 Jun 4;136(11):834-44.14. Tacconelli E, De Angelis G, Cataldo MA, Mantengoli E, Spanu T, Pan A, et al. Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study. Antimicrob Agents Chemother. 2009 Oct;53(10):4264-9.15. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 15. 2005(4):CD003543.16. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706.17. Fowler S, Webber A, Cooper BS, Phimister A, Price K, Carter Y, et al. Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series. J Antimicrob Chemother. 2007 May;59(5):990-5.

What is misuse of antibiotics?

21

Misuse of antibiotics can include any of the following18:

• When antibiotics are prescribed unnecessarily; • When antibiotic administration is delayed in critically ill

patients; • When broad-spectrum antibiotics are used too

generously, or when narrow-spectrum antibiotics are used incorrectly;

• When the dose of antibiotics is lower or higher than appropriate for the specific patient;

• When the duration of antibiotic treatment is too short or too long;

• When antibiotic treatment is not streamlined according to microbiological culture data results.

18. Gyssens IC, van den Broek PJ, Kullberg BJ, Hekster Y, van der Meer JW. Optimizing antimicrobial therapy. A method for antimicrobial drug use evaluation. J Antimicrob Chemother. 1992 Nov;30(5):724-7.

Benefits of prudent use of antibiotics

• Prudent use of antibiotics can prevent the emergence and selection of antibiotic-resistant bacteria.19-23

• Decreasing antibiotic use have also been shown to result in lower incidence of Clostridium difficile infections.24-26

Rates of Vancomycin-resistant Enterococci in hospital before and after implementation of the antibiotic management program compared with rates in National Nosocomial Infections Surveillance (NNIS) System* hospitals of similar size.27

*NNIS is now the National Healthcare Safety Network (NHSN).

Rates of nosocomial Clostridium difficile, expressed per 1,000 patient-days, before and after implementation of the antibiotic management program.28

22

19, 24. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD003543.20. Lepper PM, Grusa E, Reichl H, Hogel J, Trautmann M. Consumption of imipenem correlates with beta-lactam resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2002 Sep;46(9):2920-5. 21, 25, 27, 28. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706. 22. Bradley SJ, Wilson AL, Allen MC, Sher HA, Goldstone AH, Scott GM. The control of hyperendemic glycopeptide-resistant Enterococcus spp. on a haematology unit by changing antibiotic usage. J Antimicrob Chemother. 23. De Man P, Verhoeven BAN, Verbrugh HA, Vos MC, Van Den Anker JN. An antibiotic policy to prevent emergence of resistant bacilli. Lancet. 2000;355(9208):973-8. 26. Byl B, Clevenbergh P, Jacobs F, Struelens MJ, Zech F, Kentos A, et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia. Clin Infect Dis. 1999 Jul;29(1):60-6; discussion 7-8.

How prudent use of antibiotics can be promoted in hospitals

– the “how”

23

Multifaceted strategies can address and decrease antibiotic resistance in hospitals

• Antibiotic prescribing practices and decreasing antibiotic resistance can be addressed through multifaceted strategies including:29-31

– Use of ongoing education

– Use of evidence-based hospital antibiotic guidelines and policies

– Restrictive measures and consultations from microbiologists, infectious disease physicians and pharmacists

24

29. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD003543.30. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706.31. Byl B, Clevenbergh P, Jacobs F, Struelens MJ, Zech F, Kentos A, et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia. Clin Infect Dis. 1999 Jul;29(1):60-6; discussion 7-8.

Measures that can decrease antibiotic resistance

25

Measures that guide antibiotic prescribing are likely to decrease antibiotic resistance in hospitals.32-34 Such measures include:

Obtaining culturesTake appropriate and early cultures before initiating empiric antibiotic therapy, and streamline antibiotic treatment based on the culture results35

Monitoring local antibiotic resistance patternsBeing aware of local antibiotic resistance patterns (antibiograms) enables appropriate selection of initial empiric antibiotic therapy36

Consulting specialistsInvolve infectious disease physicians, microbiologists and pharmacists in your decisions about antibiotic therapy during your patient’s stay37-39

32, 37. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD00354333, 38. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706.34, 39. Byl B, Clevenbergh P, Jacobs F, Struelens MJ, Zech F, Kentos A, et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia. Clin Infect Dis. 1999 Jul;29(1):60-6; discussion 7-8.35. Rello J, Gallego M, Mariscal D, Sonora R, Valles J. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med. 1997 Jul;156(1):196-200.36. Beardsley JR, Williamson JC, Johnson JW, Ohl CA, Karchmer TB, Bowton DL. Using local microbiologic data to develop institution-specific guidelines for the treatment of hospital-acquired pneumonia. Chest. 2006 Sep;130(3):787-93.

Our hospital tools for prudent antibiotic prescribing

• [Hospital antibiogram if available]

• [Hospital guidelines if available]

• [Antibiotic stewardship committee if it exists]

• [Names of infectious diseases / antibiotic experts]

26

Antibiotics – handle with care

• Misuse of antibiotics leads to resistance40-42

• All hospital practitioners can play an active role in reversing the trend of antibiotic-resistant bacteria:– Take cultures before starting antibiotic therapy43

– Consult the hospital antibiotic expert44-46, [local antibiogram, and hospital antibiotic guidelines]

– Streamline antibiotic therapy based on culture results47

27

40. Singh N, Yu VL. Rational empiric antibiotic prescription in the ICU. Chest. 2000 May;117(5):1496-9.41. Lesch CA, Itokazu GS, Danziger LH, Weinstein RA. Multi-hospital analysis of antimicrobial usage and resistance trends. Diagn Microbiol Infect Dis. 2001 Nov;41(3):149-54.42. Lepper PM, Grusa E, Reichl H, Hogel J, Trautmann M. Consumption of imipenem correlates with beta-lactam resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2002 Sep;46(9):2920-5.43, 47. Rello J, Gallego M, Mariscal D, Sonora R, Valles J. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med. 1997 Jul;156(1):196-200.44. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD00354345. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706.47.Byl B, Clevenbergh P, Jacobs F, Struelens MJ, Zech F, Kentos A, et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia. Clin Infect Dis. 1999 Jul;29(1):60-6; discussion 7-8.

European Antibiotic Awareness Day – a campaign to promote prudent use of

antibiotics

28

About European Antibiotic Awareness Day

• European Antibiotic Awareness Day is marked across Europe around 18 November.

• European Antibiotic Awareness Day provides a platform and support to national campaigns about prudent antibiotic use in the community and in hospitals.

29

European Antibiotics Awareness Day:Planned local activities

• [Insert planned local activities, highlighting where involvement by the audience of this presentation would be welcome]

30

THANK YOU!

• For more information on data sources and references, please visit:– http://antibiotic.ecdc.europa.eu

– www.hpsc.ie

31

32