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![Page 1: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/1.jpg)
Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation
C Allerød1,2, DS Karbing1, P Thorgaard2, S Andreassen1, S Kjærgaard2, SE Rees1
1: Center for Model-based Medical Decision Support, Aalborg University, Denmark2: Anaesthesia and Intensive Care, Region North Jutland, Aalborg Hospital, Aarhus University, Denmark
![Page 2: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/2.jpg)
Introduction
• Several RCTs indicate that low tidal volumes are beneficial in mechanically ventilated patients
• Large variability in ventilator settings are still seen in the ICU
• But how well do physicians agree when presented to identical patients?
The ARDS Network. N Engl J Med 2000; 342:1301-8.
Young et al. Crit Care Med 2004; 32:1260-5.Esteban et al. Am J respir Crit Care Med 2008; 177:170-7
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Using INVENT for quantifying preferences
• INVENT: Model-based decision support system for mechanical ventilation– Advice on FiO2, Vt and f.
J Clin Monit Comput 2006; 20:421-9.J Crit Care 2010; 25:367-74.
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Research questions
• What is the variability in physicians’ preferences in the same patient?
• What are physicians’ opinion about other physicians’ advice?
• What are the physicians’ opinion about INVENT’s advice?
![Page 5: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/5.jpg)
Methods• Included 10 senior ICU physicians, representing the 4
Danish University Hospitals
• 10 real patient cases, presented in random order– Reflecting range of respiratory, circulatory and metabolic status in
patients with ALI/ARDS
• Asked to set FiO2, Vt and f– Assuming correct PEEP and I:E ratio, 70 kg body weight and that
model simulations were correct
• Evaluated and ranked other physicians’, and INVENT’s advice (blinded, and in random case order)
![Page 6: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/6.jpg)
Results
• What is the variability in physicians’ preferences in the same patient? Example: Vt
![Page 7: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/7.jpg)
Variability in physicians’ preferences
6 ml/kg
8 ml/kg
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Variability in physicians’ preferences
6 ml/kg
8 ml/kg
![Page 9: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/9.jpg)
Results
• What is the variability in physicians’ preferences in the same patient? Example: Vt
• What are physicians’ opinion about other physicians’ advice?
![Page 10: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/10.jpg)
Opinion’s about other physicians’ advice
Classification Average (range)
Good 21.2 % (9.9% – 26.0%)
Acceptable 45.5 % (36.4% – 56.8 %)
Unacceptable 33.3 % (25.4% – 39.9 %)
![Page 11: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/11.jpg)
Opinion’s about other physicians’ advice
Classification Average (range)
Good 21.2 % (9.9% – 26.0%)
Acceptable 45.5 % (36.4% – 56.8 %)
Unacceptable 33.3 % (25.4% – 39.9 %)
Rank Best Worst
Average 5.0 7.1
Range 2-10 2-10
![Page 12: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/12.jpg)
Results
• What is the variability in physicians’ preferences in the same patient? Example: Vt
• What are physicians’ opinion about other physicians’ advice?
• What are the physicians’ opinion about INVENT’s advice?
![Page 13: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/13.jpg)
Opinion about INVENT’s advice
Classification Average (range) INVENT
Good 21.2 % (9.9% – 26.0%) 26.0 %
Acceptable 45.5 % (36.4% – 56.8 %) 41.0 %
Unacceptable 33.3 % (25.4% – 39.9 %) 34.0 %
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Opinion about INVENT’s advice
Classification Average (range) INVENT
Good 21.2 % (9.9% – 26.0%) 26.0 %
Acceptable 45.5 % (36.4% – 56.8 %) 41.0 %
Unacceptable 33.3 % (25.4% – 39.9 %) 34.0 %
Rank Best Worst INVENT
Average 5.0 7.1 5.3
Range 2-10 2-10 3-10
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Conclusions
• Physiological models may be a beneficial tool for quantifying clinical preferences– Separate variation in preference from variation in patient
pathophysiology
![Page 16: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/16.jpg)
Conclusions
• Physiological models may be a beneficial tool for quantifying clinical preferences– Separate variation in preference from variation in patient
pathophysiology
• Large variability found in physicians’ preferences towards appropriate levels of Vt, FiO2, f, PIP, SaO2 and pH
![Page 17: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/17.jpg)
Conclusions
• Physiological models may be a beneficial tool for quantifying clinical preferences– Separate variation in preference from variation in patient
pathophysiology
• Large variability found in physicians’ preferences towards appropriate levels of Vt, FiO2, f, PIP, SaO2 and pH
• When a physician’s advice was evaluated by other physicians, a third were found unacceptable
![Page 18: Use of the INVENT system for standardized quantification of clinical preferences towards mechanical ventilation C Allerød 1,2, DS Karbing 1, P Thorgaard.](https://reader036.fdocuments.us/reader036/viewer/2022062315/5697bfd01a28abf838caa97b/html5/thumbnails/18.jpg)
Conclusions• Physiological models may be a beneficial tool for quantifying
clinical preferences– Separate variation in preference from variation in patient
pathophysiology
• Large variability found in physicians’ preferences towards appropriate levels of Vt, FiO2, f, PIP, SaO2 and pH
• When a physician’s advice was evaluated by other physicians, a third were found unacceptable
• INVENT ranked third best, evaluated similar to physicians– Prospective testing is necessary
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Thank you.