USE OF PLATELET RICH PLASMA IN AESTHETIC SURGERY
-
Upload
drkarthik777 -
Category
Education
-
view
262 -
download
5
Transcript of USE OF PLATELET RICH PLASMA IN AESTHETIC SURGERY
USE OF PLATELET RICH PLASMA
IN AESTHETIC SURGERY
DR.R.KARTHIK,
Cosmetic Surgeon,
Chennai Plast ic Surgery
• Platelets are living but terminal cytoplasmic portions of
marrow megakaryocytes
• They have no nucleus but have alpha granules which
release growth factors
INTRODUCTION
CoagulationTissue
Healing
PLATELET RICH PLASMA BIOLOGY
PLATELET DERIVED GROWTH FACTORS
Initiates connective tissue healing.
Increases mitogenesis, angiogenesis and macrophage activation
Differentiation of fibroblasts
VASCULAR ENDOTHELIAL GROWTH FACTOR
Possess potent angiogenic properties
Enhances vascular permeability
EPIDERMAL GROWTH FACTOR
Induces epithelial development
Promotes angiogenesis
TRANSFORMING GROWTH FACTOR BETA
Increases chemotaxis and mitogenesis.
Stimulates deposition of collagen
INSULIN LIKE GROWTH FACTOR
EPIDERMAL GROWTH FACTORS
Induces epithelial development
Promotes angiogenesis
PLATELET RICH PLASMA
Normal count : 2 X 105 / µL PRP : 2 million / µL
To be considered PRP, must be 4X or greater above
baseline levels
Increasing the concentration of bioactive proteins acts as
a catalyst for accelerating the wound healing process
• Early technique of isolation was
difficult because of equipment size,
cost, need for perfusionist & large
volume of blood
• The new technique is easy with the
help of AUTOMATED DUAL SPIN
PROCESS MACHINE
HARVEST SmartPREP®2
ISOLATION OF PRP
ISOLATION OF PRP
HARVEST SmartPReP2 SYSTEM
Automated Multibiologic Platform System
(15 mins. processing)
Unsurpassed AutologousBiologic Concentrate
20 – 60 cc of blood withdrawn & placed in atube containing citrate phosphate dextrose asan anticoagulant
APPLICATIONS OF PRP
SKIN REJUVENATION
Fine wrinkles around the eyes
Nasolabial grooves
Wrinkles on the lips
Acne marks
Wrinkles on the forehead & neck
Bags and dark circles under the eyes
Loose, saggy skin
HAIR RESTORATION
FAT FILLS
PRP IN FAT FILLS
• Stimulates mesenchymal stem cells found in fat deposits
(PDGF)
• Increases the adhesion of cells (PDGF)
• Increases Revascularization (PDAF)
• Stimulates Active fibroblast & collagen matrix formation
(PFGF)
• Act as stable scaffolding
ACTION OF PRP
• Increases the graft uptake
• Increases survival rate & longevity of graft
• Decreases the liponecrosis
• Decreases Lipid cyst formation
• Decreases micro calcification especially in large volume
augmentation (breast & buttocks)
ADVANTAGES
Pre - op 1 week post - op