Urine Matters: CADTH Rapid Response
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Transcript of Urine Matters: CADTH Rapid Response
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Urine MattersCADTH Rapid Response
EVIDENCE FOR POLICY AND CLINICAL DECISIONS
Presented at:Urine Matters: UTI Care Pathways for Enhanced Collaboration & Antibiotic Safety in Seniors
Charlottetown, PEI
February 10, 2015
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“ Industry/manufacturer
information is saying…”
What evidence do I need?
Where did I get this evidence?
What’s the quality of the
evidence?
How does it compare to
alternatives?
Can it be used safely and
effectively in all settings?
Do the results make practical
sense in my (local) setting?
Can we actually afford this?
Who is this benefitting – me or
my patient? The hospital? All?
Is it safe, ethical, & Health
Canada approved?
“This new policy needs
some clarification…”
“My clinical service is
thinking about buying this...”
“A colleague and I differ on
choice of treatment…”
“I have a really good idea
for a new provincial
protocol…”
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What is a health technology?
• Pharmaceuticals (drugs, blood products, vaccines)
• Diagnostics
• Medical, dental, surgical devices and procedures
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Health Technology Assessment
• Systematic evaluation of the evidence on the properties,
effects, and/or impacts of health care technology
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Role of HTA
Reliable and timely delivery of (synthesized and
appraised) evidence
• Is it safe?
• For whom does it work and when?
• Is it better than what we already have/do?
• Does it provide value for money?
• Can we afford it? Can we afford not to?
• What’s the trade-off?
• What else needs to be considered?
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Sustainability
Improved clinical
outcomes
Finding the Right Balance
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Why use HTA Evidence in Policy and
Clinical Decision-Making?
• Rigorous
• Balanced
• Relevant
• Synthesis of large volume of research
• Freely available
• Positive experience of decision-makers who have used HTA
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How to use HTA Evidence in
Decision-Making
• HTA provides the EVIDENCE piece to the decision-making
puzzle.
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But…
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“HTA reports take too long to
develop, delaying important
policy decisions impacting
patient care.”
Health Technology Assessment Task Group
Health technology strategy 1.0
Federal/Provincial/Territorial Advisory
Committee on Information and EmergingTechnologies
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What is CADTH’s Rapid Response
Service?
• Constant, rapid, and often expensive advances in health
technologies make evidence-based information essential in
healthcare decision-making.
• While comprehensive assessments are used to support
many important deliberations, the urgency of some
decisions requires a more immediate response.
• To support these time-sensitive decisions, CADTH launched
its Health Technology Inquiry Service in February of 2005.
This service is now known as CADTH’s Rapid Response
Service.
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Rapid Response – How it Works
• Rapid Response topics are requested by CADTH
customers which avoids lengthy and labour intensive
prioritization processes
• To facilitate these requests, CADTH Liaison Officers in the
provinces and territories can work with the requestors.
• Requests are acknowledged within 24 hours, and if they fall
within the scope of CADTH’s work, the process begins.
• A call with the requestor will take place to further refine the
issue, research questions are developed, and timelines are
set.
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Rapid Response – How it Works
• Modifying standard HTA review techniques to
accommodate accelerated evidence synthesis including:
• using a single-author approach
• limiting the literature search to studies published within
the last five years
• limiting the journals and grey literature that are searched
• Formal meta-analyses of the data are not performed, but
rather the findings from the literature are summarized in
narrative form and the studies critically appraised.
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CADTH Rapid Response Service
• > 60% of requests are for non-drug technologies: medical
devices, procedures, tests, interventions
Types of Reports:
• Reference list (~ 1 week)
• Summary of abstracts (~ 2 weeks)
• Summary with critical appraisal (~ 4-6 weeks)
• Systematic review (~ 4-5 months)
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CADTH’s Rapid Response Service
• Rapid Responses are always tailored to meet the needs
and timelines of the requestor and are subject to the quality
and quantity of the published literature.
• Turn-around times depend on you! When do you need the
evidence? How much appraisal or assistance do you need
for that evidence?
• Requestor information is confidential.
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61
64
57
62
39
36
43
36 2
Submission Process
Overall Service
Timeliness of Delivery
Quality of the Report
Percent Respondent Level of Satisfaction
CADTH Rapid Response Customer Satisfaction
Very Satisfied Satisfied Dissatisfied Very Disastisfied
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• To search our Rapid Response Database for completed
reports:
www.cadth.ca/RapidResponse
• To Request a New Rapid Response contact your local
Liaison Officer:
www.cadth.ca/en/services/liaison-officer
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AnExample
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“Management of Diabetes in the Long-Term Care Population:
A Review of Guidelines” (December 2013)
www.cadth.ca/media/pdf/htis/dec-
2013/RC0500_RR_RiB_Diabetes_in_LTC_population_e.pdf
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Using the Evidence in LTC Settings
Bottom line:
• Establish a policy for screening for diabetes
• Laboratory tests should be performed when diabetes is
suspected
• Test glucose levels (fasting or A1C) every three to six months
• Individualize frequency of the blood glucose monitoring
• Comprehensive monitoring is not appropriate in LTC settings.
Note that these guidelines are for all patients in long-term care
facilities, not necessarily those who are frail and elderly
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Rapid Response – For Urine Matters
Urine Testing in Long-Term Care: Guidelines
http://www.cadth.ca/media/pdf/htis/dec-
2014/RB0760%20Urine%20Testing%20LTC%20Final.pdf
• Summary of abstracts
• Looked for evidence-based guidelines for ordering of urine
C&S, dipstick, urinalysis, proper collection, and
interpretation in LTC
• NO GUIDELINES IDENTIFIED
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Rapid Response – For Urine Matters
Urine Testing in Long-Term Care: Clinical and Cost
Effectiveness
http://www.cadth.ca/media/pdf/htis/jan-
2015/RB0764%20Urine%20Testing%20Utility%20Final.pdf
• Summary of abstracts
• Looked for clinical and cost-effectiveness of urine C&S,
dipstick, and urinalysis in LTC
• 3 non-randomized studies identified
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Rapid Response – For Urine Matters
Urine Testing in Long-Term Care: Clinical and Cost
Effectiveness (con’t)
• 1st: compared dipstick to urinalysis for early UTI detection in
LTC – positive dipsticks alone not predictive of UTI
• 2nd: compared dipstick with culture – negative dipsticks to
rule out UTI (88% NPV)
• 3rd: clinical features to identify UTI in LTC (no catheter) –
painful urination, change in urine, and change in mental
status significantly associated with UTI
• No cost-effectiveness evidence found
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Rapid Response – For Urine Matters
Nitrofurantoin for the Treatment of Urinary Tract
Infections in Elderly Males: Safety
http://www.cadth.ca/media/pdf/htis/feb-
2015/RB0787%20Nitrofuratoin%20for%20UTI%20Final.pdf
• Summary of abstracts
• Looked for clinical evidence on safety of nitrofurantoin in
elderly males
• NO EVIDENCE FOUND
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Rapid Response – For Urine Matters
Treatment of Urinary Tract Infections in the Elderly:
Clinical Effectiveness and Guidelines
(web-posting pending)
• Summary of abstracts
• Looked for evidence on comparative effectiveness of long-
term prophylaxis vs. treatment, and guidelines on antibiotic
management of UTIs in the elderly
• 2 evidence-based guidelines found on UTI management
that included the elderly
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Rapid Response – For Urine Matters
Treatment of Urinary Tract Infections in the Elderly:
Clinical Effectiveness and Guidelines
• Both guidelines recommend against antibiotic prophylaxis
for UTIs
• Both recommend against antibiotic treatment of
asymptomatic bacteriuria in catheterized patients
• Scottish: symptomatic UTI in women = trimethoprim or
nitrofurantoin x 3 days (care with nitrofurantoin in elderly),
UTI in adult males = quinolone if prostatitis symptoms
• European: broad spectrum antibiotics with adjustment
based on C&S results
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Rapid Response – For Urine Matters
Development of Antibiotic Resistance to Norfloxacin in
the Treatment of Urinary Tract Infections: Clinical
Evidence (web-posting pending)
• Reference list
• Found 1 non-randomized study: community-acquired UTI
• overall: 14% resistance (norfloxacin & cipro)
• uncomplicated UTI: 8.5% resistance
• complicated UTI: 19.5% resistance
• Significantly more resistance in patients > 50 years, in
males (25% vs. 9%), and if previous antimicrobial tx
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