8/16/2019 Urinary Bladder Drugs and+their+Mechanisms+of+Action

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Urinary Bladder Drugs and their Mechanisms of Action

Category of UrinaryBladder Drug

Mechanism of Action Examples

Cholinergic agonists orparasympathomimetic agents

Clinically used to promote voiding ofurine from the urinary bladder

Bethanechol (Urecholine®,Duvoid®, Urabeth®)

 Anticholinergics orparasympatholytic drugs

Used to treat urinary incontinence by

promoting urine retention in theurinary bladder

Propantheline (Pro-Banthine®),

dicyclomine (Bentyl®), butylhyoscine(Buscpan®)

 Adrenergic agonistIncrease the tone of the urethralsphincters via both alpha and betareceptors

phenylpropanolamine(Propagest®), ephedrine (availableas a generic)

 Adrenergic antagonists

1.   Alpha-adrenergicantagonists

Clinically used to decrease the toneof urethral sphincters, (needed in thetreatment of decreased urinary tonedue to overextension of the urinary bladder.)

Phenoxybenzamine (Dibenzyline®),Prazosin (Minipress®), Nicergoline(Sermion®)

2.  Beta-adrenergicantagonists

Clinically used for hypertension Propranolol (Inderol®)

Estrogen

Sex hormone; helps maintain

urethral muscle tone in someanimals

Diethylstilbestrol (DES)

Testosterone

Sex hormone; helps maintainurethral muscle tone in someanimals

Testerone cypionate (Depo-Testosterone®), testosteronepropionate (available as ageneric)

 Alpha and beta adrenergicagonists

Stimulation of these receptorsincreases urethral tone

Phenylpropanolamine(Propagest®, Dexatrim®),ephedrine(available in generic form)

Skeletal muscle relaxants

Clinically used to treat animals thathave urge incontinence or urethralobstructions due to increasedexternal urethral sphincter tone; mayalso be used after unobstructing male

cats to limit spasticity of the externalurethral

Dantrolene (Dantrium®), Aminopropazine (Jenotone®),Diazepam (Valium®)