Update: Bio-economy Strategy

P r e s e n t a t i o n t o t h e

P o r t f o l i o C o m m i t t e e 2 7 M a y 2 0 1 5

O u t l i n e

•The Bio-economy Strategy Definition; Systems approach; Metrics; Opportunity; Challenges; & Governance

•Actions and activities: Agriculture Health Innovation Industry & Environment IKS-based Technology Innovation

Defining the Bio-economy

Refers to activities that make use of bio-innovations,

based on biological sources, materials and processes

to generate sustainable economic social and

environmental development.

In consultation with relevant stakeholders, the DST

“has identified 3 key economic sectors – agriculture,

health and industry – as being the most in need of, and

likely to benefit from key levers to drive the

implementation of the [strategy]”

Agriculture

Industry & Environment

Health

3

S o w h a t i s n e w i n

t h e B i o - e c o n o m y

s t r a t e g y ?

Opportunistic

(a) Coordinated, specific (b) Focused Value Chain (c) System enablers

PPPs eg Biovac

Small companies, eg Resyn, Kappa, Xsit, Inqaba, etc

Private sector not-for-profit

Aeras, Aurum, MMV, EDCTP MBI

Research Institutes

Bio-economy

Science Councils

Platforms & service

providers

Universities

R,D & I

ICGEB

Gates Rockerfeller, Foundations

DST

DoH DTI

Government Departments

DEA

DAFF

DRDLR

Provincial

Funding Bodies

MRC

NRF

IDC -VCs

TIA

ARC

CSIR

SAPPI/Mondi; Winter Cereals Trust; SMRI; Novartis; Pfizer; DRI;PATH; L’Oreal; Afriplex;

Nestle

Pharmaceutical; Agricultural; Industrial

Communities;

NGO’s; interface with science and business

Private sector

PUBLIC

PUB Prog

BiosafetySA Prograrmme

5

• Coordination: awareness, national objectives,

teamwork and cooperation/collaboration

• Strategic programmes to provide emphasis in

priority areas

• System support initiatives (HCD, service platforms,

IP management, entrepreneur training, pilot scale

facilities; Clinical trialing resources, etc)

Coordinating committees

National use of MRC, ARC, CSIR expertise

SYSTEMS APPROACH

Techno-feasibility assessments 6

Opportunity of Bio-innovation

√

√

√

√

√

•In 2014 South Africa’s GDP was R3,8 trillion. •Top 7 DST investee biotech co’s R1 billion turnover. •Need to benchmark current bio-economy (NACI) •US & European bio-economies target 5-6% GDP by 2030 •If SA to reach that, it would form approx R190 billion (today’s terms)

.

. 7

Challenges of Bio-innovation

• Most highly regulated scientific field(s) of endeavour.

• Most diversified applications (agric, health,

manufacturing, energy, environment, etc). High level

coordination is required.

• Applications for existing industry AND new industry

• Rapidly developing fields (knowledge, equipment,

applications).

• Some controversy (GE, stem cells & cloning).

• The days of single blockbusters are gone. Need for

sophistication, contextualisation, personalisation and

precision.

8

Measuring the Bio-economy

High Level Impacts:

1) Sophistication of products

2) Exports of technology products

3) Unit value of exports

Currently developing a ‘metrics’ approach:

9

Outcomes per theme (economic, social, environmental)

• Eg. Technologies localized; household with food security;

medicines developed; revenues generated

Outputs per theme (meeting objectives of themes)

• Publications; technologies; patents; companies; products

C r o s s c u t t i n g & o n g o i n g

a c t i v i t i e s o f t h e D e p a r t m e n t

Cross-cutting initiatives •Public Understanding of Biotechnology (NRF) •Biosafety Communication Platform (TIA) •Bioinformatics and Functional Genomics human capital development (NRF) •Bioinformatics Platform (CHPC/CSIR) •Bio-entrepreneurship training (CSIR/TIA/eGoliBio) •Bioportal development (consortium) •Bio-economy Metrics (NACI)

Platforms •Centre for Proteomic and Genomic Research (TIA) •H3D Human Drug Discovery & Development (TIA) •Metabolomics (TIA) •Bioprocessing (TIA) •Southern African Human Genome Programme (SHIP)

Overview: Agriculture implementation plan

Food safety and food nutrition

Crop Improvement

New Crops

Commercial crops

Biocontrol agents and

biopesti-cides

Animal improvement

Animal improvement

Vaccines and

Diagnostics Aquaculture

Agroprocessing and Agro-engineering

Natural Resource management

Indigenous African Knowledge based Agriculture

Cro

ss c

uttin

g in

itiativ

es

: Agric

bio

tech s

kills

, academ

ic

researc

h c

apabilitie

s, T

ech. S

erv. p

latfo

rms, B

iosafe

ty

capacity, P

ublic

aw

are

ness, IT

& b

io e

ntre

pre

neurs

hip

tra

inin

g, A

gro

-innovatio

n h

ubs

11

K e y B i o - e c o n o m y a c t i v i t i e s

o f t h e D e p a r t m e n t Agriculture - DST projects:

•Eucalyptus Genome Programme (UP + industry)

•Wheat pre-breeding platform (Grain SA + consortium)

•Feasibility study Agro-innovation hubs (part of agri-parks)

TIA projects (some):

•Cassava commercial trials- Limpopo, Mpumalanga + KZN

•Microwave egg pasteurizer (CSIR, UP, industry)

•Post-harvest biocontrol in table grapes (ARC, CSIR + industry)

•Indigenous flower bulbs (ARC)

•Sweet stem sorghum as biofuel feedstock (UKZN)

•‘Beochic’ as a growth promoter in poultry (Industry)

•AgraChem – fertilizers & biocontrol (Industry)

Build the Health Innovation System

Translational Architecture (ICTs, Knowledge Management, Modelling, Advanced Statistical Analysis)

New or improved

therapeutics &

drug delivery

New vaccines and

other biologicals

New or improved

diagnostics

Market

access /

Impact

monitoring

New medical

devices

Discovery

Development

Dissemination Product development

cycle

Technology

develop-

ment

Capacities

&

capabilities

Decision

support

Technology

&

knowledge

transfer

O v e r v i e w : H e a l t h

I m p l e m e n t a t i o n P l a n

13

K e y B i o - e c o n o m y a c t i v i t i e s

o f t h e D e p a r t m e n t Health – SHIP projects:

Vaccine & Biologicals

Therapeutics/ drug delivery

Diagnostics/ devices

HIV 8 3 2

TB 8 3 5

Malaria - 2 1

NCD - 7 8

Overview: industry & Environment

Implementation Plan

Biomanufacturing Bioprocessing

Biopharming

Biocatalysis

Biocomposites BioGROW

BioPAC

Bioresins

Biorefineries Physical Chemical Thermal Biological

Biomining, Waste

& Wastewater Beneficiation BioMining

Water Biorefineries

Priority Areas

Na

tio

na

l E

na

blin

g R

D&

I P

latf

orm

s

Commodity

chemicals

Fine

Chemicals

Pharma-

ceuticals

Vaccines

Biologics

Enzymes

Biocomposite

Bioplastics

Biosynthetic

materials

Heat

Electricity

Biodiesel

Bioethanol

Remediation

technology

Mineral, oil,

and salt

recovery

Sanitation

solutions

Biochemicals & Biologics Biomaterials Bioenergy

Biomining, Waste &

Wastewater

15

K e y B i o - e c o n o m y a c t i v i t i e s

o f t h e D e p a r t m e n t Industry & Environment: DST projects •Biocatalysis – developing human capital in useful enzymes (consortium) • Biorefinery modelling and new product development •Water Foot-printing Analysis for SA pulp Mills •From sucrose to high value commodity chemicals • Energy use reduction and monitoring opportunities in sugar factories. •Biomanufacturing Industry Development Centre (CSIR) – supporting industry start-ups. •Pyrolysis of plastic/fibre wastes

TIA •Sweet stem sorghum as biofuel feedstock (UKZN) •Continuous seed preparation for sugar processing (SMRI, Tongaat Hullet)

IK-Based Concept

Generation

Holistic Research

and Discovery

Inclusive Innovation

Local Technology Transfer and Production

Humane Business Models

and Marketing

Ubuntu Commerce and Benefit

Sharing

Ubuntu Model

(Integral)

17

Indigenous Knowledge-based Technology

Innovation

Technical

Social/Cultural

Economic

Institutional

Objective: Mainstreaming IK-based products

>80 community

members trained

Various communities

& knowledge holders

involved/participating

in validation and

prototype

development.

K e y B i o - e c o n o m y a c t i v i t i e s

o f t h e D e p a r t m e n t Indigenous Knowledge-based Technology Innovation

Platform No. of Projects

Value-Added Products

African Medicines Platform 6 Projects

3 HIV/AIDS; 1 TB; 1 Diabetes; 1 Malaria

IK-Based Cosmeceuticals 8 Projects Skin, hair, ageing IK-Based Nutraceuticals 5 Projects

Nutrition, supplements, food products

IK-Based Health Beverages 6 Projects

Moringa, Honeybush, Haw-Haw, Amaranthus, etc

IK-Based Tech Transfer 5 Projects IK-Based Commercialisation 4 projects

Moringa, Honeybush, Nutri-veg drink

K e y B i o - e c o n o m y a c t i v i t i e s

o f t h e D e p a r t m e n t

Capacity building: IKS PhD, MSc and undergraduate students

K e y B i o - e c o n o m y a c t i v i t i e s

o f t h e D e p a r t m e n t

Partnership with University of Limpopo sitting on Limpopo Agro-food Technology Station (LATS)

K e y B i o - e c o n o m y a c t i v i t i e s

o f t h e D e p a r t m e n t

Figure 2: Some of the Moringa related products that have been developed

Construction of the Tooseng Processing Facility 15/04/2015

K e y B i o - e c o n o m y a c t i v i t i e s

o f t h e D e p a r t m e n t

Figure 2: Some of the Moringa related products that have been developed

Some of the Moringa related products that have been developed

W a y f o r w a r d :

B i o - e c o n o m y 2 0 1 5 / 6 Implementation plans

•Finalization & publication

•Presentation to Treasury

Activities

•Creation of Coordinating Committees (including govt, science councils, industry, academia) to advise DST on priorities & actions.

•Development of R&D support models (similar to SHIP) at the ARC and CSIR.

•Techno-feasibility study on Agro-innovation Hubs concluded.

New budget for the Bio-economy required

S o m e B i o - e c o n o m y

s u c c e s s e s Previously reported:

•By 2014, the top 7 biotech companies had a combined annual turnover of nearly R1 billion (from a direct investment of R63million);

•Eucalyptus Genome project – already providing cost savings to industry;

•Xsit – already providing additional income to the citrus industry;

•Umbiflow – providing for better maternal healthcare;

•mTriage – better emergency care.

New additions:

•10 IK-Based Cosmeceuticals (anti-acne, anti-eczema, anti-wrinkle, anti-aging, skin toner, moisturisers and sun-screens) are ready for early commercialisation;

•Access and benefit sharing agreement entered into with various communities in Gauteng, Northern Cape, Western Cape, and Eastern Cape;

•Five new patents filed from IKS technologies.

Ndo livhuwa

Enkosi

Thank you

Baie dankie

Siyabonga

Re a leboga

Ha Khensa Enkosi Ditebo