UNIVERSITY OF PENNSYLVANIA - PERELMAN SCHOOL OF … · 1997-2009 ID 390, Bioethics intensive course...

UNIVERSITY OF PENNSYLVANIA - PERELMAN SCHOOL OF MEDICINE Curriculum Vitae

Date: 07/31/2012

Jason Karlawish, M.D.

Address: Division of Geriatrics

Ralston-Penn Center 3615 Chestnut Street

Philadelphia, PA 19104 USA If you are not a U.S. citizen or holder of a permanent visa, please indicate the type of visa you have: none (U.S. citizen) Education: 1987 B.S. Northwestern University (Honors Program in Medical

Education) 1991 M.D. Northwestern University School of Medicine (Medicine) Postgraduate Training and Fellowship Appointments: 1991-1992 Intern in Medicine, Francis Scott Key Hospital, Baltimore 1992-1994 Resident in Medicine, Francis Scott Key Hospital, Baltimore 1994-1995 Fellow, Clinical Medical Ethics, University of Chicago,

Chicago 1995-1997 Fellow, Geriatric Medicine, University of Chicago, Chicago Faculty Appointments: 1997-1998 Instructor in Medicine, Department of Medicine, University of

Pennsylvania 1998-2006 Assistant Professor of Medicine, University of Pennsylvania

School of Medicine 2004-2007 Assistant Professor of Medical Ethics, University of

Pennsylvania School of Medicine (Secondary) 2006-2011 Associate Professor of Medicine, University of Pennsylvania

School of Medicine 2007-2010 Associate Professor of Medical Ethics, University of

Pennsylvania School of Medicine (Secondary) 2008-present Associate Professor of Emergency Medicine, University of

Pennsylvania School of Medicine (Secondary) 2011-present Professor of Medicine, University of Pennsylvania School of

Medicine Hospital and/or Administrative Appointments: 1997-Present Attending Physician, Acute Care for the Elderly Unit,

Presbyterian Hospital, 1month/year


1999-Present Associate Director, Penn Memory Center (Core B,

Alzheimer's Disease Center), University of Pennsylvania 1999-Present Director, Education, Recruitment and Retention Core (Core E,

Alzheimer's Disease Center), University of Pennsylvania 2000-Present Attending Physician, Penn Memory Center 1 afternoon/week Other Appointments: 1997-present Fellow, Institute on Aging, University of Pennsylvania 1997-Present Senior Fellow, Center for Bioethics, University of

Pennsylvania School of Medicine 2001-present Senior Fellow, Leonard Davis Institute, University of

Pennsylvania 2009-present Faculty, Penn Center for Neuroscience and Society, University

of Pennsylvania Specialty Certification: 2004 Recertification American Board of Internal Medicine (original

certification 1994) 2008 Recertification of Added Qualifications in Geriatric Medicine

(1998 original certification) Licensure: 1997-2012 Pennsylvania Awards, Honors and Membership in Honorary Societies: 1984-1987 IBM Thomas J. Watson Memorial Scholar 1988-1989 Smithkline Medical Perspectives Fellowship 1989 Finalist in the William Carlos Williams Poetry Contest 1997 National Institute on Aging/Brookdale Foundation, Summer

Institute on Aging Research 1997 The Lancet 1997 Wakely Prize 1998-2000 Brookdale National Fellow 2000-2003 Paul Beeson Physician Faculty Scholar in Aging Research 2001 Dorothy Dillon Eweson Lecturer, American Federation for

Aging Research 2002-2007 Greenwall Faculty Scholar in Bioethics 2002 Philadelphia Magazine "Top 10 Doc 2002" for Geriatrics,

specialty in dementia 2002 Abstract Competition, Center for Neurodegenerative Disease

Retreat, 2nd Prize 2003-2005 Virginia Brown Fellowship for Aging and Stroke Research 2003 American Geriatrics Society, Best Paper Award for

Outstanding Excellence in Geriatrics Research, Ethics category for "Can people with Alzheimer's Disease make a decision about treating Alzheimer's Disease?"


2005 Institute on Aging 2005 Sylvan M. Cohen Annual Retreat,

second prize in the category of clinical research for "The capacity to vote of persons with Alzheimer's Disease"

2006 Institute on Aging 2006 Sylvan M. Cohen Annual Retreat, first prize in the category of clinical research for "Who best to rate an Alzheimer's Disease patient's quality of life: patient or caregiver? The case for a mixed perspective"

2007 American Geriatrics Society, Annual Meeting, Presidential Poster Session Awards in the category of Ethics and Quality of Life

2009 Institute on Aging Sylvan M. Cohen Annual Retreat, first prize in the category of education and health services for "Bring the vote to nursing homes: results of a mobile polling intervention."

Memberships in Professional and Scientific Societies and Other Professional Activities: International: 2003-Present Alzheimer's Disease Association (Member; Reviewer, Investigator Initiated Grants

Programs. Abstract reviewer: Behavioral and Social Sciences) 2004 Medical Research Council, Great Britain (Reviewer, applications) National: 1997-present American College of Physicians (1993 Associate Member; 1997 Full Member) 1997-Present American Geriatrics Society (Member, 1997-98 Public Policy Committee, 1998

Abstract Reviewer for annual meeting, 1998-2004 Ethics Committee, 1999-2004 Steering Committee for the Special Interest Group for Junior Faculty Development, 2003 Abstract Reviewer for annual meeting; 2009-Present Editor, Ethics, Public Policy, and Medical Economics for the Journal of the American Geriatrics Society)

2001-Present Alzheimer's Disease Center (External Advisory Board, University of California,

Irvine, ADRC; Carl Cottman, PI.) 2002-present Gerontological Society of America (2002 - 2004 Committee on Research, Education,

and Practice) 2002-2009 National Institutes of Health, National Institute of Mental Health (2002 Special

Emphasis Panel, ZMHI-NRB-Q(CA): NIM-02-SBIR-Phase 1 review committee, research ethics education proposals; Data Safety and Monitoring Board-B member)

2003-2004 Department of Veterans Affairs (Reviewer, Stars & Stripes Competitive Pilot Project

Peer Review)


2003-Present National Institutes of Health, National Institute of Aging (ADCC-ADRC study

section, 2003 reviewer Alzheimer's Disease Research Center's applications, 2004 reviewer Alzheimer's Disease Research Center and Alzheimer's Disease Center applications, 2007 Social and Behavioral Science (NIA-S) scientific peer review; 2009 05 Council ZAG1 ZIJ-4 M1(Beeson award))

2003-Present The Brookdale Foundation (Brookdale National Fellowship Class of 2003 and 2008

application reviews) 2005 National Institutes of Health, Psychosocial Development, Risk, and Prevention

(Study Section) 2005-Present SeniorBridge Family Companies, Inc (Advisory Board) 2006-present National Institutes of Health, Special Emphasis Panel/Scientific Review Group

(2006/10 ZRG1 HOP-E (90) (S), 2006, 2007 "research ethics study section") 2007-Present Alzheimer's Disease Cooperative Study (Chair, Internal Ethics Committee) 2007 National Institutes of Health, Fogarty International Research Ethics and Curriculum

Award (Chair, scientific peer review) 2008-Present Greenwall Foundation (Board of Directors) 2010-Present Academy Health 2011-2012 Institute for Clinical and Economic Review, Massachusetts General Hospital

(member, Policy Development Group) 2012-Present Society for Nuclear Medicine and Alzheimer's Association (Member of the taskforce

to prepare brain amyloid imaging guidelines) Local: 1997-present The College of Physicians of Philadelphia (Fellow) Editorial Positions: 1998-2004 Abstract reviewer, Annual meeting of American Geriatric Society/

American Federation on Aging Research 2000-Present Reviewer, Alzheimer's Disease and Associated Disorders 2000-Present Reviewer, Journal of the American Geriatrics Society 2000-Present Reviewer, Journal of the American Medical Association (JAMA) 2002-2003 Reviewer, MacArthur Foundation -‐ MacArthur Fellows Program 2002-2003 Reviewer, Journal of General Internal Medicine 2002-Present Reviewer, Annals of Internal Medicine


2003 Abstract reviewer, Annual meeting of the Gerontological Society of

America 2003 Reviewer, American Academy of Neurology, Position statements on

the diagnosis, treatment and early diagnosis of dementia, reviewed on behalf of the American Geriatrics Society

2003 Reviewer, Journal of Clinical Oncology 2003-2004 Reviewer, Dementia and Geriatric Cognitive Disorders 2003-Present Reviewer, Neurology 2004-Present Reviewer, American Journal of Geriatric Psychiatry 2004-Present Reviewer, American Review of Respiratory and Critical Care

Medicine 2005-2006 Reviewer, Nature -‐ Clinical Practice Neurology 2005-Present Reviewer, Lancet 2005-Present Reviewer, New England Journal of Medicine 2005 Reviewer, Medical Decision Making 2006-2007 Reviewer, American College of Physicians-American Society of

Internal Medicine, Physician Information and Education Resource (PIER) module on screening for dementia.

2006-Present Reviewer, Journal of the American Medical Association 2006-2007 Reviewer, American Psychiatric Association -‐ review of "Practice

guidelines for the treatment of patients with Alzheimer's Disease and other dementia of late life, second edition"

2007-Present Reviewer, Lancet Neurology -‐ fast track reviewer 2009-Present Editor, Ethics, Public Policy, and Medical Economics for the Journal

of the American Geriatrics Society Academic and Institutional Committees: 1997-1998 Finding Common Ground Project (palliative care and assisted

suicide policy panel) University of Pennsylvania Center for Bioethics inconjunction with American College of Physicians

2001-2003 Member, Institution Review Board #3, University of Pennsylvania 2002 Member, Research Coordinating Council, aging research theme

group, University of Pennsylvania 2003-Present Member, Master's of Bioethics Admissions Committee, University

of Pennsylvania 2009-2010 University of Pennsylvania, Social Responsibility Advisory

Committee 2009 Committee to Review the Department of Psychiatry 2009-Present Faculty Advisory Committee, Office of Human Research Major Academic and Clinical Teaching Responsibilities: 1997-2009 ID 390, Bioethics intensive course for year three medical students, 1

week/year 1997-Present Robert Wood Johnson Clinical Scholars Program, Core Faculty

Writing and Ethics Curriculum


1997-Present Center for Clinical Epidemiology and Biostatistics, EP690, "Ethical

issues in the design and conduct of clinical research" 2003-2005 Member of dissertation committee for Scott D. Halpern, B.S.,

"Improving enrollment in randomized, controlled trials: a preference-oriented approach," doctorate in clinical epidemiology.

2004-2006 ID 490, Research ethics intensive course for year one medical students, 1 week/year

2006-Present Mentor to Nabila Dahodwala, MD (Robert Wood Johnson Clinical Scholar, Assistant Professor of Neurology)

2007-2008 Mentor to Raina Merchant, MD (Robert Wood Johnson Clinical Scholar)

2007-2008 Mentor to Matt O'Brien, MD (Robert Wood Johnson Clinical Scholar)

2008-Present Attending ACE unit, Presbyterian Hospital, 2 weeks/year 2008-Present Mentor to Mark Neuman, MD (Assistant Professor of

Anesthesiology) 2008-Present Mentor to Stephanie Cosentino, PhD (Assistant Professor of

Psychology at Columbia University) 2008-2010 Mentor to Jesse Pines, MD (Associate Professor of Emergency

Medicine and Health Policy Center for Healthcare Quality, George Washington University)

2008-Present Mentor to Jonathan Rubright, MS (PhD candidate at the University of Delaware)

2009-Present Mentor to Peter Reese, MD (Assistant Professor of Medicine , Division of Renal Medicine)

2009-Present Mentor to Eran Klein, MD (Instructor, Oregon Health Sciences University)

2009-Present Mentor to Amy Tsou, MD (Robert Wood Johnson Clinical Scholar) 2009-Present Mentor to Jeff Kullgren, MD (Robert Wood Johnson Clinical

Scholar) 2010-Present Mentor to Kalpana Naranyan, MD (Robert Wood Johnson Clinical

Scholar) 2010-Present Mentor to Joshua Grill, MD (Director, Recruitment and Education

Core at University of California, Los Angeles) Lectures by Invitation: Sep, 1995 "Shared decision making" - The American Association of Critical

Care Nurses, San Francisco, California Oct, 1995 "Suggested guidelines for resolving the emergency research

controversy" - The Seventh Annual Mrs. John MacLean Conference on Clinical Medical Ethics, Chicago

Apr, 1996 "Clinical decision making: The meaning of consent" - American Association of Critical Care Nurses, Midwest Chapter, Chicago, Illinois


May, 1997 "The role of community in clinical research" - American Geriatrics

Society/American Federation of Aging Research 1997 Annual Meeting, Atlanta, Georgia

Nov, 1997 "Are waivers and modifications of informed consent guided by adequate regulations? Or, informed consent, how do I waive thee? Let me count the ways...." - Joint national meeting of the American Association of Bioethics, Society for Bioethics Consultation and Society for Health and Human Values, Baltimore, Maryland.

Jan, 1998 "Legal and ethical decisions surrounding Alzheimers Disease" - 1997-98 Seminar Series "Charting the Course," The Boettner Center of Financial Gerontology, Bryn Mawr, Pennsylvania.

Apr, 1998 "Getting the most from your doctor visit: Tips and tricks for the visit" - Partners in Healthy Living Seminar Series, Institute on Aging, Philadelphia, Pennsylvania.

Apr, 1998 "A Question of Life -- The Politics of Dying." Panel discussion of assisted suicide and issues of death and dying presented in conjunction with the Philadelphia Theater Company's production of A Question of Mercy by David Rabe.

Oct, 1998 "How to design valuable clinical research," for "Technology acquisition: The impact of clinical trials." Association for the Advancement of Medical Instrumentation, Baltimore, Maryland.

Nov, 1998 "Guiding the tube that feeds." Nutritional management of the elderly with dementia, Gerontological Society of America, Philadelphia, Pennsylvania.

Nov, 1998 "The family's role in decision-making." The Voices of Decisionmaking, American Society of Law, Medicine and Ethics, Philadelphia, Pennsylvania.

Nov, 1998 "Assessing research risks and potential benefits according to the 'logic of clinical purpose.'" Responding to the National Bioethics Advisory Commission's report on "Research involving persons with mental disorders that may affect decisionmaking capacity," Friends Research Institute, Baltimore, Maryland.

Mar, 1999 "Hospice and palliative care issues: Patients with cognitive impairment." Wissahickon Hospice, King of Prussia, Pennsylvania.

Apr, 1999 "A summary of the NBAC report on 'Research involving persons with mental disorders that may affect decisionmaking capacity,'" for the Clinical Core Meeting of the Alzheimers Disease Centers, Toronto, Canada.

Jun, 1999 "Ethical and social issues in mild cognitive impairment," for the conference Current Concepts in Mild Cognitive Impairment, Chicago, Illinois.

Oct, 1999 "Ought assisted suicide be only physician assisted?" for the Second Annual meeting of the American Society for Bioethics and Humanities, Philadelphia, Pennsylvania.


Oct, 1999 "How much risk will caregivers tolerate to treat Alzheimers

Disease?" for the Millennial Retreat of the Brookdale National Foundation, Glen Cove, New York.

Oct, 1999 "Enrolling in research: What can we teach patients and caregivers and what can they teach us?" for the Fall meeting of the Directors of the Education and Information Transfer Cores of the Alzheimers Disease Centers, Seattle, Washington.

Jan, 2000 "Current concepts in the assessment of cognitive impairment" for the Delaware Valley Geriatric Education Center Long Term Care Training Program, Saint Mary's Medical Center, Langhorne, Pennsylvania.

Feb, 2000 "Clinical perspectives on competency and decisionmaking capacity in the elderly" for the Pennsylvania Conference of State Trial Judges, 2000 Mid-Annual Meeting, Philadelphia, Pennsylvania.

Mar, 2000 "What is the value of U.S. anti-epileptic drug monotherapy clinical trials?" for the Anti-Epileptic Drug V International Conference, Miami, Florida.

Mar, 2000 "The impact of caregiving on caregivers of patients with dementia" for Bioethics Conference, Lankenau Hospital, Bryn Mawr, PA.

Apr, 2000 "Life in older Pennsylvania…America…World" for the World Affairs Council of Philadelphia, Shades of Gray: Implications of an Aging Nation and World, Philadelphia, PA.

May, 2000 "Who are we treating and how do we know we are effectively treating them?" for the symposium "Treating Alzheimer's disease: Addressing the challenges of measurement and morals" at the annual meeting of the American Geriatrics Society, Nashville, Tennessee.

May, 2000 "Learning to love your IRB and other tips on the responsible conduct of research," for the annual meeting of the American Geriatrics Society, Nashville, Tennessee.

May, 2000 "Why things are getting crazy in human subjects research," for the Albert Einstein Healthcare Network Research Recognition Day, Philadelphia, Pennsylvania.

Jul, 2000 "The research risk assessment" for the World Alzheimer's Congress, Washington, D.C.

Oct, 2000 "Empirical insights into research that involves persons with dementia" for the American Society of Bioethics and Humanities, Salt Lake City, Utah.

Nov, 2000 "The ethics and value of research: empirical data about patients' preferences, and recommendations for the responsible conduct of research." Department of Health and Human Services Office of Research Integrity, Washington DC.

Feb, 2001 "Informed consent and competency assessment in dementia research" for the California Alzheimer's Disease Centers, Los Angeles, CA.


May, 2001 "Learning to love your IRB and other tips on the responsible conduct

of research," for the annual meeting of the American Geriatrics Society, Chicago, IL.

Jul, 2001 "Deciding With Others: Enhancing caregiver-patient decisions about research," for the 10th National Alzheimer's Disease Education Conference, Chicago, IL.

Oct, 2001 "The social construction of treatment for Alzheimer's Disease" for the 4th Annual Meeting of the American Society for Bioethics and Humanities, Nashville, TN.

Oct, 2001 "Which equipoise do we mean? Which should we prefer?" for the 4th Annual Meeting of the American Society for Bioethics and Humanities, Nashville, TN.

Feb, 2002 "Research involving vulnerable subjects" for Bioethics and Bioterrorism, Center for Bioethics, University of Pennsylvania and Center for Biomedical Ethics, University of Virginia, Washington, D.C.

Feb, 2002 "The voice of the afflicted: The caregiver and patient perspective on treating Alzheimers disease," for the 15th Annual Meeting of the American Association for Geriatric Psychiatry, Orlando, FL.

Apr, 2002 "The ethics of research that involves the cognitively impaired" for Pfizer Incorporated, New York, NY.

May, 2002 "What if we could treat Alzheimers Disease?" Department of Medicine Grand Rounds, Case Western Reserve University, Cleveland, OH.

Jun, 2002 "Is aging a disease?" Annual Meeting of the Paul Beeson Scholars, Bellingham, WA.

Oct, 2002 "Can Alzheimers Disease patients make an AD treatment decision?" 5th Annual Meeting of the American Society for Bioethics and Humanities, Baltimore, MD.

Dec, 2002 "Ethical issues surrounding decisions to initiate dialysis." End Stage Renal Disease Network 4, Steering Committee; Philadelphia, PA.

Apr, 2003 "Can Alzheimers Disease patients make an AD treatment decision, and -‐ even if they can -‐ will we let them?" Columbia University, Gertrude Servgievsky Center, New York, NY.

May, 2003 "Ethical issues in early stage dementia," for the American Society of Aging and Alzheimer's Association web seminars.

May, 2003 "Meet the Expert -‐ getting competent at assessing competency," at the Annual Meeting of the American Geriatrics Society, Baltimore, MD.

May, 2003 "How the pharmaceutical industry sets the standard of care," for the Symposium "Geriatricians and the pharmaceutical industry -‐ A complex relationship," at the Annual Meeting of the American Geriatrics Society, Baltimore, MD.


Aug, 2003 "Interpreting clinical trial data: A bioethicist's perspective," as part

of the symposium "Cerebrovascular risks in the elderly: what every clinician should know," for the International Psychogeriatrics Meeting, Chicago, IL.

Nov, 2003 "Bioethics" for "Health Professionals Conference, Dementia Update: It may not be Alzheimer's" for the Delaware Valley Chapter of the Alzheimer's Association, Philadelphia, PA.

Nov, 2003 "Manufactured benefit: the science and politics of Alzheimer's Disease drug development," Department of Medicine, Grand Rounds, Johns Hopkins Bayview Medical Center, Baltimore, MD.

Nov, 2003 "Can persons with Alzheimer's disease make an AD treatment decision and, even if they can, will we let them?" Symposium for the 56th Annual Scientific Meeting of the Gerontological Society of America, San Diego, CA.

Nov, 2003 "Clinical and behavioral research in geriatric patients," for "Challenging Issues for Today's IRB -‐ IRB Education Conference, Fall 2003," Michigan State University, East Lansing, MI.

Jan, 2004 "Cultural Issues in Alzheimer's Disease Research," for the American Medical Association's Alzheimer's Disease Media Briefing, New York, NY.

Feb, 2004 "Ethical controversies in early Alzheimer's Disease." The 18th Annual Joseph & Kathleen Bryan Alzheimer's Disease Research Center Conference, Alzheimer's 2004: Targeting the Epidemic, Durham, NC.

Feb, 2004 "Is ignorance bliss? Insight, quality of life and competency in persons with Alzheimer's Disease." HRS Health and Aging Seminar Series, University of Michigan, Ann Arbor, MI.

Mar, 2004 "Measuring clinical outcomes in AD." The 10th Anniversary John Hopkins University On the Treatment of Alzheimer's Disease and Other Dementias featuring Drug Development for Alzheimer's Disease: Historical and Clinical Perspectives, Baltimore, MD.

May, 2004 "Meet the expert - mild cognitive impairment: disease, syndrome or marketing tool?" The Annual Meeting of the American Geriatrics Society. Las Vega, NV.

Jul, 2004 "Ethical issues in clinical trials," for the Psychosocial Research Symposium at the 9th International Congress on Alzheimer's Disease and Associated Disorders, Philadelphia, PA.

Jul, 2004 "Ethics of research with human subjects," The National Institutes of Health, National Institute of Aging Summer Institute on Aging Research. The Aspen Institute, Queenstown, MD.

Sep, 2004 "How do we measure the ability to make a decision?" Yale Claude D. Pepper Older Americans Independence Center Aging Research Seminar, New Haven, CT.

Oct, 2004 "Voting rights among persons with dementia," University of North Carolina, Department of Medicine, Division of Geriatrics, Grand Rounds, Chapel Hill, NC.


Apr, 2005 "From status to capacity: autonomy in a cognitive world," University

of Pittsburgh, Department of Medicine, Grand Rounds, Pittsburgh, PA.

May, 2005 "Dilemmas in the later stages of dementia care" as part of the symposium "Decisions, decisions: evidence-based management of the elderly patients from early to late stages of dementia" at the Annual Meeting of the American Geriatrics Society, Orlando, FL.

May, 2005 "What is the evidence that we can 'treat' persons with MCI?" as part of the symposium "Mild cognitive impairment: Current controversies and challenges" at the Annual Meeting of the American Geriatrics Society, Orlando, FL.


Jul, 2005 "Patient rights in research in the 21st century," Drexel University, Department of Neurology, Grand Rounds, Philadelphia, PA.

Sep, 2005 "The validity of health preference measures in patients with Alzheimer's Disease," 4th International Pharmacoeconomic Conference on Alzheimer's Disease, Stockholm, Sweden.

Nov, 2005 "Optimal Trial Design in Alzheimer's Research," for the Alzheimer's Association Research Roundtable, Washington D.C.

Mar, 2006 "Making sense of the assent and dissent in clinical research" as part of the pre-conference meeting to develop guidelines for human subjects research in long term care, for the Annual Meeting of the American Medical Directors Association, Dallas, TX.

Mar, 2006 "Individualizing treatment decisions: what makes treatment acceptable to patients and families?" as part of the symposium "Managing Neuropsychiatric Symptoms in Geriatric Patients: Evidence-based, Individualized Care" at the Annual Meeting of the American Association of Geriatric Psychiatry, San Juan, Puerto Rico.

Apr, 2006 "Addressing the challenges of translating the results of AD clinical research into clinical care" Department of Medicine, University of Iowa. Iowa City, IA.

May, 2006 "Voting by persons with cognitive impairment," Symposium presentation at the Annual Meeting of the American Psychiatric Association, Toronto, Canada.

May, 2006 "The art and science of making decisions for patients with serious and advanced illness," Meet the Expert session at the Annual Meeting of the American Geriatrics Society, Chicago, IL.

May, 2006 "Research in subjects with diminished capacity: current practices" for the conference "Protection of research subjects with diminished capacity," Center for Practical Bioethics, Kansas City, MO.

Jun, 2006 "Making sense of the ethics of research that involves persons with cognitive impairment," Boston University, Alzheimer's Disease Core Center, Boston, MA.


Jul, 2006 "Ethics of research with human subjects," The National Institutes of

Health, National Institute of Aging Summer Institute on Aging Research. The Aspen Institute, Queenstown, MD.

Nov, 2006 "Voting rights for the elderly: the implications of cognitive impairment," University of New South Wales, The Black Dog Institute, School of Psychiatry Grand Rounds. New South Wales, Australia

Dec, 2006 "How attorneys can ethically assess a person's capacity to solve everyday problems and execute legal documents," at the Elder Law Training, Indiana Continuing Legal Education Forum. Indianapolis, IN.

Mar, 2007 "Justifying the risks of research," as part of the symposium "Neuroethics" for the American Society for Experimental Neurotherapeutics 9th Annual Meeting, Washington, D.C.

May, 2007 "Diminished Capacity: An Introduction for Financial Service Professionals." FINAR annual conference, Boston, MA

Jun, 2007 "Advance planning in persons with Alzheimer's Disease," Maxnet Aging Conference V, Karolinska Institute, Hotel Hpb Erga Gard. Stockholm, Sweden.

Aug, 2007 "Facilitating voting as people age: Addressing the challenges of cognitive impairment," Annual meeting of the National Association of State Election Directors, New Orleans, LA.

Sep, 2007 "Assessing decision making capacity," Medico-Legal Conference, Geriatric Research and Education Center, University of Texas, San Antonio VA, San Antonio, TX.

Oct, 2007 "Update on Alzheimer's Disease Treatment," for the 2007 Barbara W. Bell, M.D. Memorial Lectureship, Abington Hospital Grand Rounds, Abington, PA.

Oct, 2007 "Recruitment: What We Know, What We Don't," for the national conference on Recruitment and Retentions: Challenges and Opportunities for the Alzheimer's Disease Centers, Bethesda, MD

Oct, 2007 "Putting capacity assessment into your daily practice," Philadelphia Neuropsychology Society, Philadelphia, PA.

Oct, 2007 "Research Roundtable Discussion," E. Gordon Margolin Lectureship Fund. The Jewish Hospital. Cincinnati, OH.

Jan, 2008 "Testimony to the U.S. Senate Special Committee on Aging on voting rights for the elderly." Dr. Karlawish testified on his research on voting in long term care institutions, Washington, D.C.

Feb, 2008 Presentation on elderly person's attitudes about proxy consent in research that involves persons with Alzheimer's disease to the Office of Human Research Protections, Subcommittee on the Inclusion of Individuals with Impaired Decision-making in Research, Washington, D.C.


Mar, 2008 American Medical Directors Association 31st Annual Symposium,

Assessing decision making capacity: key concepts and practical steps, as part of the symposium Impaired Decision-Making Capacity: Assessment and Management, Salt Lake City, UT.

Jun, 2008 "Informed consent" for the NINDS Pilot Therapeutics Network (NPTUNE) meeting A Pilot Trial of Lithium in Subjects with Progressive Supranuclear Palsy or Corticobasal Degeneration, Chicago, IL.


Oct, 2008 "Rethinking the ethics and science of clinical trials: the case of Alzheimer's disease drug development." The Berman Institute Seminar Series. Johns Hopkins University. Baltimore, MD.

Oct, 2008 "Keynote address," Exploring Voting Among Citizens in Long-Term Care in Virginia. The University of Virginia. Charlottesville, VA.

Nov, 2008 Discussant for the symposium "Palliative Care Needs of Frail Elders: Patient Preferences and Caregiver Perspectives." Annual Meeting of the Gerontological Society of America. Washington, D.C.

Jan, 2009 "Assessing Capacity to Consent -‐ MacCAT-CR." Alzheimer's Disease Cooperative Study startup meeting for Nerve Growth Factor (CERE-110-03) in mild to moderate Alzheimer's Disease, San Diego, CA.

Apr, 2009 "Ethical Issues Related to Research Participation by Patients diagnosed with Dementia." Annual meeting of the American Academy of Neurology, Seattle, WA.

Apr, 2009 "Ethical Issues Related to Research Participation by Patients Diagnosed with Dementia." Annual meeting of the American Academy of Neurology, Seattle, WA.

May, 2009 "Diminished Capacity: An Introduction for Financial Service Professionals." FINRA annual conference, Boston, MA.

May, 2009 "Nursing Homes as a Site for Doing Research: Putting Science into Practice." Annual meeting of the American Geriatrics Society, Chicago, IL.

Jun, 2009 "The making and unmaking of Alzheimer's disease." The Annual Jay L. Foster Memorial Lecture in Alzheimer's Disease. The University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.

Oct, 2009 "Neuroethics in the 21st Century." World Congress of Neurology, Bangkok, Thailand.

Nov, 2009 "Negative Perspectives-‐Recent publications critical of global trials." Alzheimer's Association Research Roundtable 2009, Washington, DC.


Dec, 2009 "Why we need to bring elections to nursing homes and how we

should do this." Boston University Alzheimer's Disease Center Lecture Series, Boston, MA.

Mar, 2010 "Changing Concepts of Alzheimer Disease." Indiana Alzheimer Disease Center 2010 Spring Symposia, Indianapolis, IN.

Apr, 2010 "Dementia Management in Primary Care." American College of Physicians Annual Meeting, Toronto, Canada.

Apr, 2010 "Informed consent for research that involves adults with disorders that may impair their decision-making capacity." Columbia University IRB Conference, New York, NY.

Jun, 2010 "Ethical Considerations of Sham Neurosurgical Procedures." NIH Workshop on Use of Sham Neurosurgical Procedures in Clinical Trials for Neurodegenerative Diseases, Bethesda, MD.

Jul, 2010 "The meaning of Alzheimer's disease across time and place." International Conference on Alzheimer's Disease (ICAD), Honolulu, HI.

Sep, 2010 "Digital Health Networks and Personalized Medicine: Legal, Ethical, and Policy Issues." American Association for the Advancement of Science topical meeting, Washington, DC.

Feb, 2011 "Do symptoms of cognitive impairment impact upon quality of life?", International Pharmaco-Economic Conference on Alzheimer's Disease, Royal College of Physicians, London, United Kingdom

Feb, 2011 "Do symptoms of cognitive impairment impact upon quality of life?" 6th International Pharmacoeconomic Conference on Alzheimers Disease, London, England.

Mar, 2011 "Competency in the age of assessment," Drexel University School of Medicine Grand Rounds, Philadelphia, PA

Mar, 2011 "Desktop Medicine: how risk is transforming disease and remaking medicine," Rutgers University Institute for Health, New Brunswick, NJ

Apr, 2011 "Ethical Dilemmas of Biomarker Use," University of Utah Generations Conference, Salt Lake City, UT

Apr, 2011 "Practical Implementation and Ethical Implications of Alzheimer's Disease Without Dementia," University of Utah Generations Conference, Salt Lake City, UT

Apr, 2011 "Issues in AD Clinical Research," Health Journalism Conference 2011, Philadelphia, PA

Apr, 2011 "The making and unmaking of Alzheimer's disease," Alzheimer's Association of New Jersey, Somerset, NJ

Jul, 2011 "Ethical issues in the early diagnosis of Alzheimers disease," Alzheimers Association International Congress on Alzheimers Disease (AAICAD), Paris, France.

Nov, 2011 "Health Writing for the Lay Audience," Robert Wood Johnson Foundation Clinical Scholars National Meeting 2011, Arlington, VA

Nov, 2011 "Desktop Medicine," Santa Fe Institute Annual Business Network and Board of Trustees Symposium, Santa Fe, NM


Jan, 2012 "Amyloid Imaging in the Clinic (Panel Discussion)," Human

Amyloid Imaging Conference, Miami, FL Jul, 2012 "Disclosing Amyloid Imaging Results," Alzheimer's Association

International Conference (AAIC), Vancouver, BC Organizing Roles in Scientific Meetings: Jul, 2008 Program Committee

Alzheimer's Association 2008 International Conference on Alzheimer's Disease, Chicago, IL

Jul, 2009 Program Committee Alzheimer's Association 2009 International Conference on Alzheimer's Disease, Vienna, Austria.

Jul, 2010 Program Committee Alzheimer's Association 2010 International Conference on Alzheimer's Disease, Honolulu, HI.

Grants: Pending: Disclosing amyloid biomarker results in AD prevention clinical trials, Alzheimer's

Association, 8/2012-7/2014 (Jason Karlawish, PI), $100,000/annual direct costs, 5% effort (Role in grant: PI)

Current: Social Goals and Individual Incentives to Promote Walking in Older Adults, Robert

Wood Johnson Foundation, 4/2012-9/2013 (Jason Karlawish, PI: Karen Glanz, Co-Investigator), $100,000/annual direct costs, 2% effort (Role in grant: Co-PI)

Ethical issues in Dementia Research involving Surrogate and Study Partners, National

Institute on Aging, 1RO1AG038440-01A1, 9/2011-8/2015 (Betty Black, PI), $402,303/annual direct costs, 10% effort (Role in grant: Co-investigator)

Age, Functional Status, and Survival Benefit from Kidney Transplantation, National

Institute of Health/NIDDK, R01-DK-090388-01 , 9/2011-8/2012 (Peter Reese, PI), $250,000/annual direct costs, 2.5% effort (Role in grant: Co-investigator)

Alzheimer's Disease Core Center, National Institutes Of Health, 5-P30-AG-010124-20,

7/2011-6/2016 (John Q. Trojanowski, PI), $879,148/annual direct costs (Role in grant: Co-PI, Center grant is on 2 cores)

Alzheimer's Disease Center Core B, National Institute on Aging, P30-AG-10124, 7/2011-

6/2016 (Trojanowski, John, PI), $110,825/annual direct costs, 15% effort (Role in grant: Co Investigator)

Alzheimer's Disease Center-Core E, National Institute on Aging, P30-AG-10124 ,

7/2011-6/2016 (Trojanowski, PI), $110,825/annual direct costs, 5% effort (Role in grant: Core Leader)


Risk Evaluation and Education for Alzheimer's Disease, National Institute of

Health/National Human Genome Research Institute, R01 HG002213, 9/2010-6/2013 (Robert Green, PI), $47,055/annual direct costs, 2% effort (Role in grant: Site PI)

Mechanisms Of Health Disparities In Parkinsonism, National Institute On Aging, 4/2010-

3/2015 (NABILA DAHODWALA, PI), $146,900/annual direct costs (Role in grant: Co-PI, Mentoring Nabila Dahodwala)

Developing Interactive Technologies To Improve Research And Health Behavior,

National Institute On Aging, 1RC2-AG036592-01 , 9/2009-8/2011 (KEVIN G. VOLPP, PI), $1,689,742/annual direct costs (Role in grant: Co-PI, No salary support year 1)

Parkinsons Disease And Research Consent Capacity, National Institute of Neurological

Disorders And Stroke, 1 R01 NS065087-01 , 9/2009-8/2012 (JASON KARLAWISH, PI), $502,296/annual direct costs, 10% effort (Role in grant: PI)

Investigator Award in Health Policy Research: The Making and Unmaking of Alzheimers

Disease, Robert Wood Johnson Foundation, 9/2009-8/2014 (Jason Karlawish, PI), $299,066/annual direct costs, 36% effort (Role in grant: PI)

PENN CMU Roybal Center on Behavioral Economics and Health, National Institute on

Aging, P30 AG034546 , 8/2009-7/2014 (Kevin Volpp, PI: George Loewenstein, Co-Investigator), $267,469/annual direct costs, 2% effort (Role in grant: co-investigator)

Marian S. Ware Program to Improve Participant Recruitment and Retention and the

Outcomes of Clinical Research in Patients with Alzheimer's Disease, National Philanthropic Trust, N/A, 7/2009-6/2012 (John Q. Trojanowski, PI), $216,000/annual direct costs, 5% effort (Role in grant: Co-PI)

A Double-Blind, Placebo-Controlled, Randomized, Multicenter Study Evaluating The

Efficacy And Safety Of Eighteen Months Of Treatment With Pf-04494700 (Ttp488) In Participants With Mild-To-Moderate Alzheimer'S Disease, University Of California-San Diego, CSSA 22, 3/2008-12/2011 (JASON KARLAWISH, PI), $0/annual direct costs (Role in grant: PI, Clinical Trial)

Research Center - Minority Aging Research, National Institute on Aging, 9/2007-6/2012

(Jerry C Johnson, MD, PI), $1,977,103/annual direct costs, 1.5% effort (Role in grant: Educator)

Home-Based Assessment Study, University Of California-San Diego, ADC-30, 9/2007-

12/2012 (JASON KARLAWISH, PI), $0/annual direct costs (Role in grant: PI, Clinical Trial)


Alzheimer's Disease Cooperative Study, National Institute on Aging, U01 AG10483,

9/2006-6/2012 (JASON KARLAWISH, PI), $21,782/annual direct costs, 4% effort (Role in grant: Chair, Int Ethics Comm)

Functional consequences of dementia in PD, National Institute of Neurological Disorders

and Stroke, P50-NS053488-01, 7/2006-6/2011 (Siderowf, PI), $27,489/annual direct costs, 10% effort (Role in grant: co-PI)

Clinical Importance of Drug-Drug Interactions, National Institute on Health, R01-

AG025152, 1/2006-8/2011 (Hennessey, PI), $387,036/annual direct costs, 3.5% effort (Role in grant: Co-investigator)

Robert Wood Johnson Clinical Scholars Program, Robert Wood Johnson Foundation,

7/2005-6/2013 (Metlay, PI), $18,480/annual direct costs (Role in grant: Co-Investigator) Past: Geriatric Education Center, Health Resources and Services Association, 7/2008-7/2009

(Mary Anne Forciea, PI), $391,310/annual direct costs (Role in grant: Teaching) Alzheimer's Disease Cooperative Study, National Institute on Aging, U01 -‐ AG10483 ,

7/2008-6/2009 (Paul Aisen, PI), $33,149/annual direct costs (Role in grant: Chair, Int Ethics Comm)

Voting And Accommodating Cognitive Impairments Clearinghouse and Pilot, American

Bar Association, N/A, 4/2008-12/2010 (JASON KARLAWISH, PI), $19,838/annual direct costs (Role in grant: PI)

Assent And Dissent For Dementia Research, Johns Hopkins University, 5-R21-AG-

030036-02, 9/2007-8/2009 (JASON KARLAWISH, PI), $9,438/annual direct costs (Role in grant: PI)

Voting Empowerment Study Among People With Traumatic Brain Injury, Carolinas

Health Care System, SUB TO R21-HD055202-01, 7/2007-5/2010 (JASON KARLAWISH, PI), $4,191/annual direct costs (Role in grant: PI)

Clinical Interventions for Neurological Emergencies, Greater Philadelphia-Southern New

Jersey NETT, 1-U01-NS058960-01 , 2/2007-1/2012 (Beren, PI), $189,076/annual direct costs (Role in grant: Co PI)

Clinical and Translational Science Award (CTSA), National Center for Research

Resource, RFA-RM-06-002 , 9/2006-3/2011 (Strom, PI), $41,030/annual direct costs (Role in grant: Director Res Ethics Prog, Removed myself grant in June of 2008 but the grant is ongoing. Dr. Strom is the PI)


Consent Methods And Participation In Geriatric Clinical Research, National Institutes Of

Health, 5-R01-MH-071643-04, 1/2006-12/2010 (JASON KARLAWISH, PI), $174,780/annual direct costs, 2% effort (Role in grant: PI, Carryover funds)

Enhancing Brain Health Awareness, Commonwealth Of Pennsylvania, N/A, 1/2006-

6/2006 (JASON KARLAWISH, PI), $42,608/annual direct costs (Role in grant: PI) Capacity to Appoint a Proxy for Research Consent, University of Michigan , R01-

MH075023-01 , 10/2005-8/2010 (Kim, PI: Karlawish, Co-Investigator), $36,865/annual direct costs, 10% effort (Role in grant: Co-PI)

Alzheimer's Disease Center And Institute On Aging Outreach Program, Cumberland

County, 0A05-0044, 1/2005-6/2005 (JASON KARLAWISH, PI), $60,760/annual direct costs (Role in grant: PI)

Improving Informed Consent In Alzheimer Disease Research, National Institutes Of

Health, 5-R01-AG-020627-03, 9/2004-8/2008 (JASON KARLAWISH, PI), $158,193/annual direct costs (Role in grant: PI)

Marian S. Ware Charitable Giving Fund - Continuity Of Care Component, National

Philanthropic Trust, 6/2004-5/2009 (John Trojanowski, MD, PI), $0/annual direct costs (Role in grant: CoPI)

Developing practical guidelines for voting by persons with dementia, The Greenwall

Foundation, 7/2003-8/2008 (Karlawish, PI), $231,996/annual direct costs (Role in grant: PI)

Dementia Awareness and Wandering Prevention Program , Bach Fund, 7/2003-6/2004

(Jason Karlawish, MD, PI), $5,000/annual direct costs (Role in grant: PI) Improving The Measurement Of Quality Of Life For Persons With Alzheimer's Disease,

Wyeth-Ayerst Research, ALZHEIMERS ASSESMENT, 5/2003-4/2007 (HENRY A GLICK, PI), $244,953/annual direct costs (Role in grant: Co-PI)

Cultural Concepts Of Dementia Research, Alzheimer's Association, IIRG-02-3671,

11/2002-6/2006 (JASON KARLAWISH, PI), $88,197/annual direct costs (Role in grant: PI)

Depression and Medical Care: Aging and Clinical Setting, National Institute of Mental

Health, P -30-MH-066270, 9/2002-5/2007 (Oslin, PI), $249,238/annual direct costs (Role in grant: Investigator, Operations Core, )

Validating An Informed Consent Method For Ad Trials, University Of California-San

Diego, PO #10216994-003, 9/2002-6/2006 (JASON KARLAWISH, PI), $66,190/annual direct costs (Role in grant: PI)


Do We Need Research Advance Planning And, If We Do, How Can We Do It?,

Greenwall Foundation, N/A, 7/2002-6/2009 (JASON KARLAWISH, PI), $79,750/annual direct costs (Role in grant: PI)

Validating an informed consent method for AD trials, National Institute on Aging, U01-

AG 10483, 7/2002-6/2004 (Karlawish, Jason, PI), $160,000/annual direct costs (Role in grant: PI)

Assessment Measures For Alzheimer's Disease Primary Prevention Trials, University Of

California-San Diego, N/A, 1/2002-12/2007 (JASON KARLAWISH, PI), $43,479/annual direct costs (Role in grant: PI)

Doneperzil in Outpatients with AD, Pfizer Inc., 9/2001-4/2002 (Karlawish, Jason, PI),

$0/annual direct costs Alzheimer's Disease Center Core: Csf Cortisol And Apoe Genotype, National Institutes

Of Health, 5-P30-AG-010124-15, 8/2001-6/2006 (John Q. Trojanowski, PI), $878,147/annual direct costs (Role in grant: Co-PI)

How Do Alzheimer's Disease Patients and Their Caregivers Make Dementia Treatment

Decisions?, Brookdale National Foundation , 2637, 7/2001-6/2003 (JASON KARLAWISH, PI), $14,316/annual direct costs (Role in grant: PI)

Advancement in Leadership Small Grants Program, Brookdale National Foundation ,

7/2001-6/2002 (Karlawish, Jason, PI), $20,000/annual direct costs (Role in grant: PI) Caregiver And Patient Preferences For The Benefits Of Alzheimers Disease Treatment,

American Federation For Aging Research: Paul Beeson Physician Faculty Scholars Award, N/A, 7/2000-6/2005 (JASON KARLAWISH, PI), $138,044/annual direct costs (Role in grant: PI)

ADCC Pilot, National Institute on Aging, P30-AG01024, 7/2000-6/2001 (Karlawish,

Jason, PI), $0/annual direct costs (Role in grant: PI) Community Equipoise and the ethics of clinical research., National Institute on Aging,

K01-AG00931, 10/1998-9/2003 (Karlawish, Jason, PI), $110,000/annual direct costs (Role in grant: PI)

What Are Caregivers Preferences For Alzheimers Disease Slowing Therapies, Brookdale

National Foundation, GRANT #2378, 7/1998-6/2000 (risa j lavizzo-mourey, PI), $67,500/annual direct costs (Role in grant: Co-PI)

Alzheimer's Disease Center Core: Core A & C Acct #1, National Institutes Of Health, 3-

P30-AG-010124-10S1, 7/1996-6/2001 (John Q. Trojanowski, PI), $0/annual direct costs (Role in grant: Co-PI)


Bibliography: Research Publications, peer reviewed (print or other media): 1. Karlawish J, Craig RM, Koretz R.: The effect of total parenteral nutrition on serum

albumin. Journal of Clinical Gastroenterology 19(4): 300-2, Dec 1994. 2. Karlawish JH, Hall JB.: The controversy over emergency research. A review of the

issues and suggestions for a resolution. American Journal of Respiratory & Critical Care Medicine 153(2): 499-506, Feb 1996.

3. Karlawish JH.: Shared decision making in critical care: a clinical reality and an ethical

necessity. American Journal of Critical Care 5(6): 391-6, Nov 1996. 4. Karlawish JH, Sachs GA.: Research on the cognitively impaired: lessons and warnings

from the emergency research debate. Journal of the American Geriatrics Society 45(4): 474-81, Apr 1997.

5. Karlawish JH, Lantos J.: Community equipoise and the architecture of clinical

research. Cambridge Quarterly of Healthcare Ethics 6(4): 385-96, 1997. 6. Karlawish JHT.: Permissible risk and acceptable benefit: The ethics of research

involving the cognitively impaired. Trends in Experimental and Clinical Medicine FORUM 7: 277-285, 1997.

7. Karlawish JH, Whitehouse PJ.: Is the placebo control obsolete in a world after

donepezil and vitamin E. Archives of Neurology 55(11): 1420-4, Nov 1998. 8. Karlawish JH, Quill T, Meier DE.: A consensus-based approach to providing palliative

care to patients who lack decision-making capacity. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. Annals of Internal Medicine 130(10): 835-40, May 1999.

9. Karlawish JH.: Clinical value: the neglected axis in the system of research ethics.

Accountability in Research 7(2-4): 255-64, 1999. 10. Karlawish JHT, Hougham GW, Stocking CB, Sachs GA.: What is the quality of the

reporting of research ethics in publications of nursing home research? Journal of the American Geriatric Society 47: 76-81, 1999.

11. Faber-Langendoen K, Karlawish JH.: Should assisted suicide be only physician

assisted? University of Pennsylvania Center for Bioethics Assisted Suicide Consensus Panel. Annals of Internal Medicine 132(6): 482-7, Mar 2000.


12. Casarett D, Karlawish JH, Sugarman J.: Determining when quality improvement

initiatives should be considered research: proposed criteria and potential implications. Journal of the American Medical Association 283(17): 2275-80, May 2000.

13. Casarett DJ, Karlawish JH.: Are special ethical guidelines needed for palliative care

research? Journal of Pain & Symptom Management 20(2): 130-9, Aug 2000. 14. Karlawish JH, Klocinski JL, Merz J, Clark CM, Asch DA.: Caregivers' preferences

for the treatment of patients with Alzheimer's disease. Neurology 55(7): 1008-14, Oct 2000.

15. Karlawish JH, Casarett D, Klocinski J, Sankar P.: How do AD patients and their

caregivers decide whether to enroll in a clinical trial? Neurology 56(6): 789-92, Mar 2001.

16. Casarett D, Karlawish J, Sankar P, Hirschman KB, Asch DA.: Obtaining informed

consent for clinical pain research: patients' concerns and information needs. Pain 92(1-2): 71-9, May 2001.

17. Casarett DJ, Karlawish J.: Beyond informed consent: The ethical design of pain

research. Pain Medicine 2(2): 138-146, Jun 2001. 18. Casarett D, Karlawish J, Sankar P, Hirschman KB, Asch DA.: Open label extension

studies and the ethical design of clinical trials. IRB: Ethics and Human Research 23(4): 1-5, Jul-Aug 2001.

19. Karlawish JH, Casarett D, Klocinski J, Clark CM.: The relationship between

caregivers' global ratings of Alzheimer's disease patients' quality of life, disease severity, and the caregiving experience. Journal of the American Geriatrics Society 49(8): 1066-70, Aug 2001.

20. Casarett D, Karlawish J, Sankar P, Hirschman K, Asch DA.: Designing pain research

from the patient's perspective: What trial end points are important to patients with chronic pain? Pain Medicine 2(4): 309-316, Dec 2001.

21. Casarett DJ, Marenberg ME, Karlawish JH.: Predictors of withdrawal from hospice.

Journal of Palliative Medicine 4(4): 491-7, 2001. 22. Karlawish JH, Casarett D.: Addressing the ethical challenges of clinical trials that

involve patients with dementia. Journal of Geriatric Psychiatry & Neurology 14(4): 222-8, 2001.

23. Karlawish JHT, French J.: The ethical and scientific shortcomings of current

monotherapy epilepsy trials in newly diagnosed patients. Epilepsy and Behavior 2: 193-200, 2001.


24. Casarett DJ, Karlawish JH, Byock I.: Advocacy and activism: missing pieces in the

quest to improve end-of-life care. Journal of Palliative Medicine 5(1): 3-12, Feb 2002.

25. Kim SY, Karlawish JH, Caine ED.: Current state of research on decision-making

competence of cognitively impaired elderly persons. American Journal of Geriatric Psychiatry 10(2): 151-65, Mar-Apr 2002.

26. Casarett D, Takesaka J, Karlawish J, Hirschman KB, Clark CM.: How should

clinicians discuss hospice for patients with dementia? Anticipating caregivers' preconceptions and meeting their information needs. Alzheimer Disease and Associated Disorders 16(2): 116-22, Apr-Jun 2002.

27. Karlawish JH, Casarett DA, James BD, Propert KJ, Asch DA.: Do persons with

dementia vote? Neurology 58(7): 1100-2, Apr 2002. 28. Casarett DJ, Karlawish J, Hirschman KB.: Are hospices ready to participate in

palliative care research? Results of a national survey. Journal of Palliative Medicine 5(3): 397-406, Jun 2002.

29. Halpern SD, Karlawish JH, Berlin JA.: The continuing unethical conduct of

underpowered clinical trials. Journal of the American Medical Association 288(3): 358-62, Jul 2002.

30. Casarett D, Karlawish J, Asch DA.: Paying hypertension research subjects: Fair

compensation or undue inducement? Journal of General Internal Medicine 17(8): 651-653, Aug 2002.

31. Karlawish JH, Fox E, Pearlman R.: How changes in health care practices, systems,

and research challenge the practice of informed consent. Medical Care 40(9 Suppl): V12-9, Sep 2002.

32. Karlawish JH, Knopman D, Clark CM, Morris JC, Marson D, Whitehouse PJ, Kawas

CH.: Informed consent for Alzheimer's disease clinical trials: a survey of clinical investigators. IRB: Ethics and Human Research 24(5): 1-5, Sep-Oct 2002.

33. Casarett DJ, Karlawish JH, Henry MI, Hirschman KB.: Must patients with advanced

cancer choose between a Phase I trial and hospice? Cancer 95(7): 1601-4, Oct 2002.

34. Casarett D, Karlawish J, Sankar P, Hirschman KB, Asch DA.: Obtaining informed

consent for cancer pain research: do patients with advanced cancer and patients with chronic pain have different concerns? Journal of Pain & Symptom Management 24(5): 506-16, Nov 2002.


35. Casarett DJ, Karlawish JH, Moreno JD.: A taxonomy of value in clinical research.

IRB: Ethics and Human Research 24(6): 1-6, Nov-Dec 2002. 36. Karlawish JH, Clark CM.: Addressing the challenges of transforming laboratory

advances into Alzheimer's disease treatments. Neurobiology of Aging 23(6): 1043-9, Nov-Dec 2002.

37. Karlawish JH, Casarett D, Propert KJ, James BD, Clark CM.: Relationship between

Alzheimer's disease severity and patient participation in decisions about their medical care. Journal of Geriatric Psychiatry & Neurology 15(2): 68-72, 2002.

38. Karlawish JH, Casarett DJ, James BD.: Alzheimer's disease patients' and caregivers'

capacity, competency, and reasons to enroll in an early-phase Alzheimer's disease clinical trial. Journal of the American Geriatrics Society 50(12): 2019-24, Dec 2002.

39. Clark CM, Karlawish JH.: Alzheimer's disease: current concepts and emerging

diagnostic and therapeutic strategies. Annals of Internal Medicine 138(5): 400-10, Mar 2003.

40. Karlawish JHT, Clark CM.: Diagnostic evaluation of elderly patients with mild

memory problems. Annals of Internal Medicine 138(5): 411-419, Mar 2003. 41. Karlawish JH.: Conducting research that involves subjects at the end of life who are

unable to give consent. Journal of Pain & Symptom Management 25(4): S14-24, Apr 2003.

42. Karlawish JH.: Research involving cognitively impaired adults. New England Journal

of Medicine 348(14): 1389-92, Apr 2003. 43. Casarett DJ, Karlawish JH, Hirschman KB.: Identifying ambulatory cancer patients at

risk of impaired capacity to consent to research. Journal of Pain & Symptom Management 26(1): 615-24, Jul 2003.

44. Karlawish JH, Casarett DJ, James BD, Tenhave T, Clark CM, Asch DA.: Why would

caregivers not want to treat their relative's Alzheimer's disease? Journal of the American Geriatrics Society 51(10): 1391-7, Oct 2003.

45. Halpern SD, Karlawish JH, Casarett D, Berlin JA, Townsend RR, Asch DA.:

Hypertensive patients' willingness to participate in placebo-controlled trials: implications for recruitment efficiency. American Heart Journal 146(6): 985-92, Dec 2003.

46. Halpern SD, Karlawish JH, Casarett D, Berlin JA, Asch DA.: Empirical assessment

of whether moderate payments are undue or unjust inducements for participation in clinical trials. Archives of Internal Medicine 164(7): 801-3, Apr 2004.


47. Hirschman KB, Xie SX, Feudtner C, Karlawish JH.: How does an Alzheimer's

disease patient's role in medical decision making change over time? Journal of Geriatric Psychiatry & Neurology 17(2): 55-60, Jun 2004.

48. Collins M, Crowley R, Karlawish JH, Casarett DJ.: Are depressed patients more

likely to share health care decisions with others? Journal of Palliative Medicine 7(4): 527-32, Aug 2004.

49. Karlawish JH, Bonnie RJ, Appelbaum PS, Lyketsos C, James B, Knopman D,

Patusky C, Kane RA, Karlan PS.: Addressing the ethical, legal, and social issues raised by voting by persons with dementia. Journal of the American Medical Association 292(11): 1345-50, Sep 2004.

50. Hirschman KB, Shea J, Xie SX, Karlawish, JH: The development of a rapid screen

for caregiver burden. Journal of the American Geriatrics Society 52: 1724-1729, Oct 2004 Notes: Erratum in: J Am Geriatr Soc. 2005 Mar;53:556.

51. Karlawish JH, Casarett DJ, James BD, Xie SX, Kim SY.: The ability of persons with

Alzheimer's disease (AD) to make a decision about taking an AD treatment. Neurology 64(9): 1514-9, May 2005.

52. Hirschman KB, Joyce CM, James BD, Xie SX, Karlawish JH.: Do Alzheimer's

disease patients want to participate in a treatment decision, and would their caregivers let them? The Gerontologist 45(3): 381-8, Jun 2005.

53. James BD, Xie SX, Karlawish JH.: How do patients with Alzheimer disease rate their

overall quality of life? American Journal of Geriatric Psychiatry 13(6): 484-90, Jun 2005.

54. Casarett D, Karlawish J, Morales K, Crowley R, Mirsch T, Asch DA.: Improving the

use of hospice services in nursing homes: a randomized controlled trial. Journal of the American Medical Association 294(2): 211-7, Jul 2005.

55. Appelbaum PS, Bonnie RJ, Karlawish JH.: The capacity to vote of persons with

Alzheimer's disease. American Journal of Psychiatry 162(11): 2094-100, Nov 2005.

56. Hirschman KB, Joyce CM, James BD, Xie SX, Casarett DJ, Karlawish JH.: Would

caregivers of Alzheimer disease patients involve their relative in a decision to use an AD-slowing medication? American Journal of Geriatric Psychiatry 13(11): 1014-21, Nov 2005.

57. Kohler C. Anselmo-Gallagher G, Bilker W, Karlawish J, Gur RE, Clark CM.:

Emotion-discrimination deficits in mild Alzheimer disease. American Journal of Geriatric Psychiatry 13(11): 926-33, Nov 2005.


58. Forman MS, Farmer J, Johnson JK, Clark CM, Arnold SE, Coslett HB, Chatterjee A,

Hurtig HI, Karlawish JH, Rosen H, Van Deerlin V, Lee VM, Miller BL, Trojanowski JQ, Grossman M.: Frontotemporal dementia: Clinicopathological correlation. Annals of Neurology 59(6): 952-62, Jun 2006. PMCID: PMC2629792

59. Forman MS, Mackenzie I, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri

BS, Karlawish JH, Pestronk A, Smith TW, Tu PH, Watts GDJ, Markesbery WR, Smith CD, Kimonis VE.: Novel ubiquitin neuropathology in frontotemporal dementia with VCP gene mutations. Journal of Neuropathology and Experimental Neurology 65(6): 571-81, Jun 2006.

60. Hirschman K, Kapo JM, Karlawish JH.: Why doesn't a family member of a person

with advanced dementia use a substituted judgment when making a decision for that person? American Journal of Geriatric Psychiatry 14(8): 659-67, Aug 2006.

61. Katz KA, Karlawish JH, Chiang DS, Bognet RA, Propert KJ, Margolis DJ.:

Prevalence and factors associated with use of placebo control groups in randomized controlled trials in psoriasis: A cross-sectional study. Journal of the American Academy of Dermatology 55(5): 814-22, Nov 2006.

62. Lai JM, Karlawish JH.: Assessing the capacity to make everyday decisions: A guide

for clinicians and an agenda for future research. American Journal Geriatric Psychiatry 15(2): 101-11, Feb 2007.

63. Myers A, Pittman A, Zhao A, Rohrer K, Kaleem M, Marlowe L, Lees A, Leung D,

McKeith I, Perry R, Morris C, Trojanowski J, Clark C, Karlawish J, Arnold S, Forman M, Van Deerlin V, de Silva R, Hardy J.: The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Neurobiology of Disease 25(3): 561-70, Mar 2007

64. Hennessy S, Bilker WB, Leonard CE, Chittams J, Palumbo CM, Karlawish JH, Yang

Y-X, Lautenbach E, Baine WB, Metlay JP.: Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures. Journal of Clinical Epidemiology 60(9): 911-8, Sep 2007. PMCID: PMC2042508

65. Weintraub D, Xie S, Karlawish J, Siderowf A.: Differences in depression symptoms

in patients with Alzheimer's and Parkinson's diseases: Evidence from the 15-item Geriatric Depression Scale (GDS-15). International Journal of Geriatric Psychiatry 22(10): 1025-30, Oct 2007. PMCID: PMC2085362

66. Karlawish JH, Bonnie RJ.: Voting by elderly persons with cognitive impairment:

Lessons from other democratic nations. McGeorge Law Review 38: 880-916, 2007.


67. Sankar P, Jones NL, Karlawish J.: Evaluating existing and emerging connections

among interdisciplinary researchers. BioScience 57(11): 965-72, Dec 2007. 68. Langa KM, Larson EB, Karlawish JH, Cutler DM, Kabeto MU, Kim SY, Rosen AB.:

Trends in the prevalence and mortality of cognitive impairment in the United States: Is there evidence of a compression of cognitive morbidity? Alzheimer's & Dementia 4(2): 134-44, Feb 2008. PMCID: PMC2390845

69. Tjia J, Givens JL, Karlawish JH, Okoli-Umeweni A, Barg FK.: Beneath the surface:

Discovering the unvoiced concerns of older adults with type 2 diabetes mellitus. Health Education Research 23(1): 40-52, Feb 2008.

70. Xie SX, Forman MS, Farmer J, Moore P, Wang Y, Wang X, Clark CM, Coslett HB,

Chatterjee A, Arnold SE, Rosen H, Karlawish JH, Van Deerlin VM, Lee VM-Y, Trojanowski JQ, Grossman M.: Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery & Psychiatry 79(2): 126-9, Feb 2008.

71. Karlawish JH, Kim SY, Knopman D, Van Dyck CH, James BD, Marson D.: The

views of Alzheimer disease patients and their study partners on proxy consent for clinical trial enrollment. American Journal of Geriatric Psychiatry 16(3): 240-7, Mar 2008.

72. Jefferson AL, Byerly LK, Vanderhill S, Lambe S, Wong S, Ozonoff A, Karlawish

JH.: Characterization of activities of daily living in individuals with mild cognitive impairment. American Journal of Geriatric Psychiatry 16(5): 375-83, May 2008. PMCID: PMC2682324

73. Karlawish JH, Zbrozek A, Kinosian B, Gregory A, Ferguson A, Glick H.: Preference-

based quality of life in patients with Alzheimer's Disease. Alzheimer's & Dementia 4(3): 193-202, May 2008.

74. Karlawish JH, Zbrozek A, Kinosian B, Gregory A, Ferguson A, Low DV, Glick H.:

Caregivers' assessments of preference-based quality of life in Alzheimer's Disease. Alzheimer's & Dementia 4(3): 203-11, May 2008.

75. Hirschman KB, Kapo J, Karlawish JH.: Identifying the factors that facilitate or hinder

advance planning by persons with dementia. Alzheimer Disease and Associated Disorders 22(3): 293-8, Jun 2008. PMCID: PMC2666935

76. Merchant RM, Rubright JD, Pryor JP, Karlawish JH.: Who can speak for the

emergently ill? Testing a method to identify communities and their leaders. Academic Emergency Medicine 15(6): 581-3, Jun 2008.


77. Jefferson AL, Lambe S, Moser DJ, Byerly LK, Ozonoff A, Karlawish JH.: Decisional

capacity for research participation among individuals with mild cognitive impairment. Journal of the American Geriatric Society 56(7): 1236-43, Jul 2008. PMCID: PMC2724182

78. Karlawish JH, Kim SY, Knopman D, Van Dyck CH, James B, Marson D.:

Interpreting the clinical significance of capacity scores for informed consent in AD clinical trials. American Journal of Geriatric Psychiatry 16(7): 568-74, Jul 2008.

79. Lai JM, Gill TM, Cooney LM, Bradley EH, Hawkins KA, Karlawish JH.: Everyday

decision-making ability in older persons with cognitive impairment. American Journal of Geriatric Psychiatry 16(8): 693-6, Aug 2008. PMCID: PMC2730037

80. Lai JM, Hawkins KA, Gross CP, Karlawish JH.: Self-reported distress after cognitive

testing in patients with Alzheimer's Disease. J Gerontol A Biol Sci Med Sci 63(8): 855-9, Aug 2008. PMCID: PMC2733161

81. Flaherty ML, Karlawish JH, Khoury JC, Kleindorfer D, Woo D, Broderick JP.: How

important is surrogate consent for stroke research? Neurology 71(20): 1566-71, Nov 2008.

82. Karlawish J, Cary MS, Rubright J, TenHave T.: How redesigning AD clinical trials

might increase study partners' willingness to participate. Neurology 71(23): 1883-8, Dec 2008. PMCID: PMC2649726

83. Karlawish J.: Measuring decision making capacity in cognitively impaired

individuals. Neurosignals 16(1): 91-8, 2008. PMCID: PMC2717553 84. Karlawish JH, Bonnie RJ, Appelbaum PS, Kane RA, Lyketsos CG, Karlan PS, James

BD, Sabatino C, Lawrence T, Knopman D.: Identifying the barriers and challenges to voting by residents in nursing homes and assisted living settings. Journal of Aging & Social Policy 20(1): 65-79, 2008.

85. Kim SYH, Kim HM, Langa KM, Karlawish JHT, Knopman DS, Appelbaum PS.:

Surrogate consent for dementia research: A national survey of older Americans. Neurology 72(2): 149-55, Jan 2009. PMCID: PMC2663398

86. Karlawish J, Rubright J, Casarett D, Cary M, TenHave T, Sankar P.: Older adults'

attitudes toward noncompetent subjects participating in Alzheimer's research. American Journal of Psychiatry 166(2): 182-8, Feb 2009. PMCID: PMC2635420

87. Raad R, Karlawish JH, Appelbaum PS.: The capacity to vote of persons with serious

mental illness. Psychiatric Services 60(5): 624-8, May 2009.


88. Yu FOT, Lui VWC, Lam LCW, Chiu HFK, Karlawish JHT, Appelbaum PS.:

Assessment of capacity to make financial decision in Chinese psychogeriatric patients: A pilot study. Hong Kong Journal of Psychiatry 19: 82-6, Jun 2009.

89. Xie SX, Ewbank DC, Chittams J, Karlawish JH, Arnold SE, Clark CM.: Rate of

decline in Alzheimer disease measured by a Dementia Severity Rating Scale. Alzheimer Disease and Associated Disorders 23(3): 268-74, Jul-Sep 2009. PMCID: 19812470

90. Neuman MD, Archan S, Karlawish JH, Schwartz JS, Fleisher LA.: The relationship

between short-term mortality and quality of care for hip fracture: A meta-analysis of clinical pathways for hip fracture. Journal of the American Geriatrics Society 57(11): 2046-2054, Nov 2009 Notes: Epub 28 Sep 2009.

91. Black BS, Rabins PV, Sugarman J, Karlawish JH.: Seeking assent and respecting

dissent in dementia research. The American Journal of Geriatric Psychiatry 18(1): 77-85, Jan 2010. PMCID: PMC2811536

92. Trojanowski JQ, Arnold SE, Karlawish JH, Brunden K, Cary M, Davatzikos C, Detre

J, Gaulton G, Grossman M, Hurtig H, Jedrziewski K, McCluskey L, Naylor M, Polsky D, Schellenberg GD, Siderowf A, Shaw LM, Van Deerlin V, Wang LS, Werner R, Xie SX, Lee VM.: Design of comprehensive Alzheimer's disease centers to address unmet national needs. Alzheimer's & Dementia 6(2): 150-5, Mar 2010. PMCID: PMC2842603

93. Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering

E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ.: Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment. Acta Neuropathol 119(6): 669-78, Jun 2010 Notes: Epub 2010 Mar 16. PMCID: PMC2880811

94. Rosenthal E, Brennan L, Xie S, Hurtig H, Milber J, Weintraub D, Karlawish J,

Siderowf A.: Association between cognition and function in patients with Parkinson disease with and without dementia. Movement Disorders 25(9): 1170-6, Jul 2010. PMCID: PMC2811536

95. Roberts JS, Karlawish JH, Uhlmann WR, Petersen RC, Green RC.: Mild cognitive

impairment in clinical care: A survey of American Academy of Neurology members. Neurology 75(5): 425-31, Aug 2010. PMCID: PMC2918467

96. Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey

L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ.: Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease. Acta Neuropathologica 120(3): 385-99, Sep 2010 Notes: Epub 2010 Jul 22.


97. Klein E, Karlawish J.: Challenges and opportunities for developing and implementing

incentives to improve health-related behaviors in older adults. Journal of the American Geriatrics Society 58(9): 1758-63, Sep 2010. PMCID: PMC2946121

98. Reese PJ, Caplan AL, Bloom RD, Abt PL, Karlawish JH: How Should We Use Age

to Ration Health Care? Lessons from the Case of Kidney Transplantation. Journal of the American Geriatrics Society 58: 1980-1986, Oct 2010.

99. Karlawish, J.: Desktop Medicine. Journal of the American Medical Association

304(18): 2061-2062, Nov 2010. 100. Rubright J, Sankar P, Casarett DJ, Gur R, Xie SX, Karlawish J.: A memory and

organizational aid improves research consent capacity in persons with Alzheimer's disease: Results of a randomized, controlled trial. American Journal of Geriatric Psychiatry 18(12): 1124-1132, Dec 2010. PMCID: PMC2992096

101. Jefferson AL, Lambe S, Chaisson C, Palmisano J, Horvath KJ, Karlawish J: Clinical

Research Participation among Aging Adults Enrolled in an Alzheimer's Disease Research Registry. Journal of Alzheimer's Disease 23(3): 443-452, Jan 2011. PMCID: in process

102. Kim SYK, Karlawish J, Kim HM, Wall IF, Bozoki A, Appelbaum PS.: Preservation

of the capacity to appoint a proxy decision maker: Implications for dementia research. Archives of General Psychiatry 68(2): 214-219, Feb 2011.

103. Karlawish J, Barg FK, Augsburger D, Beaver J, Ferguson A, Nunez J.: What Latino

Puerto Ricans and non-Latinos say when they talk about AD. Alzheimer's & Dementia 7(2): 161-170, Mar 2011.

104. Karlawish J, Sabatino C, Markowitz D, Rubright J, Klem E, Boruch RF.: Bringing

the vote to the residents of long-term care facilities: A study of the benefits and challenges of mobile polling. Election Law Journal 10(1): 5-14, Mar 2011.

105. Rubright JD, Cary MS, Karlawish JH, Kim SY: Measuring how people view

biomedical research: Reliability and validity analysis of the Research Attitudes Questionnaire. Journal of Empirical Research on Human Research Ethics 6(1): 63-68, Mar 2011. PMCID: PMC3253733

106. Kasner SE, Baren JM, Le Roux PD, Nathanson PG, Lamond K, Rosenberg S,

Karlawish JH.: Community Views on Neurological Emergency Treatment Trials. Annals of Emergency Medicine 57(4): 346-354, Apr 2011 Notes: Editorial: Biros, M.H. The People Speak: Community Consultation in Emergency Research. Annals Emer Med


107. Xie SX*, Baek Y*, Grossman M, Arnold SE, Karlawish J, Siderowf A, Hurtig H,

Elman L, McCluskey L, Van Deerlin V, Lee VM-Y, Trojanowski JQ *Co-first authors.: Building an integrated neurodegenerative disease database at an academic health center. Alzheimer's and Dementia 7(4): e84-e93, July 2011. PMCID: PMC3145967

108. Karlawish J: Addressing the ethical, policy, and social challenges of pre-clinical

Alzheimer's disease. Neurology 77(15): 1487-93, Oct 2011. 109. Meisel ZF, Karlawish J: Narrative vs Evidence-Based Medicine-- And, Not Or.

Journal of the American Medical Association 306(18): 2022-2023, November 2011.

110. Link JN, Kropf M, Hirsch MA, Hammon FM, Karlawish J, Schur L, Kruse D, Davis

CS: Assessing Voting Competence and Political Knowledge: Comparing Individuals with Traumatic Brain Injuries and "Average" College Students. Election Law Journal 11(1), January 2012.

111. Kesselheim AS, Karlawish J: Biomarkers Unbound - the Supreme Court's Ruling on

Diagnostic-Test Patents. New England Journal of Medicine 366(25): 2338-2340, June 2012.

112. Lui WCV, Lam CWL, Chau CMR, Fung WTA, Wong MLB, Leung TYG, Leung

KF, Chiu FKH, Karlawish JHT, Appelbaum PS: Capacity to Make Decisions on Medication Management in Chinese Older Persons with Mild Cognitive Impairment and Mild Alzheimer Disease. International Psychogeriatrics 24(7), June 2012.

113. Grill JD, Karlawish J, Elashoff D, Vickrey BG: Risk disclosure and preclinical

Alzheimer's disease clinical trial enrollment. Alzheimer's and Dementia In press 2012.

114. Grill JD, Monsell S, Karlawish JHT: Are Patients Whose Study Partners Are

Spouses More Likely to be Eligible for Alzheimer's Disease Clinical Trials? Dementia and Geriatric Cognitive Disorders 33(5), in press 2012.

115. Hu W, Holtzman D, Fagan AM, Shaw LM, Perrin R, Arnold SE, Grossman M,

Xiong C, Craig-Schapiro R, Clark CM, Pickering E, Kuhn M, Chen Y, Van Deerlin V, McCluskey L, Elman LB, Karlawish JHT, Chen-Plotkin AS, Hurtig H, Siderowf AD, Swenson F, Lee VM-Y, Morris JC, Trojanowski JQ, Soares H: Plasma multi-analyte profiling in mild cognitive impairment and Alzheimer's disease. Neurology In press 2012.


116. Jefferson AL, Carmona H, Gifford K, Sarinana SL, Byerly LK, Cantwell N,

Tripodis Y, Karlawish J: Clinical Research Risk Assessment Among Individuals with Mild Cognitive Impairment. American Journal of Geriatric Psychiatry In press 2012.

117. Tsou AY, Karlawish J, McCluskey L, Xie S, Long J: Predictors of emergent

gastronomy and tracheostomy in ALS. Amyotrophic Lateral Sclerosis In press 2012.

118. Livney MG, Clark CM, Karlawish JH, Cartmell S, Nunez-Lopez J, Vega IE,

Entenza-Cabrera F, Arnold SE.: Differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease center. American Journal of Geriatric Psychiatry In Press, 2011.

119. Neuman MD, Speck RM, Karlawish JH, Schwartz JS, Shea JA.: Hospital protocols

for the inpatient care of older adults: Results from a statewide survey. Journal of the American Geriatrics Society In Press, 2011.

120. Dahodwala N, Karlawish J, Siderowf A, Duda JE, Mandell DS: Delayed Parkinson's

disease diagnosis among African-Americans: the role of reporting of disability. Neuroepidemiology In press, 2011.

121. Dahodwala N, Siderowf A, Baumgarten M, Abrams A, Karlawish J: Screening

Questionnaires for Parkinsonism: A Systematic Review. Parkinsonism and Related Disorders In press, 2011.

122. Trojanowski JQ, Arnold SE, Karlawish JH, Naylor M, Brunden KR, Lee VM-Y: A

model for improving the treatment and care of Alzheimer patients through interdisciplinary research. Alzheimer's & Dementia In press, 2011.

Contributions to peer-reviewed clinical research publications, participation cited but not by

authorship: 1. Abrahm JL, (Karlawish JHT, member, American College of Physicians-American

Society of Internal Medicine End-of-Life Care Consensus Panel).: Management of pain and spinal cord compression in patients with advanced cancer. Annals of Internal Medicine 131: 37-46, 1999.

2. Lo B, Quill TE, Tulsky J, (Karlawish JHT, member, American College of Physicians-

American Society of Internal Medicine End-of-Life Care Consensus Panel).: Discussing palliative care with patients. Annals of Internal Medicine 130: 744-9, 1999.

3. Block SD (Karlawish JHT, member, American College of Physicians-American

Society of Internal Medicine End-of-Life Care Consensus Panel).: Assessing and managing depression in the terminally ill patient. Annals of Internal Medicine 132: 209-18, 2000.


4. Faber-Langendoen K, Lanken PN (Karlawish JHT, member, American College of

Physicians-American Society of Internal Medicine End-of-Life Care Consensus Panel).: Dying patients in the ICU: forgoing treatment, maintaining care. Annals of Internal Medicine 132: 886-93, 2000.

5. Meisel A, Snyder L, Quill TE, (Karlawish JHT, member, American College of

Physicians-American Society of Internal Medicine End-of-Life Care Consensus Panel).: Seven legal barriers to end-of-life care: myths, realities and grains of truth. Journal of the American Medical Association 204: 2495-501, 2000.

6. Quill TE, Byock IR, (Karlawish JHT, member, American College of Physicians-

American Society of Internal Medicine End-of-Life Care Consensus Panel.: Responding to intractable terminal suffering: the role of terminal sedation and voluntary refusal of food and fluids. Annals of Internal Medicine 132: 408-14, 2000.

7. Casarett D, Kutner JS, Abrahm J, (Karlawish JHT, member, American College of

Physicians-American Society of Internal Medicine End-of-Life Care Consensus Panel).: Life after death: a practical approach to grief and bereavement. Annals of Internal Medicine 134: 208-15, 2001.

8. Casarett DJ, Inouye SK, (Karlawish JHT, member, American College of Physicians-

American Society of Internal Medicine End-of-Life Care Consensus Panel).: Diagnosis and management of delirium near the end of life. Annals of Internal Medicine 135: 32-40, 2001.

9. Alzheimer's Association National Board of Directors.: Research consent for

cognitively impaired adults -‐ recommendations for institutional review boards and investigators Consensus Recommendations. Alzheimer Disease and Associated Disorders 19: 171-75, 2004.

10. Luce JM, Cook DJ, Martin TR, Angus DC, Boushey HA, Curtis JR, Heffner JE,

Lanken PN, Levy MM, Polite PY, Rocker GM, Truog RD, (Karlawish JHT, conference presenter).: The ethical conduct of clinical research involving critically ill patients in the United States and Canada -‐ principles and recommendations. American Journal of Respiratory Critical Care Medicine 170: 1375-84, 2004.

Abstracts: 1. Karlawish JHT, Hougham GW, Stocking CB, Sachs GA.: Nursing home research: The

positive effect of instructions for authors on the quality of reported research ethics. Third International Congress on Biomedical Peer Review, Prague, Czech Republic Sep 1997.


2. Karlawish JHT, Hougham GW, Stocking CB, Sachs GA.: Quality of reported research

ethics in publications of nursing home research. Journal of the American Geriatrics Society 45(S43), 1997.

3. Karlawish J, Clark CM, Klocinski J, Asch D.: What are caregivers' preferences for

slowing the progression of Alzheimer's Disease? The Gerontologist 39(S1): 331, 1999 Notes: Paper presentation at the 1999 Annual Meeting of the Gerontological Society of America.

4. Karlawish JHT, Klocinski J, Asch DA, Clark C.: What benefits of an Alzheimer's

Disease therapy are most important to caregivers? Results of a pilot study. Journal of the American Geriatrics Society 47(S8), 1999 Notes: Paper presentation at the 1999 Annual Meeting of the American Geriatrics Society.

5. Forceia M, Delsignore A, Karlawish JHT, Clark CM.: Impact of dementia on life

experience in a continuing care retirement community. The Gerontologist 40(S): 258, 2000.

6. Karlawish J, Casarett D, James B, Klocinski J, Clark CM.: The impact of burden and

depression on dementia caregivers ratings of their overall quality of life. The Gerontologist 40(S): 258, 2000.

7. Karlawish J, Casarett D, Klocinski J, Clark CM.: The relationship between caregivers'

ratings of Alzheimer's Disease patients' global quality of life and caregiver burden. Journal of the American Geriatrics Society 48(s62), 2000.

8. Karlawish J, Klocinski J, Merz JF, Clark CM, Asch DA.: How much risk will

caregivers tolerate to treat AD? Journal of the American Geriatrics Society 48(S9), 2000 Notes: Paper presentation at the 2000 Annual Meeting of the American Geriatrics Society.

9. Karlawish JHT.: The research risk assessment. Neurobiology of Aging 21(S6), 2000

Notes: Paper presentation at the World Alzheimer Congress 2000. 10. Clark CM, McGowan J, Moonis G, Lee V, Ewbank D, Karlawish JHT, Trojanowski

JQ, DeCarli C.: The association between cortical brain volume and cerebrospinal fluid tau and beta-amyloid in patients with Alzheimer's Disease. Neurobiology of Aging 22(10), 2001 Notes: Presented at the First Meeting of the Alzheimer's Imaging Consortium in conjunction with the World Alzheimer Congress 2000.

11. Karlawish J, Casarett D, James B, Klocinski J, Marenberg M, Clark CM.: The impact

of depression and dementia severity on AD patients' rating of their overall quality of life. The Gerontologist 41(S): S281, 2001.

12. Karlawish J, Casarett D, James B, Propert K, Asch DA.: Do persons with dementia

vote? The Gerontologist 41(S): S148, 2001.


13. Karlawish JHT, Casarett D, Klocinski J, Clark CM.: Alzheimer Disease patient and

caregiver performance on a clinical trial informed consent quiz to assess understanding. Journal of the American Geriatrics Society 49(S): S61, 2001.

14. Karlawish JHT, Casarett D, Propert KJ, James B, Clark CMC.: The relationship

between dementia severity and Alzheimer's Disease patients' participation in decisions about their medical care. Journal of the American Geriatrics Society 49(S): S138, 2001.

15. Casarett DJ, Karlawish JHT, Hirschman KB.: The effect of symptoms on cancer

patients' capacity to give consent for research. Journal of the American Geriatrics Society 50(S4): S31, 2002.

16. Casarett DJ, Takesaka J, Karlawish JHT, Hirschman KB, Clark CM.: How should

clinicians discuss hospice for patients with dementia? Anticipating caregivers' preconceptions and meeting their information needs. Journal of the American Geriatrics Society 50(S4): S432, 2002.

17. Karlawish J, Casarett D, James B, TenHave T, Clark CM.: What factors explain

differences between Alzheimer's Disease patients and caregivers ratings of patient quality of life (QOL)? Journal of the American Geriatrics Society 50(S): S94-S95, 2002.

18. Karlawish J, Casarett D, James BD, Tenhave T, Clark CM, Asch DA.: Why would

caregivers not want to treat their relative's Alzheimer's Disease? The Gerontologist 42(S): 205, 2002.

19. Collins M, Crowley R, Karlawish J, Casarett D.: Are depressed patients near the end-

of-life more likely to delegate decision-making to others? Journal of the American Geriatrics Society 51(S4): S171-S172, Apr 2003.

20. Cotter VT, Karlawish JH.: Dementia care: resident training in family practice. Journal

of the American Geriatrics Society 51 (S4): S62, Apr 2003. 21. Karlawish JH, Casarett D, Coyne J, Katz I.: Are depressed elderly more likely to

refuse a screening colonscopy? Journal of the American Geriatrics Society 51(S4): S110-S111, Apr 2003.

22. Karlawish JH, James BD, Casarett DJ, Kim S, Sankar P.: Can people with

Alzheimer's Disease make a decision about treating Alzheimer's Disease? Journal of the American Geriatrics Society 51 (S4): S39, Apr 2003 Notes: Paper presentation at the 2004 Annual Meeting of the American Geriatrics Society. Winner of the American Geriatrics Society, Best Paper Award for Outstanding Excellence in Geriatrics Research, Ethics category.


23. Nagahawatte N, Karlawish JH, James BD.: How do dementia patients participate in

an informed consent process? Journal of the American Geriatrics Society 51( S4): S111, Apr 2003.

24. Hirschman KB, Xie S, Karlawish JHT.: How does an Alzheimer's Disease patients'

role in medical decision-making change over time? The Gerontologist 43(S): 482, 2003.

25. Joyce CM, Hirschman KB, James BD, Casarett DJ, Xie SX, Karlawish JHT.: How do

caregivers resolve disagreements with patients in a decision to treat Alzheimer's Disease? The Gerontologist 43(S): 482, 2003.

26. Karlawish JHT, Casarett DJ, Kim SYH, James BD, Xie SX.: Can patients with

Alzheimer's Disease make an AD treatment decision? The Gerontologist 43(S): 482, 2003.

27. Karlawish JHT, Joyce CM, Hirschman KB, James BD, Casarett DJ, Xie SX.: Why do

caregivers not involve their relatives in a decision to treat Alzheimer's Disease? The Gerontologist 43(S): 482, 2003.

28. Marenberg M, Grugan P, Nathanson G, Glosser G, Karlawish J, Johnson J, Clark C.:

Screening for mild cognitive impairment in a biracial primary care population. The Gerontologist 43(S): 299, 2003.

29. Karlawish JH, Zbrozek A, Kinosian B, Gregory A, Glick H.: Is ignorance bliss?

Insight and quality of life in the persons with AD. Journal of the American Geriatrics Society 52 (S1): S163-S164, Apr 2004.

30. Gregory A, Xie S, Karlawish J, Katz I.: Self-rated performance, not actual

performance, is associated with the distress of testing in Alzheimer's Disease patients. The Gerontologist 44(S1): S21, 2004.

31. Hirschman KB, James BD, Joyce CJ, Casarett DJ, Karlawish JH.: Do Alzheimer's

Disease (AD) patients want to participate in an AD treatment decision and would their family let them? Neurobiology of Aging 25(S2): S21-S22, 2004.

32. Hirschman KB, James BD, Joyce CM, Casarett DJ, Karlawish JH.: Do Alzheimer's

Disease patients want to participate in treatment decisions and, even if they do, will their family let them? The Gerontologist 44(S1): 57, 2004.

33. Hirschman KB, Kapo J, Karlawish JHT.: What factors impact caregivers' ability to

exercise substituted judgment surrounding medical decisions for dementia patients? The Gerontologist 44(S1): 454, 2004.


34. Hirschman KB, Kapo J, Karlawish JHT.: What do family members of persons with

dementia see as the barriers and facilitators to planning for the future. The Gerontologist 45(S11): 94, 2004.

35. Karlawish J, James B, Kim S, Knopman D, vanDyck C, Marson D.: Cognitive and

functional correlates of the capacity of persons with mild to moderate AD to enroll in a clinical trial. The Gerontologist 44(S1): 102, 2004.

36. Karlawish JH, Gregory A, Zbrozek AS, Kinosian B, Glick H.: Generic measures of

health related quality of life in person with mild to moderate AD. Neurobiology of Aging 25(S2): S325, 2004.

37. Karlawish JH, Gregory A, Zbrozek AS, Kinosian B, Glick H.: Carer responses to

generic measures of health related quality of life (HR QOL) are valid in assessing patients with mild to moderate Alzheimer's Disease (AD). Neurobiology of Aging 25(S2): S323, 2004.

38. Karlawish JH, James BD, Kim S, Knopman D, vanDyck CH, Marson D.: Alzheimer's

Disease patient and caregiver attitudes about proxy informed consent. Neurobiology of Aging 25(S2): S345, 2004.

39. Karlawish JH, Lu M, Logsdon R, Whitehouse P, Aisen P.: How much do 12 month

changes in cognition and function influence changes in mild to moderate patients and caregivers ratings of patient quality of life? Neurobiology of Aging 25(S2): S325, 2004.

40. Zbrozek AS, Gregory A, Karlawish JH, Kinosian B, Glick H.: Test/Re-Test reliability

assessment of 6 health status measures in patients with suspected mild to moderate Alzheimer's Disease and their proxy caregivers. Neurobiology of Aging 25(S2): S321, 2004.

41. Cotter VT, Butler L, Gardner B, Karlawish JH.: Does an early stage support group

lead to depression and decreased quality of life in persons with Alzheimer's Disease? Journal of the American Geriatrics Society 53 Supplement 1: S115, Apr 2005.

42. Hirschman KB, Kapo J, Karlawish JH.: What are the difficult decisions family

members' of dementia patients face in the advanced stages of dementia? Journal of the American Geriatrics Society 53 (S1): S86, Apr 2005.

43. Ferguson A, Barg F, Augsburger D, Nunez J, Karlawish J.: Genes or stress? Ethnic

Perceptions About the Causes of Alzheimers Disease. Alzheimer's & Dementia 1(S1): S54, 2005.

44. Karlawish J.: Patient and family perspectives on research with individuals who have

diminished capacity. The Gerontologist 2005.


45. Bhasin M, Seeman T, Karlawish J, Sarkisian CA.: Do older adults who "adjust" for

age when rating their health have different life satisfaction? Journal of the American Geriatrics Society 54 Supplement 4: S108-S109, Apr 2006.

46. Lai JM, Gross CP, Karlawish JH.: Self-reported distress is prevalent after cognitive

testing in mild-moderate Alzheimer's Disease and is associated with patient awareness of test performance and difficulty. Journal of the American Geriatrics Society 54 Supplement 4: S148, Apr 2006.

47. Jefferson AL, Lambe S, Moser D, Ozonoff A, Wong S, Karlawish JHT.: Decisional

capacity for research participation in mild cognitive impairment. Alzheimer's & Dementia. Poster presented at the 10th International Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain (eds.). 2(3, S1): S587, Jul 2006.

48. Karlawish J, Kim S, Knopman D, James B, vanDyck C, Marson D.: The capacity of

persons with very mild to moderate AD to provide informed consent to enroll in a clinical trial. Alzheimer's & Dementia 2(3, S1): s574, 2006.

49. Zbrozek AS, Karlawish J, Kinosian B, Glick H.: Who best to rate an Alzheimer's

Disease (AD) patient's quality of life: Patient or caregiver? The case for a mixed perspective. Alzheimer's & Dementia. Poster presented at the 10th International Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain, July 2006. (eds.). 2(3): S1, 2006.

50. Zbrozek AS, Karlawish J, Kinosian B, Glick H.: How well do family caregivers'

direct judgments of very mild to moderate AD patients' health preference compare to their substituted judgments of these preferences? Alzheimer's & Dementia. Poster presented at the 10th International Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain, July 2006 (eds.). 2(3, S1): S577, 2006.

51. Rubright J, Gur R, Karlawish J.: Home or office? Orientation subscale scores vary by

administration location. Journal of the American Geriatrics Society. Winner of the category of Cognition and Neurosciences, Presidential Poster Session, at the American Geriatrics Society Annual Scientific Meeting, Seattle, WA, May 2007. 55(S1): S211, May 2007.

52. Hirschman KB, Panzer SL, Karlawish JHT.: Advance care planning and dementia.

Alzheimer's & Dementia 3(3): S144, 2007. 53. Karlawish J Rubright J.: How much risk are Alzheimer's disease patients willing to

take to treat their Alzheimer's disease? Alzheimer's & Dementia 3(3): S100, 2007. 54. Karlawish J, Cary MS.: Home visits may improve recruitment in AD clinical trials.

Alzheimer's & Dementia 3(3): S171-S172, 2007.


55. Lai JM, Cooney LM, Gill TM, Bradley EH, Hawkins KA, Karlawish JH.: Evaluating

the Ability of Older Persons with Cognitive Deficits to Solve Problems in Performing their Activities of Daily Living. Journal of the American Geriatrics Society 55(S1): D55, 2007.

56. Karlawish J, Rubright J, Xie S, Casarett DJ, Gur R, Sankar P.: A Memory and

Organizational Aid Improves Research Consent Capacity in Persons with Alzheimer's Disease. Journal of the American Geriatrics Society. Presented at the American Geriatrics Society's 2008 Annual Meeting. Washington, DC. May 2008. 56(4): S1, May 2008.

57. Kirksey D, Guerra CE, Xie S, Glick HA, Karlawish J.: Does information on

colorectal cancer risk and benefits of screening tailored to a patient with Alzheimer's disease alter a caregiver's acceptance or decision conflict about colonoscopy? Journal of the American Geriatrics Society. Presented at the American Geriatrics Society's 2008 Annual Meeting. Washington, DC. May 2008. 56(4): S61, May 2008.

58. Rubright J, Harkins K, Brookstein P.: Does race alter your attitude toward research?

Journal of the American Geriatrics Society. Presented at the American Geriatrics Society's 2008 Annual Meeting. Washington, DC. 56(4): S177, May 2008.

59. Karlawish J, Rubright J, Casarett D, Cary M, TenHave T, Sankar P.: Do older adults

support enrolling noncompetent subjects in research that does not benefit the subjects? Alzheimer's & Dementia 4(4): T440, 2008.

60. Link J, Kropf M, Hirsch M, Hammond F, Karlawish J, Schur L, Kruse D, Davis CD.:

Comparing voting competency: Political knowledge and political empowerment of Traumatic Brain Injury survivors and average college students. Midwest Political Science Association 68th Annual National Conference Apr 2010.

61. Davis CS, Nelson JM, Hirsch M, Hammond F, Karlawish J, Schur L, Kruse D, Ball

A.: An exploratory examination of political empowerment and voting among individuals with TBI. Brain Injury 24(3): 208, 2010.

62. Hirsch MA, Arrington T, Ball AM, Bickett AK, Davis CS, Hammond F, Karlawish

JHT, Kropf M, Kruse D, Lang KC, Nelson J, Saunders S, Schur L: The capacity to vote of persons with traumatic brain injury. 3rd Fedetal Interagency Conference on TBI 2010 Notes: submitted.

63. Davis C, Nelson J, Hirsch MA, Hammond FM, Karlawish J, Schur L, Kruse D, Ball

A.: An exploratory examination of political empowerment and voting among individuals with TBI. Brain Injury In Press, 2011.


Editorials, Reviews, Chapters, including participation in committee reports (print or other

media): 1. Karlawish JH.: Group G streptococcal bacteremia caused by an asymptomatic

esophageal carcinoma in an elderly man. Southern Medical Journal 87(6): 667-8, Jun 1994.

2. Karlawish JHT.: Truth telling in medicine. Archives of Internal Medicine 154: 226,

1994. 3. Karlawish JH, Smith GW, Gabrielson EW, Liu MC.: Spontaneous hemothorax caused

by a chest wall chondrosarcoma. Annals of Thoracic Surgery 59(1): 231-3, Jan 1995.

4. Karlawish JH.: A piece of my mind. The night doctor. Journal of the American

Medical Association 273(6): 454, Feb 1995. 5. Karlawish J, Siegler M.: Discontinuation of dialysis is not euthanasia. Archives of

Internal Medicine 155(15): 1681-2, Aug 1995. 6. Karlawish J.: Blindness among nursing home residents. New England Journal of

Medicine 333(13): 879-80, Sep 1995. 7. Karlawish JHT, Paris JJ, Shewchuk TR, Siegler M.: Clinical ethical concerns in the

operating room. Critical Issues in Operating Room Management. Malangoni MA. (eds.). Lippincott-Raven Pub, Philadelphia, PA, 45(4): 211-230, 1996.

8. Karlawish JH, Hall JB.: Managing death and dying in the intensive care unit. American

Journal of Respiratory & Critical Care Medicine 155(1): 1-2, Jan 1997. 9. Karlawish JH, Sachs GA.: APOE4 testing for Alzheimer's disease. Journal of the

American Geriatrics Society 45(9): 1153-4, Sep 1997. 10. Karlawish J.: A personal choice. Lancet 350(9094): 1833-1834, Dec 1997. 11. Karlawish JHT.: Our relationship with technology: A case commentary. American

Journal of Ethics and Medicine 6: 18-19, 1998. 12. Karlawish JH, Casarett D.: Sildenafil for diabetic men with erectile dysfunction.

Journal of the American Medical Association 282(10): 940-1, Sep 1999. 13. Casarett D, Karlawish JHT.: Working in the dark: The state of palliative care for

patients with severe dementia. Generations 23: 18-23, 1999 Notes: Special issue: "Care at the end-of-life: Restoring a balance."


14. Karlawish JH: Why we are not ready for a biopsychosocial approach to dementia

research and intervention: commentary on "Heterogeneity in dementia: challenges and opportunities." Alzheimer Disease and Associated Disorders 14(2): 64-7, Apr-Jun 2000.

15. Karlawish J.: Age may influence decisions to withhold life-sustaining treatment.

Evidence-Based Healthcare 4(2): 45, Jun 2000. 16. Karlawish JH, Schmitt FA.: Why physicians need to become more proficient in

assessing their patients' competency and how they can achieve this. Journal of the American Geriatrics Society 48(8): 1014-6, Aug 2000.

17. Casarett D, Karlawish JHT: Should patients in quality-improvement activities have

the same protections as participants in research studies? (author reply). Journal of the American Medical Association 284(14): 1786-1788, Oct 2000.

18. Casarett D, Karlawish JHT, Sugarman J.: Should patients in quality-improvement

activities have the same protection as participants in research studies? Journal of the American Medical Association 284(14): 1786-1788, Oct 2000.

19. Halpern SD, Karlawish JH.: Placebo-controlled trials are unethical in clinical

hypertension research. Archives of Internal Medicine 160(20): 3167-9, Nov 2000. 20. Casarett DA, Karlawish JHT, Andrews E, Caplan A.: Bioethical issues in

pharmacoepidemiology research. Pharmacoepidemiology, Third Edition. Strom BL (eds.). John Wiley & Sons, New York, NY, Page: 417-432, 2000.

21. Halpern SD, Karlawish JH.: Industry-sponsored research. University of Pennsylvania

Research Ethics Working Group. Lancet 356(9248): 2193, Dec 2000 Notes: author reply 2194.

22. Karlawish JHT, Casarett DA.: Competency and Decision-Making Capacity. Twenty

Common Problems: Ethics in Primary Care, First Edition. Sugarman J. (eds.). McGraw-Hill Co., New York, NY, Chapter 18: 225-237, 2000.

23. Karlawish JHT, Clark CM.: Dementia. Geriatric Secrets, 2nd Edition. Lavizzo-

Mourey R, Forciea M, Schwab EP. (eds.). Hanley and Belfus, Inc., Philadelphia, PA, Page: 180-186, 2000.

24. Karlawish JHT, James BD.: How to design and conduct geropsychiatric research that

is ethically and scientifically sound. Annual Review of Gerontology and Geriatrics: Psychopharmacologic Interventions in Late Life Katz I, Oslin D. (eds.). Springer Publishing Company, New York, NY, Page: 72-95, 2000.


25. Karlawish JHT.: Provider-patient relationships. The Encyclopedia of Elder Care: The

Comprehensive Resource on Geriatric and Social Care. Mezey M, Bottrell MM, Berkman BJ, Callahan CM, Fulmer TT, Mitty EL, Paveza GJ, Seigler EL, Strumpf NE. (eds.). Springer Publishing Company, New York, NY, Page: 499-502, 2000.

26. Karlawish JH, Pack AI.: Addressing the ethical problems of randomized and placebo-

controlled trials of CPAP. American Journal of Respiratory & Critical Care Medicine 163(4): 809-10, Mar 2001.

27. Halpern SD, Karlawish JH, Weijer C.: Informing patients of uncertainty in clinical

trials. Journal of the American Medical Association 285(21): 2713-4, Jun 2001. 28. Marson D, Dymek M, Karlawish J.: Competency to consent to medical treatment in

cognitively impaired patients with Parkinson's disease. Neurology 56(12): 1782-1783. Jun 2001.

29. Karlawish JHT, Casarett D.: A position statement of the American Geriatric Society

on the responsible conduct of research. Journal of the American Geriatric Society 49: 1120-1122, 2001.

30. Karlawish JHT, Peranteau WH.: Genetic screening in general internal medicine.

Genetics in the Clinic: Clinical, Ethical, and Social Implications for Primary Care. Mahowald MB, McKusick VA, Scheuerle AS, Aspinwall TJ. (eds.). Mosby, St. Louis, MO, Page: 181-187, 2001.

31. Halpern SD, Karlawish JHT, Berlin JA.: The ethics of underpowered clinical trials.

Journal of the American Medical Association 288(17): 2119, Nov 2002. 32. James BD, Karlawish JHT.: Ethical and legal issues. Clinical Neurology of the Older

Adult. Sirven JI, Malamut BL (eds.). Lippincott Williams & Wilkins, Baltimore, MD, Page: 510-523, 2002.

33. Karlawish JHT.: The search for a coherent language: The science and politics of drug

testing and approval. Ethics, Law, and Aging Review. Kapp MB. (eds.). Springer Publishing Company, New York, NY, 8(Chapter 3): 39-56, 2002.

34. Cotter VT, Clark CM, Karlawish JH.: Cognitive function assessment in individuals at

risk for Alzheimer's disease. Journal of the American Academy of Nurse Practitioners 15(2): 79-86, Feb 2003.

35. Karlawish JH, Clark CM.: Diagnostic evaluation of elderly patients with mild

memory problems. Annals of Internal Medicine 138(5): 411-9, Mar 2003. 36. Karlawish JHT.: Protection of research subjects. New England Journal of Medicine

349(2): 188-192, Jul 2003.


37. Karlawish JHT.: Protection of research subjects (author reply). New England Journal

of Medicine 349(2): 188-192, Jul 2003. 38. Adelman EE, Karlawish JH.: Ignoring the controversies: newspaper reports on

Alzheimer's disease treatments. Journal of the American Geriatrics Society 51(12): 1821-2, Dec 2003.

39. Karlawish JHT, James BD.: Ethical issues in geriatric medicine: Informed consent,

surrogate decision making and advance care planning. Principles of Geriatric Medicine and Gerontology, 5th Edition Hazzard W. (eds.). McGraw-Hill, New York, NY, Page: 353-360, 2003.

40. Karlawish JHT, Pearlman R.: Assessing decision-making capacity. Geriatric

Medicine, Fourth Edition. Cassel C. (eds.). Springer-Verlag, New York, NY Page: 1233-1242, 2003.

41. Kim SYK, Karlawish JHT.: Ethics and politics of research involving subjects with

impaired decision making abilities. Neurology 62: 1645-46, 2003. 42. Karlawish J, Clark CM.: Diagnostic evaluation of elderly patients with mild memory

problems. Annals of Internal Medicine 140(1): 72, Jan 2004. 43. Karlawish JH.: Donepezil delay to nursing home placement study is flawed. Journal

of the American Geriatrics Society 52(5): 845, May 2004 Notes: author reply 845-6.

44. Karlawish J, Whitehouse P, McShane RH.: Silence science: the problem of not

reporting negative trials. Alzheimer Disease and Associated Disorders 18(4): 180-2, Oct-Dec 2004.

45. Cotter VT, Karlawish JHT, Clark CM.: Dementia. Geriatric Secrets, 3rd Edition.

Forciea MA, Schwab EP, Raziano DB, Lavizzo-Mourey R. (eds.). Mosby, Philadelphia, PA, Page: 47-54, 2004.

46. Kapo J, Karlawish J.: Ethical challenges in end-of-‐life care for dementia patients.

Living with Grief: Alzheimer's Disease. Doka KJ. (eds.). Hospice Foundation of America, Washington, D.C. Page: 255-66, 2004.

47. Karlawish JH.: Competency in the age of assessment. Lancet 364: 1383-84, 2004

Notes: Commentary on Raymont V., Bingley W., Buchanan A. The Prevalence and Associations of Mental Incapacity in Medical In-Patients. Lancet 364;2004:1421-27.


48. Karlawish JH.: Review of Stone, J. Music from apartment eight: New and selected

poems. Book Notes. Annals of Internal Medicine. Louisiana State University Press, Baton Rouge, LA, 141: 488, 2004.

49. Karlawish JHT.: Ethics of research in dementia. Alzheimer's Disease and Related

Disorders Annual. Cummings J, Gauthier S, Scheltens P. (eds.). Martin Dunnitz Press, London, England, Page: 123-136, 2004.

50. Halpern SD, Karlawish JH, Berlin JA.: Re: "Ethics and sample size" American

Journal of Epidemiology 162(2): 195-6, Jul 2005. 51. Casarett D, Snyder L, Karlawish JH.: Industry-sponsored trials and community

doctors. Ethical Choices: Case Studies for Medical Practice, 2nd edition. American College of Physicians, Philadelphia, PA, Page: 112-118, 2005.

52. Karlawish JHT.: Ethical issues in dementia. Handbook of Dementing Illnesses,

Second Edition. Morris JC, Galvin J, Holtzman, D. (eds.). Marcel Dekker, Inc., New York, NY, Jan 2006.

53. Karlawish JH.: Alzheimer's disease clinical trials and the logic of clinical purpose

(editorial). New England Journal of Medicine 355: 1603-06, 2006. 54. Karlawish JHT, Appelbaum PS, Bonnie RJ, Karlan PS, McConnell SR.: Policy

statement on voting by persons with dementia residing in long-term care. Alzheimer's and Dementia 2: 243-245, 2006.

55. McConnell SR, Karlawish J, Vellas B, DeKosky S.: Perspectives on assessing

benefits and risks in clinical trials for Alzheimer's disease. Alzheimer's & Dementia 2: 160-63, 2006.

56. Ulrich CM, Karlawish JH.: Responsible conduct of research. Multidisciplinary

Guidebook for Clinical Geriatric Research. The Gerontological Society of America. (eds.). Washington, DC, Page: 52-62, 2006.

57. Karlawish JH.: Research on Cognitively Impaired Adults. Oxford Handbook of

Bioethics. Steinbock B. (eds.). Oxford University Press, New York, NY, Part VII Chapter 25: 597-620, Feb 2007.

58. Lai JM, Karlawish JH.: Position Statement: Ethical and Legal Issues in Stem Cell

Research. Ethics and Research Committees of the American Geriatrics Society May 2007.

59. Appelbaum PS, Bonnie RJ, Karlawish JH.: The capacity to vote of persons with

Alzheimer's disease. Research and Practice in Alzheimer's Disease. Vellas B, Winblad B, Gundman M, Fitten LLJ, Feldman H, Giacobini E, Kurz A. (eds.). Serdi Publishers, New York, NY, 12, 2007.


60. Dunn LB, Palmer B, Karlawish JH.: Frontal dysfunction and capacity to commit to

treatment or research: conceptual considerations and empirical evidence. The Human Frontal Lobes, Second Edition: Functions and Disorders. Cummings J, Miller B. (eds.). Guilford Press, New York, NY, Page: 335-344, 2007.

61. Karlawish JHT.: Ethical issues. Clinical Diagnosis and Management of Alzheimer's

Disease -‐ 3rd Edition. Gauthier S. (eds.). Informa Healthcare, Abingdon, England, Section VI Ch 25: 315-324, 2007.

62. Karlawish J.: Classics in Dementia. Classics in Geriatric Medicine with Current

Commentaries. Pignolo R, Crane M, Forciea MA. (eds.). Springer: New York, NY, Page: 47-60, Mar 2008.

63. Karlawish JH.: Emergency Research. Oxford Textbook of Clinical Research Ethics.

Emanuel EJ, Grady C, Crouch RA, Lie R, Miller F, Wendler D. (eds.). Oxford University Press, New York, NY,(Ch 27), 280-289, April 2008.

64. Karlawish JHT.: Making sense of the language of benefit for Alzheimer's Disease

treatments. Treating Dementia: Do We Have a Pill for It? Ballanger JE, Whitehouse PJ, Lyketsos CG, Rabins PV, Karlawish JHT. (eds.). The Johns Hopkins University Press, Baltimore, MD, Page: 125-32, 2009.

65. Klein E, Karlawish J.: Ethics in dementia care. Principles and Practice of Geriatric

Psychiatry, 3rd Edition. Abou-Saleh MT, Katona CLE, Kumar A. (eds.). Wiley-Blackwell, Hoboken, NJ, Page: 410-414, Jan 2011.

66. Erin D. Bigler and Jason Karlawish: Expanding the understanding of disability in

persons with traumatic brain injury. Neurology 78(19): 1454-1455, 2012. 67. Karlawish J: The Healing Art of Writing: Volume One. Bellevue Literary Review.

Joan Baranow, PhD, Brian Dolan, PhD, and David Watts, MD (eds.). Department of Medicine, NYU Langone Medical Center, 12(1): 176-178, 2012.

68. Tsou AY, Karlawish J: Ethical, Legal and Social Issues in Dementia. Dementia.

Joseph Quinn (eds.). Oxford: Wiley-Blackwell, In press 2012. 69. Karlawish JH.: Competence and autonomy: The cases of driving, voting, and

financial independence. Neuroethics and Practice. Chatterjee A, Farah MJ. (eds.). Oxford University Press, New York, NY, In Press, 2011.

Books: 1. Various: Treating Dementia: Do We Have A Pill For It? Ballenger JE, Whitehouse

PJ, Lyketsos CG, Rabins PV, Karlawish JHT (eds.). The Johns Hopkins University Press, Baltimore, MD, Sep 2009.


2. Karlawish J: Open Wound: The Tragic Obsession of Dr. William Beaumont.

University of Michigan Press, 2011. Alternative Media: 1. Karlawish JHT.: Truth telling in medicine. Persona I: 30-37, 1990. 2. Karlawish JHT.: Review of Richard Selzer's, "Raising the dead: A doctor's encounter

with his own mortality." Newsletter of the MacLean Center for Clinical Medical Ethics & Doctor Patient Studies 15: 2-3, 1995.

3. Karlawish J.: The irrelevance of medicare. Chicago Tribune 21(Section 1): 13, Feb

1996. 4. Karlawish J.: Building right reason in the republic of science: Why we must include

community values in the design and conduct of clinical research. Penn Bioethics 5(2): 1,4,7, 1998.

5. Karlawish J.: Building right reason in the republic of science: Why we must include

community values in the design and conduct of clinical research. Institute on Aging Newsletter 7: 1,4,7, 1998.

6. Karlawish J.: Ethical issues in randomized clinical trials. America Social Health

Association Page: 45, May/Jun 1999. 7. Karlawish JHT.: Dementia: palliation and terminal care. Wissahickon Hospice

University of Pennsylvania Physician Update Page: 1-2, Fall 1999. 8. Karlawish JH.: What is the ADCS? Making sense of the alphabet of Alzheimer's

Disease Research. Alzheimer's Disease Center Quarterly 1(3): 3-4, 2001. 9. Karlawish JH.: Living with dementia: caregiver perspectives. LDI Issue Brief 7(8): 1-

4, Jun 2002. 10. Karlawish J.: Emerging therapies: Thinking about memantine. Alzheimer's Disease

Center Quarterly. www.uphs.upenn.edu/ADC. 2002. 11. Karlawish JH.: Finding meaning in the age of memory. Alzheimer's Disease Center

Quarterly 2(2): 4-5, 2002. 12. Karlawish JH.: Who do we address this to? Thoughts from the publisher. Alzheimer's

Disease Center Quarterly 2(2): 1, 2002. 13. Klocinski JL, Karlawish JH.: How a urine test may one day help in diagnosing

Alzheimer's Disease. Alzheimer's Disease Center Quarterly 2(2): 3, 7, 2002.


14. Klocinski JL, Karlawish JH.: Mild cognitive impairment: pushing the diagnostic

threshold. Alzheimer's Disease Center Quarterly 2(2): 1, 2, 8, 2002. 15. Klocinski JL, Karlawish JH.: Alzheimer vaccine AN-1792 clinical trial terminated.

Alzheimer's Disease Center Quarterly 1(4): 5, 2002. 16. Klocinski JL, Karlawish JH.: Excuse me, but may we look at your brain?

Alzheimer's Disease Center Quarterly 2(1): 1, 4, 2002. 17. Karlawish JH, Krissel K.: Memantine for severe stage Alzheimer's Disease: The

choices of two caregivers. Alzheimer's Disease Center Quarterly 3(1): 4-6, 2004. 18. Karlawish JH.: A grand picture of the glorious war against forgetting. Alzheimer's

Disease Center Quarterly 3(1): 2-3, 7, 2004. 19. Karlawish JH.: How democracies can maximize voting rights and minimize fraud

when people with cognitive impairment want to vote. Alzheimer's Disease Center Quarterly 3(3): 1, 5, 7, 2004.

20. Karlawish J: When Informed Consent Is Impossible: Is Research That Enrolls

Patients With Alzheimer's Disease Ethical? ABCnews.com. http://abcnews.go.com/Health/ActiveAging/story?id=2831392&page=1&CMP=OTC-RSSFeeds0312, Jan 2007.

21. Lai JM, Karlawish JH.: Position Statement: Ethical and Legal Issues in Stem Cell

Research. The American Geriatrics Society. Ethics and Research Committees, Board Approved (eds.). http://www.americangeriatrics.org/products/positionpapers/stem_cell.shtml, May 2007.

22. Karlawish J.: Voting by older adults with cognitive impairments. LDI Issue Brief

13(4): 1-4, Feb 2008. 23. Karlawish J: From the Bedside to the Desktop: How Risk and Information

Technology Are Remaking Medicine. Science Progress. http://scienceprogress.org/2011/01/from-the-bedside-to-the-desktop/ Jan 2011.

24. Karlawish J: The Importance of Narrative in Communicating Evidence-Based

Science. Science Progress. http://scienceprogress.org/2011/11/the-importance-of-narrative-in-communicating-evidence-based-science/ Nov 2011.

25. Karlawish J: Caregivers Press for Experimental Alzheimer's Drug. National Public

Radio's Talk of the Nation. http://www.npr.org/2012/02/14/146875971/cancer-drugs-offers-hope-for-alzheimers-treatment, Feb 2012.


26. Karlawish J: What We Talk About When We Talk About Alzheimer's Disease.

Robert Wood Johnson Foundation Human Capital Blog. http://blog.rwjf.org/humancapital/2012/03/12/what-we-talk-about-when-we-talk-about-alzheimer%E2%80%99s-disease/ Mar 2012.

UNIVERSITY OF PENNSYLVANIA - PERELMAN SCHOOL OF … · 1997-2009 ID 390, Bioethics intensive course...

Documents

Transcript of UNIVERSITY OF PENNSYLVANIA - PERELMAN SCHOOL OF … · 1997-2009 ID 390, Bioethics intensive course...