University of North Carolina Department of Obstetrics ...€¦ · modules, with a total of 8 exam...

University of North Carolina Department of Obstetrics & Gynecology

in Maternal Fetal Medicine 2019-2020 Fellowship Training Program

University of North Carolina School of Medicine Department of Obstetrics & Gynecology Division of Maternal Fetal Medicine

3010 Old Clinic Building, CB 7516 Chapel Hill, NC 27599

M. Kathryn Menard, MD, MPH Director, Division of Maternal Fetal Medicine

Robert Strauss, MD Director, Maternal Fetal Medicine Fellowship

Department of Obstetrics & Gynecology

Some Tar Heel State History In the 1580s, the British established two colonies in North Carolina, both of which failed. In the 1600s permanent settlers from Virginia began to move to North Carolina, and it eventually became part of a British colony known as "Carolina." In 1629, King Charles I of England "erected into a province," all the land from Albemarle Sound to the St. John's River, which he directed should be called Carolina. The word Carolina is from the word Carolus, the Latin form of Charles. In 1861, North Carolina seceded from the Union and joined the Confederacy in the Civil War. In 1865, North Carolina troops surrendered, leaving the state to be brought back into the Union in 1868. The 20th century saw North Carolina transformed into a modern state, beginning when the Wright Brothers flew the first airplane in Kitty Hawk, North Carolina in 1903.

The University of North Carolina As the nation's first state university, The University of North Carolina at Chapel Hill was chartered in 1789 and opened to students in 1795. Carolina was the only public university to award degrees to students in the 18th century. UNC-Chapel Hill's 729-acre central campus is among the most beautiful in the nation.

Why a Ram for a Mascot?

In 1924 Vic Huggins, UNC's head cheerleader, decided that Carolina needed a mascot like N.C. State's Wolf and Georgia's Bulldog. At the time, Jack Merritt, known to his fans as the "Battering Ram," was a popular member of the football team. Making use of this nickname, Huggins hit upon the idea of a ram as the Carolina mascot.

What is a Tar Heel Anyway?

The University not only uses the nickname ‘Tar Heels”, but the entire state does as well. When Carolina was divided in 1710, the southern part was called South Carolina and the northern or older settlement, North Carolina. From this came the nickname the "Old North State." Historians have recorded that the principal products during the early history of North Carolina were "tar, pitch, and turpentine." It was during one of the fiercest

battles of the War Between the States, so the story goes, that the column supporting the North Carolina troops was driven from the field. After the battle, the North Carolinians, who had successfully fought it out alone, were greeted from the passing derelict regiment with the question: "Any more tar down in the Old North State, boys?" Quick as a flash came the answer: "No, not a bit, old Jeff's bought it all up." "Is that so; what is he going to do with it?" was asked. "He's going to put tar on you-un's heels to make you stick better in the next fight." Creecy relates that General Lee, upon hearing of the incident, said: "God bless the Tar Heel boys," and from that they took the name.

Introduction Since its beginning in 1978, the fellowship training program in Maternal Fetal Medicine at the University of North Carolina in Chapel Hill has enjoyed the reputation of being one of the finest in the country. This is reflected in the quality of both faculty and fellows who are attracted to Chapel Hill, and the number of UNC-trained clinicians and researchers who are known locally and nationally for their clinical and research accomplishments.

Our mission is to prepare highly skilled subspecialists dedicated to the care of pregnant women and their fetuses, spanning the depth and breadth of the specialty. To achieve this, the educational experiences are tailored to the fellow’s interests and needs. Acquisition and development of research skills is an important component of the educational process and critical and analytic

thinking are an expectation for completion of the fellowship. The faculty of the Division of Maternal Fetal Medicine supports the clinical and research missions of the fellowship training program by mentoring fellows to achieve future successes as clinicians, academicians and as national leaders in Maternal Fetal Medicine. There are two tracks available to achieve the educational objectives of the fellowship:

• Track 1: Basic Science/Clinical Research Track – no additional degree conferred

• Track 2: Masters in Public Health Track – fellow pursues a Master’s Degree in Public Health in Maternal Child Health, Epidemiology, Health Behavior, Health Policy and Administration, or Biostatistics, through the UNC School of Public Health. Fellow can also pursue a Masters in Science and Clinical Research (MSCR).

Fellows in either track are assigned 17 months of core Maternal Fetal Medicine clinical rotations, 18 months of dedicated research time (at which time fellows in MPH track complete their coursework), and one month of elective. The University of North Carolina Hospitals UNC Hospitals and the School of Medicine of the University of North Carolina at Chapel Hill comprise North Carolina’s most comprehensive public center for medical care, health careers education and biomedical research. UNC is one of only 4 medical centers that rank in the top 20 in both research funding and clinical care. Each year over 500,000 people from North Carolina and the Southeast come for the comprehensive medical services offered at UNC.

Obstetrical Care Facilities The North Carolina Women’s Hospital includes Labor and Delivery, an Obstetric Inpatient Unit, the Newborn Nursery, and Women’s Outpatient Services and represents the state of the art in facilities. The L and D unit (20,000 sq feet) consists of five triage rooms, four LDRPs, 10 LDRs, and three operating rooms. Located one floor above L and D is the combined postpartum unit with 28 private rooms, and the newborn nursery with 14 bassinets. Located one floor below L&D is a new 13-bed antepartum unit, dedicated to high-risk obstetrical patients.

Outpatient obstetrical care is practiced within the Women’s Clinic (~23,000 sq feet), located within the Women’s Hospital. Fellows attend their continuity clinic, consultation clinic, and High Risk Clinic under the direct supervision of a member of the Maternal Fetal Medicine faculty. The OB high-risk clinic has 4 physician modules, with a total of 8 exam rooms.

The University of North Carolina Obstetric Ultrasound Unit maintains American Institute of Ultrasound in Medicine certification and is located within the Women’s Clinic at the North Carolina Women’s Hospital. The unit is directed by David Stamilio MD, and is staffed by nine American Registry for Diagnostic Medical Sonography certified sonographers. There is a full time genetic counselor to assist in counseling of obstetric patients with fetal anomalies. Current equipment includes seven General Electric Voluson 730 with color and pulsed Doppler capability, and 3-D and 4-D capability (including STIC technology). Maternal Fetal Medicine faculty directly supervises fellows during their ultrasound rotation.

Educational Curriculum High-Risk Obstetrics and Maternal Physiology Skill in caring for the in-patient high-risk pregnancy is acquired during the Antepartum and Labor and Delivery coverage. During the Labor and Delivery coverage, the fellow manages the high-risk in-patient service, under supervision of the Maternal Fetal Medicine faculty. Also during the Labor and Delivery coverage, the fellow is responsible for coordination and execution of clinical care for all in-patient obstetrical transports, under the supervision of the faculty as back-up. The fellow acquires outpatient management skills during participation in their own weekly continuity of care clinic, and by participating in once weekly High Risk Pregnancy Clinic and once weekly High Risk Consultation Clinic, all of which are supervised by a member of the Maternal Fetal Medicine faculty

A unique opportunity for educational experience is through the Center for Maternal Infant Health. The Center for Maternal Infant Health provides a variety of services to patients and referring providers who are in need of perinatal care coordination.There is an established special program for pregnant women who have a medical emergency and need transport to UNC. The Maternal Transport

Program is designed to provide pregnant women with individualized and personalized services while they are at UNC. In addition to referral services, care coordination, and multidisciplinary clinical care, the Center for Maternal Infant Health offers perinatal hospice services to those families whose infant is not expected to survive. Fellows actively participate in the services provided by the Center, including presentation of ongoing and new cases at the weekly Perinatal Care Conference. Genetics The Reproductive Genetics Division has five Board Certified/Eligible Genetic Counselors who provide over 2,000 preconceptional or prenatal counseling visits each year. Dr. Neeta Vora, who is board certified in both Genetics and Maternal Fetal Medicine, helps to oversee this division. During the four week Genetics rotation, the fellow observes and then performs genetic counseling during eight half day sessions for such conditions as advanced maternal age, abnormal serum screening, personal or family history of genetic disorder, and current pregnancy with anomalous fetus, supervised by one of the genetic counselors. The fellow attends the Multidisciplinary Patient Care Conference, and two weekly clinical genetics conferences, one of which is dedicated to the discussion of perinatal patients. Time is spent rotating through the Cytogenetics Laboratory. During the second or third year the fellow completes the Society for Maternal Fetal Medicine Nuchal Translucency Certification. A didactic series specifically dedicated to Reproductive Genetics is conducted by our genetic counselors and Dr. Vora. Ultrasound

The fellow is assigned to seven months of specialized ultrasound training, under the direct supervision of the Maternal Fetal Medicine faculty, where responsibilities are graduated with increasing level of experience and skill. Over 12,000 ultrasound examinations, 141 amniocenteses, and 67 CVS procedures are

performed annually. The first month is spent observing targeted ultrasounds and faculty assigned to the ultrasound unit directly supervises fellows as they gain proficiency in the ultrasound equipment and basic hands-on ultrasound experience. During the second through fifth months the fellow completes basic and targeted ultrasounds, which are then reviewed by the sonographer and the attending faculty. Fellows also perform ultrasounds on suspected anomalies, present their findings to the attending in the unit and then participate in a confirmatory ultrasound. During the last two months, the fellow interprets ultrasounds independently, and then reviews images with the faculty member for feedback. Fellows are expected to

interpret ultrasound images, develop a differential diagnosis of the findings, recommend further evaluation if appropriate, and develop a management plan for the patient. During the ultrasound rotation the fellow presents fetal anomaly patients at the weekly Multidisciplinary Perinatal Care Conference, and facilitates discussion of the obstetrical and neonatal management plan. Other – Clinical Rotations During the first year, the fellow completes rotations in the following disciplines: NICU, Medical ICU, and Obstetrical Anesthesia. During these rotations the fellow acts as a member of the clinical care team, under the supervision of the faculty of that discipline. During the third year, the fellow completes a rotation in Pediatric Cardiology, under the supervision of a Pediatric Cardiologist. Departmental/Divisional Educational Conferences There are several departmental and divisional educational conferences available to fellows. Fellows are expected to attend Departmental Grand Rounds, Morbidity and Mortality Conference, as well as the Fellow’s Journal Club, Fellow’s Research meetings, and Fellow’s Didactic Series. In addition, all fellows attend the clinical conferences, including the High Risk Obstetrical Conference, the Multidisciplinary Perinatal Care Conference, and the In-Patient Care Conference. The third year fellow is expected to present at the Departmental Grand Rounds Conference. Research Curriculum Eighteen months of dedicated research time is allotted to each fellow. Typically 4 months are scheduled during the first year of fellowship, 9 months during the second year, and 5 during the third year. Research time during the first year is used to develop research ideas, identify research project(s) and appropriate mentor(s) to perform the research. Research meetings occur on a regular basis throughout the year. Progress is then monitored on a regular basis by the primary mentor and program director on a quarterly basis. It is expected the fellow will complete at least one primary research project during the fellowship; many of our fellows complete several projects. Fellows are encouraged to explore clinical, basic, or translation science research, and there are many resources available to achieve this objective. Fellows present their research every 6 months at “Work In Progress” meetings held with division members and invited guests. Departmental Resources Members of the Department of Ob/Gyn have approximately 2000 sq feet of dedicated laboratory space. The laboratories are fully equipped for basic and molecular laboratory analyses, and cell and tissue culture (four -80 °C freezers, four thermocyclers, a Stratagene real-time thermocycler, three CO2 incubators for cell culture, two biosafety cabinets for tissue culture, an isolation hood for RNA, and blot equipment). The laboratories are staffed by two full-time research specialists, one full-time post doctural scientist, and one PhD scientist. Fellows have access to all of the laboratory resources.

As members of the Maternal Fetal Medicine Network (MFMU), the fellows have available to them a group of obstetrical research nurses who are experienced in conducting clinical research. Ms. Karen Dorman, the Director of Perinatal Research, coordinates all clinical obstetrical research at UNC, and is available to assist fellows with the planning and conduct of clinical research projects. Fellows are also encouraged to submit ideas for secondary analyses and ancillary projects to on-going Network research. School of Medicine Resources Numerous campus-wide research resources are available to the fellow. The division employs a full-time research assistant, Karen Dorman, to aid in the execution of clinical research. She is available to help with IRB submissions, recruitment, collection of data or samples, and subject follow up. The North Carolina Translational and Clinical Sciences (NC TraCS) Institute is one of 60 medical research institutions working together as a national consortium to improve the way biomedical research is conducted across the country. The consortium, funded through the NIH Clinical and Translational Science Awards (CTSA), shares a common vision to facilitate laboratory discoveries and clinical research (http://tracs.unc.edu/). There are a number of resources available to all UNC investigators, including fellows. These resources include a Biostatistical/Epidemiology Consultation Service, an Informatics Core, and the Bioanalytic Core Laboratory and Mass Spectrometry Facility. There is an Investigational Drug Service (IDS), which provides comprehensive drug distribution and patient care pharmacy services for clinical trials at UNC Hospitals. IDS services include study drug randomization, blinding and protocol development for drug administration. Many state-of-the-art core laboratory facilities are available on campus, which provide efficient use of technical staff, equipment, and facilities. Core labs have combinations of state, federal, and institutional funding support for sharing, and a mandate to assist in the career development of new investigators, which would include fellows. Core facilities are numerous and range from Animal Facilities, to Molecular Genetics, to Pathology and Microscopy. In addition to the above resources, faculty in maternal fetal medicine collaborate across campus with numerous other investigators, which allows fellows to participate in multidisciplinary research. Professional Development The program directors meet regularly with the fellows to discuss issues germane to the fellowship. Research ideas and progress, questions and ideas to improve the fellowship, and overall progress are some of the topics covered at this meeting.

All fellows attend the annual meeting of the Society for Maternal Fetal Medicine. Attendance at other scientific meetings is encouraged. Many of the fellows attend several scientific meetings a year to present their research. Fellows are also invited to attend the NICHD Perinatal-Neonatal Fellow Conference, and the Molecular Biology Workshop, both offered annually. Fellows Schedule Fellows call schedule is 3 nights/month (1 weekend and 2 weekdays). Fellows do not round on weekends they are not on call. During 2 months each year each fellow does not take calls.

Standard Fellowship Track

Year 1 of 3 Year 2 of 3 Year 3 of 3 Rotation / #Months Rotation / #Months Rotation / #Months Antepartum/2 Research/9 Research/5 L&D/1 Ultrasound/2 Ultrasound/3 Ultrasound/2 Antepartum/1 Antepartum/1 Research/4 L&D / Antepartum/1 Genetics/1 Elective/1 NICU/Anesth/1 Fetal Echo/1 MICU/1 Number Patients over past year (2018)

Description Number Total Deliveries 3993 Total Obstetrical Admissions 4616 Antepartum Admissions 1053 Maternal Transports (incoming only) 285 Maternal Medical Complications Diabetes, Hypertension, Collagen Vascular, Asthma

2861

Critical care patients 61 Isoimmunized Pregnancies 129 Major Fetal Malformation/Genetic Disorder 1582 Congenital Infections 60 Ultrasounds

28,692

Genetic amniocentesis 83 Fetal therapeutic procedures 22 Cordocentesis 9 CVS 87 Genetic Counseling Visits 3097

2019-20 GME Pay and Benefits Salary Vacation 1st Year $64,168 21 days 2nd Year $66,622 21days 3rd Year $67,017 21 days Fringe Benefits Health Insurance Yes Disability Insurance Yes Life Insurance Yes Dental Yes Malpractice Insurance Yes Freedom Pay for Meals Yearly Allotment Uniforms (white coats) Yes Administrative Assistant Support Yes Discretionary Fund $1875/year Maternity/Paternity Leave Yes

1-2018

GRADUATE LEVEL COURSE Requirements for UNC MFM Fellowship Fellows are required to take a minimum of two graduate level courses, typically during the 2nd year. Unless prior graduate training, should consider taking one Epi and one Stats course, typically during the 2nd year of fellowship. For the Epi course, prefer a graduate level course over the Exxcellence course (see below), and will support one (not both) of these Epi courses. Recommended courses include: • PUBH 741: Quantitative Methods for Health Care Professionals: Offered in the fall

(J Garrett or K Faurot). Learn Stata. Designed for health care professionals needing to appraise the design and analysis of health care studies and intending to pursue academic research careers. The emphasis of the course is on applied data analysis of major health-related studies. Must E-mail the course director for permission if you are not in a degree program.

And then one of the following courses: • EPI 711: Clinical Measurement/Evaluation: Only offered in the fall (Dr. Narpravnik)

Prerequisite, epidemiology or health care and prevention major. An introduction to the fundamental concepts of epidemiology, including clinical epidemiology, for clinicians. Emphasis is to applications in clinical research and practice. This course is a lot of work.

• PUBH 742: Advanced Quantitative Methods for Health Care Professionals: Offered

in the spring (J Garrett). Continuation of PUBH 741 with understanding of exploratory data analysis, logistic regression, and survival analysis.

• Exxcellence in Clinical Research, offered by The Foundation for Exxcellence in

Women’s Health Care: This six-day curriculum provides an intensive introduction to epidemiology, research methods, and data analysis. Taught since 1987 by internationally recognized team of Drs. David Grimes and Kenneth Schulz.

.

Updated 1-1-19

1

1

MFM Fellow Reading Assignments 2018-2019

Fall 2018

Creasy 2014- Chapter 6: Immunology of Pregnancy

Creasy 2014- Chapter 7: Maternal CV, Resp, and Renal Adaptation to Pregnancy

Creasy 2014- Chapter 8: Endocrinology of Pregnancy

Spring 2019 Creasy 2014- Chapter 9: The Breast and the Physiology of Lactation

Creasy 2014- Chapter 10: Maternal Nutrition

Didactic Series

Date Time

Cat (Ultrasound,

Clinical, Genetics, Research)

Topic Faculty Speaker

(Department or Ob/Gyn Division)

July

2 - - -

9 - - -

16 2:00 C Antepartum Fetal Surveillance R Strauss (MFM)

16 3:00 R SMFM abstract review Manuck/Vladutiu (MFM)

17 Day US Simulation training for amnio and CVS (Wake Forest) B Goodnight (MFM)

23 2:30 C Billing and Coding for MFM K Menard (MFM)

25 2:00 R Intro to Statistics D Stamilio (MFM)

25 3:00 R Bias and Confounding D Stamilio (MFM)

30 - - FELLOWSHIP INTERVIEWS -

August

6 12:00 R RCTs D Stamilio (MFM)

6 3:00 R Resources available at UNC for MFM research Manuck/Vladutiu (MFM)

8 2:00 R Basics of Multivariable Statistics D Stamilio (MFM)



22 2:00 R Observational Studies D Stamilio (MFM)

22 3:00 R Clinical Prediction D Stamilio (MFM)

27 2:00 C Non-Obstetric Surgery During Pregnancy RStrauss (MFM)

September

3 - - LABOR DAY -

10 2:00 C Postterm R Strauss (MFM)

17 2:00 Gen Prenatal Screening I E Hardisty (Repro Genetics)

17 3:00 R Researc mentorship and menteeship- Getting a project off the ground Manuck/Vladutiu (MFM)

24 2:00 C Utilizing library research sources Rebecca McCall (Hlth. Sci. Library)

24 3:00 US US Module: AIUM- Fetal Face, Neck, and Head R Strauss (MFM)

October

1 2:00 US Components of the fetal ECHO B Goodnight (MFM)

1 3:00 R From idea to project design Manuck/Vladutiu (MFM)

3 8:00 C Placenta I (Anatomic Path conference room in 3 Childrens) L Scanga (Pathology)

5 8:00 C Placenta II (Anatomic Path conference room in 3 Childrens) L Scanga (Pathology)

Updated 1-1-19

2

2

8 2:00 Gen Prenatal Screening II E Hardisty (Repro Genetics)

15 2:00 Gen Prenatal Diagnosis (CVS and Amnio) E Davis (Repro Genetics)

15 3:00 R Project execution: practical issues (recruiting etc.) Manuck/Vladutiu (MFM)

22 2:00 C Components/Transfusion Therapy and Pre-tx testing Y Park (Pathology)

22 3:00 US US Module: AIUM- Skeletal Dysplasia I R Strauss (MFM)

29 8:00 C Placenta III (Microscope room in 3 Childrens) L Scanga (Pathology)

29 - - 1st YEAR FELLOWS RETREAT -

November

5 2:00 US Knobology (meet in the ultrasound unit) M Foster (OB ultrasound)

12 2:00 C Abortion Q&A A Bryant (Family planning)

19 2:00 Gen Hardy-Weinburg / Patterns of Inheritance G Holcutt (Repro Genetics)

26 2:00 C Placenta Previa R Strauss (MFM)

26 3:00 US US Module: AIUM- Skeletal Dysplasia II: Genetic Counseling R Strauss and E Hardisty (MFM)

December

3 2:00 US Complicated Mo/Di Twins B Goodnight (MFM)

3 3:00 R Biostatistics/epidemiology refresher Vladutiu (MFM)

10 2:00 C NCCC Counseling (rescheduled due to weather closure) W Price (Neonatology)

17 2:00 Gen Cytogenetics & Chromosome abnormalities Thomas Felton (Genetics)

24 - - CHRISTMAS -

31 - - NEW YEARS -

January

7 2:00 US Fetal thorax anomalies B Goodnight (MFM)

7 3:00 R Tips on preparing oral and poster scientific presentations Manuck/Vladutiu/Stuebe (MFM)

14 2:00 C Maternal mortality and severe morbidity review K Menard (MFM)

21 - - MARTIN LUTHER KING DAY -

28 2:00 C Placental abruption R Strauss (MFM)

28 3:00 US US Module: AIUM- Skeletal Dysplasia III R Strauss (MFM)

February

4 2:00 US Knobology II (meet in ultrasound unit) M Foster (OB ultrasound)

4 3:00 R SMFM presentation rehearsals Manuck/Vladutiu (MFM)

11 - - SMFM MEETING -

18 2:00 Gen Principals of genetic counseling and DTC testing R Veazey (Repro Genetics)

18 3:00 R Review of SMFM abstracts- ideas for new projects Manuck/Vladutiu (MFM)

25 2:00 C Placental abruption R Strauss (MFM)

25 3:00 US US Module- Cesarean scar pregnancy R Strauss (MFM)

March

4 2:00 US Fetal GU anomalies B Goodnight (MFM)

4 3:00 R Elements of scientific writing Manuck/Vladutiu (MFM)

11 2:00 C NCCC Counseling W Price (Neonatology)

18 2:00 Gen Principals of genetic counseling and DTC testing R Veazey (Repro Genetics)

18 3:00 R Power and sample size T Schwartz (Biostatistics)

25 2:00 C TBD- Clinical

25 3:00 US TBD- US Teaching Module

April

1 2:00 US Fetal GI tract anomalies B Goodnight (MFM)

1 3:00 R The ins and outs of completing a good article review Manuck/Vladutiu/Chescheir (MFM)


15 2:00 Gen TBD- Genetics

15 3:00 R Challenges in academic research (Authorship, ideas, sharing etc.) Manuck/Vladutiu (MFM)



Updated 1-1-19

3

3


May

6 2:00 US CNS I (Anencephay, encephalocele, ONTD, ACC) B Goodnight (MFM)

6 3:00 R Journal submission ins and outs Manuck/Vladutiu/Chescheir (MFM)



20 3:00 R Missing data A Green (Biostatistics)

27 - - MEMORIAL DAY

June

3 2:00 US Ultrasound Review- What you should know for written boards B Goodnight (MFM)

3 3:00 R Early SMFM project prep and troubleshooting and thesis troubleshooting Manuck/Vladutiu (MFM)



17 3:00 R Abstract writing, SMFM abstract submission tips and guidelines Manuck/Vladutiu (MFM)



The importance of high quality research is underscored by the successes of our fellows and faculty. Listed below are the publications and presentations by our fellows over the past three years and faculty bio sketches.

Fellow Publications & Presentations

Year 1 Fellows: (Graduating Fellow 2022)

Divya Mallampati Divya Mallampati, MD. Aspirin Strategies for Preeclampsia Prevention: A Cost -effectiveness Analysis. Society for Maternal Fetal Medicine Annual Pregnancy Meting 2019 - Poster Presentation Asha Talati Jasmine D. Johnson, MD, Asha N. Talati, MD, Anne W. Honart, MD MPhil, Catherine Vladutiu, PhD MPH, William Goodnight, MD. Tracy Manuck, MD. Recurrent Preterm Birth Phenotype and Delivery Gestational Age. Society for Maternal Fetal Medicine Annual Pregnancy Meting 2019 - Poster Presentation

Year 2 Fellows: (Graduating Fellows 2021)

Jasmine Johnson Jasmine D. Johnson, MD, Asha N. Talati, MD, Anne W. Honart, MD MPhil, Catherine Vladutiu, PhD MPH, William Goodnight, MD. Tracy Manuck, MD. Recurrent Preterm Birth Phenotype and Delivery Gestational Age. Society for Maternal Fetal Medicine Annual Pregnancy Meting 2019 - Poster Presentation Anne West Honart Jasmine D. Johnson, MD, Asha N. Talati, MD, Anne W. Honart, MD MPhil, Catherine Vladutiu, PhD MPH, William Goodnight, MD. Tracy Manuck, MD. Recurrent Preterm Birth Phenotype and Delivery Gestational Age. Society for Maternal Fetal Medicine Annual Pregnancy Meting 2019 - Poster Presentation

Year 3 Fellows: (Graduating Fellows 2020)

Kartik Venkatesh Kartik K Venkatesh, MD PhD, Wesley Jackson, MD, Brenna L Hughes, MD, Mathew M Laughon, MD John M Thorp, MD, David Stamilio, MD, MSCE. Co-prescription of opioids and psychotropic medications in a commercially insured US pregnant population and neonatal abstinence syndrome. Society for Maternal Fetal Medicine Annual Pregnancy Meting 2019 - Poster Presentation Kartik K Venkatesh, MD PhD, Virginia Pate, MS, Kim A Boggess, MD, Michele Jonsson Funk, PhD, Marcela Smid, MD MA MS. Association of chorioamnionitis and its duration with neonatal morbidity and mortality. Society for Maternal Fetal Medicine Annual Pregnancy Meting 2019 - Poster Presentation Kartik K Venkatesh, MD PhD, Mona Farhad, MS, Terry Fenton, PhD, Dhayendre Moodley, PhD, Shilpa Naik, MBBS, Clemensia Nakabiito, Lee Fairlie, MBChB, Mary Glenn Fowler, MD, Jeffrey SA Stringer, MD, Benjamin H Chi, MD, MSc. Diagnostic accuracy of clinical newborn assessment versus ultrasound to define preterm birth: the PROMISE trial. Society for Maternal Fetal Medicine Annual Pregnancy Meting 2019 - Poster Presentation Ashley N Battarbee, Kartik Venkatesh, Sofia Aliaga, Kim A Boggess. KK Venkatesh, M Farhad, T Fenton, D Moodley, S Naik, C Nakabiito, L Fairlie, B Makanani, F Saidi, T Chipato, J McIntyre, MG Fowler, BH Chi, JSA Stringer on behalf of the PROMISE 1077 team. Preterm birth among women with ultrasound-based gestational age dating PROMISE 1077BF/FF. Society for Maternal Fetal Medicine Annual Pregnancy Meting 2019 - Poster Presentation

Venkatesh KK, Kaimal AJ, Castro VM, Perlis RH.Improving discrimination in antepartum depression screening using the Edinburgh Postnatal Depression Scale. J Affect Disord. 2017 May;214:1-7. doi: 10.1016/j.jad.2017.01.042. Epub 2017 Feb 24. PMID: 28260619 Venkatesh KK, Castro VM, Perlis RH, Kaimal AJ. Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study. J Perinatol. 2017 Sep;37(9):1003-1009. doi: 10.1038/jp.2017.92. Epub 2017 Jul 6. PMID: 28682318 Carolyn Webster No current Publications

https://www.ncbi.nlm.nih.gov/pubmed/28260619




Faculty Bio-Summaries Kim Boggess, MD, Professor_________________________________________________________ Education & Training BS, Nutrition Cornell University Ithaca, NY 1982–1986 MD SUNY at Stonybrook Stonybrook, NY 1986–1990 Residency, Ob/Gyn University of Washington Seattle, WA 1990–1994 Fellowship, Infectious Disease University of Washington Seattle Washington 1994–1995 Fellowship, Maternal Fetal Medicine Duke University Medical Center Durham, NC 1995–1997 Certificate, Health Disparities University of North Carolina at Chapel Hill Chapel Hill, NC 2006 A. Research Interest Dr. Boggess is a Professor with the Division of Maternal Fetal Medicine with specialized training in Infectious Diseases and a Certificate in Health Disparities Research. She has a special interest and expertise in oral infections and pregnancy outcomes, and was the first investigator to report an association between maternal periodontal infection and preeclampsia. She currently is conducting studies on improving maternal oral health to benefit both mother and child. In addition she is a co-investigator of a study on optimal antibiotic use at time of cesarean section to reduce infectious morbidity. As the alternate PI for the Maternal Fetal Medicine Units Network she is also the Co-PI for a proposal on optimal treatment of type 2 Diabetes in pregnancy. B. Positions & Honors Positions & Employment Acting Instructor, Department of Obstetrics and Gynecology University of Washington Medical Center, Seattle, WA 07/94–06/95 Associate, Department of Obstetrics and Gynecology Duke University, Durham, NC 07/95–06/97 Assistant Professor, Department of Obstetrics and Gynecology Duke University, Durham, NC 07/97–08/09 Assistant Professor, Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill, Chapel Hill, NC 09/99–08/05 Associate Professor, Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill, Chapel Hill, NC 09/05–2011 Professor, Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill, Chapel Hill, NC 2011–present Program Director, Training Epidemiology and Clinical Trials (TECT) Fellowship UNC 2012–present Program Director, Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) 2012–present Other Experience & Professional Memberships Council Member Infectious Diseases Society for Obstetrics and Gynecology 2002–2005 Invited Reviewer Pediatric and Maternam HIV Clinical Trials Network Study Section, NICHD 2002 Invited Reviewer Pennsylvania Department of Health 2003

Invited Reviewer Australian Government National Health and Medical Research Council 2004 Invited Reviewer Pregnancy and Neonatology Study Section, NICHD 2005–present Invited Reviewer Host Interaction with Bacterial Pathogens Study Section, NIAID 2005 Select Panel Member Centers for Disease Control National Summit on Preconception Care 2005 Invited Reviewer AIDS Clinical Trial Unit Application Section 2006 National Advisory Council on Oral and Medical Health 2006 Member Biomedical Institutional Review Board, University of North Carolina 2008–present Invited Reviewer Pennsylvania Department of Health 2008 Invited Reviewer NIH Challenge Grants Panel 2009 Invited Reviewer Pennsylvania Department of Health 2010 Honors & Awards

John T. Conrad Award for Perinatal Research 1995 University of Washington Society of Maternal Fetal Medicine Foundation Fellowship Award 1997 Annual Award for Excellence in Resident Education 1997 Duke University Medical Center First Prize 1997 Fellow Research Presentation, Duke University Medical Center ACOG/3M Pharmaceutical Research Award in Lower Genital Tract Infections 1998 3M Pharmaceuticals Best Poster Award 1999 Annual Meeting of Infectious Disease Society for OB/GYN Young Investigator Grant 2000 Meeting of International Soc for the Study of Hypertension in Pregnancy Best Young Investigator Award 2000 Annual Meeting of Infectious Disease Society for OB/GYN Clinical Research Award 2004 American Academy of Periodontology Clinical Research Award 2005 American Academy of Periodontology Sunstar Foundation Clinical Periodontology Award 2009 Oliver Smithies Investigator Award 2015

C. Selected Peer-Reviewed Publications Dotters-Katz SK, Panzer A, Grace MR, Smid MC, Keku JA, Vladutiu CJ, Boggess KA, Manuck TA. “Maternal Morbidity After Previable Prelabor Rupture of Membranes.” Obstet Gynecol. 2017 Jan;129(1):101-106. PMID: 27926655 Brooks SA, Martin E, Smeester L, Grace MR, Boggess K, Fry RC. “miRNAs as common regulators of the transforming growth factor (TGF)-β pathway in the preeclamptic placenta and cadmium-treated trophoblasts: Links between the environment, the epigenome and preeclampsia. “Food Chem Toxicol. 2016 Dec;98(Pt A):50-57.PMID: 27375191 Tita AT, Szychowski JM, Boggess K, Saade G, Longo S, Clark E, Esplin S, Cleary K, Wapner R, Letson K, Owens M, Abramovici A, Ambalavanan N, Cutter G, Andrews W; C/SOAP Trial Consortium. “Adjunctive Azithromycin Prophylaxis for Cesarean Delivery.” N Engl J Med. 2016 Sep 29;375(13):1231-41. PMID: 27682034

Vora NL, Smeester L, Boggess K, Fry RC.“Investigating the Role of Fetal Gene Expression in Preterm Birth” Reprod Sci. 2016 Sep 27. [Epub ahead of print]PMID: 27678095 Berggren EK, Boggess KA, Mathew L, Culhane J.“First Trimester Maternal Glycated Hemoglobin and Sex Hormone-Binding Globulin Do Not Predict Third Trimester Glucose Intolerance of Pregnancy.” Reprod Sci. 2016 Sep 9.[Epub ahead of print]PMID: 27613817 Myrick O, Dotters-Katz S, Grace M, Manuck T, Boggess K, Goodnight W. “Prophylactic Antibiotics in Twin Pregnancies Complicated by Previable Preterm Premature Rupture of Membranes.”AJP Rep. 2016 Jul;6(3):e277-82. PMID: 27551580 Smid MC, Vladutiu CJ, Dotters-Katz SK, Manuck TA, Boggess KA, Stamilio DM.“Maternal Super Obesity and Neonatal Morbidity after Term Cesarean Delivery.”Am J Perinatol. 2016 Oct;33(12):1198-204. PMID: 27464019















Sarkar P, Mischler A, Randall SM, Collier TS, Dorman KF, Boggess KA, Muddiman DC, Rao BM. “Identification of Epigenetic Factor Proteins Expressed in Human Embryonic Stem Cell-Derived Trophoblasts and in Human Placental Trophoblasts.”J Proteome Res. 2016 Aug 5;15(8):2433-44. PMID: 27378238 Grace MR, Dotters-Katz S, Varner MW, Boggess K, Manuck TA.“Birthweight Extremes and Neonatal and Childhood Outcomes after Preterm Premature Rupture of Membranes.”Am J Perinatol. 2016 Oct;33(12):1138-44. PMID: 27367280 Aliaga S, Zhang J, Long DL, Herring AH, Laughon M, Boggess K, Reddy UM, Grantz KL. “Center Variation in the Delivery of Indicated Late Preterm Births.”Am J Perinatol. 2016 Aug;33(10):1008-16. PMID: 27120474 Berry DC, Boggess K, Johnson QB.“Management of Pregnant Women with Type 2 Diabetes Mellitus and the Consequences of Fetal Programming in Their Offspring.” Curr Diab Rep. 2016 May;16(5):36. Review.PMID: 26983624 Baker SD, Quiñonez RB, Boggess K, Phillips C.“Pregnant Women's Infant Oral Health Knowledge and Beliefs: Influence of Having Given Birth and of Having a Child in the Home.” Matern Child Health J. 2016 Jun;20(6):1288-95. PMID: 26961141 Boggess K, Gyamfi-Bannerman C.“Prediction and prevention of preterm birth and its sequelae.” Semin Fetal Neonatal Med. 2016 Apr;21(2):67. No abstract available. PMID: 26906337 Saade GR, Boggess KA, Sullivan SA, Markenson GR, Iams JD, Coonrod, DV, Pereira LM, Esplin MS, Cousins LM, Lam GK, Hoffman MK, Severinsen RD, Pugmire T, Flick JS, Fox AC, Lueth AJ, Rust SR, Mazzola E, Hsu C, Dufford MT, Bradford CL< IChetovkin IE, Fleishcher TC, Polipitiya AD, Critchfield GC, Kearney PE, Boniface JJ, Hickok DE. “Development and validation of a spontaneous preterm delivery predictor in asymptomatic women.” Am J Obstet Gynecol.2016 May;214(5):633 Epub 2016 Feb 11. PMID: 26874297

Saade GR, Boggess KA, Sullivan SA, Markenson GR, Iams JD, Coonrod DV, Pereira LM, Esplin MS, Cousins LM, Lam GK, Hoffman MK, Severinsen RD, Pugmire T, Flick JS, Fox AC, Lueth AJ, Rust SR, Mazzola E, Hsu C, Dufford MT, Bradford CL, Ichetovkin IE, Fleischer TC, Polpitiya AD, Critchfield GC, Kearney PE, Boniface JJ, Hickok DE.Am J Obstet Gynecol. 2016 Feb 11. PMID:26874297 Boggess, KA , Berggren EK. “Preconception care has the potential for a high return on investment.” Am J Obestet Gynecol 2015 Jan;212(1):1-3 PMID: 25529608

Berggren, EK, Stuebe AM, Boggess, KA, Moss K, Offenbacher S, Campbell E, Grotegut CA. “First-trimester maternal serum C-reactive protein as a predictor of third-trimester impaired glucose tolerance. “Reprod Sci 2015; Jan 22(1):90-3 PMID: 24754714

Berggren EK, Stuebe AM, Boggess KA. “Excess maternal weight gain and large for gestational age risk among women with gestational diabetes.” Am J Perinatol 2015; Feb 32(3):251-6 PMID: 24971567

Ku LC, Boggess KA^, Cohen-Wolkowiez M. “Bacterial meningitis in infants.” Clin Perinatol 2015; Mar 42(1):29-45 PMID: 25677995

Jackson JT, Quinonez RB, Kerns AK, Chuang A, Eidson RS, Boggess KA, Weintraub JA. “Implementing a prenatal oral health program through interprofessional collaboration.” J Dent Educ 2015; Mar 79(3):241-8 PMID: 25729017

Gonzalez D, Boggess KA, Cohen-Wolkowiez M. “Lessons learned in pediatric clinical research to evaluate safe and effective use of drugs in pregnancy.” Obstet Gynecol 2015; Apr 125(4):953-8 PMID: 25751205

Camelo Castillo W, Boggess K, Stümer T, Brookhart MA, Benjamin DK Jr, Jonsson Funk M. “Association of adverse pregnancy outcomes with glyburide vs. insulin in women with gestational diabetes. JAMA Pediatr 2015; May169 (5):452-8 PMID: 25822253

Smid, MC, Dotters-Katz SK, Plongla R, Boggess KA.” Leptotrichia Buccalis: “A novel cause of Chorioamnionitis.” Infect Dis Rep 22015 May; 26 7(2)5801 PMID: 26294950

Smid MC, Dorman KF, Boggess KA. “Lost in translation? English-and Spanish-speaking women’s perceptions of gestational weight gain safety, health risks and counseling.” J Perinatol. 2015; Aug 35(8)585-9. PMID: 25836322

Laine JE, Ray P, Bodnar W, Cable PH, Boggess K, Offenbacher S, Fry RC. “Placental cadmium levels are associated with increased preeclampsia risk. PLoS One 2015; Sept 3010(9) PMID: 26422011

Martin E, Ray PD, Smeester L, Grace MR, Boggess K^, Fry RC. “Epigenectics and preeclampsia: Defining Functional epimutations in the preeclamptic placenta related to the TGF –β Pathway. PLoS One 2015 Oct28; 10(10) PMID: 26510177











Vamos CA, Thompson EL, Avendano M, Daley EM, Quinonez RB, Boggess K^. “Oral health promotion interventions during pregnancy: a systematic review. Community Dent Oral Epidemiol 2015; Oct43(5)385-96 PMID: 25959402

Aliaga S, Boggess K, Ivester TS, Price WA. “Influence of neonatal practice variation on outcomes of late preterm birth.” Am J Perinatol 2014;31:659-66. PMID: 24022377

Berggren EK, Roeder HA, Boggess KA, Moss K, Offenbacher S, Campbell E, Grotegut CA. “First trimester maternal serum C-reactive protein as a predictor of third-trimester impaired glucose tolerance.” Reprod Sci 2014; Epub ahead of print. PMID: 24784714

Berggren EK, Stuebe AM, Boggess KA. Excess Maternal Weight Gain and Large for Gestational Age Risk among Women with Gestational Diabetes.Am J Perinatol. 2014 Jun 27. [Epub ahead of print]PMID:24971567

Camelo Castillo W, Boggess K, Strmer T, Brookhart MA, Benjamin DK Jr, Jonsson Funk M.Trends in glyburide compared with insulin use for gestational diabetes treatment in the United States,2000-2011.Obstet Gynecol. 2014 Jun;123(6):1177-84.PMID:24807336

Berggren EK, Roeder HA, Boggess KA, Moss K, Offenbacher S, Campbell E, Grotegut CA. Reprod Sci. First-Trimester Maternal Serum C-reactive Protein as a Predictor of Third-Trimester Impaired Glucose Tolerance. 2014 Apr 30. [Epub ahead of print] PMID: 24784714

Berggren EK, Boggess KA, Jonsson Funk M.Population health: modest glycaemic improvements in a pregnant cohort with mild glucose intolerance decreased adverse outcomes.Paediatr Perinat Epidemiol. 2014 Jul;28(4):280-6. doi: 10.1111/ppe.12124. Epub 2014 Apr 14.PMID: 24731066 Berggren EK, Boggess KA. Oral agents for the management of gestational diabetes. Clin Obstet Gynecol 2013:56:827-36. PMID: 24505130. Aliaga S, Boggess K, Ivester TS, Price WA. Influence of neonatal Practice Variation on Outcomes of Late Preterm Birth. Am J Perinatol. 2013 Sept 10.PMID: 24022377. Aliaga S, Price W, McCaffrey M, Ivester T, Boggess K, Tolleson-Rinehart S.Practice variation in late- preterm deliveries: a physician survey. J Perinatol. 2013 May;33(5):347-51. Epub 2012 Sep 27.PMID:23018796 [

Boggess KA, Berggren EK, Koskenoja V, Urlaub D, Lorenz C.Severe preeclampsia and maternal self- report of oral health, hygiene, and dental care. J Periodontol. 2013 Feb;84(2):143-51.Epub 2012 Apr 17.PMID:22509752

Aliaga SR, Smith PB, Price WA, Ivester TS, Boggess K, Tolleson-Rinehart S, McCaffrey MJ, LaughonMM.Regional variation in late preterm births in North Carolina. Matern Child Health J. 2013 Jan;17(1):33-41. PMID:22350629

D. Research Support Ongoing Research Support

1. No Number 01/01/2014–12/31/2015 NIH/PA #PA-11-261 $49,332 - 0.36 calendar month Role: Investigator (Rojas, PI) Therapeutic Potential of Invasive Trophoblast 2. No Number (Boggess, PI) 7/09/2013–7/8/2016 Research Point Corporation, Inc. $95,712 - 0.72 calendar Study of Makena The objective of this study is to perform a multi-center, non-randomized Pharmacokinetic Study of Makena (Hydroxyprogesterone Caproate Injection, 250mg/ml) and its metabolites in blood and urine of women with a singleton pregnancy and a previous singleton spontaneous preterm delivery. 3. No Number (Boggess, PI) 3/1/2014-2.28/2015 0.08 calendar 1UL1TR001111 UNC CTSA/NC TraCS Dose Escalation of Nicotinamide in Severe Preeclampsia Pilot study to determine safety of oral nicotinamide among women with severe preeclampsia. 4. 5T32HD040672 (Boggess, PI) 7/1/-2013-6/30/2015 0.96 calendar NIH/NICHD Training in Epidemiology and Clinical Trials Fellowship Training program to provide the skills needed to become an independent researcher through a Master's program in research methods combined with clinical research conducted under close faculty supervision.

http://www.ncbi.nlm.nih.gov/pubmed/24022377

5. R01 HD064729-01A1 NIH/NICHD 07/01/2010–06/30/2014 Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) Trial Funding: $481,554 Role: Co-investigator (local site PI) 6. No Grant Number Boggess (PI) 07/01/2007–06/30/2010

University of North Carolina at Chapel Hill Medical Alumni Foundation Grant Role: PI 7. U10 HD40560 NIH 04/01/06–03/31/11

Cooperative Multicenter Maternal-Fetal Medicine Units Network Role: Alternate PI

8. No Grant Number Boggess (PI) 9/15/2011–3/31/2013 Implementation of the Prenatal Oral Health Program-Breaking the Dental Caries Cycle Funding: $100,000

Nancy Chescheir, MD, Professor_______________________________________________________ Education & Training BS, Zoology University of North Carolina at Chapel Hill Chapel Hill, NC 1977 MD University of North Carolina at Chapel Hill Chapel Hill, NC 1982 Residency, Ob/Gyn University of North Carolina at Chapel Hill Chapel Hill, NC 1986 Fellowship, Maternal Fetal Medicine University of North Carolina at Chapel Hill Chapel Hill, NC 1988 A. Research Interest Dr. Nancy Chescheir is a professor of obstetrics and gynecology and a maternal-fetal medicine specialist. Her primary interests are in global women's health, fetal disorders, and high order multiple gestations. She has served in multiple administrative roles, including the chair of obstetrics and gynecology at Vanderbilt University School of Medicine, acting chair at UNC School of Medicine, Associate Dean for the Curriculum at UNC, Chief of Staff at Bokamoso Private Hospital in Botswana and scientific program director for the NICHD Randomized Controlled Trial of in utero v standard repair of fetal myelomeningocele. Currently she is serving as the Director of Prenatal Diagnosis with clinical and research interest in advanced obstetrical ultrasound and fetal therapy, clinical informatics, quality improvement and patient safety. Dr. Chescheir was recently appointed Editor in Chief of our specialty’s leading journal, Obstetrics and Gynecology. B. Positions & Honors Positions & Employment Clinical Instructor, Department of Obstetrics and Gynecology Maternal Fetal Medicine, University of North Carolina, Chapel Hill 07/86–06/88 Assistant Professor, Department of Obstetrics and Gynecology Maternal Fetal Medicine, University of North Carolina, Chapel Hill 07/88–06/94 Associate Professor, Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine, University of North Carolina 07/94–06/00 Director of Ultrasound University of North Carolina, Chapel Hill 07/90–10/99 Interim Chair, Department of Obstetrics, and Gynecology University of North Carolina, Chapel Hill 03/96–12/97 Professor (with tenure) University of North Carolina, Chapel Hill 07/00–01/05 Professor and Chair Obstetrics and Gynecology Vanderbilt University School of Medicine Nashville, Tennessee 02/05–05/08

Clinical Professor University of North Carolina, Chapel Hill 12/08–present Chief of Staff; Director, Women‘s and Children‘s Services Bokamoso Private Hospital, Gaborone, Botswana 07/08–07/10 Director, Prenatal Diagnosis University of North Carolina, Chapel Hill, NC 07/11–05/14 Editor in Chief, Obstetrics and Gynecology 01/13–present Consultant, MED-CPU OB Program 2015–present Other Experience & Professional Memberships Board of Directors member, Society of Maternal Fetal Medicine 2003–2006 Secretary, Council on University Chairs of Obstetrics and Gynecology 2006–2008 University Health system Consortium Obstetrical Steering Committee 2007–present Tennessee Department of Health‘s Perinatal Advisory Committee 2007–2008 ACOG, Committee on Obstetrics 2008–present ACOPG, Committee to write ―Pregnancy, Birth and Beyond‖ 2nd (1995), 3rd (1998 – 1999), 4th (2003 – 2004), 5th editions 2008–present ACOG Precis 2008–present Honors Academy of Educators elected member, UNC 2009–present Top 100 Reviewers (top 5%) for AJOG 2006–2007 Betty and Lonnie S. Burnett Endowed Chair 2005, 2008 in Obstetrics and Gynecology at Vanderbilt 2003–2005 Best Doctors in America 2003–2012 America‘s Top Doctors, Castle Connolly Medical Ltd. 2003–2004, 2006–2008 C. Selected Peer-Reviewed Publications Afshar Y, Beltran FV, Brooks H, Chescheir NC.“Connect the Dots-February 2017.” Obstet Gynecol. 2017 Jan 9. [Epub ahead of print] No abstract available.PMID: 28079784 Parikh LI, Benner RS, Riggs TW, Hazen N, Chescheir NC.“Subspecialty Influence on Scientific Peer Review for an Obstetrics and Gynecology Journal With a High Impact Factor.”Obstet Gynecol. 2017 Jan 9. [Epub ahead of print]PMID: 28079780 Chescheir NC.“Focus on Clinical Practice and Quality.” Obstet Gynecol. 2017 Jan;129(1):1-2. No abstract available.PMID: 27926658 Eke AC, Bukowski K, Hall E, Chescheir NC.“Connect the Dots-January 2017.”Obstet Gynecol. 2017 Jan;129(1):200-201. No abstract available.PMID: 27926657 McHugh KW, Milton SH, Cutler AS, Chescheir NC.“Connect the Dots-December 2016.” Obstet Gynecol. 2016 Dec;128(6):1443-1444. No abstract available.PMID: 27824765 Miller LA, Chen MJ, Eke AC, Chescheir NC“Connect the Dots-November 2016.”.Obstet Gynecol. 2016 Nov;128(5):1177-1178. No abstract available.PMID: 27741187 Saunders KT, Washington KL, McAdow M, Chescheir NC.“ Connect the Dots-September 2016.”Obstet Gynecol. 2016 Sep;128(3):653-4. No abstract available.PMID: 27500325 Chescheir NC.“Drilling Down on Maternal Mortality.”Obstet Gynecol. 2016 Sep;128(3):427-8. No abstract available.PMID: 27500323 Chescheir NC.“In Reply.”Obstet Gynecol. 2016 Aug;128(2):410. No abstract available.PMID: 27454723 Eke AC, Barnard EP, Desai AN, Chescheir NC.“Connect the Dots-August 2016.”Obstet Gynecol. 2016 Aug;128(2):403-4. No abstract available.PMID: 27399994 Caranta DG, Leung A, Bukowski K, Chescheir NC.“Connect the Dots-July 2016.”Obstet Gynecol. 2016 Jul;128(1):203-4. No abstract available.PMID: 27275814 Combs JC, Attwood EM, Preus E, Chescheir NC.“Connect the Dots-June 2016.”Obstet Gynecol. 2016 Jun;127(6):1168-9. No abstract available.PMID: 27159767 Washington K, Miller LA, Zeal C, Chescheir NC.“Connect the Dots-May 2016.”Obstet Gynecol. 2016 May;127(5):961-2. No abstract available.PMID: 27054946

Chescheir NC.“Editor's Note.”Obstet Gynecol. 2016 Apr;127(4):805 No abstract available.PMID: 27008229
















Racek AR, Desai AN, Preus E, Chescheir NC.“Connect the Dots--February 2016.” Obstet Gynecol. 2016 Feb;127(2):401-2. No abstract available.PMID: 26942373 Chescheir, NC. “Happy New Year from the Green Journal.” Obstet Gynecol. 2016 Jan;127(1):1-2 PMID: 26646141 Chescheir, NC, Zeligs KP, Easter SR, Evans ML. “Connect the Dots-January 2016.” Obstet Gynecol. 2016 Jan;127(1):159-60 Chescheir, NC. “Not your grandfather’s prescription pad.” Obstet Gynecol. 2015 Sept;126(3):462-4 PMID: 26244526 Zahn CM, Chescheir NC. “A new approach to delivering important publications from the American College of Obstetrians and Gynecologists.” Obstet Gynecol. 2015 Sept;126(3):461-2 PMID: 26244524 Dotters-Katz SK, Grace MR, Strauss RA, Chescheir N, Kuller JA. “Chikungunya Fever: Obstetric considerations on an emerging virus.” Obstet Gynecol Surv. 2015 Jul;70(7):453-7 PMID: 26185916 Chescheir NC. “In Repl.” Obstet Gynecol. 2015 Apr;125(4):987 PMID: 25798975 Chescheir NC. “In Reply.” Obstet Gynecol. 2015 Apr;125(4):986 PMID: 25798973 Chescheir NC. “In Reply.” Obstet Gynecol. 2015 Apr;125(4):985 PMID: 25798971 Vora NL, Chescheir N. “Delivery of the growth restricted preterm fetus.” Lancet. 2015 May 30;385(9983):2126-8 Chescheir NC. “Enough Already!” Obstet Gynecol. 2015 Jan;125(1):2-4 Chescheir NC. “The 61st year of Obstetrics & Gynecology: 2014 in review.” Obstet Gynecol. 2014 Dec;124(6):1067-8 Chescheir NC. “Information for readers and authors.” Obstet Gynecol. 2014 Jul;124(1):5-7 PMID: 24901283 Goodnight W, Chescheir N. Keepsake prenatal ultrasound: pros and cons of non-medically indicated imaging. NC Med J. 2014 Mar-Apr;75(2):138-9. No abstract available. PMID:24663140 Chescheir NC. Information for readers and authors. Obstet Gynecol. 2014 Jul;124(1):5-7. No abstract available. PMID:24901283 Berrien K, Devente J, French A, Cochran KM, McCaffrey M, Horton BJ, Chescheir N.The perinatal quality collaborative of North Carolina's 39 weeks project: a quality improvement program to decrease elective deliveries before 39 weeks of gestation.N C Med J. 2014 May-Jun;75(3):169-76. PMID:24830487 Chescheir NC, Goodnight W. Improving live birth rates: a role for preconception aspirin? Lancet. 2014 Apr 1. pii: S0140-6736(14)60112-4. No abstract available.PMID:24702834 Goodnight W, Chescheir N.Keepsake prenatal ultrasound: pros and cons of non-medically indicated imaging.NC Med J. 2014 Mar-Apr;75(2):138-9. No abstract available.PMID:24663140 Chescheir NC. So very much to learn.Obstet Gynecol. 2014 Mar;123(3):497-9. No abstract available. PMID:24499767 Chescheir NC. Enthusiasm for the Future at obstetrics and Gynecology. Obstet Gynecol. 2013 Nov 6 No abstract available. PMID 24201694. Herrera CA, Eichelberger KY, Chescheir NC. Antiviral Resistant Fulminant Herpes Hepatitis in Pregnancy. Am J Perinatol Rep 2013; 03(02):087-090. PMID: 24147242 Chescheir NC.Tribute to James R. Scott, MD, Editor of Obstetrics & Gynecology, 2001-2013.Obstet Gynecol. 2013 Jun 5. [Epub ahead of print] No abstract available. PMID:23743473 Farrow VA, Anderson B, Chescheir N, Schulkin J. Sex Differences Among Obstetrician-Gynecologists: A Review of Survey Studies. CME Review Article. Obstetrical and Gynecological Survey; Volume 68, Number 3, February 2013. PMID: 23945840


D. Research Support Ongoing Research Support

1. Patient Safety Implementation Program Funding $ 268,000 Source: AHRQ 8/2011–2/2013

William Goodnight III, MD, MSCR, Associate Professor___________________________________ Education & Training BS with Honors, Biology University of North Carolina at Chapel Hill Chapel Hill, NC 1990 MD University of North Carolina at Chapel Hill Chapel Hill, NC 1994 Residency, Ob/Gyn Medical College of Virginia Richmond, VA 1998 MSCR, Clinical Science Medical University of South Carolina Charleston, SC 2008 Fellowship, Maternal Fetal Medicine Medical University of South Carolina Charleston, SC 2008 A. Research Interest William Goodnight, MD, MSCR is an Assistant Professor whose current research interests include prenatal diagnosis and ultrasound with projects including evaluating the natural history of ventriculomegaly in fetuses with open neural tube defects, long term neurological outcomes of newborns following PPROM compared to PTB for other indications, creation of a database for NAFTNET for twins complicated by TTTS, and establishing a biobank at UNC for fetus with fetal anomalies. Dr. Goodnight is also interested in decision analyses, and is collaborating with the school of public health on a decision analysis evaluating the cost effectiveness of Amnisure for the diagnosis of PPROM. His current clinical activities include prenatal diagnosis and management of medical complications of pregnancy. He is the Medical Director for the UNC Rex MFM Consultative practice in which he directs MFM physicians, sonographers, and genetic counselors providing consultative services to community obstetricians. In addition to his clinical activities, Dr Goodnight is active in medical student education as the Assistant Ob/Gyn Clerkship Director. During fellowship in MFM, he has completed a master‘s degree in clinical research. He has received research funding centering on maternal health and nutrition and has mentored MFM Fellows in research resulting in multiple presentations. Based on these interests he has been asked to review current IOM guidelines for maternal weight gain in pregnancy. His current research interests include multiple gestations, prenatal diagnosis and ultrasound, and maternal nutrition in pregnancy including vitamin D and Omega-3 metabolism. B. Positions & Honors Positions & Employment Ob/Gyn 1998–2005 Women‘s Health Center of Virginia, Private Practice Blacksburg, VA Instructor, Department of Obstetrics and Gynecology 2005–2008 Medical University of South Carolina, Charleston, SC Assistant Professor, Division of Maternal Fetal Medicine 2008–present University of North Carolina at Chapel Hill, Chapel Hill, NC Medical Director, UNC Rex, MFM, Consult Practice, Raleigh NC 2008–present Medical Director, UNC Fetal Care Program, UNC Chapel Hill NC 2012–present Honors Phi Beta Kappa 1990 University of North Carolina Academic Merit Award for academic achievement 1991, 1992

University of North Carolina School of Medicine Hausner Pupil Award 1992 Awarded by medical school class University of North Carolina School of Medicine Alumni Loyalty Merit Award 1993 University of North Carolina School of Medicine Alpha Omega Alpha 1994 University of North Carolina School of Medicine William C. Langdon Award 1997 Medical College of Virginia, Department of Obstetrics and Gynecology Lucien Wood and Ida Talley Roberts Award 1999 Medical College of Virginia, Department of Obstetrics and Gynecology Best Doctors in America 2009–2013 Golden Tarheel Award 2011 C. Selected Peer-Reviewed Publications Myrick O, Dotters-Katz S, Grace M, Manuck T, Boggess K, Goodnight W.“Prophylactic Antibiotics in Twin Pregnancies Complicated by Previable Preterm Premature Rupture of Membranes.”AJP Rep. 2016 Jul;6(3):e277-82. PMID: 27551580 Smid MC, Waltner-Toews R, Goodnight W.“Spontaneous Posterior Uterine Rupture in Twin-Twin Transfusion Syndrome.”AJP Rep. 2016 Mar;6(1):e68-70. PMID: 26929874 Moise KJ Jr, Moldenhauer JS, Bennett KA, Goodnight W, Luks FI, Emery SP, Tsao K, Moon-Grady AJ, Moore RC, Treadwell MC, Vlastos EJ, Wetjen NM.“Current Selection Criteria and Perioperative Therapy Used for Fetal Myelomeningocele Surgery.”Obstet Gynecol. 2016 Mar;127(3):593-7.PMID: 26855109 Goodnight W.Clinical Application of Progesterone for the Prevention of Preterm Birth, 2016.Am J Perinatol. 2016 Feb;33(3):253-7Review.PMID: 26788788 Robinson C, Goodnight W. “Hypertension-Management of Hypertensive Disorders of Pregnancy According to International Guidelines: A Panel Discussion (Case 1: Role of Proteinuria)” Am J Perinatol. 2015 April 17. PMID: 25891776 Stringer EM, Chibewesha C, Stoner M, Vwalika B, Joseph Chi BH, Kaunda E, Goodnight W, Stringer JS. “A population-based cohort study of stillbirth among twins in Lusaka, Zambia”. Int J Gynaecol Obstet. 2015 Jul;130(1):74-8 PMID: 25862294

Goodnight W, Robinson C. “Society for Maternal Fetal Medicine 2015 Annual Pregnancy Meeting supplemental episode 7: Post-Meeting Round up (Part 3 of 3)”. Am J Perinatol. 2015 March 20 PMID: 25794195

Goodnight W, Robinson C. “Society for Maternal Fetal Medicine 2015 Annual Pregnancy Meeting supplemental episode 6: Post Meeting Round-up (Part 2 of 3)” Am J Perinatol. 2015 March PMID: 25768979

Goodnight W, Robinson C. “Society for Maternal Fetal Medicine 2015 Annual Pregnancy Meeting supplemental episode 5: Post-Meeting Round-up (Part 1 of 3).” Am J Perinatol 2015 March 6 PMID: 25750027

Robinson C, Goodnight. “Society for Maternal Fetal Medicine 2015 Annual Pregnancy Meeting supplemental episode 4: Meeting Highlights-Friday.” Am J Perinatol. 2015 Feb. 5 PMID: 25654493

Goodnight W, Robinson C. “Society for Maternal Fetal Medicine 2015 Annual Pregnancy Meeting supplemental epidsode 3: Meeting Highlights-Thursday.” Am J Perinatol. 2015 Feb 5. PMID: 25654492

Goodnight W, Robinson C. “Society for Maternal Fetal Medicine 2015 Annual Pregnancy Meeting supplemental episode 2: Looking Ahead to the Scientific Program”. Am J Perinatol. 2015 Jan 27. PMID: 25625534

Patel EM, Goodnight WH, James AH, Grotegut CA. “Temporal trends in maternal medical conditions and stillbirth.” Am J Obstet Gynecol. 2015 May;212(5):673.e1-11 PMID: 25530599

Bovbjerg ML, Siega-Riz AM, Evenson KR, Goodnight W. “Exposure analysis methods impact associations between maternal physical activity and cesarean delivery.” J Phys Act Health. 2015 Jan;12(1):37-47 PMID: 24509873

Robinson C, Goodnight W. The Impact of Noninvasive Prenatal Testing on the Practice of Maternal-Fetal Medicine-Podcast #7. Am J Perinatol. 2014 Dec 27. [epub ahead of print] PMID: 25543052 Patel EM, Goodnight WH, James AH, Grotegut CA. Temporal trends in maternal medical conditions and stillbirth. Am J Obstet Gynecol. 2014 Dec 18. PMID: 25530599







Robinson C, Goodnight W. Society for Maternal-Fetal Medicine 2015 Annual Pregnancy Meeting supplemental episode: A Guide to San Diego. Am J Perinatol. 2014 Dec 17. [epub ahead of print] PMID: 25519195 Robinson C, Goodnight W. Tranexamic Acid to Reduce Postpartum Hemorrhage: A MANDATE Systematic Review and Analyses of Impact on Maternal Mortality-Podcast #6. Am J Perinatol. 2014 Nov 27. PMID: 25429441 Robinson C, Goodnight W. The Timing of Adverse Events with Foley Catheter Preinduction Cervical Ripening: Implications for Outpatient Use-Podcast #5. Am J Perinatol. 2014 Oct 27. PMID: 25347060 Bovbjerg ML, Siega-Riz AM, Evenson KR, Goodnight W. Exposure analysis methods impact associations between maternal physical activity and cesarean delivery. J Phys Act Health. 2014 Feb 5PMID: 24509873. Chescheir NC, Goodnight W. Improving livebirth rates: a role for preconception aspirin? Lancet. 2014 Apr 1. pii: S0140-6736(14)60112-4. No abstract available. PMID:24702834 Goodnight W, Chescheir N.Keepsake prenatal ultrasound: pros and cons of non-medically indicated imaging. N C Med J. 2014 Mar-Apr;75(2):138-9. No abstract available.PMID:24663140 Berry DC, Neal M, Hall EG, Schwartz TA, Verbiest S, Bonuck K, Goodnight W, Brody S, Dorman K, Menard MK, Stuebe AM. Rationale, design, and methodology for the optimizing outcomes in women with gestational diabetes mellitus and their infants study. BMC Pregnancy Childbirth. 2013 Oct 10;13:184 PMID: 24112417. Osborne, CM, Hardisty E, Devers P, Kaiser-Rogers K, Hayden MA, Goodnight W, Vora NL. Discordant noninvasive prenatal testing results in a patient subsequently diagnosed with metastatic disease. Prenat Diagn. 2013 Jun;33(6):609-11 PMID 23559449. D. Research Support Ongoing Research Support

1. 2015- current MORe AHEC NC AHEC Innovation Grant PI: William Goodnight $32,665 (5% effort)

2. 2012-current Randomized trial to prevent congenital Cytomegalovirus Infection. NICHD – Maternal Fetal Medicine Network Units. PI Brenna Anderson UNC Site PI: Goodnight (0% effort)

3. August 2011 - current Early Brain Development in Twins National Institutes of Health (NIH) A05-1368-012 PI: John Gilmore $640,124.00 Goodnight (5% effort)

Thomas Ivester, MD, MPH, Associate Professor___________________________________________ Education & Training BS, Zoology North Carolina State University Raleigh, NC 1987 – 1991 MD East Carolina University Greenville, NC 1992 – 1996 Residency, Ob/Gyn Christina Care Health Services Wilmington, DE Fellowship, Maternal Fetal Medicine University of Tennessee Health Services Center Memphis, TN

A. Research Interest Dr. Ivester is an Associate Professor and his research activities and interests include clinical and operational quality improvement and implementation science, both domestically and in low- and middle-income settings. Past and current projects focus on the development of interdisciplinary teams and local collaborators designed to address the multiple facets of implementation and improvement. He has been participating in NIH- sponsored network trials and other research for 14 years. One of his current roles is directing the design and implementation of a comprehensive, integrated electronic health information system and network. Key aspects of the design include constructing a research-quality database and providing a platform for regional information exchange. He serves as chair of the quality committee for NC Women’s and Children’s Hospitals where he oversees data and services relevant to quality of healthcare services. He also actively participates in local and international collaborative research on an ongoing basis. A. Positions & Honors Positions & Employment Resident, Department of Obstetrics & Gynecology 1996–2000 Medical Center of Delaware (Christiana Hospital) Newark, DE Chief Resident, Department of Obstetrics & Gynecology 1999–2000 Medical Center of Delaware Newark, DE Fellow, Maternal-Fetal Medicine, Department of Obstetrics & Gynecology 2000–2000 Columbia University / NY Presbyterian Hospital NY, NY (transferred) Fellow, Maternal-Fetal Medicine, Dept. of Obstetrics & Gynecology 2001–2003 University of Tennessee Health Sciences Center Memphis, TN Assistant Director – Section for Ultrasound & Prenatal Diagnosis, 2002–2003 Dept. of Obstetrics & Gynecology University of Tennessee Health Sciences Center Memphis, TN Assistant Professor, Division of Maternal-Fetal Medicine, 2003–2010 Dept. of Obstetrics & Gynecology University of North Carolina School of Medicine, Chapel Hill, NC Associate Professor, Division of Maternal –Fetal Medicine, 2010–present University of North Carolina School of Medicine, Chapel Hill, NC Medical Director for Quality and Patient Safety, Obstetrics, UNC Health Care 2012–present Associate Chief Medical Officer for UNC Hospitals 2015–present Other Experience and Professional Memberships Volunteer Medical Officer, Children‘s Hospital, Lublin, Poland 1993 Volunteer Medical Officer, Gov‘t of Ghana, Accra Ghana 1997 Council on Resident Education in Ob/Gyn-Leadership Workshop 1997 NIH / NICHD Conference on Maternal / Fetal-Neonatal-Reproductive Medicine 2001 Founder / Director, Evidence-based medicine seminars, Memphis, TN 2 001–2003 Co-chair – Consensus Committee on Perinatal Outcomes, Memphis, TN 2002–2003 Marketing & public relations for Regional Medical Center at Memphis 2002–2003 Advisory board to production team-The Learning Channel (TLC), for ―World 2002 Birthday 2002 Committee member- UNC Clinical Workstation group & CPOE2004 2004–present Strategic Planning Committee-UNC Hospitals IT Initiative2005 2005 Executive Board-Perinatal Quality Collaborative of North Carolina2007 2007–2009 IT Advisory Council-UNC Hospitals IT Initiative2008 2008 Board of Directors-Kybele Worldwide, Inc. systems expert and co-investigator 2008 for 2008–present International quality improvement in perinatal care Chair-Quality for Women‘s & Infants Quality Improvement Committee, 2008UNCH 2008–2010 Honors Award of Commendation, Medical Center of Delaware 2000 Fellow’s plenary oral presentation, Society for Maternal-Fetal Medicine 2002 Society of Maternal Fetal Medicine American College of Obstetricians & Gynecology, Junior Fellow Association of Professors in Gynecology & Obstetrics American Institute of Ultrasound in Medicine American Medical Association Golden Tarheel 2007, 2008, 2009, 2011 Best Doctors in America 2009, 2010

B. Selected peer-reviewed publications Smid M, Ahmed Y, Ivester T. “Special considerations-induction of labor in low-resource settings.” Semin Perinatol. 2015 Oct;39(6):430-6 PMID: 26323239

Sorensen A, Poehlman J, Bollenbacher J, Riggan S, Davis S, Miller K, Ivester T, Kahwati L. “Training for teamwork through in situ simulations.” BMJ Innov. 2015 Jul;1(3):144 PMID: 26294962

Siedhoff MT, Schiff LD, Moulder JK, Toubia T, Ivester T. “Robotic-assisted laparoscopic removal of cesarean scar ectopic and hysterotomy revision.” Am J Obstet Gynecol. 2015 May;212(5):681 PMID: 25499261

Aliaga S, Boggess K, Ivester TS, Price WA. Influence of Neonatal Practice Variation on Outcomes of Late Preterm Birth. Am J Perinatol. 2013 Sept 10 [Epub ahead of print] PMID: 24022377. Aliaga S, Price W, McCaffrey M, Ivester T, Boggess K, Tolleson-Rinehart S. Practice variation in late-preterm deliveries: a physician survey. J Perinatol, 2013 May: 33(5): 347-51. PMID: 23018796 Linthavong OR, Franasiak J, Ivester T.Febrile illness in pregnancy: disseminated herpes simplex virus. Obstet Gynecol. 2013 Mar;121(3):675-81 No abstract available. PMID:23635632 Ninidze N, Bodin S, Ivester T, Councilman L, Clyne B, Owen M.Advancing obstetric anesthesia practices in Georgia through clinical education and quality improvement methodologies.Int J Gynaecol Obstet. 2013 Mar;120(3):296-300. Epub 2012 Dec23.PMID:23267751 Aliaga SR, Smith PB, Price WA, Ivester TS, Boggess K, Tolleson-Rinehart S, McCaffrey MJ, Laughon MM.Regional variation in late preterm births in North Carolina. Matern Child Health J. 2013 Jan;17(1):33- 41.PMID:22350629 Srofenyoh E, Ivester TS, Engmann A, Olufulabi Y, Owen M. Advancing obstetric & neonatal care in a regional hospital in Ghana via continuous quality improvement. Int J. Gynec & Obstet, 2012 Jan;116 (1):17-21. doi: 10.1016/j.ijgo.2011.08.010. Epub 2011 Oct 29.PMID:22040863 Aliaga S, Smith, P, Price W, Ivester TS, et al. Regional variation in late preterm births in North Carolina. Matern Child Health J. 2012 Feb 15. D. Research Support Ongoing Research Support Principal Investigator: Ivester T. Co-investigators: Olufulabi Y, Owen M, Engmann C. Application of Quality Improvement Methodologies to Perinatal Care in a Developing Country Setting. Accra, Ghana. 2008 – Present. Co-investigator: Perinatal Safety Implementation Program – Developing national set of comprehensive modules and guidelines around key drivers of quality and patient safety for inpatient obstetrics. AHRQ – Sponsored collaboration among UNC, Vanderbilt University, and Research Triangle Institute. Principal Investigator: Task Shifting to Improve Adherence to Intrapartum Fetal Monitoring Guidelines & Reduce Stillbirth. Accra, Ghana. 2010 – Present. Principal Investigator: Systematic Review of Improvement and Implementation Sciences in Maternity Care in Low- and Middle-income Settings. Ongoing Principal Investigator: Systematic Review of Quality Improvement Initiatives in Perinatal Care in Low- and Middle-Income Settings. Principal Investigator: A sustainability model for perinatal care in a developing nation setting – the local QI team. (Multiple concurrent projects focused on communication, team work, clinical coaching). Accra, Ghana. 2009 – Present. Co-PI & Research Preceptor. Identifying Barriers to Contraceptive Use in a Developing Nation Using Community-Based Focus Groups. Guatemala. Co-PI & Research Preceptor. Quality Improvement Methods in Perinatal Care in a Low Resource Setting. Rural Northern India Co-Principal Investigator: Team STEPPS™ Application on Labor and Delivery – (1) Prospective evaluation of team communication on Labor and Delivery, (2) Use of a communication tool to improve neonatal handoffs. 2009 – Present. Principal Investigator: Chang P. Co-PI: Ivester T. “Prevalence of Asymptomatic Left Ventricular Dysfunction during Pregnancy” (the PAVED study). Collaborative study examining possible predictive factors for the subsequent development of peripartum cardiomyopathy. UNC School of Medicine.

Principal Investigator: Ivester T. Co-Investigators: Moos MK, Menard M, Gopalan R. “Implementation of a Regional Health Information Network.” Extensive collaborative between UNC Hospitals and regional public health facilities to implement fully integrated information network. We will examine numerous measures of quality practice and outcomes.

Julie M. Johnson, MD, Clinical Assistant Professor________________________________________ Education & Training BS in Biology University of North Carolina Chapel Hill, NC 1992-1996 MD Wake Forest University School of Medicine Winston Salem, NC 1999-2003 Residency, Obstetrics and Gynecology Palmetto Richland Memorial Hospital University of SC, School of Medicine Columbia, SC 2003-2007 Fellowship, Maternal Fetal Medicine Women & Infants Hospital of Rhode Island Warren Alpert School of Medicine at Brown University Rhode Island 2007-2010 A. Research Interest A graduate of the University of North Carolina at Chapel Hill with a B.S. degree in biology, Dr. Johnson earned her medical degree from the Wake Forest University School of Medicine. She completed a residency in obstetrics and gynecology at Palmetto-Richland Memorial Hospital/University of South Carolina School of Medicine and a fellowship in maternal-fetal medicine at Women & Infants Hospital of Rhode Island/the Warren Alpert School of Medicine at Brown University. Board certified in obstetrics & gynecology, she was previously a member of the active medical staff at Women & Infants Hospital and at Rhode Island Hospital, both in Providence, R.I., and a consulting physician for four hospitals in Massachusetts and Rhode Island. Dr. Johnson expects that most of her practice at Moore Regional will involve patients in the following three categories: women who have complicated medical problems that are not related to their pregnancy, women who have problems that are directly related to their pregnancy, and healthy women who are carrying a fetus with a medical problem or problems. “Pregnant women are generally healthy, but they can develop complications,” she says. “The fact that you’re dealing with two patients at one time (the mother and her baby) adds to the complexity of the problem and changes your perspective. That makes the problem-solving even more of a challenge.” B. Positions & Honors Administrative Chief for the year 2006-2007 Residency in Obstetrics and Gynecology Palmetto Richland Memorial Hospital University of SC, School of Medicine Columbia SC Awards and honors Berlex Best 2nd Year Resident Teaching Award 2005 Highest Resident Oral Exam Award 2006 Fellow Excellence-in-Teaching Award 2008 Hospital-based Faculty Excellence-in-Teaching Award 2012 Medical Students Hospital-based Faculty Teaching Award given by Chief Resident Class 2012

C. Selected Peer-reviewed Publications

Johnson JM, Anderson BL. “Cytomegalovirus: should we screen pregnant women for primary infection?”Am J Perinatol. 2013 Feb;30(2):121-4 PMID: 23292913

Johnson JM, Chauhan SP, Lopes V, Sibai B, Abuhamad AZ. “Society of Maternal Fetal Medicine Annual Meeting and a continuing medical education course: results of pre-and post course survey.” Am J Perinatol. 2012 Nov;29(10):833-41

Munson B, Johnson JM, Edwards J. “The role of experience in the perception of phoetic detail in children’s speech: a comparison between speech-language pathologists and clinically untrained listerners.” Am J Speech Lang Pathol

Tracy Manuck, MD, Assistant Professor___________________________________________________ Education & Training BA in Chemistry Wake Forest University Winston Salem, NC 1996-1999 MD Wake Forest University Winston Salem, NC 1999-2003 Residency Wake Forest University Winston Salem, NC 2003-2007 MASc, Clinical Investigation University of Utah Salt Lake City, UT 2007-2010 Fellowship Maternal Fetal Medicine University of Utah Salt Lake City, UT 2007-2010 A. Research Interest Dr. Manuck is board certified in Obstetrics and Gynecology and board certified in the subspecialty of Maternal-Fetal Medicine. She completed her Maternal-Fetal Medicine Fellowship at the University of Utah in 2010. Dr. Manuck has worked as a physician with CURE International in Honduras. She is actively involved in research at the University. Her research and clinical interests and expertise include preterm labor (including cervical insufficiency and preterm premature rupture of membranes), multiple gestations (including complicated twin, triplet, and higher order multiples), and caring for pregnancies complicated by fetal chromosomal or structural anomalies. B. Positions & Honors Awards and honors National Institutes of Health Summer Research Fellowship award recipient 2000 Wellsford and Mildred Clark Memorial Merit Medical Scholarship (Waterbury, CT) 2002 Alpha Omega Alpha, medical honor society 2003 Wake Forest University School of Medicine Gray Matter service award 2003 Wake Forest University School of Medicine Obstetrics & Gynecology student merit award 2003 Medical student teaching award, Wake Forest University School of Medicine 2006 Wake Forest University Department of Obstetrics & Gynecology - administrative chief resident 2006–2007 Senior resident research award, Wake Forest University School of Medicine 2007 NICHD Aspen Conference on Maternal-Fetal-Neonatal-Repro Medicine, invited participant 2008 University of Utah Pediatric Research Enterprise grant writing workshop, invited participant 2008 “Outstanding Reviewer” (Top 10%), Obstetrics and Gynecology 2008–2011

Primary Children’s Medical Center Foundation “New Investigator” grant award 2009 March of Dimes National Award for the Best Research in Prematurity (for ‘Progesterone Receptor Polymorphisms and Clinical Response to 17-alpha Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm Birth’) 2009 NIH Extramural Loan Repayment Program for Clinical Research Award (initial 2 year award) 2009–2010 NIH Summer Institute in Maternal-Fetal Pharmacology, selected participant 2010 New Investigator award for oral concurrent presentation – Society of Gynecologic Investigation (for ‘Admixture mapping identifies a potential preterm birth susceptibility locus in African-Americans’) 2010 Best Concurrent Oral Presentation Award - Society for Maternal Fetal Medicine (for ‘The Effect of Uterine Tachysystole on Intrapartum Fetal Heart Rate Tracings’) 2010 University of Utah Pediatric Clinical and Translational Research (PCAT) Scholar Program, selected participant 2010–2012 University of Utah Personalized Medicine Travel Grant Recipient 2011 NIH Extramural Loan Repayment Program for Clinical Research Award - 1st Renewal 2011 NIH Extramural Loan Repayment Program for Clinical Research Award - 2nd Renewal 2012 NIH Extramural Loan Repayment Program for Clinical Research Award - 3rd Renewal 2013 March of Dimes National Award for the Best Research in Prematurity (for ‘Genetic variation in key biologic processes may influence response to 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention’) 2014 NIH Extramural Loan Repayment Program for Clinical Research Award – 4th Renewal 2014 Radiological Society of North America (RSNA) Certificate of Merit for excellence of educational exhibit (for ‘At Your Cervix! What Radiologists Need to Know about Imaging the Cervix in Pregnancy’) 2014

C. Selected Peer-reviewed Publications Dotters-Katz SK, Panzer A, Grace MR, Smid MC, Keku JA, Vladutiu CJ, Boggess KA, Manuck TA.“Maternal Morbidity After Previable Prelabor Rupture of Membranes.”Obstet Gynecol. 2017 Jan;129(1):101-106.PMID: 27926655 Dotters-Katz SK, Smid MC, Manuck TA, Metz TD.“Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana.”J Matern Fetal Neonatal Med. 2016 Dec 6:1-19. PMID: 27921445 Manuck TA, Stoddard GJ, Fry RC, Esplin MS, Varner MW.“Nonresponse to 17-alpha hydroxyprogesterone caproate for recurrent spontaneous preterm birth prevention: clinical prediction and generation of a risk scoring system.”Am J Obstet Gynecol. 2016 Nov;215(5):622.e1-622.e8. PMID: 27418444 Monson MA, Gibbons KJ, Esplin MS, Varner MW, Manuck TA.“Pregnancy Outcomes in Women With a History of Previable, Preterm Prelabor Rupture of Membranes.”Obstet Gynecol. 2016 Nov;128(5):976-982. Erratum in: Obstet Gynecol. 2017 Jan;129(1):209.PMID: 27741176 Wong LF, Wilkes J, Korgenski K, Varner MW, Manuck TA.“Intrapartum Cervical Laceration and Subsequent Pregnancy Outcomes.”AJP Rep. 2016 Jul;6(3):e318-23. PMID: 27621953 Smid MC, Vladutiu CJ, Dotters-Katz SK, Manuck TA, Boggess KA, Stamilio DM.“Maternal Super Obesity and Neonatal Morbidity after Term Cesarean Delivery.”Am J Perinatol. 2016 Oct;33(12):1198-204. PMID: 27464019 Eichelberger KY, Manuck TA.“Progesterone has no place in the prevention of preterm delivery: AGAINST: A call for a measured response to the OPPTIMUM trial.”BJOG. 2016 Aug;123(9):1511. No abstract available.PMID: 27440593 Dotters-Katz SK, Carlson LM, Johnson J, Patterson J, Grace MR, Price W, Vladutiu CJ, Manuck TA, Strauss RA.“Management of Pregnancy and Survival of Infants with Trisomy 13 or Trisomy 18.”Am J Perinatol. 2016 Oct;33(12):1121-7. PMID: 27437608 Grace MR, Dotters-Katz S, Varner MW, Boggess K, Manuck TA.“Birthweight Extremes and Neonatal and Childhood Outcomes after Preterm Premature Rupture of Membranes.”Am J Perinatol. 2016 Oct;33(12):1138-44. PMID: 27367280 Kamyar M, Clark EA, Yoder BA, Varner MW, Manuck TA.“Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation.”AJP Rep. 2016 Mar;6(1):e148-54.PMID: 27054046 Manuck TA, Levy PT, Gyamfi-Bannerman C, Jobe AH, Blaisdell CJ.“Prenatal and Perinatal Determinants of Lung Health and Disease in Early Life: A National Heart, Lung, and Blood Institute Workshop Report.”JAMA Pediatr. 2016 May 2;170(5):e154577. PMID: 26953657 Manuck TA“The genomics of prematurity in an era of more precise clinical phenotyping: A review.”Semin Fetal Neonatal Med. 2016 Apr;21(2):89-93. Review.PMID: 26851828
























Manuck TA, Patel RM.“Obstetrical and Neonatal Perspectives on Prematurity.”Am J Perinatol. 2016 Feb;33(3):221. No abstract available.PMID: 26821306 Gibbins KJ, Manuck TA.“Reply.”Am J Obstet Gynecol. 2016 May;214(5):670. No abstract available.PMID: 26802580 McPherson JA, Manuck TA“Genomics of Preterm Birth--Evidence of Association and Evolving Investigations.”.Am J Perinatol. 2016 Feb;33(3):222-8. Review.PMID: 26799966 Manuck TA, Rice MM, Bailit JL, Grobman WA, Reddy UM, Wapner RJ, Thorp JM, Caritis SN, Prasad M, Tita AT, Saade GR, Sorokin Y, Rouse DJ, Blackwell SC, Tolosa JE; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network..“Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort.”Am J Obstet Gynecol. 2016 Jul;215(1):103.e1-103.e14. PMID: 26772790 Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomics and Proteomics Network for Preterm Birth Research (GPN-PBR)..“Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth.”Am J Obstet Gynecol. 2016 Mar;214(3):376.e1-8. PMID: 26692181 Manuck TA.“Pharmacogenomics of preterm birth prevention and treatment.” BJOG. 2016 Feb;123(3):368-75. Review.PMID: 26542879 Manuck TA, Herrera CA, Korgenski EK, Jackson M, Stoddard GJ, Porter TF, Varner MW.“Tocolysis for Women With Early Spontaneous Preterm Labor and Advanced Cervical Dilation.”Obstet Gynecol. 2015 Nov;126(5):954-61. PMID: 26444115 Wong LF, Wilkes J, Korgenski K, Varner MW, Manuck TA.“Risk factors associated with preterm birth after a prior term delivery.”BJOG. 2016 Oct;123(11):1772-8. PMID: 26412012 Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J.“Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms.”Am J Obstet Gynecol. 2015 Sep;213(3):429.e1-9. doi: 10.1016/j.ajog.2015.06.011.PMID: 26070700 Kamyar M, Manuck TA, Stoddard GJ, Varner MW, Clark E“Magnesium sulfate, chorioamnionitis, and neurodevelopment after preterm birth.”.BJOG. 2016 Jun;123(7):1161-6.PMID: 26036660 Gibbins KJ, Weber T, Holmgren CM, Porter TF, Varner MW, Manuck TA.“Maternal and fetal morbidity associated with uterine rupture of the unscarred uterus.”Am J Obstet Gynecol. 2015 Sep;213(3):382.e1-6. PMID: 26026917 Manuck TA, Barbour K, Janicki L, Blackwell SC, Berghella V.“Conversion of Society for Maternal-Fetal Medicine abstract presentations to manuscript publications.”Am J Obstet Gynecol. 2015 Sep;213(3):405.e1-6. PMID: 25981850 Wu W, Fraser A, Clark EAS, Rogers A, Stoddard GJ, Witherspoon D, Manuck TA, Chen K, Esplin MS, Smith KR, Varner MW, Jorde LB. “The Heritability of Gestational Age in a Two-million Member Cohort: Implications for Spontaneous Preterm Birth.” Human Genetics 2015 Jul;134(7):803-8. PMID 25920518

Manuck TA, Barbour K, Janicki L, Blackwell S, Berghella V. “Conversion of Society for Maternal Fetal Medicine Abstract Presentations to Manuscript Publications.” Am J Obstet Gynecol 2015 Sep;213(3):405.e1-6. PMID: 25981850. Gibbins KJ, Weber T, Holmgren CM, Porter TF, Varner MW, Manuck TA. “Maternal and fetal morbidity associated with uterine rupture of the unscarred uterus.” Am J Obstet Gynecol 2015 Sep;213(3):382.e1-6. PMID: 26026917. Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. “Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms.” Am J Obstet Gynecol 2015 Sep;213(3):429.e1-9. PMID:26070700. Kamyar M, Manuck TA, Stoddard GJ, Varner MW, Clark EAS. “Magnesium sulfate, chorioamnionitis, and neurodevelopment after preterm birth.” BJOG 2015 Jun 3 PMID 26036660. Wong LF, Wilkes J, Korgenski K, Varner MW, Manuck TA. “Risk factors associated with preterm birth after a prior term delivery.” BJOG 2015 Sep 28 PMID:26412012. Manuck TA, Herrera CA, Korgenski EK, Jackson GM, Stoddard GJ, Porter TF, Varner MW. “Tocolysis for women with early spontaneous preterm labor and advanced cervical dilation.” Obstet Gynecol 2015 Nov;126(5):954-61. PMID 26444115. Manuck TA. “Pharmacogenomics of preterm birth prevention and treatment: A Review.” BJOG 2015 Nov 6 [PMID 26542879. Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andres W, Saade G, Sadovsky Y, Reddy UM, Ilekis J; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomics and





















Proteomics for Preterm Birth Research(GPN_PBR). “Predictors of response to 17-alpha hydrooxyprogesterone caproate for prevention of recurrent spontaneous preterm birth.” Am J Obestet Gynecol. 2015 Dec 12. PMID: 26692181 SMFM Publications Committee. “SMFM Statement: benefit of antihypertensive therapy for mild-to-moderate chronic hypertension during pregnancy remains uncertain.” Am J Obstet Gynecol. 2015 Jul;213(1):3-4 PMID: 26004324 Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J: Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomics and Proteomics Network for Preterm Birth Research. “The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool.” Am J Obstet Gynecol 2015 Apr;212(4):487 PMID: 25687564 Abramovici A, Salazar A, Edvalson T, Gallagher N, Dorman K, Tita A; National Perinatal Research Collaborative. “Review of multicenter studies by multiple institutional review boards: characteristics and outcomes perinatal studies implemented by a multicenter network.” Am J Obstet Gynecol. 2015 Jan;212(1):110 PMID: 25088862

Wong LF, Holmgren CM, Silver RM, Varner MW, Manuck TA. Outcomes of expectantly managed pregnancies with multiple gestations and preterm premature rupture of membranes prior to 26 weeks. Am J Obstet Gynecol 2015 Feb;212(2):215.e1-9. PMID 25218125. Manuck TA, Varner MV. Neonatal and early childhood outcomes following early vs. later preterm premature rupture of membranes. Am J Obstet Gynecol 2014 Sep;211(3):308.e1-6, PMID 24858202 Manuck TA, Sheng X, Yoder BA, Varner MW. Correlation between initial neonatal and early childhood outcomes following preterm birth. Am J Obstet Gynecol 2014;210(5):426.e1-9. PMID 24793722 Manuck TA, Watkins SW, Moore B, Esplin MS, Varner MW, Jackson GM, Yandell M, Jorde L. Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention. Am J Obstet Gynecol 2014;210(4):321.e.1-321.e21. PMID 24594138 Bowman ZS, Manuck TA, Eller AG, Simons M, Silver RM. Risk factors for unscheduled delivery in patients with placenta accreta. Am J Obstet Gynecol 2014;210(3):241.e1-6. PMID 24096181 Heuser CC, Knight S, Esplin MS, Eller AG, Holmgren CM, Manuck TA, Richards D, Henry E, Jackson GM. Tachysystole in term labor: incidence, risk factors, outcomes, and effect on heart rate tracings. Am J Obstet Gynecol 2013; 209:e1-6. PMID 23571133 Wu W, Clark EAS, Stoddard GJ, Watkins WS, Esplin MS, Manuck TA, Xing J, Varner MW. Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis. BMC Genet. 2013 Apr 25;14:30. PMID 23617681

D. Research Support Ongoing Research Support NIH K23 Award – 1K23HD067224 Duration: 5 years (2/1/2011 – 1/31/2016) Amount: $685,800 Role: Principal Investigator Project Title: The Pharmacogenomics of Preterm Birth Prevention and Treatment Cefalo-Bowes Young Researcher Foundation Project Title: The Pharmacogenomics of Preterm Birth Prevention Duration: 1 year (6/2015-6/2016) Amount: $6,000 Principal Investigator: Jessica McPherson, M.D. Role: Co-Investigator/Primary Mentor Percent effort: 0% (no salary support or % effort allowed for this small pilot grant) Cefalo-Bowes Young Researcher Foundation Project Title: The Effect of Blood Loss on Antibiotic Levels at the time of Cesarean section Duration: 1 year (6/2015-6/2016) Amount: $5,000 Principal Investigator: Sarah Dotters-Katz, M.D Role: Co-Investigator/Primary Mentor Percent effort: o% (no salary support or % effort allowed for this small pilot grant)

University of Utah - Utah Genome Project Pilot Project Award Duration: 1 year, 11/2013-11/2014 Amount: $49,800 Role: Co-Investigator (PI: Erin Clark, MD) Project Title: Mapping Genetic Susceptibility to Spontaneous Preterm Birth Susceptibility Using Family Based Linkage Analysis and Whole Exome Sequencing University of Utah Personalized Healthcare DNA Sequencing Grant Award Duration: 1 year, extended (10/2011-present) Amount: $40,000 Role: Principal Investigator Project Title: The Pharmacogenomics of Spontaneous Preterm Birth Prevention NIH K23 Award – 1K23HD067224 Duration: 5 years (2/1/2011 – 1/31/2016) Amount: $685,800 Role: Principal Investigator Project Title: The Pharmacogenomics of Preterm Birth Prevention and Treatment

Jessica McPherson, MD, Assistant Professor________________________________________________ Education & Training_ Bas in Biopsychology and Cognitive Science University of Michigan Ann Arbor, Michigan 2001-2005 MD University fo Michigan Medical School Ann Arbor, Michigan 2005-2009 Residency Washington University School of Medicine Department of Obgyn St Louis, Missouri 2009-2013 MASc, Clinical Research University of North Carolina at Chapel Hill, Gillings School of Global Public Health 2014-2016 Fellowship Maternal Fetal Medicine University of North Carolina at Chapel Hill 2013-2016 A. Research Interest Dr. McPherson is board certified in Obstetrics and Gynecology and board certified in the sub-specialty of Maternal-Fetal Medicine. She completed her Maternal-Fetal Medicine fellowship at The University of North Carolina at Chapel Hill in 2016. She is actively involved in research at the University and she is interested in the use of large databases to answer clinical questions. A majority of her research during fellowship focused on administering maternal magnesium sulfate to provide fetal neuroprotection to preterm infants. Although this is considered the standard of care, there is a great deal that remains unknown, such as how much magnesium is needed to provide protective benefit and if other groups of women may benefit. She also did some translational work that employed a preterm birth model in mice to evaluate genetic susceptibility to preterm labor. Most recently, she is working to create a large database of women who received an ultrasound and delivered at UNC to answer important clinical questions related to the management of fetal growth restriction. B. Positions & Honors Awards and honors Cefalo Bowes Young Researcher Award 2015 Orpha L Irwin Scholarship 2005–2009

C. Selected Peer-reviewed Publications McPherson JA, Smid MC, Smiley S, Stamilio DM.“Association of Maternal Obesity with Child Cerebral Palsy or Death.”Am J Perinatol. 2016 Nov 17. PMID: 27855463 McPherson J, Manuck T. “ Genomics of preterm birth-Evidence of association and evolving investigations.” Am J Perinatol. 2016;33:222-228 PMID: 26799966 McPherson J, Smiley S, Stamilio D. “Maternal obesity and neuroprotective magnesium sulfate.” Am J Obstet Gynecol. 2015;213(4):582 PMID: 26116874 Palatnik A, Rouse D, Stamilio D, McPherson J, Grobman W. The association between cerebral palsy or death and umbilical cord blood magnesium concentration. 2015 Nov:32(13):1263-1267. PMID: 26058371 McPherson, J, Rouse D, Grobman W, Palatnik A, Stamilio D. Association of duration of neuroprotective magnesium sulfate with neonatal and maternal outcomes. Obstet Gynecol. 2014:124(4):749-55. PMID:25198275 McPherson J, Strauss R, Stamilio D. Non-reassuring fetal status during trial of labor after cesarean. Am J Obstet Gynecol. 2014:211(4):408.e1-8. PMID: 24907702

M. Kathryn Menard, MD, MPH, Vice Chair of Obstetrics and Gynecology, Director, Maternal Fetal Medicine, Director, MFM Fellowship Program, Director, Center for Maternal and Infant Health,___ Past President, Society of Maternal Fetal Medicine, Full Professor______________________________ Education & Training BS with Honors, Zoology & Psychology Duke University Durham, NC 1977–1981 MD University of Medicine and Dentistry of New Jersey Newark, NJ 1981–1985 Residency, Obstetrics & Gynecology Hospital of the University of Pennsylvania Philadelphia, PA 1985–1989 MPH, Epidemiology University of North Carolina at Chapel Hill Chapel Hill, NC 1989–1991 Fellowship, Maternal Fetal Medicine University of North Carolina at Chapel Hill Chapel Hill, NC 1989–1992 Robert Wood Johnson Clinical Scholar, Fellowship in Maternal Fetal Medicine University of North Carolina at Chapel Hill Chapel Hill, NC 1989–1991 A. Research Interest Dr. Menard serves as an Upjohn Distinguished Professor; Vice Chairman of Obstetrics; Division Director, Maternal Fetal Medicine; and Co-Director, Center for Maternal and Infant Health. Dr. Menard also serves as the Director of the Maternal Fetal Medicine fellowship program. She is interested in the study of maternal health services delivery, preconception and interconception care, strategies to prevent preterm birth. She currently serves as the President of the Society for Maternal – Fetal Medicine. She is also the obstetric consultant to Community Care of North Carolina that designed North Carolina’s Pregnancy Medical Home for Medicaid recipients. She is interested in the study of maternal health services delivery, preconception and interconception care, strategies to prevent preterm birth.


B. Positions & Honors Chief Resident, Department of Obstetrics and Gynecology 1988–1989 Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania Clinical Instructor, Department of Obstetrics and Gynecology 1989–1992 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Assistant Professor, Obstetrics and Gynecology and Biometry and Epidemiology 1992–1998 Division of Maternal-Fetal Medicine, Medical University of South Carolina Charleston, South Carolina Associate Professor, Obstetrics and Gynecology and Biometry and Epidemiology 1998–2004 Division of Maternal-Fetal Medicine, Medical University of South Carolina Charleston, South Carolina Associate Dean for Physician Practice Affairs, Chief Medical Officer 1998–2004 Medical University of South Carolina, Charleston, South Carolina Professor, Obstetrics and Gynecology, Division of Maternal-Fetal Medicine 2004–2006 Medical University of South Carolina, Charleston, South Carolina Professor and Vice Chairman, Obstetrics and Gynecology 2006–present Director of Division of Maternal-Fetal Medicine Director, Center for Maternal and Infant Health University of North Carolina, Chapel Hill, North Carolina State, regional and national leadership South Carolina Department of Health and Environmental Control Perinatal Consultant 1991–2006 State Council on Maternal, Infant and Health South Carolina, Governor appointed 1993–1995 South Carolina Medical Association, Maternal and Child Health Committee 1995–2004 American College of Obstetricians and Gynecologists, District IV South Carolina Section 1995–2000 Representative to the Maternal Mortality Committee American College of Obstetricians and Gynecologists, Task Force on Cesarean Delivery 1997–2000 American College of Obstetricians and Gynecologists, National Fetal and Infant Mortality, 1997–2000 Review Program Advisory Committee American Board of Obstetrics and Gynecology, Obstetrics and Gynecology Examiner 1999–present Maternal Fetal Medicine Subspecialty Examiner (2007 – present) University Health Consortium, Ambulatory Care Council Steering Committee 2003–2006 South Carolina Health and Human Services, Senior Medical Advisory Group 2004–2007 Medicaid Clinical Advisory Committee, Obstetrics representative 2004–2007 North Carolina Health and Human Services, Physician Advisory Council 2006–present Society of Maternal and Fetal Medicine, Elected Board Member. Chairman, Informatics 2007–2010 Committee Society of maternal and Fetal Medicine, President Elect (President Feb 2012) Feb 2011 Awards and honors Humanness in Medicine Award from Obstetrical Society of Philadelphia 1988 The Best Doctors in America: Maternal - Fetal Medicine, Marfeh S and Smith GW (eds) 1994–present Woodard and White Board Certification: American Board of Obstetrics and Gynecology, Specialty 1994–present Obstetrics and Gynecology, 1994 Subspecialty, Maternal and Fetal Medicine, 1996 Edgar O Horger III Award for outstanding achievement in Maternal and Child Health 1999 Medical University of South Carolina Hedwig van Ameringen Executive Leadership in Academic Medicine Program for Women 2001 Golden Tarheel award for excellence in teaching 2006–2008

C. Selected Peer-reviewed Publications Bernstein PS, Martin JN Jr, Barton JR, Shields LE, Druzin ML, Scavone BM, Frost J, Morton CH, Ruhl C, Slager J, Tsigas EZ, Jaffer S, Menard MK. National Partnership for Maternal Safety: Consensus Bundle on Severe Hypertension During Pregnancy and the Postpartum Period. Obstet Gynecol.2017 Aug;130(2):347-357. PMID: 28697093

Stringer EM, Vladutiu CJ, Batra P, Stringer JS, Menard MK.“Operationalizing 17α-Hydroxyprogesterone Caproate to Prevent Recurrent Preterm Birth: Definitions, Barriers, and Next Steps.”Obstet Gynecol. 2016 Dec;128(6):1397-1402.PMID: 27824772

Austin AE, Vladutiu CJ, Jones-Vessey KA, Norwood TS, Proescholdbell SK, Menard MK. “Improved Ascertainment of Pregnancy-Associated Suicides and Homicides in North Carolina.” Am J Prev Med. 2016 Nov;51(5S3):S234-S240. PMID: 27745612 Verbiest S, McClain E, Stuebe A, Menard MK.“Postpartum Health Services Requested by Mothers with Newborns Receiving Intensive Care.”Matern Child Health J. 2016 Nov;20(Suppl 1):125-131.PMID: 27357697







Frayne DJ, Verbiest S, Chelmow D, Clarke H, Dunlop A, Hosmer J, Menard MK, Moos MK, Ramos D, Stuebe A, Zephyrin L.“Health Care System Measures to Advance Preconception Wellness: Consensus Recommendations of the Clinical Workgroup of the National Preconception Health and Health Care Initiative.”Obstet Gynecol. 2016 May;127(5):863-72. PMID: 27054935 Stringer EM, Vladutiu CJ, Manuck T, Verbiest S, Ollendorff A, Stringer JS, Menard MK.“17-Hydroxyprogesterone caproate (17OHP-C) coverage among eligible women delivering at 2 North Carolina hospitals in 2012 and 2013: A retrospective cohort study.”Am J Obstet Gynecol. 2016 Jul;215(1):105.e1-105.e12. PMID: 26829508 Berrien K, Ollendorff A, Menard MK.“Pregnancy Medical Home Care Pathways Improve Quality of Perinatal Care and Birth Outcomes.”N C Med J. 2015 Sep-Oct;76(4):263-6. PMID: 26509523 Tucker CM, Berrien K, Menard MK, Herring AH, Daniels J, Rowley DL, Halpern CT. Predicting Preterm Birth Among Women Screened by North Carolina's Pregnancy Medical Home Program. Matern Child Health J. 2015 Jun 26. PMID 26112751 Menard MK, Main EK, Currigan SM. In Reply. Comment on Posterm, Postdates and Prolonged Pregnancy: Need for Simplification of Terminology. Obstet Gynecol. 2015 Apr (4):981. No abstract available. PMID: 25730234 Louis JM, Menard MK, Gee RE. Racial and Ethnic Disparities in Maternal Morbidity and Mortality. Obstet Gynecol.2015 Mar;125(3):690-4. PMID: 25730234 Levels of Maternal Care. American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine with the assistance of Menard, MK, Kilpatrick S, Saade G, Hollier LM, Joseph GF Jr, Barfield W, Callaghan W, Jennings J, Conry J. Levels of Maternal Care. Am J Obstet Gynecol. 2015 March:212(3):259-71 PMID 25620372. Society for Maternal-Fetal Medicine (SMFM) Special Report: the maternal-fetal medicine subspecialists’ role within a health care system. Society for Maternal-Fetal Medicine (SMFM), Sciscione A, Berghella V, Blackwell S, Boggess K, Helfgott A, Iriye B, Keller J, Menard MK, O’Keeffe D, Riley L, Stone J. Am J Obstet Gynecol. 2014 Dec:211(6). Epub 2014 Oct 17 PMID: 25439812 D’Alton ME, Main EK, Menard MK, Levy BS. In Reply. Comment on the National Partnership for Maternal Safety. Obstet Gynecol. 2014 Oct;124(4):840. PMID 25244453 Eichelberger KY, Bengtson AM, Tolleson-Rinehart S, Menard MK. Training Needs in Operative Obstetrics for Maternal-Fetal Medicine Fellows. J Matern Fetal Neonatal Med. 2014 Sept 10:1-4 PMID: 25164775 Menard M Kathryn, Main Elliott, Currigan Sean. Executive Summary of the Revitalized Initiative: Standardizing Obstetric Data Definitions. Current Commentary in Obstetrics & Gynecology. Issue: Vol 124(1), July 2014, p150-3. Reddy UM, Abuhamad AZ, Levine D, Saade GR. Fetal Imaging Workshop Invited Participants Fetal Imaging: Executive Summary of a Joint Eunice Kennedy Shriver National Institute of Child Health and Human Development. Society of Maternal-Fetal Medicine. American Institute of Ultrasound in Medicine, American College of Obstetricians and Gynecologists. American College of Radiology, Society for Pediatric Radiology and Society of Radiologists in Ultrasound Fetal Imaging Workshop. Am J Obstet Gynecol. 2014 May;210(5):387-97. PMID:24793721 Reddy UM, Abuhamad AZ, Levine D, Saade GR. Imaging Workshop Invited Participants Fetal Imaging: Executive Summary of a Joint Eunice Kennedy Shriver National Institute of Child Health and Human Development. Society of Maternal-Fetal Medicine. American Institute of Ultrasound in Medicine, American College of Obstetricians and Gynecologists. American College of Radiology, Society for Pediatric Radiology and Society of Radiologists in Ultrasound Fetal Imaging Workshop. Am J Obstet Gynecol. 2014; 123(5):1070-82. PMID: 24785848 Dalton ME, Maine EK, Menard MK, Levy BS. Current Commentary in The National Partnership for Maternal Safety; Obstet Gynecol. 2014 May:123(5):973-7. PMID:24785848 Menard MK, Main E. In Reply. Comment on Maternal Mortality: Time for National Action. Obstet Gynecol. 2014 Feb; 123(2 pt1):362-3. PMID: 24451666. Cohen AR, Couto J, Cummings JJ, Johnson A, Joseph G, Kaufman BA, Litman RS, Menard MK, Moldenhauer JS, Pringle KC, Schwarts MZ, Walker WO Jr, Warf BC , Wax JR, MMC Maternal-Fetal Management Task Force. Am J Obstet Gynecol. 2014 Feb;210(2):107-11. doi: 10.1016/j.ajog.2013.09.016. Epub 2013 Sep 18. PMID: 24055581 [PubMed - indexed for MEDLINE] Menard MK, Main EK, Currigan SM. Executive Summary of the reVITALize Initiative: Standardizing Obstetric Data Definitions.Obstet Gynecol. 2014 Jul;124(1):150-3. PMID:24901267[PubMed - in process] Fetal imaging: Executive summary of a Joint Eunice Kennedy Shriver National Institute of Child Health and Human Development, Society for Maternal-Fetal Medicine, American Institute of Ultrasound in Medicine, American College of Obstetricians and Gynecologists, American College of Radiology, Society for Pediatric Radiology, and Society of Radiologists in Ultrasound Fetal Imaging Workshop.








Reddy UM, Abuhamad AZ, Levine D, Saade GR; Fetal Imaging Workshop Invited Participants.Am J Obstet Gynecol. 2014 May;210(5):387-97. Review.PMID:24793721[PubMed - in process] Fetal imaging: executive summary of a joint Eunice Kennedy Shriver National Institute of Child Health and Human Development, Society for Maternal-Fetal Medicine, American Institute of Ultrasound in Medicine, American College of Obstetricians and Gynecologists, American College of Radiology, Society for Pediatric Radiology, and Society of Radiologists in Ultrasound Fetal Imaging Workshop. Reddy UM, Abuhamad AZ, Levine D, Saade GR; Fetal Imaging Workshop Invited Participants.Obstet Gynecol. 2014 May;123(5):1070-82. PMID:24785860 DAlton ME, Main EK, Menard MK, Levy BS. The National Partnership for Maternal Safety. Obstet Gynecol. 2014 May;123(5):973-7. PMID:24785848 Menard MK, Main E.In reply: Obstet Gynecol. 2014 Feb;123(2 Pt 1):362-3. PMID:24451666 Berry DC, Neal M, Hall EG, Schwartz TA,Verbeiest S, Bonuck K, Goodnight W, Brody S, Dorman KF, Menard MK, Steube AM. Rationale, design, and methodology for the optimizing outcomes in women with gestational diabetes mellitus and their infants study. BMC Pregnancy Childbirth. 2013 Oct 10;13(1):184. Main EK, Menard MK. Maternal Mortality: Time for National Action. Obstet Gynecol, Vol 122,Number 4, August 2013. Pp 735-736. Vladutiu CJ, Marshall SW, Poole C, Casteel C, Menard MD, Weiss HB. Adverse pregnancy outcomes following motor vehicle crashes. Am J Prev Med. 2013 Nov; 45(5);629-36. PMID;24139777 Berry DC, Neal M, Hall EG, Schwartz TA, Verbiest S, Bonuck K, Goodnight W, Brody S, Dorman KF, Menard MK, Stuebe AM. BMC Pregnancy Childbirth. 2013 Oct 10; 13(1):184. PMID 24112417. Main EK, Menard MK. Maternal Mortality: time for national action. Obstet Gynecol. 2013 Oct; 122(4):735-6. No abstract available. PMID 2408452 Vladutiu CJ, Poole C, Marshall SW, Casteel C, Menard MK, Weiss HB.Pregnant driver-associated motor vehicle crashes in North Carolina, 2001-2008. Accid Anal Prev. 2013 Jun;55:165-71. Epub 2013 Mar 13.PMID:23545268 D. Research Support Ongoing Research Support

1. Principle Investigator – Duke Endowment Grant June 2014–May 2016 North Carolina preterm Prevention, Telemedicine Network $528,858.00 2. Principle Investigator - Hologic Inc July 2013–January 2017 Prospective Phase III evaluation of fetal fibronectin in a high risk asymptomatic population for the prediction of spontaneous preterm birth. $211,246.00 3. 1R21DK09275001A1 June 1, 2012–May 31, 2015 Optimizing Outcomes in Women with Gestational Diabetes Mellitus and their Infants. (NIH) National Institutes of Health: The National Institute of Diabetes And Digestive and Kidney Disease 2012-2014 PIs: Diane Berry and Alison Stuebe, Senior Research Advisor (In Kind – No salary support)

4. 1 U13 HD067777-01 NICHD Jan 2011-Dec 2013 Academic-Community Partnership to Reduce Heath Disparities in Infant Mortality $90,000 (0% salary support) PI: Menard

5. 1 R21 NR011487-01 NIH Apr 2011–Mar 2013 End-of-Life Care after Severe Fetal Diagnosis PI: Beth Black, Co PI: Menard $407,000 (<5% salary support)

David A. Stamilio, MD, Professor__________________________________________________ Education & Training BS Bucknell University (Biology) Lewisburg, Pennsylvania 1984-1988 M.D. Hahnemann University School of Medicine Philadelphia, Pennsylvania 1988-1992 Intern in Obstetrics and Gynecology Medical Center of Delaware Newark, Delaware 1992-1993 Intern in Obstetrics and Gynecology Medical Center of Delaware Newark, Delaware 1992-1993 Resident in Obstetrics and Gynecology Medical Center of Delaware (Currently Christiana Care Health System) Newark, Delaware 1993-1996 Clinical Fellow in Maternal-Fetal Medicine Department of Obstetrics and Gynecology Hospital of the University of Pennsylvania Philadelphia, Pennsylvania 1996-1998 M.S.C.E. University of Pennsylvania Philadelphia, Pennsylvania 1997-2003 Research Fellow in Reproductive Epidemiology (NIH funded fellowship for clinical research and a Master’s of Science of Clinical Epidemiology) Department of Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 1997-1999 Leadership Development for Physicians in Academic Health Centers. Department of Health Policy and Management, Harvard School of Public Health Boston, Massachusetts 2010 A. Research Interest Dr. Stamilio joined the Department of OB/GYN faculty in the Division of Maternal-Fetal Medicine at UNC on July 1, 2013 and before that was at Washington University in St. Louis from October 2006 til July 1, 2013. Prior to that, he was on the faculty at the University of Pennsylvania in the departments of OB/GYN and Epidemiology. Dr. Stamilio has a keen interest in perinatal clinical research, including general obstetrical issues (e.g. vaginal birth after cesarean), prenatal complications (e.g. preeclampsia & gestational diabetes) and the prediction and prevention of preterm birth. He has been a co-investigator and principal investigator on clinical research grants funded by the NIH, USAF Office of the Surgeon General and the Pennsylvania Department of Health. He has over 35 peer-reviewed publications related to clinical research in obstetrics. He serves as an editorial consultant for several obstetric, general medical and epidemiologic journals and is on the editorial board for Postgraduate Obstetrics & Gynecology. His

clinical interests include non-invasive and minimally invasive prenatal diagnosis, prenatal management of maternal chronic disease and preventive treatment for premature delivery. B. Positions & Honors Hospital Appointments Professor Department of Obstetrics & Gynecology, UNC School of Medicine 2013–present

Employment History Instructor in Obstetrics and Gynecology Department of Obstetrics and Gynecology University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 7/96–6/98 Instructor in Obstetrics and Gynecology Division of Maternal-Fetal Medicine University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 7/98–6/99 Instructor, Division of Maternal-Fetal Medicine Obstetrics and Gynecology Residency David Grant USAF Medical Center Travis Air Force Base, California 7/99–8/01 Instructor in Obstetrics and Gynecology Division of Maternal Fetal Medicine Darnall Army Hospital, San Antonio Uniformed Services Health Education Consortium, Ob/Gyn Residency Fort Hood, Texas 9/01–9/03 Assistant Professor of Obstetrics and Gynecology Hospital of the University of Pennsylvania University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 10/03–9/06 Associate Scholar Center for Clinical Epidemiology and Biostatistics University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 1/06–9/06 Associate Professor of Obstetrics and Gynecology Washington University School of Medicine St. Louis, Missouri 10/06–2013 Director, Division of Maternal Fetal Medicine Department of Obstetrics & Gynecology Washington University in St. Louis, School of Medicine St. Louis, Missouri 7/08–12/11 Clinical Professor, UNC, Dept of Ob/Gyn, MFM 07/13–present Medical Director, Ob Ultrasound for UNC Campus 12/14–present Medical Director, Ob/MFM Telemedicine 12/14–present

Honors and Awards Phi Beta Sigma Honor Society, Bucknell University 1985 Alpha Lambda Delta Honor Society, Bucknell University 1985 Wyeth-Ayrest ACOG Residency Reporter Program 1994 Resident Research Award, Medical Center of Delaware 1995 Elected to attend the 9th Annual NICHD Aspen Conference on Maternal-Fetal-Neonatal-Reproductive Medicine Research 1997 Society for Maternal-Fetal Medicine, 19th annual meeting, Research Poster Award (Abstract #345) 1999 Outstanding Resident Educator, 1999-2000, David Grant USAF Medical Center, Department of Obstetrics and Gynecology 2000 Outstanding Family Practice Resident Teacher, David Grant USAF Medical Center 2001 Darnall Army Community Hospital Commander Award for Excellence of Service 2001

Top 10% of Reviewers as Editorial Consultant for Annals of Internal Medicine 2004 Best of Reviewers as Editorial Consultant for Pharmacoepidemiology and Drug Safety 2004 Top 10% of Reviewers as Editorial Consultant for Obstetrics and Gynecology – 4 annual commendations 2004–2007 Top 10% of Reviewers as Editorial Consultant for Annals of Internal Medicine 2005 Washington University School of Medicine II OB/GYN Course Award for Best Lecture Syllabus 2007 OB/GYN Resident Teaching Award, Washington University School of Medicine 2007 Outstanding Reviewer (top 5%) as Editorial Consultant for American Journal of Obstetrics & Gynecology 2012 Societies Fellow, American College of Obstetricians and Gynecologists Society for Maternal-Fetal Medicine St. Louis Gynecologic Society American Board of Obstetrics and Gynecology (ABOG) Board Examiner (Maternal-Fetal Medicine), Dallas, Texas 2010 Other Activities D. Selected Peer-Reviewed Publications McPherson JA, Smid MC, Smiley S, Stamilio DM.“Association of Maternal Obesity with Child Cerebral Palsy or Death.”Am J Perinatol. 2016 Nov 17. PMID: 27855463 Smid MC, Edwards RK, Biggio JR, Dorman K, Leduke RC, Lesher LL, Manuck TA, Saade GR, Salazar AE, Stamilio DM, Stuebe AM, Tita AT, Torres CM, Varner MW, Wapner RJ.Class III Obese Women's Preferences and Concerns for Cesarean Skin Incision: A Multicenter Survey.Am J Perinatol. 2016 Aug 17. PMID: 27533104 Smid MC, Vladutiu CJ, Dotters-Katz SK, Manuck TA, Boggess KA, Stamilio DM.“Maternal Super Obesity and Neonatal Morbidity after Term Cesarean Delivery.”Am J Perinatol. 2016 Oct;33(12):1198-204.PMID: 27464019 Vora NL, Robinson S, Hardisty EE, Stamilio DM.“The utility of a prerequisite ultrasound at 10-14 weeks in cell free DNA fetal aneuploidy screening.”Ultrasound Obstet Gynecol. 2016 Jun 14. PMID: 27300317 Smid MC, Smiley SG, Schulkin J, Stamilio DM, Edwards RK, Stuebe AM. “The Problem of the Pannus: Physician Preference Survey and a Review of the Literature on Cesarean Skin Incision in Morbidly Obese Women.” Am J Perinatal. 2015 Oct 28. PMID: 26510932. Smid MC, Kearney MS, Stamilio DM. “Extreme Obesity and Postcesarean Wound Complications in the Maternal-Fetal Medicine Unit Cesarean Registry.” Am J Perinatol. 2015 Oct 21. PMID: 26489063. McPherson J, Smiley S, Stamilio DM. “Maternal obesity and neuroprotective magnesium sulfate.” Am J Obstet Gynecol. 2015 Oct;213(4):582.e1-6. Epub 2015 Jun 24. PMID: 26116874. Palatnik A, Rouse DJ, Stamilio DM, McPherson JA, Grobman WA. “Association between Cerebral Palsy or Death and Umbilical Cord Blood Magnesium Concentration.” Am J Perinatol. 2015 Jun 9. PMID: 260 McPherson JA, Rouse DJ, Grobman WA, Palatnik A, Stamilio DM. Association of Duration of Neuroprotective magnesium Sulfate Infusion with Neonatal and Matenal Outcomes. Obstet Gynecol. 2014 Oct;124(4):749-55. PMID: 25198275

Stamilio DM, Scifres CM. Extreme Obesity and Postcesarean Maternal Complications. Obstet Gynecol. 2014 Aug;124(2 Pt 1):227-32. PMID: 25004353

McPherson JA, Strauss RA, Stamilio DM Nonreassuring fetal status during trial of labor after cesarean.Am J Obstet Gynecol. 2014 Jun 4. pii: S0002-9378(14)00559-6. PMID:24907702

Conner SN, Cahill AG, Tuuli MG, Stamilio DM, Odibo AO, Roehl KA, Macones GA. Interval From Loop Electrosurgical Excision Procedure to Pregnancy and Pregnancy Outcomes. Obstet Gynecol. 2013 Nov 6. PMID: 24201682

Macones GA, Chang JJ, Stamilio DM, Odibo AO, Wang J, Cahill AG. Prediction of cesarean delivery using the fetal-pelvic index. Am J Obstet Gynecol. 2013 Nov;209(5):431.e1-8. PMID: 23791690

Harper LM, Odibo AO, Stamilio DM, Macones GA. Radiographic measures of the mid-pelvis to predict cesarean delivery. Am J Obstet Gynecol. 2013 Mar.

Stout MJ, Scifres CM, Stamilio DM, Diagnostic utility of urine protein-to-creatinine ratio for identifying proteinuria in pregnancy. J Maternal Fetal Neonatal Med. 2013 Jan;26(1):66-70.






Frey HA, Stout MJ, Odibo AO, Stamilio DM, Cahill AG, Roehl KA, Macones GA. Risk of cesarean delivery after loop electrosurgical excision procedure. Obstet Gynecol.2013 Jan;121(1):39-45.

D. Research Support Ongoing Research Support Cefalo-Bowes Young Researcher Award (Beckham/Stamilio) June 2015 Role: Faculty advisor and Co-investigator Resident Pl: Jenna Beckham, MD, MSPH Direct Costs: $1695.00 Peripartum Prediction of Postpartum Preeclampsia Goal: This is a retrospective case-control study (using NCTracs data) designed to develop a clinical prediction model for postpartum preeclampsia requiring re-admission. Duke Endowment Grant: (PI: Menard) 6/1/2014–5/31/2016 $291,429.00 Annual Direct Costs Role: Co-investigator North Carolina Preterm Birth Prevention TeleHealth Network Goals include: establishing a 10-site telemedicine network, creating and disseminating educational tools for providers, training sonographers and tracking prematurity-related perinatal outcomes to see if project interventions improve pregnancy outcomes. I am medical director for the project. I am responsible for the development of the Perinatal Education Bundles (working closely with the lead CCNC physician champion for each bundle), including making sure that all clinical content is accurate. I also work with project director on outreach to practice sites in the AccessCare Network and provide telemedicine consult services. BJH Foundation Grant (Stamilio/Scifres) 1/1/2008-12/31/2009 Role: PI $100,00 Annual Direct Costs The goal of this project is to investigate whether hyper-oxygenation in the intra-& post-operative period reduces the risk of postoperative infection in cesarean patients. R01 HD039441 (Macones/Stamilio) NIH/NICHD 7/3/2004-3/31/2007 Role: Co-PI Predicting Labor Outcomes in Women Attempting VBAC The goal of this proposal is to assess the sensitivity and specificity of the fetal pelvic index for the success/failure of a trial of labor among those with a prior caesarian and to develop a clinical predictive index to define groups of patients at high risk for a failed trial of labor among women with a prior cesarean section who are attempting a vaginal delivery. Center of Excellence for Research in Pregnancy Outcomes Pennsylvania Department of Health 6/2004-5/2008 (personal support ended 10/2006) Role: Co-Investigator (Macones, PI) $9,005 Annual Direct Costs Goals: The major goal of this multidisciplinary investigation is to determine if screening and treating periodontal disease reduces the risk of spontaneous preterm birth. Prematurity Risk of Infection & Genotypes National Institute of Health (Loan Repayment Program) 7/2004–6/2006 Role: Principal Investigator $27,631 Annual Direct Costs Goals: The major goals of this project are to further characterize the association between genetic variation at candidate susceptible cytokine gene loci and the risk spontaneous preterm delivery and to evaluate the impact of the interaction between the candidate polymorphism and bacterial vaginosis, on the likelihood of spontaneous preterm delivery. Secondary analysis of a randomized clinical trial of hyper-oxygenation in the intra- & post-operative period to reduce the risk of postoperative infection in cesarean patients. The secondary analysis estimates the effect of extreme obesity on cesarean complications. (Analysis complete and manuscript submitted for consideration for publication) Secondary analysis of the NICHD-funded MFM Units Network Beneficial Effects of Antenatal Magnesium Sulfate (BEAM) trial to estimate the effect of magnesium duration on neonatal and maternal outcomes. (Analysis complete and manuscript being prepared for submission for publication) Secondary analysis of the NICHD-funded MFM Units Network Beneficial Effects of Antenatal Magnesium Sulfate (BEAM) trial to estimate the effect of magnesium cord blood level and whether magnesium was being administered during delivery on neonatal and outcomes. (Analysis is complete and manuscript being prepared for submission for publication) Retrospective cohort study of outcomes of pregnancies complicated by Polyhydramnios Objective: To estimate the effect of varying degrees of Polyhydramnios on the perinatal outcomes of pregnancies. The cohort is derived from an ultrasound diagnosis and perinatal database encompassing UNC patients from 2000 to 2012. (Analysis is in progress)

Multi-center randomized clinical trial of incentives versus standard care for smoking cessation during pregnancy. Objective: to determine if use of incentives offered to pregnant women who smoke increases smoking cessation rate and decreases preterm birth or low birth weight rate. (Protocol is in development for submission to the NIDA, projected this fall 2014) Inherited thrombophilias and pregnancy complications: Gene-environment interactions. The design of this proposed study of the associations between maternal inherited thrombophilias and adverse perinatal outcomes (growth restriction, fetal demise, preterm birth, and preeclampsia) is a retrospective case-cohort study that will be performed within the National Collaborative Perinatal Project (NCPP) cohort. The proposal was submitted previously to the NICHD and was scored at the 28th %ile. (in the process of preparing for resubmission to NICHD)

Robert Strauss, MD, Associate Director, MFM Fellowship Program and Medical Director of Labor and Delivery, Professor Education & Training BA, Arts and Biology Franklin and Marshall College Lancaster, PA 1982–1986 MS, Biomedical Science Drexel University Philadelphia, PA 1986–1987 MD Temple University School of Medicine Philadelphia, PA 1988–1992 Internship Saint Barnabas Medical Center Livingston, NJ 1992–1993 Residency Saint Barnabas Medical Center Livingston, NJ 1993–1996 Fellowship, Maternal Fetal Medicine University of North Carolina at Chapel Hill Chapel Hill, NC 1996–1998 A. Research Interest Robert Strauss, MD is a Professor in Obstetrics and Gynecology, and also serves as Medical Director of Labor and Delivery at UNC Hospitals. In this role, he serves as leader of the Physicians Service Line with oversight from the hospital‘s Chief of Staff and Dean of the Medical School. He serves on the Quality for Women‘s Improvement Performance Committee, and also leads UNC‘s Perinatal Quality Collaborative of North Carolina. These efforts have resulted in improvement of Press-Ganey patient surveys and more efficient and safe patient care in our unit. He is also responsible for patient safety and satisfaction on labor and delivery. Dr. Strauss also serves as the Associate Director of the Maternal-Fetal Medicine Fellowship and is a beloved teacher and mentor. Having served as the Ob/Gyn residency director, his interest in resident and fellow education and research has resulted in several teaching awards. His research interests are focused on clinical obstetrics, including preterm birth, placental abruption, gestational diabetes, and fetal lung maturity studies. He has also received grant funding for research in prevention of preterm birth, as well as having mentored several resident and fellow research projects resulting in publication. B. Positions & Honors Hospital Appointments Associate Residency Program Director 2000–2003 Department of Obstetrics & Gynecology, UNC School of Medicine Residency Program Director 2003–2008 Department of Obstetrics & Gynecology, UNC School of Medicine Medical Director, Labor and Delivery 2005–present Chair, Quality for Women and Infant Performance Committee 2005–2007 Physician Service Leader for Obstetrics 2009–present Associate Director, MFM Fellowship 2011–present

Employment History Assistant Professor 1998–2004 Department of Obstetrics & Gynecology, UNC School of Medicine Associate Professor 2004–2011 Department of Obstetrics & Gynecology, UNC School of Medicine Professor 2011–present Department of Obstetrics & Gynecology, UNC School of Medicine Honors and Awards William Droegemueller-Watson A. Bowes‖ Faculty Teaching Award 1999 School Of Medicine Dean‘s Excellence in Teaching Award 1999 William Droegemueller-Watson A. Bowes‖ Faculty Teaching Award 2000 William Droegemueller-Watson A. Bowes‖ Faculty Teaching Award 2001 School Of Medicine Dean‘s Excellence in Teaching Award 2001 William Droegemueller-Watson A. Bowes‖ Faculty Teaching Award: 2003 Awarded by the residents to a junior faculty member for excellence in teaching and commitment to patient care. School Of Medicine Dean‘s Excellence in Teaching Award 2003 Faculty Golden Tar Heel Award 2005 Faculty Golden Tar Heel Award 2006 Robert C. Cefalo Distinguished Professor Award: Awarded by the 2007 Chief resident class to a faculty member who has excelled in teaching and mentoring during their 4 years Faculty Golden Tar Heel Award 2007 Faculty Golden Tar Heel Award: Awarded by the Third Year Medical 2009 Students to the faculty who scored at or above the 90th percentile on the end of clerkship resident evaluation CREOG Faculty Award for Excellence in Resident Education: 2009 Awarded by the residents to the faculty member who has excelled in their teaching and mentoring Robert C. Cefalo Distinguished Professor Award 2010 CREOG Faculty Award for Excellence in Resident Education 2010 CREOG Faculty Award for Excellence in Resident Education 2011 Faculty Golden Tar Heel Award 2013 CREOG Faculty Award for Excellence in Resident Education 2014 Faculty Golden Tarheel Award 2015 UNC Health Care and Faculty Physicians Carolina Care Excellence Leader 2016 Faculty Golden Tarheel Award 2016 Professional Duties/Memberships Journal Reviewer Obstetrics and Gynecology 1999–present BJOG: An International Journal of Obstetrics and Gynecology 2006–present Societies Fellow, American College of Obstetricians & Gynecologists Society of Maternal-Fetal Medicine American Medical Association Robert A. Ross Obstetrical & Gynecological Society Other Activities Director, Fourth year student Maternal-Fetal Medicine Elective 2000–present Director, Perinatal M&M Conference 2000–2007 Resident Obstetrical Evaluations 2002–present Director, Departmental M&M Conference 2004–2007 Interim Director, Raleigh office Maternal-Fetal Medicine 2005–2008 Group Leader, PQCNC (Perinatal Quality Collaborative of North Carolina) 2009–2011 C. Selected Peer-Reviewed Publications Strauss, RA. “Management of the fetus in transverse lie.” CJ Lockwood (Ed.)June 2018 http://www.uptodate.com/contents/management-of-the-fetus-in-transverse-lie Smid M, Strauss RA. “Maternal Anemoa. In: Berghella V (Ed.) Maternal-Fetal Evidence Based Guidelines,” 3rd Edition, 2016. O'Connell RV, Dotters-Katz SK, Kuller JA, Strauss RA.“Gastroschisis: A Review of Management and Outcomes.”Obstet Gynecol Surv. 2016 Sep;71(9):537-44. PMID: 27640608


Dotters-Katz SK, Carlson LM, Johnson J, Patterson J, Grace MR, Price W, Vladutiu CJ, Manuck TA, Strauss A.“Management of Pregnancy and Survival of Infants with Trisomy 13 or Trisomy 18.”Am J Perinatol. 2016 Oct;33(12):1121-7. PMID: 27437608 Dotters-Katz SK, Kuller JA, Grace MR, Laifer SA, Strauss RA.“Management Considerations for Ongoing Pregnancies Complicated by Trisomy 13 and 18.”Obstet Gynecol Surv. 2016 May;71(5):295-300. PMID: 27182826 Eichelberger KY, Baker AM, Woodham PC, Haeri S, Strauss RA, Stuebe AM.“Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia.”Obstet Gynecol. 2015 Oct;126(4):725-30. PMID: 26348183 Smith D, Stringer E, Vladutiu CJ, Zink AH, Strauss R**. “Risk of uterine rupture among women attempting vaginal birth after cesarean with an unknown uterine scar.” Am J Obstet Gynecol. 2015, Feb 4. PMID 25659467. Beamon C, Carlson L, Rambally B, Berchuck S, Gearhart M, Hammett-Stabler C, Strauss R**. “Predicting neonatal respiratory morbidity by lamellar body count and gtestational age.” J Perinatal Med. 2015, Feb 20. PMID 25719290. Dotters-Katz SK, Grace M, Strauss RA^, Chescheir N, Kuller JA. Chickungunya fever: “Obstetric considerations on an emerging virus.” Obstetrical and Gynecological Survey. 2015, 70(7):453-457. PMID 26185916. Eichelberger KY, Baker AM, Woodham PC, Haeri S, Strauss RA^, Stuebe AM. “Second-Trimester Maternal serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia.”Obstetrics and Gynecology. 2015; 126:725. PMID 26348183. Wood EW, Strauss RA, Janus C, Carrico CK. “The use of telemedicine in oral and maxillofacial surgery.” J Oral Maxillofac Surg. 2015 Nov 30 PMID: 26707428 Wood EW, Strauss RA, Janus C, Carrico CK. “ Telemedicine consultations in oral and maxillofacial surgery: A follow-up study.” J Oral Maxillofac Surg 2016 Feb;74(2):262-8 PMID: 26501427 Dotters-Katz SK, Grace MR, Strauss RA, Chescheir N, Kuller JA. “Chikungunya Fever: Obstetric considerations on emerging virus.” Obstet Gynecol Surv. 2015 Jul;70(7):453-7 PMID: 26185916 Meyliker RG, Strauss RA. “Periosteal osteosarcoma of the mandible: a case report.” J Oral Maxillofac Surg. 2015 Apr;73(4):787 PMID: 25795582

McPherson JA, Strauss RA, Stamilio DM. Nonreassuring fetal status during trial of labor after cesarean. Am J Obstet Gynecol. 2014 Jun 4 PMID:24907702 2012 Eichelberger KY, Devers PL, Strauss RA, Chescheir NC.Pitfalls in prenatal diagnosis of a fixed retroflexed fetal head.Ultrasound Obstet Gynecol. 2012 Dec;40(6):726-7. PMID:22350930 Hickman MA, McBride R, Boggess KA, Strauss R: Metformin compared with insulin in the treatment of pregnant women with over diabetes: A randomized controlled trial. Am J Perinatol. 2013 Jun;30(6):483-90. doi: 10.1055/s-0032-1326994. Epub 2012 Oct 24. Eichelberger KY, Cantrell LA, Balthazar U, Boggess KA, Strauss RA, Boggess JF: Robotic resection of adnexal masses during pregnancy. Am J Perinatology, 2013 May;30(5):371-5. Epub 2012 Aug 14. Eichelberger KY, Devers PL, Strauss RA, Chescheir NC.Pitfalls in prenatal diagnosis of a fixed retroflexed fetal head.Ultrasound Obstet Gynecol. 2012 Dec;40(6):726-7. PMID:22350930 Hickman MA, McBride R, Boggess KA, Strauss R.Metformin Compared with Insulin in the Treatment of Pregnant Women with Overt Diabetes: A Randomized Controlled Trial.Am J Perinatol. 2012 Oct 24. PMID:23096052 Eichelberger KY, Cantrell LA, Balthazar U, Boggess KA, Strauss RA, Boggess JF.Robotic Resection of Adnexal Masses during Pregnancy.Am J Perinatol. 2013 May;30(5):371-6. Epub 2012 Aug 14.PMID:22893553 Strauss RA, Wang N.Cone beam computed tomography and obstructive sleep apnoea.Aust Dent J. 2012 Mar;57 Suppl 1:61-71..PMID:22376098







D. Research Support Ongoing Research Support Mom2B Intervention Study: A hospital-based randomized clinical trial Source: OPTIVA Corp. UNC grant #558396 Project period: 4/25/00-08/01/03 Principal Investigator: Stephen Offenbacher, DDS, PhD Role of R.A. Strauss: Co-PI, 15% effort Total Funding: $915,279 Secondary analysis of MFMU Cesarean Study, including types of regional anesthesia and neonatal outcome among preeclamptic patients, as well as an analysis of patients undergoing trial of labor with an unknown scar. Analysis of neonatal outcomes among patients who have amniocentesis for fetal lung maturity, with focus on lamellar body counts. Prospective evaluation of cervical length screening with abdominal versus transvaginal ultrasound. Elizabeth M Stringer, MD, MSc, Assistant Professor_______________________________________ Education & Training BS, Biology Davidson College, Davidson NC 1991 MD University of Alabama, Birmingham AL 1993–1997 Residency Ob/Gyn University of Alabama, Birmingham AL 1997–2001 Fellowship International Women’s Health University of Alabaman, Birmingham AL 2001–2004 MSc Epidemiology University of London London School of Hygiene & Tropical Medicine 2006 Fellowship MFM University of North Carolina at Chapel Hill Chapel Hill, NC 2012–2015 A. Positions & Honors Assistant Professor, Dept of ObGyn, UNC Sept 2015–present Clinical Instructor/Fellow, Department of ObGyn, UNC July 2012–2015 Lecturer (Honorary), University of Zambia School of Medicine Sept 2001–present Visiting Associate Professor, Department of ObGyn, UNC Jan–June 2012 Associate Professor, Dept of ObGyn, University of Alabama at Birmingham Oct 2000–Dec 2011 Assistant Professor, Dept of ObGyn, University of Alabama at Birmingham June 2001–June 2004 Instructor/fellow, Dept of ObGyn, University of Alabama at Birmingham June 2001–June 2004

Other Experience and Professional Memberships Board Member of the American School of Tangier, Morocco (2013–present) Member, Global Health Committee, Society for Maternal Fetal Medicine (2012–present) American College of Obstetrics and Gynecology (2003–present) Zambian Society of Obstetrican Gynecologists (2001–present) Technical advisor, World Health Organization, Review of priorities in research on hormonal March 13–15,2007 contraception and IUDs and HIV infection Honors 2013 Golden Tar Heel Award for Teaching 2001 UAB Dept Ob-Gyn – Career in Research Award 2000 John J. Sparkman Center Award for Public Health Education 1997 Caduceus Club Scholarship for International Health Research (Bangkok, Thailand) B. Positions & Honors Hospital Appointments Assistant Professor, Dept of ObGyn, UNC Sept 2015–present Clinical Instructor/Fellow, Department of ObGyn, UNC July 2012–2015 Visiting Associate Professor, Department of ObGyn, UNC Jan–June 2012 Associate Professor, Dept of ObGyn, University of Alabama at Birmingham Oct 2000–Dec 2011 Assistant Professor, Dept of ObGyn, University of Alabama at Birmingham June 2001–June 2004 Instructor/fellow, Dept of ObGyn, University of Alabama at Birmingham June 2001–June 2004 Other Activities C. Selected Peer Reviewed Publications Smid MC, Ahmed Y, Stoner MC, Vwalika B, Stringer EM, Stringer JS.“Association of previous severe low birth weight with adverse perinatal outcomes in a subsequent pregnancy among HIV-prevalent urban African women.”Int J Gynaecol Obstet. 2017 Feb;136(2):188-194 PMID: 28099740 Vwalika B, Stoner MC, Mwanahamuntu M, Liu KC, Kaunda E, Tshuma GG, Somwe SW, Ahmed Y, Stringer EM, Stringer JS, Chi BH.“Maternal and newborn outcomes at a tertiary care hospital in Lusaka, Zambia, 2008-2012.”Int J Gynaecol Obstet. 2017 Feb;136(2):180-187. PMID: 28099725 Stringer EM, Vladutiu CJ, Batra P, Stringer JS, Menard MK.“Operationalizing 17α-Hydroxyprogesterone Caproate to Prevent Recurrent Preterm Birth: Definitions, Barriers, and Next Steps.”Obstet Gynecol. 2016 Dec;128(6):1397-1402.PMID: 27824772 Gravett C, Eckert LO, Gravett MG, Dudley DJ, Stringer EM, Mujobu TB, Lyabis O, Kochhar S, Swamy GK; Brighton Collaboration Non-reassuring fetal status Working Group..“Non-reassuring fetal status: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.”Vaccine. 2016 Dec 1;34(49):6084-6092.PMID: 27461459 Chibwesha CJ, Zanolini A, Smid M, Vwalika B, Phiri Kasaro M, Mwanahamuntu M, Stringer JS, Stringer EM.“Predictors and outcomes of low birth weight in Lusaka, Zambia.”Int J Gynaecol Obstet. 2016 Sep;134(3):309-14. PMID: 27365291 Stoner MC, Vwalika B, Smid MC, George S, Chi BH, Stringer EM, Stringer JS.“A retrospective study of HIV, antiretroviral therapy, and pregnancy-associated hypertension among women in Lusaka, Zambia.”Int J Gynaecol Obstet. 2016 Sep;134(3):299-303. PMID: 27365290 Lazear HM, Stringer EM, de Silva AM.“The Emerging Zika Virus Epidemic in the Americas: Research Priorities.”JAMA. 2016 May 10;315(18):1945-6. PMID: 26963564 Rahangdale L, Cates J, Potter J, Badell ML, Seidman D, Miller ES, Coleman JS, Lazenby GB, Levison J, Short WR, Yawetz S, Ciaranello A, Livingston E, Duthely L, Rimawi BH, Anderson JR, Stringer EM; HOPES (HIV OB Pregnancy Education Study) Group..“Integrase inhibitors in late pregnancy and rapid HIV viral load reduction.”Am J Obstet Gynecol. 2016 Mar;214(3):385.e1-7. PMID: 26928154 Smid MC, Stringer EM, Stringer JS.“A Worldwide Epidemic: The Problem and Challenges of Preterm Birth in Low- and Middle-Income Countries.”Am J Perinatol. 2016 Feb;33(3):276-89. PMID: 26841086 Stringer EM, Vladutiu CJ, Manuck T, Verbiest S, Ollendorff A, Stringer JS, Menard MK.“17-Hydroxyprogesterone caproate (17OHP-C) coverage among eligible women delivering at 2 North Carolina hospitals in 2012 and 2013: A retrospective cohort study.”Am J Obstet Gynecol. 2016 Jul;215(1):105.e1-105.e12. PMID: 26829508 Hancock NL, Chibwesha CJ, Stoner MC, Vwalika B, Rathod SD, Kasaro MP, Stringer EM, Stringer JS, Chi BH.“Temporal Trends and Predictors of Modern Contraceptive Use in Lusaka, Zambia, 2004-2011.”Biomed Res Int. 2015;2015:521928. PMID: 26819951 Chi BH, Stringer EM.“Increasing PMTCT uptake through integrated faith-based activities.”Lancet Glob Health. 2015 Nov;3(11):e657-8.PMID: 26475002






















Chi BH, Tih PM, Zanolini A, Stinson K, Ekouevi DK, Coetzee D, Welty TK, Bweupe M, Shaffer N, Dabis F, Stringer EM, Stringer JS.“Implementation and Operational Research: Reconstructing the PMTCT Cascade Using Cross-sectional Household Survey Data: The PEARL Study.”J Acquir Immune Defic Syndr. 2015 Sep 1;70(1):e5-9 PMID: 26068722 Stringer EM, Stoner M, Vwalika B, Chibwesha C, Chi BH, Stringer JSA. “A population-based cohort study of stillbirths in twins in Lusaka, Zambia.” Int J of Gynecol. Obstet. 2015 March 22. Stringer EM, Stoner M, Vwalika B, Chibwesha C, Chi BH, Stringer, JSA. A population-based cohort study of stillbirths in twins in Lusaka, Zambia. Int J of Gynaecol Obstet. 2015 March 22. Wiegand SL, Stringer EM, Stuebe AM, Jones H, Seashore C, Thorp J. Buprenorphine and Naloxone Compared with Methadone Treatment in Pregnancy. Obstet and Gynecol. 2015 Feb;125(2):363-8 Smith D, Stringer E, Vladutiu CJ, Zink AH, Strauss R. Risk of uterine rupture among women attempting vaginal birth after cesarean with an unknown uterine scar. Am J Obstet Gynecol. 2015 Feb 4. Liu KC, Farahani M, Mashamba T, Mawela M, Joseph J, Van Schaik N, Honey E, Gill M, Jassat W, Stringer EM, Chintu N, Marlink RG. Pregnancy outcomes and birth defects from an antiretroviral drug safety study of women in South Africa and Zambia. AIDS. 2014 Sep 24;28(15):2259-68. Chi BH, Musonda P, Lembalemba MK, Chintu NT, Gartland MG, Mulenga SN, Bweupe M, Turnbull E, Stringer EM, Stringer JS. Universal combination antiretroviral regimens to prevent mother-to-child transmission of HIV in rural Zambia: a two-round cross-sectional study. Bull World Health Organ. 2014 Aug 1;92(8):582-92. Stringer EM, Meltzer-Brody S, Kasaro M, Stuebe AM, Wiegand SL, Paul R, Stringer JSA. Depression, pregnancy, and HIV: the case for strengthening mental health services for pregnant and postpartum women in sub-Saharan Africa. Lancet Psychiatry. 2014 July; 1(2):159-162. Meltzer-Brody S and Stringer EM. Global maternal, newborn, and child health. New Engl J Med. 2014 Mar 13; 370 (11): 1072 Stringer JS, Stinson K, Tih PM, Giganti MJ, Ekouevi DK, Creek TL, Welty TK, Chi BH, Wilfert CM, Shaffer N, Stringer EM, Dabis F, Coetzee D. Measuring Coverage in MNCH: Population HIV-Free Survival among Children under Two Years of Age in Four African Countries. PLoS Med. 2013 Sep;10(5):e1001424. Liu KC, Joseph JA, Nkole TB, Kaunda E, Stringer JS, Chi BH, Stringer EM. Predictors and pregnancy outcomes associated with a newborn birth weight of 4000 g or more in Lusaka, Zambia. Int J Gynaecol Obstet. 2013 Aug; 122(2): 150-5. Waters E, Li M, Mugisa B, Bowa K, Linyama D, Stringer E, Stringer J. Acceptability and Uptake of Neonatal Male Circumcision in Lusaka, Zambia. AIDS Behav. 2013 Jul; 17 (6) 2114-22. Gartland MG, Chintu NT, Li MS, Lembalemba MK, Mulenga SN, Bweupe M, Musonda P, Stringer EM, Stringer JS, Chi BH. Field effectiveness of combination antiretroviral prophylaxis for the prevention of mother-to-child HIV transmission in rural Zambia. AIDS. 2013 May 15; 27(8): 1253-62. Bowa K, Li MS, Mugisa B, Waters E, Linyama DM, Chi BH, Stringer JS, Stringer EM. A controlled trial of three methods for neonatal circumcision in Lusaka, Zambia. J Acquir Immune Defic Syndr. 2013 Jan 1;62(1):e1-6. D. Research Support Ongoing Research Support Improving Access to and Delivery of HIV/AIDS Services by Strengthening Community-Based services Funding Agency: US CDC Grant Number: 5U2GPS002793-02 Dates: 9/30/10–9/29/15 Awarded: $4,000,000.00 Role: PI Effort: 10%-20% Description: This award supported the implementation of services to prevent perinatal HIV transmission in the Eastern Province of Zambia. Activities included traning, procurement of commodities and supplies, and conduct of several innovative performance monitoring practices. Dr. Stringer served as PI until June 2012, when she entered her maternal-fetal medicine fellowship and relinquished the grant to another investigator. Title: Centre for Infectious Disease Research in Zambia HIV/AIDS Clinical trials unit Funding Agency: NIH/NIAID Grant number: U01-A1069455 Dates: 05/10/07–11/30-13 Awarded: $20,866,573 Role: Investigator; Site PI for ACTG Network Effort: 20% Description: This grant from NIH/NIAID supported our integrated clinical trials unit at CIDRZ-Zambia. We affiliated with 4 DAIDS-sponsored networks through this grant: the AIDS Clinical Trials Group (ACTG; for adult HIV therapeutic trials), the International Maternal Pediatric Adolescent AIDS Clinical trials Network (IMPAACT, for maternal and child HIV prevention and treatment studies), the Microbicides Trials Network (MTN, for microbicide prevention trials); and the HIV Prevention Trials



Network (HPTN; for adult HIV prevention studies). Dr. Stringer led the ACTG network activities at our Zambia site. Alison Stuebe, MD, MSc, Associate Professor, Department of Obstetrics and Gynecology________ Education & Training BS, Biology Duke University Durham, NC 1995 MD Washington University St. Louis, MO 2001 MSc, Epidemiology Harvard School of Public Health Boston, MA 2008 A. Positions & Honors Resident, Brigham and Women‘s Hospital / Massachusetts 2001–2005 General Hospital Integrated Residency in Obstetrics and Gynecology Fellow, Maternal Fetal Medicine, Brigham and Women‘s Hospital 2005–2008 Assistant Professor, Department of Obstetrics and Gynecology, 2008–present University of North Carolina Assistant Professor, Department of Maternal and Child Health, 2010–present Gillings School of Global Public Health, University of North Carolina Other Experience and Professional Memberships Member, American Medical Women‘s Association 1996–present Member, Massachusetts Medical Society. Resident/fellow 2001– present Member, Perinatal Welfare Committee, 2006–2007 Member, American Medical Association 2001–present Member, American College of Obstetrics and Gynecology 2001–present Member, Academy of Breastfeeding Medicine. 2002–present Board member, Academy of Breastfeeding Medicine 2009–present Communications committee chair, 2009–present Member, Massachusetts Breastfeeding Coalition. 2002–2008 Board member, Mass Breastfeeding Coalition 2005–2007 Member, Society for Maternal-Fetal Medicine 2006 –present Communications committee member 2009–present Communications committee chair 2011–present Honors Angier B Duke Scholar (full tuition merit award) 1991–1995 Barry M. Goldwater Scholar 1993 Harry S Truman Scholar 1994 Distinguished Student Scholar / Mr. and Mrs. Spencer T. Olin Fellow (full tuition merit award) 1997–2001 Alpha Omega Alpha 2001 Excellence in Teaching Award 2002/2005 Berlex Resident Teaching Award 2003 Best Clinical Research Presentation, New England Perinatal Society 2006/2007 SMFM Award of Research Excellence 2007 Wyeth Presenter's Award, Society for Gynecologic Investigation 2008 Expert Panel Member: DHHS, Call to Action on Breastfeeding, Washington D.C. 2009 Invited participant, NICHD Scientific Vision Workshop on Developmental Origins of Health And Disease 2011 B. Positions & Honors Hospital Appointments Medical Director of Lactation Services UNC HealthCare 02/2013–present Assistant Professor (joint appointment) Department of Maternal and Child Health UNC Gillings Global School of Public Health 07/2010–present

Assistant Professor Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill Chapel Hill, NC 07/2008–present Employment History 2001–2005 Resident, Brigham and Women’s Hospital / Massachusetts General Hospital Integrated Residency in Obstetrics

and Gynecology 2005–2008 Fellow, Maternal Fetal Medicine, Brigham and Women’s Hospital. 2008– Assistant Professor, Department of Obstetrics and Gynecology, University of North Carolina 2010– Assistant Professor, Department of Maternal and Child Health, Gilling’s School of Global Public

Health, University of North Carolina 2013– Medical Director for Lactation Services, UNC Health Care 07/2014– Associate Professor (joint appt) MFM and UNC Gilling’s School of Public Health 06/2015– Distinguished Scholar in Infant and Young Child Feeding, MFM and UNC Gilling’s School of Public Health Honors and Awards 1991–1995 Angier B Duke Scholar (full tuition merit award) 1993 Barry M. Goldwater Scholar 1994 Harry S Truman Scholar 1997–2001 Distinguished Student Scholar / Mr. and Mrs. Spencer T. Olin Fellow (full tuition merit award) 2001 Alpha Omega Alpha 2002, 2005 Excellence in Teaching Award 2003 Berlex Resident Teaching Award 2006, 2007 Best Clinical Research Presentation, New England Perinatal Society 2007 SMFM Award of Research Excellence 2008 Wyeth Presenter's Award, Society for Gynecologic Investigation 2009 Expert Panel Member: DHHS, Call to Action on Breastfeeding, Washington D.C. 2011 Invited participant, NICHD Scientific Vision Workshop on Developmental Origins of Health and Disease 2011 Golden Tar Heel Teaching Award 2012 SMFM Award of Research Excellence 2013 Jefferson Pilot Faculty Scholar

Professional Duties/Memberships 2001– Member, Massachusetts Medical Society. Resident/fellow member, Perinatal Welfare Committee, 2006-2007 2001– Member, American Medical Association 2001– Member, American College of Obstetrics and Gynecology 2002– Member, Academy of Breastfeeding Medicine. Board member 2009-. Communications committee chair, 2009- 2002–2008 Member, Massachusetts Breastfeeding Coalition. Board member 2005-2007. 2006– Member, Society for Maternal-Fetal Medicine. 2011–2012 Communications committee chair, Society for Maternal-Fetal Medicine 2012– External communications committee chair, Society for Maternal-Fetal Medicine 2013– Member, ACOG Obstetric Practice Committee 2013– UNC Epic Physicians Informatics Council Other Activities C. Selected Peer Reviewed Publications Vladutiu CJ, Meyer ML, Malek AM, Stuebe AM, Mosher A, Aggarwal S, Kleindorfer D, Howard VJ.“Racial Differences in the Association between Parity and Incident Stroke: Results from the REasons for Geographic and Racial Differences in Stroke Study.”J Stroke Cerebrovasc Dis. 2016 Nov 7PMID: 27839767 Bartick MC, Jegier BJ, Green BD, Schwarz EB, Reinhold AG, Stuebe AM.“Disparities in Breastfeeding: Impact on Maternal and Child Health Outcomes and Costs.”J Pediatr. 2016 Nov 10. PMID: 27837954 Martin CL, Siega-Riz AM, Sotres-Alvarez D, Robinson WR, Daniels JL, Perrin EM, Stuebe AM. J Nutr. 2016 Nov;146(11):2281-2288.“Maternal Dietary Patterns during Pregnancy Are Associated with Child Growth in the First 3 Years of Life.”PMID: 27683873 Stuebe AM, Bonuck K, Adatorwovor R, Schwartz TA, Berry DC.“A Cluster Randomized Trial of Tailored Breastfeeding Support for Women with Gestational Diabetes”Breastfeed Med. 2016 Dec;11:504-513.PMID: 27782758










Bartick MC, Schwarz EB, Green BD, Jegier BJ, Reinhold AG, Colaizy TT, Bogen DL, Schaefer AJ, Stuebe AM.“Suboptimal breastfeeding in the United States: Maternal and pediatric health outcomes and costs.”Matern Child Nutr. 2017 Jan;13(1). PMID: 27647492 Smid MC, Edwards RK, Biggio JR, Dorman K, Leduke RC, Lesher LL, Manuck TA, Saade GR, Salazar AE, Stamilio DM, Stuebe AM, Tita AT, Torres CM, Varner MW, Wapner RJ“Class III Obese Women's Preferences and Concerns for Cesarean Skin Incision: A Multicenter Survey.”.Am J Perinatol. 2016 Aug 17.PMID: 27533104 Kleppel L, Suplee PD, Stuebe AM, Bingham D.“National Initiatives to Improve Systems for Postpartum Care.”Matern Child Health J. 2016 Nov;20(Suppl 1):66-70.PMID: 27531012 American College of Obstetricians and Gynecologists’ Committee on Obstetric Practice., et al.“Committee Opinion No. 670: Immediate Postpartum Long-Acting Reversible Contraception.”Obstet Gynecol. 2016 Aug;128(2):e32-7. PMID: 27454734 Wouk K, Stuebe AM, Meltzer-Brody S.“Postpartum Mental Health and Breastfeeding Practices: An Analysis Using the 2010-2011 Pregnancy Risk Assessment Monitoring System.”Matern Child Health J. 2016 Jul 22. PMID: 27449655 Colaizy TT, Bartick MC, Jegier BJ, Green BD, Reinhold AG, Schaefer AJ, Bogen DL, Schwarz EB, Stuebe AM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network..“Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants.”J Pediatr. 2016 Aug;175:100-105.e2. PMID: 27131403 Stuebe AM, Bryant AG, Lewis R, Muddana A.“Association of Etonogestrel-Releasing Contraceptive Implant with Reduced Weight Gain in an Exclusively Breastfed Infant: Report and Literature Review.”Breastfeed Med. 2016 May;11:203-6. PMID: 27032034 Vladutiu CJ, Siega-Riz AM, Sotres-Alvarez D, Stuebe AM, Ni A, Tabb KM, Gallo LC, Potter JE, Heiss G.“Parity and Components of the Metabolic Syndrome Among US Hispanic/Latina Women: Results From the Hispanic Community Health Study/Study of Latinos.”Circ Cardiovasc Qual Outcomes. 2016 Feb;9(2 Suppl 1):S62-9. PMID: 26908862 Martin CL, Siega-Riz AM, Sotres-Alvarez D, Robinson WR, Daniels JL, Perrin EM, Stuebe AM. “Maternal Dietary Patterns are Associated with Lower Levels of Cardiometabolic Markers during Pregnancy.”Paediatr Perinat Epidemiol. 2016 May;30(3):246-55. PMID: 26848932 Wouk K, Lara-Cinisomo S, Stuebe AM, Poole C, Petrick JL, McKenney KM. “Clinical interventions to promote breastfeeding by Latinas: A meta-analysis.” Pediactrics. 2015 Dec 14 PMID: 26668300 Smid MC, Smiley SG, Schulkin J, Stamilio DM, Edwards RK, Stuebe AM. “The problem of the pannus: Physician preference survery and a review of the literature on cesarean skin incision in morbidly obese women.” Am J Perinatol. 2015 Oct 28 PMID: 26510932 Berry D, Verbiest S, Hall EG, Dawson I, Norton D, Willis S, McDonald K, Stuebe A. “A postpartum community-based weight management intervention designed for low-income women: feasibility and initial efficacy testing. J Natl Black Nurses Assoc. 2016 Jul;26(1):29-39PMID: 26371358 Eichelberger KY, Baker AM, Woodham PC, Haeri S, Strauss RA, Stuebe AM. “Second-trimester maternal serum paraxanthine, CYPA1A2 activity, and the risk of severe preeclampsia.” Obstet Gynecol. 2015;126(4):725-730 PMID: 26348183 Twigger AJ, Hepworth AR, Lai CT, Chetwynd E, Stuebe AM, Blackcafort P, Hartmann PE, Geddes DT, Kakulas F. “Gene expression in breastmilk cells is associated with maternal and infant characteristics.”SCi Rep. 2015:5:12933 PMID: 26255679 Zera CA, Bates DW, Stuebe AM, EckerJL, Seely EW. “Diabetes screening reminder for women with prior gestational diabetes: A randomized controlled trial.” Obstet Gynecol. 2015 Jul;126(1):109-114 PMID: 26255679 Grace MR, Hardisty E, Green NS, Davidson E, Stuebe AM, Vora NL. “Cell free DNA testing-interpretation of results using an online calculator. Am J Obstet Gynecol. 2015 May 5 PMID: 25957020 Stuebe AM, Meltzer-Brody S, Pearson B, Pedersen C, Grewen K. “Maternal neuroendocrine serum levels in exclusively breastfeeding mothers.” Breastfeed Med. 2015 May;10:197-202 PMID: 25831434 Lopez LM, Grey TW, Stuebe AM, Chen M, Truitt ST, Gallo MF. Combined hormonal versus nonhormonal versus progestin-only contraception in lactation. Cochrane. Database Syst Rev. 2015 Mar 20;3:CD003988.















Cox EQ, Stuebe A, Pearson B, Grewen K, Rubinow D, Meltzer-Brody S. Oxytocin and HPA stress axis reactivity in postpartum women. Psychoneuroendocrinology.2015 Feb 25;55:164-172.

Wiegand SL, Stringer EM, Stuebe AM, Jones H, Seashore C, Thorp J. Buprenorphine and Naloxone Compared with Methadone Treatment in Pregnancy. Obstet Gynecol. 2015 Feb;125(2):363-8.

Stuebe AM, Landon MB, Lai Y, Klebanoff M, Ramin SM, Wapner RJ, Varner MW, Rouse DJ, Sciscione A, Catalano P, Saade G, Sorokin Y, Peaceman AM; Is there a threshold Oral Glucose Tolerance Test Value for Predicting Adverse Pregnancy Outcome? For the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, MD. Am J Perinatol. 2015 Jan16.

Perng W, Rifas-Shiman SL, Rich-Edwards JW, Stuebe AM, Oken E. Inflammation and weight gain in reproductive-aged women. Ann Hum Biol. 2014 Dec 16:1-5. Perng W, Stuart J, Rifas-Shiman SL, Rich-Edwards JW, Stuebe A, Oken E. Preterm Birth and Long-term Maternal Cardiovascular Health. Ann Epidemiol, 2015 Jan;25(1):40-5. Epub 2014 Oct 18. Stuebe AM. Enabling Women to Achieve Their Breastfeeding Goals. Obstet Gynecol. 2014 Mar;123(3):643-52.

Latuga, MS, Stuebe A, Seed PC. A review of the source and function of microbiota in breast milk. Semin. Reprod. Med. 2014 Jan;32(1):68-73 Berggren EK, Stuebe AM, Boggess KA. Excess Maternal Weight Gain and Large for Gestational Age Risk among Women with Gestational Diabetes. Am J Perinatol. 2014 Jun 27. PMID:24971567 In reply.Stuebe AM.Obstet Gynecol. 2014 Jul;124(1):162. PMID:24945446 Poole AT, Vincent KL, Olson GL, Patrikeev I, Saade GR, Stuebe A, Bytautiene E. Effect of lactation on maternal postpartum cardiac function and adiposity: a murine model.Am J Obstet Gynecol. 2014 Jun 3. pii: S0002-9378(14)00565-1. PMID:24905416 Stuart GS, Lesko C, Stuebe A, Bryant A. Breastfeeding and postpartum insertion of the levonorgestrel intrauterine system: a randomized trial.Obstet Gynecol. 2014 May;123 Suppl 1:15S. PMID: 24770058 Harmon QE, Engel SM, Wu MC, Moran TM, Luo J, Stuebe AM, Avery CL, Olshan AF. Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia.Am J Reprod Immunol. 2014 May;71(5):472-84Epub 2014 Apr 4.PMID:24702779 Stuebe AM, Horton BJ, Chetwynd E, Watkins S, Grewen K, Meltzer-Brody S.J Prevalence and risk factors for early, undesired weaning attributed to lactation dysfunction.Womens Health (Larchmt). 2014 May;23(5):404-12. PMID:24655291 Starling AP, Engel SM, Richardson DB, Baird DD, Haug LS, Stuebe AM, Klungsyr K, Harmon Q, Becher G, Thomsen C, Sabaredzovic A, Eggesb M, Hoppin JA, Travlos GS, Wilson RE, Trogstad LI, Magnus P, Longnecker MP. Perfluoroalkyl substances during pregnancy and validated preeclampsia among nulliparous women in the Norwegian Mother and Child Cohort Study.Am J Epidemiol. 2014 Apr 1;179(7):824-33 PMID:24557813 Stuebe AM. Enabling women to achieve their breastfeeding goals.Obstet Gynecol. 2014 Mar;123(3):643-52. PMID:24499748 Latuga MS, Stuebe A, Seed PC. A review of the source and function of microbiota in breast milk. Semin Reprod Med. 2014 Jan;32(1):68-73. Epub 2014 Jan 3.PMID:24390923 Bonuck K, Stuebe A, Barnett J, Labbok MH, Fletcher J, Bernstein PS.Effect of primary care intervention on breastfeeding duration and intensity. Am J Public Health. 2014 Feb;104 Suppl 1:S119-27. PMID:24354834 Latuga, MS, Stuebe A, Seed PC. A review of the source and function of microbiota in breast milk. Semin. Reprod. Med. 2014 Jan;32(1):68-73 Stuebe AM. Commentary on ‘Women’s intentions to breastfeed: a population-based cohort study’. BJOG. 2013 Nov;120(12):1499

Meltzer-Brody S, Stuebe A. The long-term psychiatric and medical prognosis of perinatal mental illness. Best Pract Res Clin Obstet Gynaecol. Epub 2013 Aug 27. Hassiotou F, Hepworth AR, Beltran AS, Mathews MM, Stuebe AM, Hartmann PE, Filgueira L, Blancafort P.Expression of the Pluripotency Transcription Factor OCT4 in the Normal and Aberrant Mammary Gland.Front Oncol. 2013 Apr 11;3:79. Print 2013.PMID:23596564 Stuebe AM, Grewen K, Meltzer-Brody S.Association between maternal mood and oxytocin response to breastfeeding.J Womens Health (Larchmt). 2013 Apr;22(4):352-61. PMID:23586800 Stuebe AM, Wise A, Nguyen T, Herring A, North KE, Siega-Riz AM.Maternal Genotype and Gestational Diabetes.Am J Perinatol. 2013 Mar 1.PMID:23456907 Faupel-Badger JM, Arcaro KF, Balkam JJ, Eliassen AH, Hassiotou F, Lebrilla CB, Michels KB, Palmer JR, Schedin P, Stuebe AM, Watson CJ, Sherman ME.Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop.J Natl Cancer Inst. 2013 Feb6;105(3):166-74. PMID:23264680 Connolly A, Ryan DH, Stuebe AM, Wolfe HM Reevaluation of discriminatory and threshold levels for serum -hCG in early pregnancy.Obstet Gynecol. 2013 Jan;121(1):65-70. doi: http://10.1097/AOG.0b013e318278f421. PMID:23262929[PubMed - in process] D. Research Support Ongoing Research Support

1. EPC V – RFTO #35 Medium Systematic Review: Breastfeeding and Maternal Health Outcomes in Developed Countries Role: Co-I 10% effort

2. 2016-2019 R40MC29455 Care4Moms Role: PI $196,707 (Year 1), 10% effort

3. 2016-2021

R01DA038215 Cocaine and Maternal Behavior: Effects on Trajectory of Infant Brain Development Role: Co-I PI: Karen Grewen $538,740.00 (year 1), 3% effort

4. 2014-2016

AHA SWA Winter 2014 Beginning Grant-in-Aid 14BGIA20480229 Lactation, oxytocin, and maternal cardiometabolic health later in life

PI: Egle Bytautiene Role: Consultant Description: To study the role of lactation and oxytocin in the development of cardiovascular disease and metabolic syndrome in women later in life in a mouse model

5. 2012-2017 R01 MH095992-01 Identifying Biomarkers for Post-Partum Depression in African-American Women Role: Co-I Co-PI: David Rubinow and Patrick Sullivan $706,405 (year 1), $4,928,522 (total) 5% effort

6. 2013-2020 N01-HC65233 Coordinating Center, Hispanic Community Health Study / Study of Latinos Role: Co-I PI: Jianwen Cai $23,484,803. (total), $2,764,746 (year 1), 8% effort

http://10.0.4.73/AOG.0b013e318278f421.PMID%3A23262929

7. 2013-2018 NIH-NICHD_DESPR-2013-17-1 Diet, Obesity, and Weight Change in Pregnancy Role: Co-I PI: Miles Faith, Department of Nutrition, UNC Gillings School of Global Public Health $1,800,919 (total), $611,716 (first 18 months), 5% effort

8. 2013-2017 R01HL109216-01A1 Lactation Effects on Postnatal Endothelial Function and Vascular Inflammation Role: Co-I PI: Grewen $307,067 (year 1), $1,249,581 (total), 15% effort

9. 2012-2014 R21DK092750 Improving Outcomes for Women with GDM and their Infants We will conduct a pilot study of a combined pre- and post-natal lifestyle intervention to reduce the risk of maternal Type 2 Diabetes and childhood obesity among mother-infant dyads with gestational diabetes. Role: Co-PI $150,000 (year 1), $275,000 (total) 5% effort.

10. 2013-2018 R01 HD073220-01 Mood, mother and infant: The psychobiology of impaired dyadic development The goal of this project is to elucidate the mechanisms through which maternal depression and anxiety affect breastfeeding, maternal-infant interactions, and development of infant attachment. Role: PI 340,974 (year 1), $1,962,078 (total), 25% effort

11. 2012-2017

R01 MH095992-01 Identifying Biomarkers for Post-Partum Depression in African-American Women Role: Co-I Co-PI: David Rubinow and Patrick Sullivan

$706,405 (year 1), $4,928,522 (total) 5% effort

John Thorp, MD, Director, Women‘s Primary Health, Professor________________ Education & Training BA, Zoology University of North Carolina at Chapel Hill Chapel Hill, NC 1979 MD Eastern Carolina University Greenville, NC 1983 Residency, Obstetrics and Gynecology University of North Carolina at Chapel Hill Chapel Hill, NC 1987 Fellowship, Maternal-Fetal Medicine University of North Carolina at Chapel Hill Chapel Hill, NC 1989 MPH, Health Sciences in Clinical Leadership Duke University Durham, NC 2009

A. Personal Statement Dr. Thorp has long-standing interest and expertise in both clinical obstetrics and perinatal epidemiology. He was a founding investigator of the Pregnancy, Infection, Nutrition cohort (n>5,000) at UNC and has led the UNC team in the MFMU Network since joining the Network a decade ago. He likewise is one of the original principal investigators in NICH‘s Community Child Health Network and the lead obstetrician to the UNC- Duke-Batelle contracts within the National Children‘s Study, including the vanguard Duplin site. His leadership within the MFMU Network has allowed UNC to expand from two sites with around 7,000 annual birth to the four sites proposed herein, with 19,000 births annually. Also our team has advanced in recruitment ranking within the MFMU Network from one of two new Centers in 1999 to 4th out of 14 in 2010. B. Positions and Honors Positions and Employment 1990–1995 Assistant Professor, Division of Maternal-Fetal Medicine, Obstetrics and Gynecology, UNC 1990– Assistant Professor, Radiology, UNC 1995–2000 Associate Professor, Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, UNC 1995– Associate Chair, Obstetrics and Gynecology, UNC School of Medicine 1997– Fellowship Director, Division of Maternal-Fetal Medicine Obstetrics and Gynecology, UNC 1999–2004 Co-Director, Program for Women‘s Health Research, UNC School of Medicine 2000– Professor, Obstetrics and Gynecology, UNC School of Medicine 2001– McAllister Distinguished Professor of Obstetrics and Gynecology, UNC School of Medicine 2003– Fellow, Carolina Population Center, UNC-CH 2004–2006 Deputy Director, Center for Women‘s Health Research, UNC School of Medicine 2004– Director, Biomedical Core, Carolina Population Center, UNC-CH 2006– Director, Division of Women‘s Primary Healthcare, Dept of OB/GYN, UNC School of Medicine 2006– Interim Director, Center for Women‘s Health Research, UNC School of Medicine 2008– Deputy Director, Center for Women‘s Health Research, UNC School of Medicine Honors 1990, 1991 William Droegemueller, Watson A. Bowes, Jr. Faculty Teaching Award, UNC 1992 APGO/CREOG Departmental Teaching Award 1992 Professor's Teaching Award, Ob/Gyn, UNC School of Medicine 1995 Faculty Award for Excellence in Resident Education, Council on Resident Education, Ob/Gyn 1998 Faculty Teaching Award 1999 Presenter, Third Annual ACOG Leadership Program in Women‘s Health Policy at UNC-CH 1999 Developmental Disabilities and substance abuse recognition award for outstanding service to women and

children, NC Division of Mental Health 2002–04 Recognized as a top reviewer for Obstetrics and Gynecology 1999 Perinatal Health Model of Excellence, awarded by the North Carolina Dept of Health and

Human Services in conjunction with the March of Dimes 2000 Robert C. Cefalo Faculty Teaching Award, Ob/Gyn, UNC School of Medicine 2002 Hugh McAllister Distinguished Professorship in Ob/Gyn 2005 Robert C. Cefalo Faculty Teaching Award, Ob/Gyn, UNC School of Medicine 2005, 2006 Golden Tar Heel Medical Student Teaching Award 2006–2007 Recognized as a top reviewer for Obstetrics and Gynecology C. Selected Peer-reviewed Publications Varner MW, Rice MM, Landon MB, Casey BM, Reddy UM, Wapner RJ, Rouse DJ, Tita AT, Thorp JM, Chien EK, Saade GR, Peaceman AM, Blackwell SC, Vandorsten JP; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network..“Pregnancies After the Diagnosis of Mild Gestational Diabetes Mellitus and Risk of Cardiometabolic Disorders.”Obstet Gynecol. 2017 Feb;129(2):273-280. PMID: 28079773 Guardino CM, Dunkel Schetter C, Hobel CJ, Gaines Lanzi R, Schafer P, Thorp JM, Shalowitz MU; Community Child Health Network (CCHN)..“Chronic Stress and C-Reactive Protein in Mothers During the First Postpartum Year.”Psychosom Med. 2016 Dec 13. [Epub ahead of print]PMID: 27977503 Blackwell SC, Landon MB, Mele L, Reddy UM, Casey BM, Wapner RJ, Varner MW, Rouse DJ, Thorp JM Jr, Sciscione A, Catalano P, Saade G, Caritis SN, Sorokin Y, Grobman WA; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network..“Relationship Between Excessive Gestational Weight Gain and Neonatal Adiposity in Women With Mild Gestational Diabetes Mellitus.” Obstet Gynecol. 2016 Dec;128(6):1325-1332.PMID: 27824768 Froehlich RJ, Sandoval G, Bailit JL, Grobman WA, Reddy UM, Wapner RJ, Varner MW, Thorp JM Jr, Prasad M, Tita AT, Saade G, Sorokin Y, Blackwell SC, Tolosa JE; MSCE, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network..“Association of Recorded Estimated Fetal Weight and Cesarean Delivery in Attempted Vaginal Delivery at Term.”Obstet Gynecol. 2016 Sep;128(3):487-94. PMID: 27500344








Grobman WA, Lai Y, Iams JD, Reddy UM, Mercer BM, Saade G, Tita AT, Rouse DJ, Sorokin Y, Wapner RJ, Leveno KJ, Blackwell SC, Esplin MS, Tolosa JE, Thorp JM, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network..” Prediction of Spontaneous Preterm Birth Among Nulliparous Women With a Short Cervix.”J Ultrasound Med. 2016 Jun;35(6):1293-7.PMID: 27151903 Harper LM, Mele L, Landon MB, Carpenter MW, Ramin SM, Reddy UM, Casey B, Wapner RJ, Varner MW, Thorp JM Jr, Sciscione A, Catalano P, Harper M, Saade G, Caritis SN, Sorokin Y, Peaceman AM, Tolosa JE; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network..” Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes.”Obstet Gynecol. 2016 May;127(5):893-8. PMID: 27054932 Berger GS, Thorp JM Jr, Weaver MA.“Effectiveness of bilateral tubotubal anastomosis in a large outpatient population.”Hum Reprod. 2016 May;31(5):1120-5. PMID: 26980770 Straub H, Simon C, Plunkett BA, Endres L, Adam EK, Mckinney C, Hobel CJ, Thorp JM, Raju T, Shalowitz M.“Evidence for a Complex Relationship Among Weight Retention, Cortisol and Breastfeeding in Postpartum Women.”Matern Child Health J. 2016 Jul;20(7):1375-83. PMID: 26968183 Rice MM, Landon MB, Varner MW, Casey BM, Reddy UM, Wapner RJ, Rouse DJ, Biggio JR Jr, Thorp JM Jr, Chien EK, Saade G, Peaceman AM, Blackwell SC, VanDorsten JP; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units Network (MFMU)..“Pregnancy-Associated Hypertension in Glucose-Intolerant Pregnancy and Subsequent Metabolic Syndrome.”Obstet Gynecol. 2016 Apr;127(4):771-9. PMID: 26959208 Langen ES, Weiner SJ, Bloom SL, Rouse DJ, Varner MW, Reddy UM, Ramin SM, Caritis SN, Peaceman AM, Sorokin Y, Sciscione A, Carpenter MW, Mercer BM, Thorp JM Jr, Malone FD, Iams JD; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network..“Association of Cervical Effacement With the Rate of Cervical Change in Labor Among Nulliparous Women.”Obstet Gynecol. 2016 Mar;127(3):489-95.PMID: 26855099 Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita AT, Reddy UM, Saade GR, Rouse DJ, McKenna DS, Clark EA, Thorp JM Jr, Chien EK, Peaceman AM, Gibbs RS, Swamy GK, Norton ME, Casey BM, Caritis SN, Tolosa JE, Sorokin Y, VanDorsten JP, Jain L; NICHD Maternal–Fetal Medicine Units Network..“Antenatal Betamethasone for Women at Risk for Late Preterm Delivery.”N Engl J Med. 2016 Apr 7;374(14):1311-20.PMID: 26842679 Manuck TA, Rice MM, Bailit JL, Grobman WA, Reddy UM, Wapner RJ, Thorp JM, Caritis SN, Prasad M, Tita AT, Saade GR, Sorokin Y, Rouse DJ, Blackwell SC, Tolosa JE; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network..“Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort.”Am J Obstet Gynecol. 2016 Jul;215(1):103.e1-103.e14 PMID: 26772790 Bailit JL, Grobman WA, Rice MM, Wapner RJ, Reddy UM, Varner MW, Thorp JM Jr, Caritis SN, Iams JD, Saade G, Rouse DJ, Tolosa JE; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network..“Evaluation of delivery options for second-stage events.”Am J Obstet Gynecol. 2016 May;214(5):638.e1-638.e10. PMID: 26596236 Borowski KS, Clark EA, Lai Y, Wapner RJ, Sorokin Y, Peaceman AM, Iams JD, Leveno KJ, Harper M, Caritis SN, Miodovnik M, Mercer BM, Thorp JM Jr, O'Sullivan MJ, Ramin SM, Carpenter MW, Rouse DJ, Sibai B; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network..“Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids.”Am J Perinatol. 2015 Oct;32(12):1126-32. PMID: 26445141 Basraon SK, Mele L, Myatt L, Roberts JM, Hauth JC, Leveno KJ, Varner MW, Wapner RJ, Thorp JM Jr, Peaceman AM, Ramin SM, Sciscione A, Tolosa JE, Sorokin Y; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network..“Relationship of Early Pregnancy Waist-to-Hip Ratio versus Body Mass Index with Gestational Diabetes Mellitus and Insulin Resistance.”Am J Perinatol. 2016 Jan;33(1):114-21. PMID: 26352680 Ramey S, Schafer P, DeClerque J, Lanzi R, Hobel C, Shalowitz M, Chinchilli V, Raju T, Thorp J for the Community Child Health Network; The Preconception Stress and Resiliency Pathways Model: A Multi-Level Framework on Maternal, Paternal, and Child Health Disparities Derived by Community-Based Participatory Research. Maternal Child Health J (2015) 19:707-719 Rachel Peragallo Urrutia, Alexander A Berger, Amber A Ivins, A Jenna Beckham, John M Thorp Jr, Wanda K Nicholson; Internet Use and Access Among Pregnant Women via Computer and Mobile Phone: Implications for Delivery of Perinatal Care. JMIR MHEALTH AND UHEALTH (JMIR mHealth uHealth 2015;(1):e25) Koch E, Chireau M, Pliego F, Stanford J, Haddad S, Calhoun B, Aracena P, Bravo M, Gatica S, Thorp J: Abortion, legislation, maternal healthcare, fertility, female literacy, sanitation, violence against women and maternal deaths: a natural experiment in 32 Mexican states. BMJ Open 2014;4:e006013.



















Wiegand SL, Stringer EM, Stuebe AM, Jones H, Seashore C, Thorp J. Buprenorphine and naloxone compared with methadone treatment in pregnancy. Obstet Gynecol. 2015 Feb;125(2):363-8. ISSN: 0029-7844/15 Endres L, Straub H, McKinney C, Plunkett B, Minkovitz C, Schetter C, Ramey S, Wang C, Hobel C, Raju T, Shalowitz, for the Community Child Health Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Postpartum Weight Retention Risk Factors and Relationship to Obesity at 1 Year, The American College of Obstetricians and Gynecologists, Volume 125, NO.1, Jan 2015 Cantu J, Clifton R, Roberts J, Leveno K, Myatt L, Reddy U, Varner M, Wapner R, Thorp JM, Mercer B, Peaceman A, Ramin S, Samuels P, Sciscione A, Saade G, Sorokin Y, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (MFMU) Original Research: Laboratory Abnormalities in Pregnancy-Associated Hypertension; Frequency and Association With Pregnancy Outcomes, The American College of Obstetricians and Gynecologists, Volume 124, NO.5, Nov 2014 Thorp JM, BJOG Editor’s Choice: Sex sells www.bjog.org BJOG: an International Journal of Obstetrics and Gynaecology, DOI: 10.1111/1471-0528.13100 Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy Jennifer Namazy, MD1 Michael D. Cabana, MD2 Angela Scheuerle, MD3 John M. Thorp, Jr., MD4 Hubert Chen MD,5 Gillis Carrigan PhD,5 Yan Wang PhD,5 Elizabeth B. Andrews, PhD6Scripps Clinic, La Jolla, California, USA; 2Department of Pediatrics, University of California, San Francisco, California, USA; 3Tesserae Genetics, Dallas, Texas, USA; 4School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA; 5Genentech, Inc., South San Francisco, California, USA; 6RTI Health Solutions, Research Triangle Park, North Carolina, USA J Allergy Clin Immunol 2014 Grobman W, Bailit J, Rice M, Wapner R, Varner M, Thorp JM, Keveno K, Caritis S, Iams J, Tita A, Saade G, Sorokin Y, Rouse D, Tolosa J, Van Dorsten JP, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The MFMU Network APEX study. Am J Obstet Gynecol 2014;211:147.e1-16. Thorp J.BJOG Editor's Choice.BJOG. 2014 Jul;121(8):i. No abstract available.PMID:24958575 Varner MW, Marshall NE, Rouse DJ, Jablonski KA, Leveno KJ, Reddy UM, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Thorp JM, Malone FD, Carpenter M, O'Sullivan MJ, Peaceman AM, Hankins GD, Dudley DJ, Caritis SN; The Association of Cord Serum Cytokines with Neurodevelopmental. Outcomes for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network.Am J Perinatol. 2014 Jun 17. PMID:24936937 Casey BM, Mele L, Landon MB, Spong CY, Ramin SM, Wapner RJ, Varner MW, Rouse DJ, Thorp JM Jr, Catalano P, Harper M, Saade G, Sorokin Y, Peaceman AM. Does Maternal Body Mass Index Influence Treatment Effect in Women with Mild Gestational Diabetes? for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Perinatol. 2014 May 16. PMID:24839145 Peaceman AM, Lai Y, Rouse DJ, Spong CY, Mercer BM, Varner MW, Thorp JM, Ramin SM, Malone FD, O'Sullivan MJ, Hankins GD; Length of Latency with Preterm Premature Rupture of Membranes before 32 Weeks' Gestation, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.Am J Perinatol. 2014 May 12. PMID:24819145 Grobman WA, Bailit JL, Rice MM, Wapner RJ, Reddy UM, Varner MW, Thorp JM Jr, Leveno KJ, Caritis SN, Iams JD, Tita AT, Saade G, Sorokin Y, Rouse DJ, Blackwell SC, Tolosa JE, Van Dorsten JP; Frequency of and factors associated with severe maternal morbidity.Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network.Obstet Gynecol. 2014 Apr;123(4):804-10. PMID:24785608 Thorp JM Jr. Reintroducing Kielland forceps.BJOG. 2014 Apr;121(5):547PMID:24636312 Grobman WA, Bailit JL, Rice MM, Wapner RJ, Varner MW, Thorp JM Jr, Leveno KJ, Caritis SN, Iams JD, Tita AT, Saade G, Sorokin Y, Rouse DJ, Tolosa JE, Van Dorsten JP; Can differences in obstetric outcomes be explained by differences in the care provided? The MFMU Network APEX study. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.Am J Obstet Gynecol. 2014 Mar 12. pii: S0002-9378(14)00222-1 PMID:24631441 Sutton AL, Mele L, Landon MB, Ramin SM, Varner MW, Thorp JM Jr, Sciscione A, Catalano P, Harper M, Saade G, Caritis SN, Sorokin Y, Grobman WA; Delivery timing and cesarean delivery risk in women with mild gestational diabetes mellitus. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.Am J Obstet Gynecol. 2014 Mar 4 PMID:24607755 Catalano PM, Mele L, Landon MB, Ramin SM, Reddy UM, Casey B, Wapner RJ, Varner MW, Rouse DJ, Thorp JM Jr, Saade G, Sorokin Y, Peaceman AM, Tolosa JE; Inadequate weight gain in overweight and obese pregnant women: what is the effect on fetal growth?Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.Am J Obstet Gynecol. 2014 Feb 11. pii: S0002-9378(14)00121-5. PMID:24530820

Thorp J. BJOG editor's choice.BJOG. 2014 Jan;121(1):i. PMID:24354704 Thorp JM, BJOG Editor’s Choice: Wither the amniocentisis www.bjog.org BJOG: An International Journal of Obstetrics and Gynaecology, 121:i. DOI: 10.1111/1471-0528.12765 Bodnar LM, Rouse DJ, Momirova V, Peaceman AM, Sciscione A, Spong CY, Varner MW, Malone FD, Iams JD, Mercer BM, Thorp JM, Sorokin Y, Carpenter MW, Lo J, Ramin SM, Harper M; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (MFMU) Maternal 25-Hydroxyvitamin D and Preterm Birth in Twin Gestations. Obstet Gynocol. 2013 Jul: 122(1):91-98 PMID:23743453.PMCID:PMC Iams JD, Grobman WA, Lozitska A, Spong CY, Saade G, Mercer BM, Tita AT, Rouse DJ, Sorokin Y, Wapner RJ, Leveno KJ, Blackwell SC, Esplin MS, Tolosa JE, Thorp JM, Caritis SN, Van Dorsten PJ; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (MFMU) Adherence to criteria for transvaginal ultrasound imaging and measurement of cervical length. Am J Obstet Gynecol. 2013 Oct; 209(4):365. PMID:23958649.PMCID:PMC Thorp JM, Rice MM, Harper M, Klebanoff M, Sorokin Y, Varner MW, Wapner RJ, Caritis SN, Iams JD, Peaceman AM, Mercer BM, Sciscione A, Rouse DJ, Ramin SM, Anderson GB; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (MFMU) Advanced lipoprotein measures and recurrent preterm birth AM J Obstet Gynecol. 2013 Oct; 209(4):342 PMID: 23770464 PMCID:PMC Caritis SN, Venkataramanan R, Thom E, Harper M, Klebanoff MA, Sorokin Y, Thorp JM, Varner MW, Wapner RJ, Iams JD, Carpenter MW, Grobman WA, Mercer BM, Sciscione A, Rouse DJ, Ramin S, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (MFMU) and Obstetric-Fetal Pharmacology Research Units Network. Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth. AM J Obstet Gynecol. 2013 Oct 7. PMID:24113254 PMCID:PMC Harper M, Li L, Zhao Y, Klebanoff MA, Thorp JM, Sorokin Y, Varner MW, Wapner RJ, Caritis SN, Iams JD, Carpenter MW, Peaceman AM, Mercer BM, Sciscione A, Rouse DJ, Ramin SM, Anderson GD, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (MFMU) Change in mononuclear leukocyte responsiveness in midpregnancy and subsequent preterm birth. Obstet Gynecol. 2013 Apr, 121(4):805-11. PMID:23635681 PMCID:PMC Constantine M, Lai Y, Bloom S, Spong CY, Varner MW, Rouse DJ, Ramin SM, Caritis S, Peaceman AM, Sorokin Y, Sciscione A, Mercer BM, Thorp JM, Malone F, Harper M, Iams JD, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (MFMU) Population versus Customized Fetal Growth Norms and Adverse Outcomes in an Intrapartum Cohort Amer J Perinatol, 2013; 30(04): 335-342 PMID: Gilbert SA, Grobman WA, Landon MB, Spong CY, Rouse DJ, Leveno KJ, Varner MW, Wapner RJ, Sorokin Y, O’Sullivan MJ, Sibai BM, Thorp JM, Ramin SM, Mercer BM, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (MFMU) Cost-effectiveness of trial of labor after previous cesarean in a minimally biased cohort. Am J Perinatol. 2013 Jan 30(1):11-20 . D. Research Support Ongoing Research Support 1. 5U10HD040560-13 (Thorp) 04/18/2001–03/31/2016 1.20 calendar NIH/NICHD $499,000 Cooperative Multicenter Maternal Fetal Medicine Units Networks The Maternal-Fetal Medicine Units Network conducts clinical studies to improve maternal, fetal and neonatal health emphasizing randomized-controlled trials. 2. R21-DK095189-01A1 (Nicholson) 4/1/13–3/31/15 2.40 calendar NIH $228,000 A Transgenerational e-Intervention for Gestational Diabetics and their Offspring Gestational diabetes, defined as glucose intolerance that first occurs or is first identified in pregnancy, is part of a vicious cycle that contributes to the epidemic of diabetes and obesity across generations. In utero alterations to fetal metabolism due to prolonged glycemic exposure have life-long consequences for the newborn; namely an 8-fold risk of diabetes, obesity and the metabolic syndrome. If effective, intervention could significantly change how GDM is currently treated in clinical practice.

3. No Number Thorp (PI) 01/01/94–present Model Program for Perinatal Substance Abuse HORIZONS. This is a demonstration project of a novel paradigm to treat perinatal substance use problems by combining perinatal and mental health care. It combines an array of treatment resources including a residential program in which families can receive substance abuse treatment. Role: PI 4. 5 U10 HD040560-11 Thorp (PI) 04/18/01–03/31/16 NICHD Maternal Fetal Medicine Units Networks The Maternal-Fetal Medicine Units Network conducts clinical studies to improve maternal, fetal and neonatal health emphasizing randomized-controlled trials. Role: PI

Neeta L. Vora, MD, Director of the Genetics Lab, Associate Professor ______________________ Education & Training BA, Government, Cum Laude Dartmouth College Hanover, NH 1994-1998 MD Medical College of Ohio Toledo, OH 1998-2002 Residency, Obstetrics and Gynecology Department of Obstetrics and Gynecology Boston, Mass 2002-2006 Combined Fellowship, Maternal-Fetal Medicine and Department of Genetics Tufts Medical Center Boston, Mass 2006-2010 A. Personal Statement Dr. Vora is an Associate Professor with the Department of Obstetrics and Gynecology. She has completed fellowship training in both Maternal-Fetal Medicine and Genetics and serves as Director of Reproductive Genetics. Dr. Vora’s research has focused on cell free fetal DNA in the maternal circulation. She is interested in obesity and has investigated the levels of cell free fetal DNA in obese versus lean patients. She also has an interest in the differences in fetal gene expression in obese versus lean mothers using cell free fetal nucleic acids in amniotic fluid. B. Positions and Honors Positions and Employment 2002–2010 Clinical Instructor, Department of Obstetrics and Gynecology, Tufts Medical Center 2006–2010 Clinical Instructor, Department of Pediatrics, Tufts Medical Center 2011–2012 Assistant Professor, Department of Obstetrics and Gynecology, Tufts Medical Center 2012–present Assistant Professor, Department of Ob/Gyn, Division Maternal Fetal Medicine University of North Carolina – Chapel Hill 2012–present Director of Reproductive Genetics, Department of Ob/Gyn, Division Maternal Fetal Medicine University of North Carolina – Chapel Hill Honors 2003 Excellence in Teaching Award from Tufts Medical School 2006 Outstanding Clinician Award, Tufts Medical School 2010 Excellence in Clinical Research Participant, Jackson Hole, WY 2011 Excellence in Teaching Award from Tufts Medical School C. Selected Peer-reviewed Publications Wiegand SL, Swortwood MJ, Huestis MA, Thorp J, Jones HE, Vora NL.“Naloxone and Metabolites Quantification in Cord Blood of Prenatally Exposed Newborns and Correlations with Maternal Concentrations.”AJP Rep. 2016 Oct;6(4):e385-e390.PMID: 27896019 Vora NL, Smeester L, Boggess K, Fry RC.“Investigating the Role of Fetal Gene Expression in Preterm Birth.”Reprod Sci. 2016 Sep 27. pii: 1933719116670038. [Epub ahead of print]PMID: 27678095 Grace MR, Hardisty E, Dotters-Katz SK, Vora NL, Kuller JA.“Cell-Free DNA Screening: Complexities and Challenges of Clinical Implementation.”Obstet Gynecol Surv. 2016 Aug;71(8):477-87. doi: 10.1097/OGX.0000000000000342.PMID: 27526871






Vora NL, Robinson S, Hardisty EE, Stamilio DM.“The utility of a prerequisite ultrasound at 10-14 weeks in cell free DNA fetal aneuploidy screening."Ultrasound Obstet Gynecol. 2016 Jun 14. doi: 10.1002/uog.15995. [Epub ahead of print]PMID: 27300317 Crooks K, Edwardsen G, O’Connor S, Powell C, Vargo D, Vora N, Kaiser-Rogers K. “Cell-free DNA testing in a trisomy 21 pregnancy with confined placental mosaicism for a cell line with trisomy for both chromosomes 18 and 21.” Clinical Case Reports. 2015 Nov 9;4(1);19-22 PMID: 26783428 Grace MR, Hardisty E, Green NS, Davidson E, Stuebe AM, Vora NL. “Cell free DNA testing-Interpretation of results using an online calculator.” Am J Obstet Gynecol. 2015 Jul;213(1):30 PMID: 25957020 Bianchi DW, Chudova D, Sehnert AJ, Bhatt S, Murray K, Prosen TL, Garber JE, Wilkins-Haug L, Vora NL, Warsof S, Goldberg J, Ziaina T, Haulks-Miller M. “Noninvasive prenatal testing and incidental dectection of occult maternal malignancies.” JAMA. 2015 Jil 14;314(2);162-169 PMID: 26168314 Adams MC, Berg JS, Pearlman MD, Vora NL. “Look before you leap: Genomic screening in obstetrics and gynecology. Obstet and Gynecol. 2015 June; 125(6): 1299-305. PMID: 26000500. Vora NL, Chescheir N. Delivery of the growth restricted preterm fetus. Lancet. 2015 Mar 4 [Epub ahead of print] PMID: 25747580. Hardisty EE, Vora NL. Advances in genetic prenatal diagnosis and screening. Curr Opin Pediatr. 2014 Dec; 26: 634-8. PMID: 25211161. Vora NL, O’Brien BM. In reply. Obstet Gynecol. 2014 Aug; 124: 379-80. PMID: 25050763. Vora NL, OBrien BM. Noninvasive prenatal testing for microdeletion syndromes and expanded trisomies: proceed with caution.Obstet Gynecol. 2014 May;123(5):1097-9. PMID:24785862 Beamon CJ, Hardisty EE, Harris SC, Vora NL. A single center's experience with noninvasive prenatal testing.Genet Med. 2014 Mar 27. doi: 10.1038/gim.2014.20. [Epub ahead of print] PMID:24675675 Vora N, Hardisty E, Asiaii A, Wolfberg A, Borrell A. More chorionic villi obtained at a single center compared to previously published reports.J Matern Fetal Neonatal Med. 2014 Apr 9. PMID:24597734 Edlow AG, Vora NL, Hui L, Wick HC, Cowan JM,Bianchi Maternal obesity affects fetal neurodevelopmental and metabolic gene expression: a pilot study. DW.PLoS One. 2014 Feb PMID:24558408 Siedhoff MT, Smith DM, Lippmann QK, Findley AD, Steege JF, Vora NL. Cornual placenta accreta managed by postpartum total laparoscopic hysterectomy. J Minim Invasive Gynecol. 2014 Jan-Feb;21(1):17-22. PMID:23706677 Harris SC, Vora NL. Non-invasive Prenatal Testing: An update on prenatal screening and testing options. Neoreviews. January 2014. In press. Vora NL, O’Brien BM. Non-invasive Prenatal Testing for Microdeletion Syndromes and Expanded Trisomies: Proceed with Caution. Obstet Gynecol. November 2013. In press. Beamon C, Hardisty EH, Harris, SC, Vora NL. A single center’s experience with noninvasive prenatal testing. Genetics in Medicine. November 2013. In press. Osborne CM, Hardisty E, Devers P, Kaiser-Rogers K, Goodnight W, Vora NL. False positive noninvasive prenatal testing results in a patient subsequently diagnosed with metastatic cancer. Prenat Diagn. 2013 Jun 33: 609-11. D. Research Support Ongoing Research Support NIH k12 NICHS 2015-2018 Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) A New Era of Genomics in Fetal Diagnosis Role: PI $80,000. 75% effort; Number: HD001441 NIH K23 NICHD; Submitted 10/2015 A New Era of Genomics in Fetal Diagnosis Role: PI $75,000, 75% effort



NIH R01 NHGRI; Submitted 02/2016 Evaluating Provider Education Resources to Promote Patient Informed Decision-Making in Prenatal Genomic Screening. Role: Co-Investigator $283,000, 15% effort 2016-2016 Doris Duke Charitable Foundation Caregiver Award; Submitted 6/2015 A New Era of Genomics in Fetal Diagnosis Role: PI $45,000 award/year, 75% effort 2016-2021 Bill and Melinda Gates Young Researcher Award; Submitted 6/2015 A New Era of Genomics in Fetal Diagnosis Role: PI $150,000 award/year, 75% effort TRACS $50,000 Transformative Technology Grant 2014–015 NIH CTSA at UNC A window into fetal genetic mutations by exome sequencing. Role: PI 50,000, 0% effort; Number: TTR11403 NIH: RO3 NICHD 2014-2016 Determination of fetal gene expression in women with preterm and term birth. Role: PI 150,000, 7.5% effort; Number: HD080788 Industry 2013–present Noninvasive prenatal testing, Natera Prenatus study Prenatal Non-invasive Aneuploidy Testing Utilizing SNPs Study (PreNATUS). The purpose of this multi-center collaborative study is to evaluate the diagnostic capability of using Natera’s Parental Support™; a method that can detect trisomy in a fetus from the genetic measurements made on a maternal blood sample that contains small amounts of fetal DNA mixed with maternal DNA Role: Site PI $480 per patient, 0% effort NIH 1U19HD077632-01 Powell (PI) 2013–2019 NC Nexus: North Carolina newborn exome sequencing for universal screening. The purpose of this project is to apply whole exome sequencing technology to disorders currently included in newborn screening panels and to other disorders that may be amenable to early identification through whole exome sequencing. Role: Co-Investigator No grant number Vora (Site PI) 2013– Natera Prenatus study Prenatal Non-invasive Aneuploidy Testing Utilizing SNPs Study (PreNATUS) The purpose of this multi-center collaborative study is to evaluate the diagnostic capability of using Natera’s Parental SupportTM ; a method that can detect trisomy in a fetus from the genetic measurements made on a maternal blood sample that contains small amounts of fetal DNA mixed with maternal DNA. Role: Site PI No grant number Vora (PI) 2013– Cefalo-Bowes Research Award Determination of second trimester fetal gene expression in women with spontaneous preterm and term birth Role: PI $10,000, 0% effort R03 pending. Vora (PI) 2014– Scored at 8th percentile. Determination of second trimester fetal gene expression in women with spontaneous preterm and term birth Role: PI

Directions to Maternal Fetal Medicine at UNC Hospitals

1. Please park in the Dogwood Visitor Deck (starred below) across Manning Drive from the UNC

Hospital complex

2. Please follow the Pedestrian Skywalk right (pink on map) to the NC Cancer Hospital entrance

3. Please follow the arrows left (orange on map) through all four Lobbies to the Memorial Hospital

Information Desk

4. Go around the information desk

5. Up one flight of escalators 6. Continue down that hall past Chaplains office and Chapel on the left 7. Make a left at the intersection and follow the signs that lead you towards the mail room. You

will be turning left to go into the Old Clinic section of the hospital. 8. Take the elevator located on the right hand side (just before the mail room) to the 3rd floor. 9. Once on the 3rd floor of the Old Clinic – step off the elevator and go left 10. Go through the brown wooden door and turn left at the end of the hall 11. MFM Suite up the hallway on the left in Room 3010 – Old Clinic Building

If you need assistance, please contact us:

MFM Office Front Desk: 919.966.1601

To Franklin Street

Manning Drive

Mason Farm Road

Wes

t Driv

e

East

Drive

South

Columbia

Stree

t

To 15/501South

To 15/501North

HealthSciencesCampusU

NC

UNC HOSPITALS 44. N.C. Clinical Cancer Center 41. N.C. Memorial Hospital 43. N.C. Neurosciences Hospital42. N.C. Women's and Children's Hospitals40. Old Clinic

SCHOOL OF MEDICINE 5. Aycock Family Medicine (see Inset UNC Campus Map) 20. Berryhill Hall72. Bioinformatics Building 21. Bondurant Hall22. Brinkhous-Bullitt25. Burnett Womack70. EPA Building74. Genetic Medicine66. Glaxo Building17. Health Affairs Book Store23. Health Sciences Library62. Lineberger Comprehensive Cancer Center 24. MacNider Hall 61. Mary Ellen Jones Building 64. Medical Biomolecular Research Building 67. Medical Building A 73. Medical Building B 26. Medical School Wings 71. MRI Building 63. Neurosciences Research Building65. Isaac M. Taylor Hall 60. Thurston Bowles Building

OUTPATIENT SERVICES 80. Ambulatory Care Center (ACC) SCHOOL OF DENTISTRY 30. Brauer Hall31. Dental Office Building32. Dental Research Center 33. Old Dental Building 34. Tarrson Hall (dental clinics)

SCHOOL OF NURSING 16. Carrington Hall

SCHOOL OF PHARMACY 12. Banks Kerr Hall13. Beard Hall

SCHOOL OF PUBLIC HEALTH16. Hooker Research Center 14. McGavran Greenberg 15. Rosenau Hall

SCHOOL OF SOCIAL WORK 11. Tate-Turner-Kuralt

UNIVERSITY LANDMARKS(See Inset UNC Campus Map) 2. Bell Tower 4. Dean Smith Center 3. Kenan Stadium 1. Old Well MISCELLANEOUS10. Global Education 18. Taylor Campus Health Services

PARKING STRUCTURES 50. Cardinal Deck (Staff) 51. Dogwood Deck (Visitors)52. Jackson Circle Parking DeckN

Indicates Building Entrance

UNC Campus Map

4

1

2

3

5

11

10

13

1415

16

17

20

21

2223

24

2532

33

34

2640

41

4243

44

18

6061

62

63

6465

6766

50

51

70

71

72

7380

31

30

12

16

74

52

We here at the Division of Maternal Fetal Medicine hope that you enjoyed your visit. Please let us know if you have any questions about your visit, the fellowship program or the department. Qiana Davis, Fellowship Coordinator [email protected] Robert Strauss, Fellowship Director [email protected] 919.966.1601 – MFM Front Desk https://www.med.unc.edu/obgyn/mfm/copy_of_fellowship/

Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine

mailto:[email protected]

mailto:[email protected]

https://www.med.unc.edu/obgyn/mfm/copy_of_fellowship/

University of North Carolina Department of Obstetrics ...€¦ · modules, with a total of 8 exam...

Documents

Transcript of University of North Carolina Department of Obstetrics ...€¦ · modules, with a total of 8 exam...