University of Groningen A tubulo-centric view on ...Table of contents 1. Introduction and outline 9...
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University of Groningen A tubulo-centric view on cardiorenal disease Sinkeler, Steef Jasper IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Sinkeler, S. J. (2016). A tubulo-centric view on cardiorenal disease. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 17-02-2021
Transcript of University of Groningen A tubulo-centric view on ...Table of contents 1. Introduction and outline 9...
University of Groningen
A tubulo-centric view on cardiorenal diseaseSinkeler, Steef Jasper
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.
Document VersionPublisher's PDF, also known as Version of record
Publication date:2016
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):Sinkeler, S. J. (2016). A tubulo-centric view on cardiorenal disease.
CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.
Download date: 17-02-2021
A tubulo-centric view on cardiorenal disease
Publication of this thesis was made possible by donations from the Graduate School
of Medical Sciences, the Groningen University Institution on Drug Exploration, the
Rijksuniversiteit Groningen and the University Medical Center Groningen.
ISBN: 978-94-6233-307-9
Cover design: Matthijs Kuiper
Layout: Gildeprint, Enschede
© 2016 S.J. Sinkeler.
All rights reserved. No parts of this publication may be reported or transmitted, in any
form or by any means, without prior permission by the author.
A tubulo-centric view on cardiorenal disease
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
29 juni 2016 om 16.15 uur
door
Steef Jasper Sinkeler geboren op 16 september 1985
te Nijmegen
Promotores: Prof. dr. G.J. Navis
Prof. dr. S.J.L. Bakker
Beoordelingscommissie: Mw. Prof. dr. M.C. Verhaar
Prof. dr. B. Meijers
Prof. dr. D.J. van Veldhuisen
Paranimfen
Mw. Dr. E. van den Berg
Mw. Drs. F.S. Sinkeler
Table of contents
1. Introduction and outline 9
2. Validation of prediction equations for 24-hour urine creatinine excretion rate
in the general population and development of a new equation: the LifeLines study 23
3. Creatinine excretion rate and mortality in type II diabetes and nephropathy 45
Diabetes Care. 2013 Jun;36(6):1489-94
4. Higher body mass index is associated with higher fractional creatinine
excretion in healthy subjects 61
Nephrol Dial Transplant. 2011 Oct;26(10):3181-8
5. Higher fractional excretion of creatinine is associated with lower risk of
cardiovascular events and all-cause mortality in renal transplant recipients 83
6. Association of extracellular volume with long-term risk for cardiovascular
events in renal transplant recipients 101
7. A re-appraisal of volume status and renal function impairment in chronic
heart failure: combined effects of pre-renal failure and venous congestion
on renal function 119
Heart Fail Rev. 2012 Mar;17(2):263-70
8. Endogenous plasma erythropoietin, cardiovascular mortality and all-cause
mortality in renal transplant recipients 137
Am J Transplant. 2012 Feb;12(2):485-91
9. Erythropoietin is reduced by combination of diuretic therapy and RAAS
blockade in proteinuric renal patients with preserved renal function 153
Nephrol Dial Transplant. 2010 Oct;25(10):3256-60
10. High levels of endogenous erythropoietin and expanded extracellular
volume are independently associated with cardiovascular events in renal
transplant recipients 165
11. Discussion and future perspectives 185
Nederlandse samenvatting 206
Dankwoord 212
A tu
bu
lo-cen
tric view o
n card
ioren
al disease
S.J. Sinkelerr
on cardiorenal disea e
