University of Brunei Darussalam 20140429 Springer
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Transcript of University of Brunei Darussalam 20140429 Springer
Author Workshop: Effectively Communicating Your Research
Universiti Brunei Darussalam29 April 2014
Jeffrey Robens, PhD
Download at: edanzediting.com/brunei
Publication output in Brunei
S
Your goal is not only to be published, but also to be widely read/cited
http://www.scimagojr.com/countryrank.php
Be an effective communicator
SChoose the best journal to reach your target audience
Logically present your research in your manuscript
Prepare effective titles and abstracts
Convey the significance of your work to journal editors
Your goal should not only to be published, but also to be widely read/cited in the field
Journal selection
Section 1
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Journal selection Factors to consider when choosing a journal
Aims & scope Readership
Open access
Which factor is most important to you?
Indexing
Journal selection Evaluating significance
How new are your findings?Novelty
How broadly relevant are your findings?Relevance
What are the important real-world applications?Appeal
Journal selection
Insert your proposed abstract
Journal Selector – www.edanzediting.com/journal_sele
ctor
Journal selection
Recommended journals
Filter by:Impact factor
Publishing frequencyOpen access
Journal Selector – www.edanzediting.com/journal_sele
ctor
Journal selection
Semantic matching terms
Journals IF, Aims & Scope, and Frequency
Similar published articles
Have they published similar articles recently?Have you cited some of these articles?
Journal Selector – www.edanzediting.com/journal_sele
ctor
Journal selection Tips to identify the most suitable journal
S
Identify the interests of the journal editor
Identify the interests of the
readers
• Editorials• Review articles• Special issues
• Most viewed• Most cited
Manuscript structure
Section 2
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Coverage and Staffing PlanManuscript
structure Introduction
General introduction
Specific aimsAims
Current state of the field
Problem in the field
Coverage and Staffing PlanManuscript
structureWriting the Introduction
Beginning should demonstrate relevance/interest
Lung cancer is the leading cause of cancer mortality for men and women. Despite smoking prevention and cessation programs and advances in early detection, the 5-year survival rate for lung cancer is only 16% with current therapies. Although lung cancer incidence rates have recently declined in the United States, more lung cancer is now diagnosed when considered together in former- and never-smokers than in current smokers. Thus, even if all of the national anti-smoking campaign goals are met, lung cancer will remain a major public health problem for decades. New ways to treat or prevent lung cancer are therefore needed.
Interest
Important problem in the field
Busch et al. BMC Cancer. 2012; 13: 211.
Coverage and Staffing PlanManuscript
structure
Your aims should directly address this problem
This study explored the hypothesis that inhibition of TNKS by pharmacological or genetic means would inhibit lung cancer growth in vitro and in vivo…
Writing the Introduction
New ways to treat or prevent lung cancer are therefore needed.
Busch et al. BMC Cancer. 2012; 13: 211.
Coverage and Staffing PlanManuscript
structure Methods
How it was done
General methodsSpecific techniques(discuss controls)
Quantification methodsStatistical tests
Who/what was used
Samples or participantsMaterials
How it was analyzed
Study design
Consult a statistician
Coverage and Staffing PlanManuscript
structure Results
1. Initial observation2. Characterization3. Application
Logical presentation
Example:1. Synthesis of nanoparticles2. Characterize their physical and/or chemical
properties, SEM, determine biocompatability3. Demonstrate improved rate of drug delivery
Coverage and Staffing PlanManuscript
structure Results
1. Initial observation2. Characterization3. Application
Each subsection corresponds to
one figure
What you found, not what it means
Logical presentation
Subsections
Factual description
Coverage and Staffing PlanManuscript
structure Discussion
Summary of findings
Relevance of findings
Implications for the field
Similarities/differencesUnexpected resultsLimitations
Coverage and Staffing PlanManuscript
structure Linking your ideas
General background
Objectives
Methodology
Results and figures
Summary of findings
Implications for the field
Relevance of findings
Problems in the field
Logically link your ideas throughout your manuscript
Current state of the fieldIntroduction
Methods
Results
Discussion
Coverage and Staffing PlanManuscript
structure Linking your ideas
New ways to treat or prevent lung cancer are therefore needed.
This study explored the hypothesis that inhibition of TNKS…would inhibit lung cancer growth…
Pharmacological or genetic inhibition of TNKS1 and TNKS2…reduces lung cancer proliferation...
Problem
Objectives
Conclusion
Discussion
Introduction
Busch et al. BMC Cancer. 2012;13:211.
Coverage and Staffing PlanManuscript
structureWriting effective
conclusions
Your conclusion is a summary of your findings
Your conclusion should be the answer to your research problem that is supported by your findings
Emphasizes how your study will help advance the field
Titles and abstracts
Section 3
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Customer ServiceTitles and abstracts
Important points
Summarize key finding Contains keywords Less than 20 words
Avoid
Effective titles
Your title should be a concise summary of your most important finding
QuestionsDescribing methodsAbbreviations“New” or “novel”
Customer ServiceTitles and abstracts Abstract
First impression of your paper
Importance of your results
Validity of your conclusions
Relevance of your aims
Judge your writing style
Probably only part that will be read
Customer ServiceTitles and abstracts Sections of an abstract
Aims
Background
Methods
Results
Conclusion
Why the study was done
Your hypothesis
Techniques
Most important findings
Conclusion/implications
Concise summary of your research
Customer ServiceTitles and abstracts Unstructured abstract
Our understanding of the mechanisms by which ducts and lobules develop is derived from model organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the mechanophysical properties associated with epithelial morphogenesis are poorly understood. We performed multidimensional live-cell imaging analysis to track the morphogenetic process starting from a single cell to the development of a multicellular, spherical structure composed of polarized epithelial cells surrounding a hollow lumen. We report that in addition to actively maintaining apicobasal polarity, the structures underwent rotational motions at rates of 15–20 μm/h and the structures rotated 360° every 4 h during the early phase of morphogenesis. Rotational motion was independent of the cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or Pard3, or by inhibition of dynein-based microtubule motors. Interestingly, none of the structures derived from human cancer underwent rotational motion. We found a direct relationship between rotational motion and assembly of endogenous basement membrane matrix around the 3D structures, and that structures that failed to rotate were defective in weaving exogenous laminin matrix. Dissolution of basement membrane around mature, nonrotating acini restored rotational movement and the ability to assemble exogenous laminin. Thus, coordinated rotational movement is a unique mechanophysical process observed during normal 3D morphogenesis that regulates laminin matrix assembly and is lost in cancer-derived epithelial cells.
Wang et al. PNAS. 2013; 110: 163‒168.
Customer ServiceTitles and abstracts Unstructured abstract
ConclusionThus, coordinated rotational movement is a unique mechanophysical process observed during normal 3D morphogenesis that regulates laminin matrix assembly and is lost in cancer-derived epithelial cells.
Results
We report that in addition to actively maintaining apicobasal polarity, the structures underwent rotational motions at rates of 15–20 μm/h and the structures rotated 360° every 4 h during the early phase of morphogenesis. Rotational motion was independent of the cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or Pard3, or by inhibition of dynein-based microtubule motors. Interestingly, none of the structures derived from human cancer underwent rotational motion. We found a direct relationship between rotational motion and assembly of endogenous basement membrane matrix around the 3D structures, and that structures that failed to rotate were defective in weaving exogenous laminin matrix. Dissolution of basement membrane around mature, nonrotating acini restored rotational movement and the ability to assemble exogenous laminin.
MethodsWe performed multidimensional live-cell imaging analysis to track the morphogenetic process starting from a single cell to the development of a multicellular, spherical structure composed of polarized epithelial cells surrounding a hollow lumen.
BackgroundOur understanding of the mechanisms by which ducts and lobules develop is derived from model organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the mechanophysical properties associated with epithelial morphogenesis are poorly understood.
Wang et al. PNAS. 2013; 110: 163‒168.
Customer ServiceTitles and abstracts Writing your abstract
Our understanding of the mechanisms by which ducts and lobules develop is derived from model organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the mechanophysical properties associated with epithelial morphogenesis are poorly understood. We performed multidimensional live-cell imaging analysis to track the morphogenetic process starting from a single cell to the development of a multicellular, spherical structure composed of polarized epithelial cells surrounding a hollow lumen. We report that in addition to actively maintaining apicobasal polarity, the structures underwent rotational motions at rates of 15–20 μm/h and the structures rotated 360° every 4 h during the early phase of morphogenesis. Rotational motion was independent of the cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or Pard3, or by inhibition of dynein-based microtubule motors. Interestingly, none of the structures derived from human cancer underwent rotational motion. We found a direct relationship between rotational motion and assembly of endogenous basement membrane matrix around the 3D structures, and that structures that failed to rotate were defective in weaving exogenous laminin matrix. Dissolution of basement membrane around mature, nonrotating acini restored rotational movement and the ability to assemble exogenous laminin. Thus, coordinated rotational movement is a unique mechanophysical process observed during normal 3D morphogenesis that regulates laminin matrix assembly and is lost in cancer-derived epithelial cells.Conclusions
Results
Methods
Background
Wang et al. PNAS. 2013; 110: 163‒168.
Customer ServiceTitles and abstracts Link ideas in your abstract
ConclusionThus, coordinated rotational movement is a unique mechanophysical process observed during normal 3D morphogenesis that regulates laminin matrix assembly and is lost in cancer-derived epithelial cells.
BackgroundOur understanding of the mechanisms by which ducts and lobules develop is derived from model organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the mechanophysical properties associated with epithelial morphogenesis are poorly understood.
Wang et al. PNAS 2013; 110:163‒168.
However, the mechanophysical properties associated with epithelial morphogenesis are poorly undersood.
Thus, coordinated rotational movement is a unique mechanophysical process…
Problem
Answer
Cover letters
Section 4
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Cover letters
Abstract:First impression for readers
Cover letters are the first impression for the Journal Editor
SignificanceRelevance
Writing styleInteresting to their readers?
Is your work important?
Cover letters
Dear Dr Lippman,
Please find enclosed our manuscript entitled “Evaluation of the Glasgow prognostic score in patients undergoing curative resection for breast cancer liver metastases,” which we would like to submit for publication as an Original Article in the Breast Cancer Research and Treatment.
The Glasgow prognostic score (GPS) is of value for a variety of tumours. Several studies have investigated the prognostic value of the GPS in patients with metastatic breast cancer, but few studies have performed such an investigation for patients undergoing liver resection for liver metastases. Furthermore, there are currently no studies that have examined the prognostic value of the modified GPS (mGPS) in these patients. The present study evaluated the mGPS in terms of its prognostic value for postoperative death in patients undergoing liver resection for breast cancer liver metastases.
A total of 318 patients with breast cancer liver metastases who underwent hepatectomy over a 15-year period were included in this study. The mGPS was calculated based on the levels of C-reactive protein and albumin, and the disease-free survival and cancer-specific survival rates were evaluated in relation to the mGPS. Prognostic significance was retrospectively analyzed by univariate and multivariate analyses. Overall, the results showed a significant association between cancer-specific survival and the mGPS and carcinoembryonic antigen level, and a higher mGPS was associated with increased aggressiveness of liver recurrence and poorer survival in these patients.
This study is the first to demonstrate that the preoperative mGPS, a simple clinical tool, is a useful prognostic factor for postoperative survival in patients undergoing curative resection for breast cancer liver metastases. This information is immediately clinically applicable for oncologists treating such patients. As a premier journal covering the broad field of cancer, we believe that the Breast Cancer Research and Treatment is the perfect platform from which to share our results with the international medical community.
Give the background to the research
What was done and what was found
Interest to journal’s readers
A good cover letter
We would also like to suggest the following reviewers for our manuscript…
Editor’s name Manuscript title
Publication type
Recommend reviewers
“Must-have” statements
Cover letters
“Must-have” statements
Not submitted to other journals
Source of funding
Authors agree on paper/journal
Original and unpublished
No conflicts of interest
Authorship contributions
Disclaimers about publication ethics
Cover letters Recommending reviewers
Where to find them?
From your reading/references, networking at conferences
How senior? Aim for mid-level researchers
Who to avoid? Collaborators (past 5 years),researchers from same institution
Look for reviewers who have published in your target journal
Cover letters Choose internationally
• 1 or 2 reviewers from Asia• 1 or 2 reviewers from Europe• 1 or 2 reviewers from North America
Journal Editors want to see an international list for 2 reasons:
1. Shows that you are familiar with your field worldwide
2. Shows that your research is relevant worldwide• Increased readership → increased citations → increased impact factor
Be an effective communicator
SChoose the best journal to reach your target audience
Logically present your research in your manuscript
Prepare effective titles and abstracts
Convey the significance of your work to journal editors
Your goal should not only to be published, but also to be widely read/cited in the field
Thank you!
Any questions?
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Like us on Facebookfacebook.com/EdanzEditing
Download and further readingedanzediting.com/brunei
Jeffrey Robens: [email protected]