ULCERATIVE LESIONS OF THE ORAL · PDF fileULCERATIVE LESIONS OF THE ORAL CAVITY SAM J....
Transcript of ULCERATIVE LESIONS OF THE ORAL · PDF fileULCERATIVE LESIONS OF THE ORAL CAVITY SAM J....
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ULCERATIVE LESIONS OF
THE ORAL CAVITY
SAM J. CUNNINGHAM, MD, PhD
Faculty Advisor: FRANCIS B. QUINN, JR., MD, FACS
The University of Texas Medical Branch
Department of Otolaryngology
Grand Rounds Presentation
October 16, 2002
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ORAL CAVITY
LIPS
TEETH
GINGIVA
ORAL MUCOUS MEMBRANES
PALATE
TONGUE
ORAL LYMPHOID TISSUES
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Acute: small, recent onset, short
duration, recurrent
Trauma
Recurrent Aphthous Stomatitis
Behcet’s
Herpesvirus Infection
Herpangina
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Trauma:
Cheek Biting
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Trauma:
Ill-Fitting dentures
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Trauma:
Chemical Burns
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Trauma:
Abrasions from Teeth
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Recurrent Aphthous Stomatitis(RAS)
Most common ulcerative lesion of oral cavity
Recurrent, painful ulcers
Confined to soft mucosa
Subdivided into three types:
Minor aphthae
Major aphthae
Herpetiform aphthae
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Recurrent Aphthous Stomatitis(RAS)
Minor aphthae: Less than 1 cm
Heal completely in 7-10 days without scarring
Painful
Prodromal stage
Shallow and round to oval
Gray to yellow membrane
Clusters of up to 5 ulcers
Steroids
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Recurrent Aphthous Stomatitis (RAS)
Minor apthae
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Recurrent Aphthous Stomatitis (RAS)
Major Aphthae
Uncommon
Irregular, deep ulcers
1-3 cm in size
Raised borders
Heal in 4-6 weeks
Extensive scarring and distortion
BIOPSY!!
Steroids
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Recurrent Aphthous Stomatitis (RAS)
Major apthae
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Recurrent Aphthous Stomatitis (RAS)
Herpetiform Aphthae
Uncommon
Crops of up to 150 very small (<3mm)
ulcers
Heal completely in 7-10 days
COMPLETELY UNRELATED TO
HERPESVIRUS
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Recurrent Aphthous Stomatitis (RAS)
Herpetiform aphthae
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Behcet’s
Symptom complex of:
Recurrent aphthous ulcers of the mouth
Painful genital ulcers
Uveitis or conjuctivitis
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Behcet’s
Affects persons of Mediterranean,
Middle Eastern, or Japanese decent
Easily confused with Stevens-Johnson
syndrome or Reiter’s disease
Need referral for systemic treatment
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Behcet’s
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Herpesvirus Infection
HSV-1 and/or HSV-2
Primary Infection
Secondary Infection
Varicella zoster virus (HHV-3)
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Herpesvirus Infection
Primary Infection
Herpetic gingivostomatitis
Younger patients
Often asymptomatic
May be associated with fever, chills,
malaise
Vesicles-ulcers-crusting
Anywhere in the oral cavity
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Herpesvirus Infection
Primary Infection
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Herpesvirus Infection
Primary Infection
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Herpesvirus Infection
Secondary Infection
Reactivation of latent virus
Not associated with systemic symptoms
Small vesicles
Occur only on the hard palate and gingiva
Prodromal signs
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Herpesvirus Infection
Secondary infection
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Herpesvirus Infection
Varicella zoster virus (HHV-3)
Latent infection
Oral ulcers
Dermatomal distribution
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Herpesvirus Infection
Varicella zoster virus
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Herpesvirus Infection
Varicella zoster virus
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Herpangina
NOT caused by Herpesvirus
Coxsackie A virus
Children < 10 years of age
Common in summer and fall
Often subclinical presentation
Headache/Abdominal pain 48hrs prior to
papulovesicular lesions on tonsils and uvula.
Sore throat
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Herpangina
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Chronic: longer duration, well
circumscribed, raised borders, indurated
base with crater
Trauma
Infection
Neoplasm
Necrotizing sialometaplasia
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Trauma:
Ill-Fitting dentures
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Infection
Rare
HIV/AIDS patients
Bacterial
Deep mycotic infection
Candida
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Infection
Bacterial
Usually secondary infection
Primary infection: syphilis, tuberculous, or
actinomycosis
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Infection
Bacterial-Syphilis
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Infection
Bacterial-Syphilis
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Infection
Mycotic
Blastomycosis
Histoplasmosis
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Infection
Histoplasmosis
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Infection
Candida
Candida albicans
Most common
Normal flora
Predisposing factors
White creamy patches
KOH prep
Nystatin oral suspension
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Infection
Candida
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Neoplasm
Squamous cell carcinoma (SCC)
Most common
Irregular ulcers with raised margins
May be exophytic, infiltrative or verrucoid
Mimic benign lesions grossly
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Neoplasm
Squamous cell carcinoma
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Neoplasm
Squamous cell carcinoma
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Neoplasm
Squamous cell carcinoma
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Necrotizing Sialometaplasia
Inflammatory condition
Ischemia to minor salivary glands
Deep ulcers of the hard palate
Resolves in 6 weeks
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Sialometaplasia
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Sialometaplasia
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Generalized: broad classification
encompassing a wide variety of causative
agents or conditions
Contact stomatitis
Radiation mucositis
Cancer chemotherapy
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Dermatologic Disorders: cutaneous
and oral manifestations
Erythema multiforme
Lichen planus
Benign mucous membrane pemphigoid
Bullous pemphigoid
Pemphigus vulgaris
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Dermatologic Disorders
Erythema multiforme
Rapidly progressive
Antigen-antibody complex deposition in
vessels of the dermis
Target lesions of the skin
Diffuse ulceration, crusting of lips, tongue,
buccal mucosa
Self-limited, heal without scarring
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Dermatologic Disorders
Erythema multiforme
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Dermatologic Disorders
Lichen planus
Chronic disease of skin and mucous membranes
Destruction of basal cell layer by activated lymphocytes
Reticular: fine, lacy appearance on buccal mucosa (Wickman’s striae)
Hypertrophic: resembles leukoplakia
Atrophic or erosive: painful
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Dermatologic Disorders
Lichen planus
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Dermatologic Disorders
Lichen planus
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Dermatologic Disorders
Lichen planus
![Page 54: ULCERATIVE LESIONS OF THE ORAL · PDF fileULCERATIVE LESIONS OF THE ORAL CAVITY SAM J. CUNNINGHAM, MD, PhD Faculty Advisor: FRANCIS B. QUINN, ... Recurrent aphthous ulcers of the mouth](https://reader034.fdocuments.us/reader034/viewer/2022050902/5ab7cbc57f8b9ad5338c0117/html5/thumbnails/54.jpg)
Dermatologic Disorders
Benign mucous membrane pemphigoid Tense subepithelial bullae of skin and mucous
membranes
Rupture, large erosions, heal without scarring
Sloughing (Nikolsky sign)
Bullous pemphigoid Cutaneous lesions more common
Both show subepithelial clefting with dissolution of the basement membrane IgG in basement membrane
![Page 55: ULCERATIVE LESIONS OF THE ORAL · PDF fileULCERATIVE LESIONS OF THE ORAL CAVITY SAM J. CUNNINGHAM, MD, PhD Faculty Advisor: FRANCIS B. QUINN, ... Recurrent aphthous ulcers of the mouth](https://reader034.fdocuments.us/reader034/viewer/2022050902/5ab7cbc57f8b9ad5338c0117/html5/thumbnails/55.jpg)
Dermatologic Disorders
Benign mucous membrane pemphigoid
![Page 56: ULCERATIVE LESIONS OF THE ORAL · PDF fileULCERATIVE LESIONS OF THE ORAL CAVITY SAM J. CUNNINGHAM, MD, PhD Faculty Advisor: FRANCIS B. QUINN, ... Recurrent aphthous ulcers of the mouth](https://reader034.fdocuments.us/reader034/viewer/2022050902/5ab7cbc57f8b9ad5338c0117/html5/thumbnails/56.jpg)
Dermatologic Disorders
Benign mucous membrane pemphigoid
![Page 57: ULCERATIVE LESIONS OF THE ORAL · PDF fileULCERATIVE LESIONS OF THE ORAL CAVITY SAM J. CUNNINGHAM, MD, PhD Faculty Advisor: FRANCIS B. QUINN, ... Recurrent aphthous ulcers of the mouth](https://reader034.fdocuments.us/reader034/viewer/2022050902/5ab7cbc57f8b9ad5338c0117/html5/thumbnails/57.jpg)
Dermatologic Disorders
Pemphigus vulgaris
Severe, potentially fatal
Jewish and Italians
Intraepithelial bullae and acantholysis
Nikolsky’s sign
Loss of intracellular bridges
Autoimmune response to desmoglein 3
Intraepithelial clefting
![Page 58: ULCERATIVE LESIONS OF THE ORAL · PDF fileULCERATIVE LESIONS OF THE ORAL CAVITY SAM J. CUNNINGHAM, MD, PhD Faculty Advisor: FRANCIS B. QUINN, ... Recurrent aphthous ulcers of the mouth](https://reader034.fdocuments.us/reader034/viewer/2022050902/5ab7cbc57f8b9ad5338c0117/html5/thumbnails/58.jpg)
Dermatologic Disorders
Pemphigus vulgaris
![Page 59: ULCERATIVE LESIONS OF THE ORAL · PDF fileULCERATIVE LESIONS OF THE ORAL CAVITY SAM J. CUNNINGHAM, MD, PhD Faculty Advisor: FRANCIS B. QUINN, ... Recurrent aphthous ulcers of the mouth](https://reader034.fdocuments.us/reader034/viewer/2022050902/5ab7cbc57f8b9ad5338c0117/html5/thumbnails/59.jpg)
Dermatologic Disorders
Pemphigus vulgaris