2019

5TH ANNUALUC DAVISCHEMICAL BIOLOGYRETREAT

SEPTEMBER 5 -6 , 2019   • GRANLIBAKKEN TAHOE725 Granlibakken Road, Tahoe City, CA 96145

TABLE OF CONTENTS

FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )

FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF

HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?

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TABLE OFCONTENTS

AGENDA

SESSION DETAILS

NOTED SPEAKERS

POSTER PRESENTERS

MENUS

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RETREAT AGENDA

Thursday, September 5 Friday, September 6

BREAKFAST 7:30 A.M. - 9 A.M.GRANHALL

SESSION I 1:10 P.M. - 2:30 P.MMOUNTAIN ROOM

BREAKOUTSESSION I

2:45 P.M. - 3:45 P.MMOUNTAIN ROOM

COFFEE & TEABREAK

2:30 P.M. - 2:45 P.MMOUNTAIN ROOM

SESSION IIKEYNOTE TALK

4:45 P.M. - 5:45 P.MMOUNTAIN ROOM

POSTER SESSION& SOCIAL

7:30 P.M. - 9:00 P.MPAVILION(Heaters will be provided)

HAPPY HOUR 5:45 P.M. - 7:00 P.MGRANHALL

DINNER 6:00 P.M. - 7:15 P.MGRANHALL

LUNCH 12 P.M. - 1 P.M.GRANHALL

WELCOME &INTRODUCTIONS

1:00 P.M. - 1:10 P.MMOUNTAIN ROOM

CAREER PANELW/ Q&A

8:20 A.M. - 9:00 A.M.MOUNTAIN ROOM (Food permitted)

BREAKOUTSESSION II

9:00 A.M. - 10:00 A.M.MOUNTAIN ROOM

COFFEE & TEABREAK/CHECKOUT OF ROOMS

10:00 A.M. - 10:40 A.M.MOUNTAIN ROOM

SESSION III 10:40 A.M. - 12:00 P.M.MOUNTAIN ROOM

CLOSINGREMARKS &PHOTOS

12:00 P.M. - 12:15 P.M.MOUNTAIN ROOM

LUNCH PICK UPAND DEPART!(HIKING/HOME)

12:15 P.M. - 12:30 P.M.SOLARIUM

BREAK/CHECK-IN 3:45 P.M. - 4:45 P.MGRANHALL

FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )

FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF

HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?

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SESSION DETAILS

Thursday, September 5 Friday, September 6

SESSION I1:10 P.M. - 2:30 P.M. MOUNTAIN ROOM

1:10 P.M. - 1:30 P.M. Dr. Patrick Shih1:30 P.M. - 1:50 P.M. Morgan Matson

1:50 P.M. - 2:10 P.M. Ami Rose2:10 P.M. – 2:30 P.M. SeHee Park

CAREER PANEL W/ Q&A8:20 A.M. - 9:00 A.M. MOUNTAIN ROOM

(Food permitted)

Dr. Jennifer HeemstraDr. Maique Weber BivattiDr. Michael J. Stevenson

4:45 P.M. - 5:45 P.M. MOUNTAIN ROOMSESSION II KEYNOTE TALK

A Chemical Biology Toolbox for RNA Post-Transcriptional Modification and Capture

Dr. Jennifer Heemstra

BREAKOUT SESSION I2:45 P.M. - 3:45 P.M. MOUNTAIN ROOM

Elevator Pitches & Audiencesfacilitated by Dr. Sheila David

BREAKOUT SESSION II9:00 A.M. - 10:00 A.M. MOUNTAIN ROOM

Ethics in Chemical Biology Researchfacilitated by Dr. Andrew Fisher

SESSION III10:40 A.M. - 12:00 P.M. MOUNTAIN ROOM

10:40 A.M. – 11:00 A.M. Diedra Shorty11:00 A.M. - 11:20 A.M. Cindy Khuu

11:20 A.M. – 11:40 A.M. Nate Harder11:40 A.M. – 12:00 P.M. Cindy McReynolds

POSTER SESSION & SOCIAL

7:30 P.M. - 9:00 P.M. PAVILION(Heaters will be provided)

Please see page 5 for poster information

FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )

FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF

HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?

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FEATURED SPEAKERSKEYNOTE - Dr. Jennifer HeemstraJen received her B.S. in Chemistry from the University of California, Irvine, in 2000. At Irvine, sheperformed undergraduate research with Prof. James Nowick investigating the folding ofsynthetic beta-sheet mimics, which instilled in her a love of supramolecular chemistry.  Jen  thenmoved to the University of Illinois, Urbana-Champaign, where she completed her Ph.D. with Prof.Jeffrey Moore in 2005 studying the reactivity of pyridine-functionalized phenylene ethynylenecavitands. After a brief stint in industry as a medicinal chemist, she moved to HarvardUniversity to pursue postdoctoral research with Prof. David Liu exploring mechanisms fortemplated nucleic acid synthesis. In 2010, Jen began her independent career in the Departmentof Chemistry at the University of Utah, and was promoted to Associate Professor with tenure in2016.    In 2017,  Jen  and her research group moved to the Department of Chemistry at EmoryUniversity. Research in the Heemstra lab is focused on harnessing the molecular recognition andself-assembly properties of nucleic acids for applications in biosensing and bioimaging. Outsideof work,  Jen  enjoys spending time with her husband and two sons, as well as rock climbing,cycling, and running.

Career Panel Q& A - Dr. Maique Weber BiavattiGraduated in Pharmacy from the Federal University of Paraná (1993), Master in Chemistry fromthe Federal University of Paraná (1994) and PhD in Chemistry from the Federal University ofSão Carlos (2001). She is currently a professor at the Federal University of Santa Catarina(UFSC). Editor-in-Chief of the Brazilian Journal of Pharmacognosy (2017 - 2019), Vice-Presidentof the Brazilian Society of Pharmacognosy (2014-2016). Has experience in Pharmacognosy,focusing on Study of Extracts and Substances of species of the Asteraceae family, acting on thefollowing subjects: isolation, characterization and quantification of natural substances. She worksin the postgraduate program in Pharmacy, guiding master and doctorate students in projectsfocused on the research of natural, semi-synthetic and synthetic products with potentialbiological activity. Participates in the Research Network Natural Products against NeglectedDiseases (ResNet NPND), that is a global network of researchers uniting their forces againstND.

Career Panel Q& A - Dr. Michael J. StevensonMichael Stevenson obtained a BS in Biochemistry from the University of Washington in 2009and a PhD in Chemistry from Dartmouth College in 2016 studying the thermodynamics of metalsbinding to proteins. He was a postdoctoral scholar at Ohio State University where he workedwith Professor Hannah Shafaat on designing a light driven artificial hydrogenase mimic. He iscurrently a postdoctoral scholar working with Professor Marie Heffern focusing on the role ofmetal ions in regulating and modulating peptide hormones. After this position, he hopes tobecome a professor at a primarily undergraduate institution where he can build on hisunderstanding of metals in biology.

FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )

FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF

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POSTERS

MATTHEW ORELLANA,BIO-ORGANIC CHEMISTRYDevelopment of an In Vitro High-ContentImaging Screen for Antidepressants

ERIN DOHERTY, CHEMISTRYIncreasing A to I Editing Efficiency of ADAR2Using Cytidine Analolgs

LEANNA MONTALEONEBIO-ORGANIC CHEMISTRYImproving Editing and Binding to Disease Targetswith Adenosine Deaminase Acting on RNA (ADAR)

PEISHAN HUANG , BIOPHYSICSEvaluating the Relationship Between T50 and TMas well as the Performance of Thermal StabilityPrediction Tools for an Enzyme Mutant Library

HANNAH BRINKMAN, CHEMISTRYDesign and Implementation of a High ThroughputScreen for ADAR gRNAs for Rett Syndrome

ANDREA M. COLEMAN, CHEMISTRYRole of Alpha-Actinin in Surface Localizationof the L-type Ca2+ Channel Cav1.2

RJ TOMBARI, CHEMICAL BIOLOGYEx Vivo Analysis of Tryptophan MetabolismUsing 19F NMR

ANGELA ZHANG, BIO-ORGANIC CHEMISTRYMicrobial Production of Human Milk Oligosaccharides

DR. MICHAEL J. STEVENSON BIO-INORGANIC CHEMISTRY

Analysis of Metal Effects on C-Peptide Structure andInternalization

Co-authors: Ian C. Farran, Kylie S. Uyeda, Jessica A. SanJuan, Marie C. Heffern

ELIZABETH R. LOTSOFCHEMICAL BIOLOGYExcision of oxidatively damaged bases in G-quadruplexes by the DNA glycosylases NEIL1 andNEIL3

SAM HARTANTO, STRUCTURAL BIOLOGYCharacterization of the sulfur assimilation complexCysDNC in Mycobacterium tuberculosis

AGYA KARKI, CHEMISTRYBiochemical Analysis of AdenosineDeaminase Acting on RNA1 XANDER WILCOX , BIOPHYSICAL CHEMISTRY

Expanding the Genome Editing Toolbox: Towards theDevelopment of Targetable Genome Editing withAdenosine Deaminase Acting on RNA (ADARs)

SARAH DISHMAN, CHEMISTRYAsymmetric Synthesis of XanthoneNatural Products by C-H Insertion ofDonor/Donor Rhodium Carbenes

ALEXANDER THUY-BOUNSTRUCTURAL BIOLOGY/BIOCHEMISTRY Structural and Functional investigation of anAdenosine deaminase acting on RNA 2 proteinhomodimer

FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )

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RIGOBERTO ARENASSTRUCTURAL BIOLOGYStructural Biology of Anthracyclines Metabolism

ELYS RODRIGUEZ, CHEMISTRYSelectivity and structural understanding ofglycosyltransferases to enable proteindesign efforts towards cardiac glycosides

ALBERT LIU, BMCDBStructurally-Guided RuBisCO EngineeringInspired by Novel Metagenomic Protein

CALVIN LY, CHEMICAL BIOLOGYDevelopment of an In Vitro High-ContentImaging Screen for Antidepressants

XIAOHONG YANG, CHEMISTRY 'A Bacterial Exo-α-N-AcetylglucosaminidaseShows Potential for Heparin/Heparan SulfateStructural Analysis

MENUSThursday, September 5

Friday, September 6

BREAKFAST 7:30 A.M. - 9 A.M. GRANHALL

Build Your Own Chopped Saladand Smoothies Lunch Buffet:

Mango Yogurt Naked Juice SmoothieStrawberry Banana Naked Juice Smoothie

Salad BarNuts: Almonds, Pecans, Pistachios

Telara Rolls, Gluten Free RollsFresh Roasted Cubed Turkey (Dg,Gf)

Sustainable Harvested WhiteAlbacore Tuna Salad:

Contains Mayo, Celery, Relish, Hot Sauce, Red BellPepper, Black Pepper, OnionsGrilled/Blackened CertifiedSustainable Cod (Df, Gf)

Vegan/Gluten Free: Healthy Loaded Sweet PotatoSkins: With Onions, Garlic, Bell Peppers,

Tomatoes, Black Beans, Vegan Yogurt, Vegan Mozzarella

DINNER6:00 P.M. - 7:15 P.M GRANHALL

LUNCH12 P.M. - 1 P.M. GRANHALL

LUNCH PICK UP AND DEPART!(HIKING/HOME)

12:15 P.M. - 12:30 P.M. SOLARIUM

Dinner BuffetStrawberry Salad

Chopped Kale Salad withEdamame, Carrot and Avocado

BBQ Shrimp/Bell Pepper/Onion/MushroomKabobs with a Lime Marinade

BBQ Chicken (GF, DF)Vegan/Gluten Free BBQ Beyond Italian Spicy

Sausages BrochettesOven Roasted Sweet Potatoes

Grilled Corn On the Cob (GF, DF)Fresh Fruits, Lemon Cake

(Contains gluten and dairy) (HT)

Labeled bag lunches with sign up sheet theevening prior to confirm any dietary needs again

with the lodgePiece of fruit

Italian sandwichBag of chipsGranola bar

Chocolate chip cookieWater & napkin

Traditional Breakfast Buffet includes

various proteins (eggs, sausage, etc.)Baked goods

Hot and cold cerealFruit

Cofee, tea juice & more

FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )

FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF

HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?

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