Tumour models London 1-3 December 2015 Agenda

Christian GerdesHead of Pharmacology, Roche Pharma Research & Early DevelopmentRoche Innovation Center Zürich

17 Expert Speakers Include:

Jürgen MollDirector Pharmacology & Translational ResearchBoehringer-Ingelheim

Sukhvinder SidhuHead of Pharmacology, Oncology Drug Discovery & Preclinical DevelopmentSanofi

Giovanni Di VeroliAssociate Director of Systems PharmacologyAstraZeneca

Marie DutreixDirector of ResearchInstitut Curie

Harness the Latest Humanized, Syngeneic, PDX & Ex Vivo Models to:• Enhance Validation & Lead Optimisation of Discoveries • Improve Preclinical Predictions & Translational Decisions• Ensure Clinical Success & Enhanced Patient Outcomes

1-3 December 2015 LONDON, UK

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Tumour Models London | 1-3 December 2015, London, UK

Welcome Back to Tumour Models London 2015

Tumour Models London 2015, now in its 4th year,is the leading meeting dedicated to improve preclinical predictability and translational success of oncology discoveries. Tackling clinical failures rates, preclinical strategies and translational challenges, this Summit will enable you to translate your discoveries from model to human studies with superior predictability to future proof clinical success.

With the explosion of cancer immunotherapies and combination therapies, the 4th Tumour Models London Summit will bring together scientific leaders from pharma, biotech and academia, who will equip you to advance therapies through innovative in vitro, in vivo and

ex vivo models. Discover the innovative ways the industry is developing humanized mice and the preclinical data being generated to advance immunotherapies across the translational gap.

With the field poised for success, optimise your preclinical strategies to accelerate your understanding of your drug candidates by making faster strategic decisions. Tumour Models London will detail the latest work and case studies from those striving to create a step-change in improving preclinical predictability and translational success.

2. Learn how ex vivo models are being utilised to mimic the tumour microenvironment

2. Discover how the industry are developing humanized mice models for routine use in preclinical trials

5 Key Benefits to Takeaway

1. Discover how syngeneic models are optimising preclinical predictions for the development cancer immunotherapies

1. Enhance your current preclinical strategies to better predict the clinical outcomes of your drug candidates

3. Uncover and interpret early clinical data to better understand the preclinical predictions generated from PDX models

3. Harness the immuno-competent models being applied for the development of cancer immunotherapies

4. Discover the strategies being applied to develop combination therapies to overcome resistance mechanisms

4. Capture how PDX models are optimising preclinical predictions through reverse-translation

5. Understand the latest developments in optimising metastasis models to capture the heterogeneous patient population

5. Optimise your data interpretation from preclinical studies to enhance the clinical success of your drug candidates

5 Key Ideas to Implement

Increase Speed and Efficiency of Progressing Your Most Promising Drug Candidates Across the Translational Gap




Speakers

SEARCH GROUPS FOR: Tumor Models London 2015 to join the online community.

Andrew McKenzieDirector, Scientific Operations

Michael LisantiDirector, Breast Cancer Now Research Unit, Institute of Cancer Sciences

Giovanni Di VeroliAssociate Director of Systems Pharmacology

Marie DutreixDirector of Research

Kelli RyanSenior Scientist

Julie StockPreclinical & RaDCom Project Manager

Neal GoodwinVP, Corporate Research Development

Adam O’SheaScientist

Sophia KaragiannisSenior Lecturer in Translational Cancer Immunology, Head of Cancer Antibody Discovery & Immunotherapy

Brian SoperTechnical Information Scientist

Bruno GomesSenior Project LeaderSociety

Anne ChessexSenior Scientific Officer, Pharmacology & Screening

Christian GerdesHead of Pharmacology, Roche Pharma Research & Early Development

Jürgen Moll,Director Pharmacology & Translational Research

Sukhvinder SidhuHead of Pharmacology, Oncology Drug Discovery & Preclinical Development

Christoph SchatzSenior Scientist

Mustafa DjamgozProfessor of Cancer Biology

Excellent conference, very good balance of presentation between suppliers, academics, large pharma and biotech. The quality of talks was good and the informal networking was very useful

Past Tumour Models London attendee, e-Therapeutics plc




Workshop A

This interactive workshop will give you the chance to learn from a highly experienced senior scientist and other leading researchers within the field of cancer immunotherapy and the current developments of immuno-competent models.

Key takeaway and questions to be addressed include:• Exploring the different strategies of immune system humanization in mice• How predictive are the humanized mouse models (predictive validity, efficacy/

safety/biomarkers)?• Exploring humanized models to select combinations of immunotherapies• Discussing the further improvements required and how other models could

support them

Bruno Gomes has more than ten years of experience in pharmaceutical companies as a in vivo study director in oncology, head of in vivo oncology, and finally a senior project leader in immunotherapies. He has developed strong expertise in oncology, immunology and the drug development process, leading preclinical programs with kinase inhibitors and onco-immunology drugs. He has been focusing on increasing the translational relevance of preclinical models (including syngeneic tumour models in mice, xenografts and PDX tumour models in mice, humanized mice models and spontaneous canine tumours).

Workshop leaderBruno Gomes Senior Project Leader SocietyiTeos Therapeutics

Is Using Mice in an Humanized Immune System Really Improving the Clinical Translation of New Immunotherapies?Tuesday 1st December 2015 | Time: 9.00-12.00

A structured networking session - run like speed dating- especially designed to facilitate quickintroductions to the majority of attendees within the preclinical oncology field. Use the timewisely to meet new contacts, reconnect with old friends and identify those you want to spendmore time with.

Take part in facilitated discussion sessions focused around specific, high priority issues surrounding preclinical models. Discuss your experiences and observations within focus groups then share your and the other groups’ findings with the main conference.

In between the formal presentations the networking carries on. Use the multiple refreshment and lunch breaks to continue your discussions in an informal relaxed atmosphere. Move from scientific discoveries into meaningful collaborations.

Speed Networking

Round Table Discussions

Structured Networking Breaks

Networking at Tumour Models London 2015




08.00 Registration & Breakfast

09.00 Chairman’s Opening RemarksMustafa Djamgoz, Professor of Cancer Biology, Imperial College London

Preclinical Modelling to Elevate All Discoveries

9.10 Identifying Responsive Patient Populations in the Preclinic: Adopting Clinically-Relevant Models Across Oncology Therapeutics• Developing CDX and PDX modelling for breast and prostate cancer for enhanced

translational success

• How to satisfy the demand for clinically relevant models for understanding disease progression

Andrew McKenzie, Director, Scientific Operations, Crown Bioscience

9.40 Predictive Value of Preclinical In Vitro and In Vivo Models• Hear examples of predictability of cell based and in vivo models

• Learn about the current limitations and pitfalls using CDX, PDX and syngeneic in vivo models

• Discover how organoids are an emerging technology at the transition of cell based and in vivo models

Jürgen Moll, Director Pharmacology & Translational Research, Boehringer-Ingelheim

10.10 Morning Refreshments & Speed Networking

Modelling the Next Wave of Immunotherapies

11.10 Modelling Efficacy of Cancer Immunotherapies• Clinical entrance de-risking strategies for immunotherapy platforms

• Discuss lessons learnt from modelling antibody dependent cell cytotoxicity immunotherapies

• How to develop preclinical strategies to further enhance the development of immunotherapies

Christian Gerdes, Head of Pharmacology, Roche Pharma Research & Early Development , Roche Innovation Center Zürich

11.40 Humanized NSGTM Mice for Evaluation of Immuno-Oncology Therapeutics• Learn how the use of NSGTM mouse, JAX® In Vivo Pharmacology Services has

combined the human CD34+ hematopoietic stem cell engrafted NSG with human patient derived xenograft to create a platform for humanized preclinical studies in immuno-oncology

• Find out how this platform has been used to evaluate immune checkpoint inhibitors such as Keytruda

• Address how we are evaluating NSG-SGM3 mice for humanization and co-engraftment of PDX, as these mice express human IL-3, GM-CSF, and KIT ligand, that allow improved development of regulatory T cells and myeloid cells

• Discover how several PDX tumours have been successfully engrafted in the hu-CD34 NSG-SGM3 hosts, enabling further research into both the basic biology and development of therapeutics in human immuno-oncology

Brian Soper, Technical Information Scientist, The Jackson Laboratory

12.10 Immunologically-Relevant Tumour Models to Interrogate Antibody Efficacy and to Bridge the Translational Gap• Interrogating direct mechanisms of action and effector functions and efficacy of

anti-tumour antibodies by employing a combination of tailored in vitro and in vivo evaluations

• Design of cancer models relevant to antibody biology, human immunity and human malignant disease to interrogate antibody efficacy and safety

• Translating antibodies of different classes/subclasses through interrogating humanized, PDX and surrogate in vivo models

Sophia Karagiannis, Senior Lecturer in Translational Cancer Immunology, Head of Cancer Antibody Discovery & Immunotherapy, King’s College London

Conference Day OneWednesday 2nd December 2015




4.40 Chair’s Closing Remarks Mustafa Djamgoz, Professor of Cancer Biology, Imperial College London

5.00 Drinks Reception Hosted by Crown Bioscience

Maximise the use of in vivo and in vitro models to better predict drug-related toxicities at the preclinical

stage, detect adverse events and avoid costly mistakes in

the clinic

4.

12.40 Networking Lunch

Microenvironment & Combination Cancer Therapies

1.40 Combinations of Targeted Therapies with Radiotherapy: The Dbait Repair Inhibitors to Fight Resistance• Challenges of pre-clinic studies with radiotherapy: The need of dedicated platforms

• Safety issues: Planned combinations versus incidental associations

• Discover how to address radiosensitizers

• The repair inhibitor Dbait: Using an agonist to disable all DNA repair pathways

• From bench-to-bedside. What did we learn?

Marie Dutreix, Director of Research, Institut Curie

2.10 Driving Early Phase Combinations in the UK• The Combinations Alliance is a joint initiative between the Cancer Research UK

Centre for Drug Development (CDD), the Experimental Cancer Medicines Centre network (ECMC) and industry collaborators

• Identify and deliver the best early phase combination trials to maximise treatment options for people with cancer by driving forward industry and academia collaborations

• Learn about how these collaborations will bring together strengths from both fields, in particular using the academic expertise to ensure the correct animal models are used for preclinical work

• Explore the CRUK funding available to build preclinical evidence to support the progression of novel drug combinations into early phase trials, including radiotherapy-drug combinations

Julie Stock, Preclinical & RaDCom Project Manager, Cancer Research UK

2.40 Targeting Tumour Metabolism to Eradicate Cancer Stem Cells: In Vitro and In Vivo Models of Tumourigenesis• Disease models and target biology: How to relate cancer biology to

preclinical models

• How can we truly understand the metastatic microenvironment?

• Discuss models that accurately recapitulate human tumour biology at the level of morphology, heterogeneity and genomics

Michael Lisanti, Director, Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester

3.10 Afternoon Refreshments & Poster Session

3.40 Breakout Roundtables: Bridging the Gap Between Discovery and the Clinic

Improving the understanding of your immunotherapies: Lessons learned and data generated from

syngeneic models, humanized models and ex vivo approaches

Sukhvinder Sidhu, Head of Pharmacology, Oncology

Drug Discovery & Preclinical Development, Sanofi

1.

Preclinical Phase II Trials - How

to effectively run coupled/co-clinical

trials?

2.

Advancing tumour models that physiologically represent the tumour microenvironment to enhance prediction of patient

clinical outcomesMichael Lisanti, Director,

Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of

Manchester

3.




08.00 Registration & Breakfast

09.00 Chairman’s Opening RemarksMustafa Djamgoz, Professor of Cancer Biology, Imperial College London

Translational Research: Personalised Models for Personalised Medicines

9.10 Selecting Preclinical Models for Immunotherapy• Immunotherapy is an emerging field in oncology and different preclinical systems

are required compared to tumour therapies

• Refine in vivo model selection more effectively by following comprehensive profiling of the model

• Understand the immune context of the tumour allows response hypotheses to be built based on immunological criteria

• Link mouse model data to human clinical sample analysis to allow hypotheses to be further refined to guide translational and clinical strategy

Kelli Ryan, Senior Scientist, MedImmune

9.40 PDX-Directed Programs for Clinical Advancement• A PDX platform where patient tumours are engrafted to form models for predictive

personalised treatment testing

• Address the therapeutic treatment responses in the PDX being used prospectively to guide patient treatment and responses

• Learn to design downstream predictive treatment algorithms using biomarker data analysed to ascertain signatures of molecular response

• PDX resources for conducting efficient high-throughput translational medicine screens across multitudes of models

Neal Goodwin, VP, Corporate Research Development, Champions Oncology

10.10 Drug Repurposing for the Development of Novel Cancer Therapies• Characterisation of novel mechanisms operating in cancer to form the bases of

targeted therapies which, in part, can be made possible by ‘repurposing’ drugs from other fields of medicine

• Targeting metastasis with anti-epileptic and anti-anginal drugs, which have been shown to be anti-invasive in vivo

Mustafa Djamgoz, Professor of Cancer Biology, Imperial College London

10.40 Morning Refreshments

Optimal Predictors of Clinical Outcomes

11.10 Naturally Occurring Canine Cancer as a Translational Model for Novel Anti-Cancer Therapies• What comparative oncology tells us about the interests of spontaneous canine

tumours as models for cancer research• An example of clinical pharmacology study in naturally occurring canine lymphoma• How this model could be useful for translational studies of new immunotherapies

Bruno Gomes, Senior Project Leader, Society, iTeos Therapeutics

11.40 Use of Patient-Derived Material in Translational Research to Support Drug Development in Oncology Highlighting the following:• In vitro tumour colony formation assays using PDX for indication screening• Ex vivo explants from fresh tumour biopsies to investigate drug combinations• In vivo mouse trials: Study design, data interpretation and translation to the clinics

Anne Chessex, Senior Scientific Officer, Pharmacology & Screening, Debiopharm

Conference Day TwoThursday 3rd December 2015




12.10 Identification of Potential Biomarkers to Predict Therapeutic Efficacy to Drive Preclinical to Clinical Translation• Preclinical identification of predictive biomarkers for cancer treatment

• Learn to identify biomarkers for patient stratification and molecular signatures of drug response

• Use PDX models as predictive tools to prepare clinical trials

Christoph Schatz, Senior Scientist, Bayer Healthcare

1.10 Networking Lunch

2.10 Development of Preclinical Models in Radioimmunotherapy• Radioimmunoconjugate therapy: Working with radioactivity in preclinical

cancer models

• Highlighting specific problems with using immune compromised mice for radioimmunotherapy studies

• How to measure toxicity and efficacy of radioimmunotherapy in mouse models?

Adam O’Shea, Scientist, Nordic Nanovector ASA

2.40 The Analysis of Drug Combinations in Tumour Models• Identify combination benefits through mathematical modelling

• Use mathematical models of synergy to develop potential combination therapies

• Evaluate the combinations’ toxicity vs. efficacy to improve clinical outcomes

Giovanni Di Veroli, Associate Director of Systems Pharmacology, AstraZeneca

3.10 Afternoon Refreshments

Novel Models to Accurately Guide Next Generation Cancer Therapies

3.40 Panel Discussion: Highlight Cutting Edge Advances in In Vivo, In Vitro and In Silico Modelling to Facilitate a Discussion About Effective Translational Approaches in Cancer Research• Can preclinical models predict the results of phase 3 clinical trials?

• What toolkit of models does a preclinical research need to harness, when should they use them and when should they invest?

• Best practice for implementing novel strategies of preclinical cancer research

• Innovative in vitro models for minimising preclinical mistakes and ultimately clinical failures

• How to effectively evaluate novel cancer therapeutics as well as to identify predictive biomarkers in early stages of drug development

Moderator: Mustafa Djamgoz, Professor of Cancer Biology, Imperial College London

Sukhvinder Sidhu, Head of Pharmacology, Oncology Drug Discovery & Preclinical Development, Sanofi

Michael Lisanti, Director, Manchester Breakthrough Breast Cancer Research Unit, University of Manchester

4.10 Chairman’s Closing RemarksMustafa Djamgoz, Professor of Cancer Biology, Imperial College London

4.15 Close of Tumour Models London 2015

Outstanding meeting with first class speakers. I learned a lot and I will certainly recommend the meeting to my colleagues

Past Tumour Models London attendee, Sanofi Aventis




Partners

Crown Bioscience

Crown Bioscience provides Translational Platforms focused on fast-tracking candidates to identify biomarkers and patient responders based on the pharmacological response of human surrogate models. Power your Drug Discovery using the world’s largest commercial collection of well-characterised PDX in passage (HuPrime) plus a curated, searchable database of patient, genotypic and phenotypic data as well as pharmacological response (HuBase). Identify potential biomarkers (HuSignature™) based on pharmacological response or use your biomarker signature to identify models available for screening to confirm patient responder and non-responder populations (HuTrials™). Fast forward your drug discovery programs today.

www.crownbio.com

Champions Oncology

Champions Oncology was founded by renowned specialists in the field of cancer diagnosis, treatment, and research. The Champions Oncology team is comprised of seasoned oncology professionals passionately dedicated to working to accelerate oncology drug development, improve treatment outcomes and extend lives. Our core platform, the Champions TumorGraft™ offers an enhanced xenograft mouse avatar model for growing and testing human tumours. Champions Personalized TumorGrafts™ empower patients and physicians using an in vivo xenograft mouse avatar based diagnostic model that has shown to be predictive of a patients’ clinical response to cancer treatments and anticancer therapies.

www.championsoncology.com

The Jackson Laboratory

The Jackson Laboratory is an independent, nonprofit biomedical research institution and a National Cancer Institute-designated Cancer Center. Founded in 1929, the Laboratory applies its eight decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and empowers the global biomedical community by providing critical data, tools and services.

www.jax.org

Harlan Laboratories

Harlan Laboratories is a leading global provider of research models and services to the worldwide Pharmaceutical, Biotech, Contract Research and Academic/Government sectors. Global availability of high quality nude mice, SCID mice, nude rats and general purpose models for your area of oncology research with proven performance in tumour update and growth.

www.harlan.com

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Tumour models London 1-3 December 2015 Agenda

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