TRIGGER POINTS The Evidence€¦ · MYOFASCIAL PAIN SYNDROMES Psychological Impact Unsure if part...
Transcript of TRIGGER POINTS The Evidence€¦ · MYOFASCIAL PAIN SYNDROMES Psychological Impact Unsure if part...
TRIGGER POINTS
The Evidence
Peter Brukner
Sports Physician
Melbourne, Australia
OUTLINE
• Definition
• Diagnosis
• Theories
• Treatment
– Vapocoolant spray
– Injections
– Dry needling
Historical perspective
• 1938 - Kellgren identified referred pain from points in muscle
• 1938 – Gutstein (Good)
• 1941 – Kelly (Australia)
• 1940s onwards – Janet Travell
• Travell & Rinzler (1951)
• Travell & Simons (1983)
• Smythe & Moldofsky (1965, 1977) – Fibrositis syndrome
• Fibromyalgia – Yunus et al, 1981
– Wolfe et al, 1990
DEFINITION
Presence of exquisite tenderness at a nodule in a
palpable taut band. …..if the patient recognises the
pain elicited by digital pressure on (or needle
penetration of) the trigger point, the trigger point is
clinically active, not just latent.
(Travell & Simons 1983)
What are trigger points?
• Localised areas of deep tenderness and
increased resistance within a tight band
of muscle
• Local Twitch Response or “Jump sign”
in response to pressure
• Some positional similarities to
acupuncture points for the relief of pain
SYMPTOMS
Active vs latent trigger points
Local or referred
Muscle dysfunction that may perpetuate the
phenomenon
Active vs Latent Trigger Points
• Latent points cause increased muscle
tension and shortening only
• Active points present with pain that is
reproducible with pressure +/- referred
symptoms
• Latent points may be activated by a
number of influences
Active vs Latent Trigger Points
ACTIVE LATENT
Local tenderness + +
Taut band + -
Local twitch response + -
Referred pain + -
ACTIVE TRIGGER
POINTS
Responsible for presenting complaint
PAIN
Weakness/ parasthesia/ temperature changes
+/- referred sensations
+/- satellite trigger points
LATENT TRIGGER
POINTS
Present with muscle shortening or restriction
Pain occurs on application of external pressure
May become activated by a variety of stimuli
Distal Effects of Trigger Points
• Satellite trigger points
• Muscle spasm - agonist, antagonist or
distal
• Muscle inhibition
• Sensory symptoms
• Autonomic changes
TP development
Thought to develop after:
• Unaccustomed eccentric and concentric
loading
• Low-load repetitive tasks
• Sustained postures
• Respiratory stress such as over-breathing
• In association with visceral pain and
dysfunction
POSSIBLE PRECIPITANTS
Perpetuating factors
Stress
Overuse
Poor postural control/ core stability
EXAMINATION
FINDINGS
Local tender spot within tight muscle
band
Reproduction of the patient’s
symptoms
Local twitch response to snapping
palpation or dry needling
EXAMINATION
RELIABILITY
Inter and intra rater assessment by palpation
unreliable (Lew et al 1997)
4 clinicians could reliably identify TP’s after
training extensively together (Sciotti et al 2001)
Unreliable in untrained, marginally reliable after
training (Hsieh et al 2000)
Local twitch response least reliable feature
(Gerwin et al 1997)
Presence of taut band, tenderness, jump sign highly
reliable in r.c. tendinitis (Al-Shenqiti & Oldham, 2005)
MYOFASCIAL PAIN
SYNDROMES
Pain or autonomic phenomena
referred from active TrPs with
associated dysfunction
Probably fit under CRPS type II
criteria
•Trigger points
•Generalised hyperalgesia
•Psychological disturbance
MYOFASCIAL PAIN SYNDROMES
Presentations
Regional muscle disturbance
Generalised muscle pain
+/- inciting factor
(Injury/overuse/joint disease)
Defined by presence of tender points
and trigger points
Pain
MYOFASCIAL PAIN SYNDROMES
Psychological Impact
Unsure if part of the pathology or secondary
to the chronic pain state.
Some indication that treating chronic pain
improves psychological state (Bogduk 2000)
Disturbance can impact a patient’s
interpretation of pain and the response to
treatment
PATHOLOGY
There is no gold standard
pathological test for the
identification of trigger points
PATHOLOGY
Histology
Most studies negative
(Yunus et al 1986, Russell et al 1992)
Non specific fibrosis and absence of
inflammatory cells have been noted
PATHOLOGY
EMG
SPONTANEOUS ELECTRICAL ACTIVITY
(SEA)
Low amplitude background noise
Superimposed high amplitude spike activity
PATHOLOGY
EMG
Examples of spontaneous electrical
activity
Reproduced from Simons et al
PATHOLOGY
EMG
Said to represent motor end plate noise (EPN)
(Travell & Simons 1983)
May reflect stimulation of intrafusal muscle fibres (Hubbard et al 1993)
Endplate noise characteristic of, but not restricted to,
the region of a MTrP (Simons 2002)
Irritability of an MTrP highly correlated with
prevalence of EPN in upper trap muscle (Kuan et al, 2007)
PATHOLOGY
EMG
Noise may represent excessive ACH release at
nerve terminals
Spikes are said to be pathological, but are likely
to represent the response of muscle to needle
stimulation (ie physiological).
BIOCHEMISTRY
No theory has been conclusively proven.
BIOCHEMISTRY
Higher concentrations of protons, bradykinin,
calcitonin gene-related peptide, substance P, tumor
necrosis factor-alpha, interleukin-1 beta, serotonin
and noradrenaline in active TrP, lower pH.
Shah et al, 2005
Increased 5-HT and glutamate, increased anaerobic
metabolism in TrP
Rosendal et al, 2004
BIOCHEMISTRY
Muscle contraction
Trigger points - ? Primarily muscle or neurologic
phenomenon
Basic understanding of muscle contraction required to
understand popular theories of formation
BIOCHEMISTRY
Muscle contraction
IMAGING
We have no reliable method of imaging trigger
points to date
IMAGING
Thermography
Can We See Them?
Thermography
Technique of detecting heat emission from the body
Thought that it may be increased over trigger points
Blinded trials showed no significant difference in
reliability compared with controls (Diakow, 1992 Swerdlow & Dieter 1992)
Probably just measuring skin blood flow
IMAGING
Thermography
Hot spots do not necessarily correspond to trigger
points
No difference in imaging findings patients vs
controls (Swerdlow et al 1992, Diakow, 1992)
NOT VALID
Can We See Them?
Ultrasound
One study
Experienced operator unable to determine any
difference between trigger points and control points (Lewis et al 1999)
IMAGING
31P NMR
Early research indicated some promise, but has not
been followed up. (Kushmerick 1989, Mather 1988)
Based on detecting the different forms of phosphate
(energy compounds) in the muscle, thus giving an
idea of the metabolic status of the muscle.
No clear indication of changes expected in
myofascial pain.
Can We See Them?
MRI
????
IMAGING
MRI
No data to date.
Pilot investigation revealed no imaging evidence of
changes in the region of clinically detected trigger
points.
(unpublished data)
ACUPUNCTURE
Traditional
Chinese Medicine
has many
similarities with
trigger points and
the therapies used
today
ACUPUNCTURE
Acupuncture & trigger points
71% correlation between trigger point locations
and acupuncture points described for the relief
of pain
(Melzack 1977)
TRIGGER POINT THERAPY
Non-Invasive
Spray and stretch, TENS,
ultrasound, laser, iontophoresis
Invasive
Injection, dry needling
Vapocoolant spray
• Travell & Simons (1992) • “Single most effective non-invasive method”
• Jaegar and Reeves (1986) • Improved pain threshold (p<0.01)
• Improved VAS (p<0.004)
• No correlation between the two
Vapocoolant spray
• Originally ethyl chloride spray
• Alternatively …..
• Dichlorodifluoromethane-trichloromono-
fluoromethane (Fluori-Methane)
Massage
Massage Techniques
• Ischemic compression therapy (Trapezius)
effective for immediate pain relief
• Combination with hot pack plus active ROM
and stretch with spray, hot pack with active
ROM and stretch with spray and TENS or
interferential current are most effective for
easing MTrP pain and increasing cervical
ROM Hou et al, 2002
TRANSCUTANEOUS
ELECTRICAL NERVE
STIMULATION (TENS)
• TENS vs placebo (Graff Redford, 1989)
– No change with low frequency TENS
– High frequency (100Hz) reduced pain
without change in pressure threshold
(p<0.05)
– Postulated for pain relief only
TENS
Hsueh (1997)
– ENS (60Hz) – 57% improvement in pain intensity
– 46% pain threshold
– 15% ROM
– EMS – 15% pain intensity and threshold
– 83% ROM
– p<0.05
Ultrasound
Gam (1998) » massage, exercise, U/S
» massage, exercise
» no intervention
• Reduction in number and sensitivity of
tp’s in intervention groups (p<0.05)
• No change in VAS
Laser • Thorsen (1992)
– LLLT not different from placebo on functional or resting VAS (6 treatments)
– 43% reported subjective benefits of placebo, 17% of laser
• Cecchereli (1989)
– Diode laser reduced pain (p<0.001)
– Significant only at sessions 7,10,11,12 and at 3 months
• Hakguder et al (2003)
– LLLT beneficial for pain in MPS
Botulinum Toxin A
Systematic review (Ho & Tan, 2006)
• effective in one trial
• not effective in four trials
Kuan et al (2002)
• Suppressed EPN in MTrP of rabbit
skeletal muscle
Local Anaesthetic Injection
• Frost (1980)
– Saline better than mepivicaine
• Hameroff (1981)
– Bupivacaine vs etidocaine vs saline
– At 24 hours, LA better (p<0.05)
– 7 days, average pain better (p<0.005)
– Some extra benefits from etidocaine, but
most parameters not significantly different
Local Anaesthetic Injection
• Frost (1986) single blinded trial
comparing lidocaine with diclofenac.
– Non significant trend to better results on
VAS with NSAID over 5 hour follow up
– Became significant only at 3 hours
(p<0.05)
• May indicate significant inflammatory
contribution
Local Anaesthetic Injection
• Carlson (1993)
– 2% lidocaine reduced pain and EMG
activity. (p<0.001)
– No correlation between the two.
Local Anaesthetic Injection
• Fine (1988) - naloxone vs placebo in
reversing effects of local anaesthetics • return of pain (VAS) from 5 minutes (p<0.002)
• relapse in ROM from 30 minutes (p<0.05)
• May explain prolonged analgesic effects
• However • small numbers - 10 patients
• unusually high analgesic effect
Dry needling
Deep or Superficial
Dry Needling
Lewit (1979) - described the “needle
effect” - immediate complete analgesia
Case report - needle effect seen in 271
of 312 structures
All but 43 had some improvement
Dry Needling
Unilateral needle stimulation to active
MTrP resulted in bilateral EMG activity
Audette et al, 2004
Dry Needling
Deep needling to MTrPs more effective in
treatment of LBP than standard acupuncture or
superficial needling
(Itoh et al, 2004)
Trigger point acupuncture greater short term
effects on LBP than sham acupuncture
(Itoh et al, 2006)
DN versus LA Injection
• Hong (1994)
– No significant difference in immediate
response LA vs DN (100% if LTR seen)
(p<0.05)
– LTR’s needed for optimal effect (p<0.05)
– Effect fades over time
– Post injection soreness worse and
prolonged with DN - 100% vs 42%, 1.5 vs
5 days (p<0.05)
Our Research
Common myofascial
syndromes
Headache
Number of studies shown presence of TrPs in headache and
migraine patients
Calandre et al, 2006
Couppe et al, 2007
Fernandez-de-Las-Penas, 2005, 2006
Headache
Upper arm/shoulder pain
Neck-shoulder pain
trapezius TrPs (Ge 2006, Al-Shenqiti 2005, Voerman
2006)
Frozen shoulder
subscapularis (Jancovic, 2006)
Upper arm pain
Low back pain
TrP deep dry needling greater short term effects on LBP than
sham acupuncture or superficial needling
Itoh et al, 2004, 2006
Low back pain
Hamstring pain
REFERENCES
Simons DG, Travell JG, Simons LS. Travell
& Simons' Myofascial pain and dysfunction:
the trigger point manual. 2d ed. Baltimore:
Williams & Wilkins, 1999
Rachlin ES. Trigger points. In: Rachlin ES,
ed. Myofascial pain and fibromyalgia: trigger
point management. St. Louis: Mosby 1994
REFERENCES
Alvarez DJ, Rockwell PG Trigger Points:
Diagnosis and Management Am Fam
Physician. 2002;65(4):653-661
Domerholt J. Dry needling — peripheral and
central considerations J Man Manip Ther
2011;19(4):223–227
REFERENCES
Kietrys DM et al ―Effectiveness
of dry needling for upper-quarter myofascial
pain: A systematic review and meta-analysis,‖
J Orthop Sports Phys Ther 2013;43(9):620-
634.
Furlan A, Tulder M, Cherkin D, et al.
Acupuncture and dry-needling for low back
pain: an updated systematic review within the
framework of the Cochrane collaboration.
Spine 2005;30:944–63