Trichuriasis
description
Transcript of Trichuriasis
TRICHURIASISBy Ryan Johnson
General Overview NTD
>20% of human population infected
Locally underestimated
Public health crucial
Trichuris Nematodes Coevolved with Man
Infects old and new world monkeys
Discovered in 1740
Morphology
Fecal-Oral Transmission
Soil to mouth
Embryonic Development Must Occur Outside of the Human
3 weeks later
I won’t be able to hatch in your stomach if you eat me now. Gimme 3 weeks!
Time’s up… …EAT ME!!!
Signs and Symptoms Light infestation – asymptomatic Severe infestation – GI problems
Treatment Mebendazole
Prevents Microtubule Polymerization
Preventive Chemotherapy Heaviest burden
on kids
Treatment 2x a year
1 dose = fraction USD
http://en.wikipedia.org/wiki/Trichuriasis Fernando, Ranjan L; Tropical infectious diseases :
epidemiology, investigation, diagnosis and management; London : Greenwich Medical Media, 2004.
http://www.who.int/intestinal_worms/en/index.html Hutchinson, et al; Clinical Trial of Mebendazole, A
Broad-spectrum Anthelminthic; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681918/pdf/brmedj01446-0019.pdf/?tool=pmcentrez
Miller, et al; Mebendazole, An Effective Anthelmintic for Trichuriasis and Enterobiasis; http://jama.ama-assn.org/cgi/reprint/230/10/1412.pdf