Trichuriasis
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Transcript of Trichuriasis
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TrichuriasisAbigail Nix
Tuesday, April 3rd, 2012Biology 402
UNC Chapel Hill
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Trichuriasis is one of the seven most prevalent Neglected Tropical Diseases
WHO
WHO
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NTDs coexist with poverty because they thrive where access to clean water and sanitation are limited and people live without
protection from disease vectors.
iconsinmedicine.wordpress.com
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Trichuriasis is one of the three common diseases caused by soil-transmitted
helminths
Forgotten people, forgotten diseases
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Approximately 604-795 million people in the world are infected with
whipworm
WHO 2002
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Trichuriasis is caused by the parasitic nematode Trichuris trichiura
Bodyfixer.com
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Trichuriasis is transmitted through the oral-fecal route
Sabin.org handwashingforlife.com
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Adult whipworms live in the large intestine of humans
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Unembryonated Trichuris eggs must develop in the soil for at least 2 weeks
naturalhealthtechniques.comStanford.edu
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Two types of Trichuriasis infection: heavy and light
smartplanet.com
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A stool sample is used to diagnose trichuriasis
Wikipedia.org
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Trichuriasis is one of the neglected tropical diseases that can be controlled by mass drug administration
cdc.gov
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Three first line medications for trichuriasis: mebendazole, albendazole and ivermectin
Stanford.edu
fredunpharmaceuticals.com
Indiamart.com
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Benzimidazoles inhibit the polymerization of tubulin and assembly of tubulin into microtubules
Stanford.edu Cureforneedy.org
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Benzimidazoles inhibit the polymerization of tubulin and assembly of tubulin into microtubules
Stanford.edu Cureforneedy.org
Ivermectin binds to and deactivates glutamate-gated chloride channels
Filariajournal.com
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Prevention measures for
trichuriasis focus on basic
sanitation and educational
efforts as well as mass drug
administrationsStanford.edu
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Could whipworm and other helminth infections be used as future therapeutic
treatments?
landesbioscience.com
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Sumers R W et al.
Summers R W et al. Gut 2005;54:87-90
Fleming J O et al.
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References"About the Neglected Tropical Disease Program." NTD Program: Neglected Tropical Diseases. USAID, 28 Mar. 2012. Web. <http://www.neglecteddiseases.gov/index.html>.
DrugBank: Open Data Drug & Drug Target Database. University of Alberta, 13 June 2005. Web. <http://www.drugbank.ca/>.
Fleming, J. O., et al. "Probiotic Helminth Administration in Relapsing-remitting Multiple Sclerosis: A Phase 1 Study." Multiple Sclerosis 17.6 (2011): 743-54. Print.
Hotez, Peter J. Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development. Washington DC: ASM, 2008. Print.
Hotez, Peter J. "Rescuing the Bottom Billion through Control of Neglected Tropical Diseases." Lancet 373 (2009): 1570-575. Print.
Summers, R. W., et al. "Trichuris Suis Therapy in Crohn's Disease." GUT 54 (2005): 87-90. Print.
Summers, R. W. , et al. "Trichuris Suis Therapy for Active Ulcerative Colitis: A Randomized Controlled Trial." Gastroenterology 128.4 (2005): 825-32. Print.
"Trichuriasis." Centers for Disease Control. 2 Nov. 2010. Web. <http://www.cdc.gov/parasites/whipworm/>.