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Treatment as Prevention The Key to an AIDS & HIV free Generation or Harnessing the Full Power of...
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![Page 1: Treatment as Prevention The Key to an AIDS & HIV free Generation or Harnessing the Full Power of Administrative and Clinical Data - Julio Montaner](https://reader033.fdocuments.us/reader033/viewer/2022051818/549bfbc8ac7959ab2a8b45e2/html5/thumbnails/1.jpg)
Slide 1 of 42
IAS–USA
Julio Montaner, MD Professor of Medicine, and Head, Div. of AIDS, University of British Columbia
Director, BC-Centre for Excellence in HIV/AIDS at Providence Health Care Past President, International AIDS Society (2008-2010)
Treatment as Prevention The Key to an AIDS & HIV free Generation
or Harnessing the Full Power of
Administrative and Clinical Data
AU EDITED FINAL: 03-18-13
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Slide 2 of 44
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Year
Dea
ths
per 1
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opul
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n
Unintentional injury Cancer
Heart disease Suicide
HIV infection
Homicide
Chronic liver disease Stroke
Diabetes
USA - Trends in Annual Rates of Death Ages 25 to 44
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Vancouver 1996 “One World One Hope”
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Impact of HAART in BC-CfE
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Death Rate per 1000
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1993-94 1995-96 1997-98 1999-00 2001-02 2003-04
Life Expectancy at age 20
Modified from Hogg et al, Lancet. 2009
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New HIV and Syphilis in BC
BC-CDC, 2005
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HAART stops HIV replication
↓
HIV load falls to undetectable levels in plasma
as well as in sexual fluids ↓
Sharp reduction in HIV transmission
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Cost of Medical Management of 1 HIV infection over a lifetime = $250,000
“HIV deficit” in BC in 2005: 400
TasP is Cost-Averting
Averted lifetime Rx cost up to 2001 US $96.4M A total of 3,963 pts were on HAART in BC in 2005
Total actual drug cost (using patented drugs) in 2005 $49 million US
800 cases per year
400 cases per year
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If the cost of Medical Management of 1 HIV infection over a lifetime is about $250,000
Averted lifetime Rx cost up to U$A 100M A total of 3,963 pts were on HAART in BC in 2005
Total actual drug cost (using patented drugs) in 2005
U$A 50M
“HIV deficit” in BC in 2005: 400
TasP is Cost-Averting
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Incremental net benefit (Millions of CDN $) over
30 years
K Johnston et al, AIDS, 2010
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January 2004
Summer of 1996
Year
Summer of 2000
Phase I Phase II Phase III
Montaner et al, Lancet, 2010
Increasing HAART Coverage within Evolving Guidelines in BC
N = 7492 by the end of 2011
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BC: All Cause Mortality (#) All Cause Mortality in BC
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1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
Years
Frequency
Montaner et al, TasP Workshop, April 2012
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Slide 13 of 44 AIDS New Cases for BC by year, 1996-2011
Montaner et al, Under Review, 2013
1996$ 1997$ 1998$ 1999$ 2000$ 2001$ 2002$ 2003$ 2004$ 2005$ 2006$ 2007$ 2008$ 2009$ 2010$ 2011$AIDS$0$BCCDC$Rate$ 6.9$ 4.3$ 4.4$ 4.2$ 4.3$ 2.5$ 3.2$ 3.3$ 3.1$ 3.1$ 2.8$ 2.6$ 2.7$ 2.1$ 1.6$ 1.4$
AIDS$and$CD4$Rate$ 15.6$ 9.8$ 8.9$ 8.6$ 8.1$ 6.9$ 7.8$ 8.4$ 7.7$ 8.3$ 7.6$ 7.6$ 7.1$ 5.5$ 4.5$ 3.8$
AIDS$0$BCCDC$Cases$ 269$ 170$ 177$ 168$ 172$ 101$ 131$ 137$ 130$ 130$ 117$ 110$ 118$ 93$ 72$ 64$
AIDS$and$CD4$Cases$ 604$ 386$ 355$ 343$ 329$ 280$ 319$ 348$ 318$ 347$ 321$ 329$ 311$ 246$ 205$ 176$
HIV0related$Mortality$Rate$ 6.5$ 3.0$ 2.8$ 2.6$ 3.0$ 2.7$ 2.6$ 3.1$ 2.5$ 3.5$ 3.3$ 2.3$ 1.8$ 1.4$ 1.2$ 1.3$
HIV0Related$Mortality$Cases$ 253$ 117$ 110$ 103$ 122$ 111$ 106$ 127$ 105$ 146$ 142$ 100$ 79$ 63$ 54$ 59$
0$
2$
4$
6$
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16$
Rate%per%100,000%pop
ula.
on%
1996$ 1997$ 1998$ 1999$ 2000$ 2001$ 2002$ 2003$ 2004$ 2005$ 2006$ 2007$ 2008$ 2009$ 2010$ 2011$AIDS$0$BCCDC$Rate$ 6.9$ 4.3$ 4.4$ 4.2$ 4.3$ 2.5$ 3.2$ 3.3$ 3.1$ 3.1$ 2.8$ 2.6$ 2.7$ 2.1$ 1.6$ 1.4$
AIDS$and$CD4$Rate$ 15.6$ 9.8$ 8.9$ 8.6$ 8.1$ 6.9$ 7.8$ 8.4$ 7.7$ 8.3$ 7.6$ 7.6$ 7.1$ 5.5$ 4.5$ 3.8$
AIDS$0$BCCDC$Cases$ 269$ 170$ 177$ 168$ 172$ 101$ 131$ 137$ 130$ 130$ 117$ 110$ 118$ 93$ 72$ 64$
AIDS$and$CD4$Cases$ 604$ 386$ 355$ 343$ 329$ 280$ 319$ 348$ 318$ 347$ 321$ 329$ 311$ 246$ 205$ 176$
HIV0related$Mortality$Rate$ 6.5$ 3.0$ 2.8$ 2.6$ 3.0$ 2.7$ 2.6$ 3.1$ 2.5$ 3.5$ 3.3$ 2.3$ 1.8$ 1.4$ 1.2$ 1.3$
HIV0Related$Mortality$Cases$ 253$ 117$ 110$ 103$ 122$ 111$ 106$ 127$ 105$ 146$ 142$ 100$ 79$ 63$ 54$ 59$
0$
2$
4$
6$
8$
10$
12$
14$
16$Ra
te%per%100,000%pop
ula.
on%
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BC: HIV Prevalence and TB Incidence
James Johnston, in prepara/on, May 2013
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Slide 15 of 44
HAART Use & New HIV Diagnoses for BC by year, 1996-2012
1996$ 1997$ 1998$ 1999$ 2000$ 2001$ 2002$ 2003$ 2004$ 2005$ 2006$ 2007$ 2008$ 2009$ 2010$ 2011$ 2012$HIV$Incidence$ 632$ 551$ 490$ 461$ 461$ 476$ 489$ 495$ 490$ 472$ 446$ 418$ 408$ 387$ 382$ 380$ 368$New$HIV$Diagnoses$ 702$ 519$ 471$ 416$ 400$ 420$ 418$ 408$ 442$ 400$ 361$ 391$ 345$ 337$ 301$ 289$ 238$New$HIV$Diagnoses$(ever$IDU)$ 352$ 215$ 177$ 159$ 152$ 132$ 156$ 136$ 137$ 125$ 115$ 118$ 65$ 64$ 52$ 34$ 29$AcAve$on$HAART$ 837$ 1960$ 2596$ 2994$ 3079$ 3120$ 3211$ 3356$ 3585$ 3913$ 4256$ 4654$ 5123$ 5595$ 5999$ 6298$ 6260$HIV$Prevalence$ 7900$ 8228$ 8593$ 8933$ 9150$ 9408$ 9690$ 9936$ 10216$ 10398$ 10566$ 10790$ 11040$ 11280$ 11500$ 11700$ 11972$
0$
1000$
2000$
3000$
4000$
5000$
6000$
7000$
0$
100$
200$
300$
400$
500$
600$
700$
800$
Number$o
s$individuals$on$HAART$
Number$of$new$cases$and$new$diagnoses$
HIV Incidence
Active on HAART
New HIV Diagnoses (All)
New HIV Diagnoses (Ever IDU)
HAART Use & New HIV Diagnoses for BC by year, 1996-2012
1996$ 1997$ 1998$ 1999$ 2000$ 2001$ 2002$ 2003$ 2004$ 2005$ 2006$ 2007$ 2008$ 2009$ 2010$ 2011$ 2012$HIV$Incidence$ 632$ 551$ 490$ 461$ 461$ 476$ 489$ 495$ 490$ 472$ 446$ 418$ 408$ 387$ 382$ 380$ 368$New$HIV$Diagnoses$ 702$ 519$ 471$ 416$ 400$ 420$ 418$ 408$ 442$ 400$ 361$ 391$ 345$ 337$ 301$ 289$ 238$New$HIV$Diagnoses$(ever$IDU)$ 352$ 215$ 177$ 159$ 152$ 132$ 156$ 136$ 137$ 125$ 115$ 118$ 65$ 64$ 52$ 34$ 29$AcAve$on$HAART$ 837$ 1960$ 2596$ 2994$ 3079$ 3120$ 3211$ 3356$ 3585$ 3913$ 4256$ 4654$ 5123$ 5595$ 5999$ 6298$ 6260$HIV$Prevalence$ 7900$ 8228$ 8593$ 8933$ 9150$ 9408$ 9690$ 9936$ 10216$ 10398$ 10566$ 10790$ 11040$ 11280$ 11500$ 11700$ 11972$
0$
1000$
2000$
3000$
4000$
5000$
6000$
7000$
0$
100$
200$
300$
400$
500$
600$
700$
800$Number$os$individuals$on$HAART$
Number$of$new$cases$and$new$diagnoses$
HIV Incidence
Active on HAART
New HIV Diagnoses (All)
New HIV Diagnoses (Ever IDU)
Updated from Montaner et al, Lancet, 2010
HAART use and HIV new Diagnoses Bri/sh Columbia, 1996 -‐ 2012
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Slide 16 of 44
1 1HIV+ Birth
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Slide 17 of 44
5
0
10
15
20
1995 1998 2001 2004 2007 2010
B.C.
Ontario
QuébecAlberta
Manitoba
Manitoba
Sask.
Sask.
Atlantic
B.C.Ontario
QuébecAlberta
Atlantic
HIV
Dia
gnos
es
per
100,
000
Pop
ulat
ion
Year
HIV Diagnoses by Region and Year!Public Health Agency of Canada!
Hogg et al, HIV Medicine, 14, 581-2, 2013
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Slide 18 of 44 When to start: Potential scenarios
Recommended Since 2002
CD4 ≤ 200
CD4 ≤ 350 +
CD4 ≤ 350 +
Expanded CD4 independent condi6ons
Test and treat
All HIV+
Estimated millions of people eligible for ART in lower & middle-income countries in 2011
11 15 23 >25 32
1 2 3 5
International AIDS Society Conference, KL, July 2013
CD4 ≤ 500
4
ART regardless of CD4s: -‐ HIV-‐SD couples • TB/HIV • HBV/HIV • Pregnant women • Children ≤ 5yo
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Slide 19 of 44
Status Quo 2011
Enhanced Investment 2012
2013 WHO Guidelines
2013 WHO Guidelines plus Optimized PrEP and HIV Vaccine
Manuscript under preparaGon
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Slide 20 of 44
Granich et al
Lives Saved (x 1,000) U$A Billions
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Slide 21 of 44
Treatment 2.0:
A new prevention-treatment
paradigm in the global response
to HIV/AIDS -
UNGASS
New York - 9 June 2010
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Slide 22 of 44
Feb 2011: China Embraces TasP February 24th 2011
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Slide 23 of 44
Oct 3rd 2013
Oct 17th 2013 Few could have imagined that we’d be talking about the real possibility of an AIDS-free generation. But that’s what we’re talking about…make no mistake, we are going to win this fight.
President Obama, December 1, 2011 PS: By the end of 2013, PEPFAR will directly support more than 6 M people on HAART– 2M more than previously targeted.
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Slide 24 of 44
"To cut new infections in half, we'll have to heed Julio Montaner's years of pleas to implement Treatment as Prevention and implement combination prevention programs. We can save a lot of lives
if all this is done..." President Clinton, Washington AIDS Conference, 2012
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Slide 25 of 44
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Premier Christy Clark announces AIDS 2015 -‐ The 8TH IAS Conference on HIV Pathogenesis, Treatment and Preven/on, Vancouver, July 2015
July 3rd 2013 | Kuala Lumpur, Malaysia