Translating Exposure Science for Decision-makers and the ......An Opportunity for Collaboration EPA...
Transcript of Translating Exposure Science for Decision-makers and the ......An Opportunity for Collaboration EPA...
1 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
Translating Exposure Science for Decision-makers and the Informed Public:
An Opportunity for Collaboration
EPAExposureScienceCommunityofPrac6ceConferenceCallJanuary12,2010
EliseMiller,M.Ed.Director
Collabora6veonHealthandtheEnvironment1646DowRoad,Freeland,WA98249Ph:360‐331‐7904;Fax:360‐331‐7908
Email:[email protected]:www.healthandenvironnment.org
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Interacting factors that influence health and development
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Heredity Gene‐environmentinterac6ons Exposurestotoxicchemicals Pharmaceu6cals Infec6ousdisease Socioeconomicstatus Nutri6on Stress
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Environmental exposures
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Timingofexposure Bioaccumula6onandpersistance Mechanismsofdisrup6on Variablesensi6vity Evidenceofexposures(bodyburden) Mixtures
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Child Health Exposures Prenatal
transplacental developmentalwindows
Postnatal poundperpoundchildreneat,drinkandbreathfarmorethanadults
prolongedgastricemptying
increasedmetabolicrate increased6meindoors&onfloors(hand‐to‐mouthac-ons)
breastmilk(s-llbesttobreas4eed,butbreastmilknowcontainsmanycontaminants)
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Environmental agents
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LeadMercuryPCBsPBDEsBPAPhthalates
ArsenicSolventsPAHsPes6cidesManganeseDioxins
Environmentalagentsthatareknownorsuspected
tointerferewithhealthydevelopment:
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Lead
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Whatwasconsidereda“safe”thresholdforexposuretoleadcon6nuestodrop
Thereisnosafelevelofleadexposureforchildren
60
40
3025
2015
10
20
10
20
30
40
50
60
Bloo
d Le
ad (u
g/dl
)
CDC1960
CDC1973
CDC1975
CDC1985
WHO1986
EPA1986
CDC1990
CDCWhen?
Agency and Year
Acceptable Childhood Blood Lead Levels Globalmarkets
Environmentaljus6ce
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Endocrine disrupting chemicals
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DosedoesNOTmakethepoison–LaboratoryexperimentsshowthatexposuretoEDCscanhaveimpactsatlevelsfarlowerthanhadbeenconsideredpossibleintradi6onaltoxicology.
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Endocrine Society’s Statement
ReleasedJune2009
“…Theevidenceforadversereproduc-veoutcomes(infer-lity,cancers,malforma-ons)fromexposuretoendocrinedisrup-ngchemicalsisstrong,andthereismoun-ngevidenceforeffectsonotherendocrinesystems,includingthyroid,neuroendocrine,obesityandmetabolism,andinsulinandglucosehomeostasis….”
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Collaborative on Health and the Environment (CHE)
Diseasedatabase Consensusstatements,whitepapersandfactsheets
10Workinggroups
Na6onalcallswithexpertsonspecifictopics Conferencesandworkshops
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CHE Fertility and Reproductive Health Working Group
VallombrosaConsensusstatement
“ShapingourLegacy”summit “Girl,Disrupted”report “Naviga6ngtheScience”
conference
Resourcedatabase Workinggroupcalls New:Sciencetrainingsfor
advocates
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CHE Learning and Developmental Disabilities Initiative (LDDI)
Educa6ngstateandna6onallearninganddevelopmentaldisabili6es(LDD)groups.
Transla6ngemergingscienceintoinforma6onandfactsheetstobeusedatworkshopsandonwebsitesforlayaudiences.
Holdingmee6ngsna6onallyandregionallytobuildcollabora6vepartnershipsbetweenLDDgroups,researchers,healthprofessionalsandenvironmentalhealthadvocates.
Cul6va6ngopportuni6esforinterestedgroupstoeducatepolicymakersonspecificbillsthatwouldeliminateneurotoxicants.
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LDDI: Specific Steps Forward
LDA,AAIDD,ASA,NADDini6a6ves “Prac6cePreven6on”columns LDDIScien6ficConsensusStatement LDDIPolicyStatement
Bi‐weeklye‐bulle6ns Na6onalcalls New:LDDIBiomonitoringProject
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LDDI Biomonitoring Project
Firstbiomonitoringstudyonahealth‐affectedgroup
11par6cipants Testedover60substancesinbloodandurine
Mediarelease Congressionalbriefing
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CHE Cancer Working Group
Scien6ficconsensusstatement Presenta6onsforPresident’sCancerPanel Factsheets
• IndustrialManufacturing• AgriculturalExposures
• Indoor/OutdoorAirPollu6onandWaterContamina6on
• NuclearFallout,Electromagne6cFields,andRadia6onExposure
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Science-based Policy
Somecurrentrelevantpoliciesunderconsidera6on:
‐TSCAreform
‐EndocrineDisrup6ngChemicalsAct
‐SafeCosme6cs(phthalates)
‐BPA
‐PBDEs
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Some stakeholder concerns Con6nuetoimproveCDCNHANES‐manychemicalsnotyettested,e.g.,thosewithshorterhalf‐lives
Addressexposurestomixturesandimpactonvulnerablepopula6ons
Includenonlinearandlowdose‐responseassessments
Makeconsciousdesignformula6ondecisionsearlyinriskassessmentprocess
Ensureexposureinforma6onisuser‐friendly
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For more information
JoinCHE‐www.healthandenvironment.org
Contactme: EliseMiller,MEd,Director Collabora6veonHealth andtheEnvironment(CHE) Ph:360‐331‐7904 [email protected]