Transcript of “299 with Dr Veech”

© The Bulletproof Executive 2013

Transcript of “299 with Dr Veech”

Bulletproof Radio podcast #299

Bulletproof Radio Podcast #299, Dr. Richard Veech

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Speaker1: BulletproofRadio,astateofhighperformance.

Dave: Hey,DaveAspreywithBulletproofRadio.Today'scoolfactofthedayisaboutKetosis.Didyou

knowthatyouralcoholtoleranceisseverelylowerwhileyou'reinKetosis?Thereareacoupleofreasonsforthat.Thefirstisthatthealcoholyoudrinkwhenyou'reinKetosiswillgetmetabolizedimmediatelybeforeyourbodykeepsburningketonesforenergy.Thecarbsinyoursystemthatarenormallyusedto"soakupalcoholinthestomach"andslowdowntheintoxicationprocessprobablywon'tbethereifyouaredrinkingwhileyou'reinKetosis.Nottomention,it'sdifficulttostayinKetosiswhileyou'redrinking.Yougottoaskyourself,"IsitreallyworthittohavebeerwhichisgoingtotakeyououtofKetosisorredwinewhichisgoingtotakeyououtofKetosisorvodkawhichmayormaynottakeout?"Idon'treallythinkit'sworthit.

Youdon'tgetalotofperformancebenefitsfromthosethings.Theycanbefun,therearelotsofotherwaystohavefunthoughtooaswell.Beforewegetintotoday'sinterview,whichisoneoftheLuminariesinthefieldofKetosis,thisisthebrandnewBulletproofinsta-mix.It'saproductI'vebeenworkingonforthreeyearstogetitmadejustright.Thisisamixofgrass-fedbutterandbrainoctaneoilthatwefinallygotintoastablepowderthatmixeseasily,justputitinasealedBulletproofcoffeemug,shakeituporhititwithalittletinyhand-blenderthing.YouhaveBulletproofcoffee,somethingyoucanbrewwithourKeurigcompatiblepodsorifyoujustmakealittleFrenchpressatyourdesk,theideaisyoucanhaveBulletproofcoffeeanywhereandthat'scoolbecauseit'sgotnocarbsthataregoingtotakeyououtofKetosisandbecauseittastesgoodanditdoesthosethings.Rightnow,hundredsofthousandsofpeoplerelyonBulletproofcoffeeinthemorningtogetalittlebumpintheirketones.

Theygetanunnaturallittlebumpbecauseofthebrainoctanethat'spartofthecorerecipe.Itworksdifferentlythanjustsay,coconutoil.I'vebeenworkingonthisforsolong,I'msostokedtobringittoyouwithoutanyofthecrapadditivessoI'mexcited.We'regoingtotalkaboutitandgoevendeeperintoday'sshowwithKetosisbecauseourguestisDr.RichardVeechwhoisseniorresearcherandlaboratorychiefattheNationalInstituteofHealth,andwinneroftheNIHDirector'sAwardwhichisveryprestigious.Hehasbeenworkingtounderstandthemechanismsbehindcellularenergyhomeostasisforthelast47years.Hehasgottwodegrees,adoctorateofmedicinefromalittleuniversityyoumayhaveheardofcalledHarvard,andistheforemostresearcherandexpertofallthingsKetoneesters.Dr.Veech,welcometotheshow.

Dr.Veech: Thankyou.

Dave: Whatdidyoubeforeyoubecomeamedicaldoctor?Whatdidyoustudyinyourundergradthatmaybegaveyouadifferentperspectivecomparedtotheaveragejust-doctor?

Dr.Veech: Asanundergraduateintheuniversity,Istudiedhistoryandliterature,whichwasaveryinterestingdepartment.Itwasfoundedbyachemist,CharlesY.EliotwhodecidedthateveryonethatwaseducatedneedtohaveknowledgeoftheBible,Shakespeare,Greekhistory,Greektragedy,Russiannovel,andaforeignlanguage.Youhadthree-houroralexams.Itwasverygood,verygood,verygoodundergraduateeducation.


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Dave: Youstartedoutwithsomethingthatisn'ttraditionalforsomeonethatwenttomedicalschool.

Youalso,alongtheway,gotaPhDasaresearchbiochemistaswell,right?

Dr.Veech: That'sright.Yeah.IdidthatafterIwasatmyresidencyinmedicine.

Dave: Thereareveryfewphysicianswhoalsostudybiochemistryatthatlevel.Whydidyoudecidetodothat?Idon'twanttosayalmostunheardof,butit'ssorareanditgivesyousuchadifferentperspectiveonthings.Whatmadeyougotothatlevelofeffort?

Dr.Veech: Well,ifyouhavebeenaninternandresidentandyou'veseenafewpeopledie,yourealizethatyoureallydon'tknowverymuchatall.Youbettergolearnsomemore.That'swhatIdid.Ilookedinabunchofdifferentlabs,Iendedupgoingtoalab,Ithoughtwasthebestintheworld,Ithinkthatwasright.ItwasatOxfordandIstudieswithSirHansKrebs.Heis,Ithink,stillthebestbiochemistofthecentury.That'swhereIlearnedmybiochemistry.

Dave: Forpeoplelistening,thisisnoneotherthantheguywhodiscoveredtheKrebsCycle,whichiswhyit'snamedafterhim,right?

Dr.Veech: That'sright.

Dave: ThisisthecoreofhowourcellsmakeenergyviaATP.Inmyownlosingof100poundsandgettingmybrainback,IreadallofKrebs'thingsandeverythingIcouldaboutthecitricacidcycletofindwaystomakeitworkbetter.Wow,ifyoufixedyourmitochondriaandimprovetheirperformance,evenasmallpercentage,itjustpaysdividendseverywhereinyourbody.That'swhyIwasamazedyouactuallystudywiththeman.

Dr.Veech: Well,theessenceofwhatwe'resayingandhowketonesworkispreciselyintheKrebscycle.Manymanydiseases,forinstance,you'retobecongratulatedforlosing100pounds.Peoplethatareoverweight,haveanimpairedKrebscycle.Theyhaveanimpairmentintheirentirecellandinasensejustdoesn'tworkverywell.KetonesbypassthatblockofPDH.Allofthethingswe'resayingaboutKetosisareapplicabletoType2diabetes,areapplicabletoinjury,toinfectionandevenanumberofdiseases.Forinstance,Alzheimer'sdiseaseisablockinPDHinthebrain.It'sacentralgatewayintotheKrebscyclebutit'sveryeasilydisturbed.Whenit'sdistrubed,youcangetaroundthatdisturbancebygivingketones.

AnotherthingI'dsayisketones,doctorstendedtofear...KetonesarediscoveredinGermanyinthe1880's.Peopleareafraidofthembecausetheyknewaboutdiabeticketoacidosis.Ontheotherhand,amannamedGeorgeCahill,whowasprofessorofmedicineatHarvardshowedthatthebrain,theonlysubstancethatthebraincouldusetoproduceenergyasidefromglucosewasketones.Hefurthershowedthatreally,ketonesoccurnormallywhenyoustarve.Istarveyouforfivedays,yourketonesareupto7millimolar.Thisallowsyoutolive.Manistheonlyanimalthatgetketosisnormallyandthat'sbecauseyou'vegotthisveryhugebrainthatyou'vegottosupport.Ifyouhadtosupportonglucose,you'dbedeadinsixdaysasitis.Anormalweightcanlive76days.Anobesemanlive,lessthan,definitely.That'sreallythesubstanceofketones.


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Thereisnothingdangerousabout,it'sanormalstateofman.BeforewehadMcDonald'soneverycorner,wefastedinbetweenthetimewewerechasingthemammothandwecaughtthemammoth.Inordertodothat,youneededtobeketotic.That'swhywehaveketosis.

Dave: Now,whenyousaythereisnothingdangerousaboutketosis,Iwonder,Iknowmanypeoplewhocangoinketosis,andtheystaythereforyearsandthey'rehappyasclams.WhenItriedanexperimentofextremelowcarbs,likeoneservingofvegetablesaday,therestfatandsomeprotein,triedtomimicanInuit-stylediet.Ididn'tdosowell.Iendedupinmybookrecommendingcyclicalketosiswhereyougointoketosis,youcomeout.Yougoin,youcomeout,ratherthanconstantlybeinginheavyketosis.DoyouthinkthereareriskstobeinginketosisforlongperiodsoftimeorisitsomethingthatjustworksformostpeopleandI'manexceptiononthatone?

Dr.Veech: No.SomeCanadians,nameofIcan'trememberrightnow,studiedtheInuitdiet.Theyatejustnothingbutfatandmeat,fatandmeat.Theyfeltreallysickanddidn'tdoverywell.

Dave: Yeah,that'stotallywhathappenedtome.

Dr.Veech: Yeah,theycouldn'tfigureoutwhatitwas.ItturnsoutwhenyougoupandlookattheInuits,theydrinkthebroth.They'reeatingalargeamountofsaltandsotheycangetawaywithit.IfyoudowhatyouthinktheInuitsaredoing,whichtheydidn'tdo,youdon'tdoverywell.Youfeelsick.

Dave: Yeah.

Dr.Veech: Icanremembertheman'sname.

Dave: IthinkIreadthattoo.Thereisalsotheso-calledanimalstarchcollagenwhichfunctionsinthegutasafermentablesubstrateforbacteriatomakeshort-chainedsaturatedfats.Ithinkatthetime,Iwasn'tusingmycollagenwhenIwasmakingbonebroth.TheInuitsweredefinitelyboilingwhalebonesanddoingalltheothercrazystuff.IthinkImadesomemistakesthere.Thecorethingthere,evenifwe'renotgoingquitetheInuitsideofthings,IhavetalkedtoDominicAgustinowhoIhavegreatrespectfor,andoftheotherresearchersinthisfield,Iwasanearlyketoneadvocate.Istilldon'tknowtheanswer.Irealizedtoreachthemaximumnumberofpeoplegoinginandoutofketosisseemtobethebroadestthingtoprovidebenefits.Istilldon'thavefromanexpert,"Everyoneshouldgoandketosisandstaytheremostofthetimeornot,"or"It'ssaferforthemtodoitbutit'suptothem."What'syourtake?YouhavemoreexperienceinthisthanhonestlyanyoneI'vemet.

Dr.Veech: Well,itdependshowyoudoketosis.Ifyou'redoingitwithaveryveryhighfatdiet,peoplecan'tdoitverylongbecauseit'ssounpalatable.Theycan'tstanditortheygetnauseousortheygetdiarrhea.That'soneway.Ifyou'rejuststarvingandeatingwaterandwhatnot,thereisnotaproblemwithit.Infact,you'reveryhungrierwithofcourseforfivedays;afteraboutfivedays,you'renolongerhungry.

Dave: Yeah.IknowthatwhenI'mdoinganormalhighfatdiet,thathungerthing,theinductionperiod


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yougetatketosisthatAtkinsIthinkfirstpopularized.

Dr.Veech: Yeah.

Dave: Itmakesyoufeel,liketheflu.Youfeelreallycrappy.WhatI'vebeendoingforthepast10yearsorsoisshortcircuitingthatbecauseIfinallyfoundtheresearchthatIthinkexplainsit.Thatwhenyouhavealevelofjusta0.05,aprettyfarcryfrom7millimolar.YourCCKandyourghrelin,theseareyourhormonesforfulfillment,forfeelingfullandyourcravinghormone,yourhungerhormone.Theygetshiftedbyjustasmallamountofketone.You'renotquiteinnutritionalketosisbutyou'rewayhigherthannormal.Allofasudden,allofthecarbfluthingsthatIwasusedtohaving,whereIjustfeelcrappy,theyjustwentawaybecausemyhunger,Iwasn'tcraving.Ididn'tcareaboutfoodthefirstdayIdid.ThatcomesfromputtingbrainoctanewhichgoestoBHP,whichthengoestoketonesinBulletproofcoffee.

Thereisnocarbs.Thereissomethingthatjustgavemealittlebumpofketones,notabigbump.Thatseemedtohelp,butwhatyou'retalkingaboutisgettinghugebumpsofketonesbecauseweknowtherearethreekindsofketonesthatareuseddifferentlyinthebody.Canyougointomoreaboutthedifferentkindsofketonesandthathungersuppressionthing?

Dr.Veech: Well,thesuppressionofhungerreallyisafunctionofbeta-hydoxybutyrate,acetoacetatedoesn'tworkverywell.Thethirdthingiscalledaketone,isacetone.Itreallyshouldn'tbecalledaketone.It'sverysmallinamountandithasacompletelydifferentmetabolicpath.You'vegottwomajorformsofketones,ketonebodies.Oneiscalledbeta-hydoxybutyrate,andoneiscalledacetoacetate.Now,ifyoueatalotofacetoacetate,itcanbemetabolized.Itdoesn'thavetheenergythatbeta-hydoxybutyrate.It'sgoingtogoand...

Dave: HowwouldIgoabouteatingacetoacetate?

Dr.Veech: Well,youcanbuyit.Therearepeoplethatmakeesterwithit.

Dave: Okay.

Dr.Veech: Idon'trecommendit.ReasonisKrebsinthelate1960'sshowedthatyoucouldtakeahurtheartthatwasn'tworkingandprofuseitwithacetoacetateanddidjustfine.Ifyoudidaworkingheartandyouprofuseitwithacetoacetate,itfailedimmediate,instantly.Ifyoufeditbeta-hydoxybutyrate,itpumpednormally.That'swhatwedidintheSATApaper.Thereasonisit'sgoinginthemitochondria.Whentheketonebodygoesinthemitochondriaandyou'regivingitacetoacetate,afteralittlecap,it'scalledNADcapulle,getsoxidized.Withbeta-hydoxybutyrate,itgetsreduced.Aremarkablethingaboutmetabolizingbeta-hydoxybutyrateisitreducedtheNADbutyouoxidizethenextstepuptheQ.YouincreasetheredoxspanbetweenNADHandQ,thatdeterminestheenergyatATP.

Thisiswhyyougetmoreenergy.It'swhytheheartgets38,Ican'tremember,38%moreenergywhenit'smetabolizingketonesbodiesanditiswhenit'smetabolizingglucose.ItoldaveryfamousbiochemistnamedHenryLardywhofindtheenzymeattheUniversityofWisconsin.Isaid,"Dr.Lardy,I'veincreasedtheenergyoftheheartby38%."Hesaid,"Idon'tbelieveyou."I


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said,"Allright,whatnumberdoyouwantmetochange?"Thereisjustpressureinvolume,thatjoules.Thenhelookedbackathiswork,hewaspreservingbullspermforthedairyindustry.Hefoundthatbeta-hydoxybutyratewasthebestsubstratehecameacross.Hecouldn'tunderstandwhy.Now,I'mtellingyouwhythathappens.

Dave: It'sbecausemitochondrialovethatstuffandspermareincrediblyincrediblyhighinmitochondriabecausetheyhavetoswimortheydon'tsurvive.

Dr.Veech: That'sright.Ifyou'retryingtoimpregnateacow,it'sveryimportantthatyouhavehealthysperm.ThedairyindustrywasveryhappyofLardy...Hehadaquestioninhisnotebook,heshowedme,"Whydoesthishappen?"HeneverwentintoitbutIjusttoldyouthereasonthatithappened.

Dave: WhatI'vediscoveredinmyownlifeis...ItakeaprecursortoBHB,that'sbrainoctane.I'veneverheardthe38%numberbefore.Ifeelsuchahugeperformanceupgradebecausetheplacewithmoremitochondrialdensityinthecardiacsystemisthepre-frontalcortex,Iactuallyfoundstudiesofmitochondrialdensity.They'reactuallyhardtofind.IdidatonofthiswhenIwaswritingmyBulletproofDietBooktoexplainwhydoIfeellikeIgotmybrainbackwhenIdothisversuswhyIdon't.IthinkyoujustnamedanumberthatIdidn'thaveinmyresearchwhichisannoying.38%betterfromhavingBHBpresentversushavingjustglucosepresent.

Dr.Veech: That'sright.MCTsorMidChainTriglycerides,theydo10%ofthat,thatgoesdirectlyintothemitochondriaandisdirectlyconvertedtoketone,probably90%ismetabolizedbybeta-oxidation.

Dave: Doesn'tthatdependonwhichMCTitis?Becauselauricaciddoesn'tworkatall,whichisthemostcommonMCT.

Dr.Veech: The8isthemaximum,togettomaximumketonebodyproduction...

Dave: That'swhat'sinbrainoctane.Allitisis8.Itakeawaythe10and12and6,yeah.

Dr.Veech: Sure,well,Imean,peoplelikeMaryNewportrecommendtheC12becauseittastesgood,coconutoiltastesgood.Fromabiochemicalpointofview,wedon'tcareifittastesgood.

Dave: It'strue.ThereisnoflavortoC8whenit'sproperlydistilled.Youcan'ttasteanything,it'saflavorenhancerbutbyitself,it'sevenlessthanaKonoloOilintermsofflavor.Iwouldeatifittastedlikeratliver,itdoesn'tmatterbecauseyoufeeldifferent.That'smywholeethos,I'deatabowlofgravelforbreakfastifthat'swhatmademefeellikethis.Whatyou'vedonethoughis,in47yearsofresearch,you'vealsoworkedwithsomeotherguyslikeDr.GeorgeCahill,whoisoneofthemainthings.CanyoutellmesomeofthestoriesaboutDr.GeorgeCahillandyourworkwithhimindiscoveringallthesethings?

Dr.Veech: GeorgeCahillreally,thisworkallcomesfromGeorgeCahillbecausehe,Itoldyou,wasthefirstmantoshowthatthebraincoulduseketone.Beforethat,beforehistime,itwasthoughtitcouldonlyuseglucose.Heshowedthatitcoulduseketones.Now,hethenwasagoodfriendof


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KrebsandwasinameetinginMinneapolis.HeaskedKrebswhattheredoxstateoftheNADPsystemwas.Nooneknew.IgottoOxford,Krebscalledmeinandsaid,"That'syourproject.TellmeabouttheNADP,andfreeratioofNADPandBHbecausethat'sinvolvedinallfatcensorsandreducingfreeradical."Iworkedforayearinplanningouttheanswer,whenIhadshowedittoKrebs,hesaid,"Well,thatcan'tberight."Isaid,"Well,itisright."Hedidn'tsayanythingabouttwoweeks.Hethoughtaboutitfortwoweeksandhecamebackandhestartedwriting.Thatwasthelongestpaperheeverwrote.ThatpapershowstherelationshipbetweentheredoxstatesofthethreegreatnucleotidesandhowtheyrelatedtoATPbecausetheenergyofATPisredoxenergy.

Anotherfactthatketonesdo,asidefromincreasingtheenergyofATPistheyincreasethereducingpoweroftheNADPsystem.IfyouhaveincreasedfreeradicalssayinParkinsonsdiseaseoraosteoporosis,orinanuclearbomb,thiswillprotectyoufromthatradiation.That'samajoreffect,theonlythirdmajoreffectofketonesistherealevelofdecreasedenzymeflammatoryreactionswhichisadifferentmechanism.

Dave: Theenzymeflammatoryeffectsofketones,Ilearnedaboutthoseinapaperjustalittlewhileago,Iwasblownaway.Theanti-radiationeffect,Ihadnoidea.Doesthisprotectyoufromallformsofradiation?

Dr.Veech: Inwhatyoucallionizingradiation,yes.

Dave: Woah.BasicallyIran,Fukishima,weshouldbedosingeveryonewithanythingthatraisesketones?

Dr.Veech: Absolutely.

Dave: Ohmygood.Okay.TheBulletproofDiet,Ijustsold100,000copiesoftheBulletproofDietinJapanwithouttrying.IamsothankfulyousaidthatbecausewhenIgotoJapantotalkaboutthis,Icantalkaboutthisbecausenoonehasofferedanykindofprotectionforionizingradiation.Youjustblewmeaway,Dr.Veech.

Dr.Veech: TheTokyoPowerCompany,Iactuallytrend,Japanesescientist.Theyreallyweren'tthatinterestedinit.Why?That'sIdon'tthinkquitewellbutwhatIwasinterestedinitwasaquestionofnuclearterrorism.Itseemsverylikelysoonerorlaterthatwe'regoingtohavearougenuclearbombsittinginLatvia,parkacrossmyhouse.Wehavenothingtoprotectourpolicemen.Ifyou'rewithinamile,aton,megatonbomb,you'redead.You'reashes,right?Inthisareaoutsideofthatwhereyou'regettingthefallout,thatshallmakeadifference.I'mveryinterestedwiththeuseforradiationforprotectionatNB-stockpile.

Dave: I'mblownaway.MygrandparentsmetontheManhattanprojectinChicago.

Dr.Veech: Really?

Dave: TheymovedtoLosAlamos.MygrandmotherisanuclearengineerandmygrandfatherisPhDphysicalchemist.I'maketoneguy,Ihadneverheardthisbefore,Dr.Veech.You'reblowingme


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outofthewaterhere.Thisissocool.

Dr.Veech: Well,thereismorecorrelationsinthat.Cahill'swifewasthedaughterofCrawfordGreenewalt.CrawfordGreenewaltwastheCEOofDuPont.HeistheonethatbuilttheplantthatHanford.AllofourabilitytoproducenuclearbombsinthesecondworldwarcamefromCrawfordGreenewalt.HewroteadefinitivebookonHummingbird.HeranDuPont.HedidthatinthemorningbeforehewenttorunDuPont.BrookChantandIwentuptovisithislab,inthelabinBloomington.AllhewantedtotalkaboutwasAlzheimer'sdiseasebecausehiswifehadAlzheimer'sdisease.Icansaythisnowbecausethey'rebothdead.Cahill'swifewasthegranddaughterofCrawfordGreenewalt.ShesuffersfromanddiedfromAlzheimer'sdisease.

Dave: Wow.

Dr.Veech: Ofcourse,hewasimportantinManhattanproject,very.

Dave: Very.

Dr.Veech: I'msurehewouldhavebeennotsurprisedatall.Hewasaveryverysmartmantosaytheleast.

Dave: Wow.Theconnectionstheregosofarback,thatlabatHanfordusedaprocessIthinkitwascalledthepermutex.Thatprocessforseparatingplutoniumiswhatmygrandfatherinvented.

Dr.Veech: Isthatright?

Dave: It'sstillusedtoday.Ohmygod.Permex,Ididn'tgethisnamebut...

Dr.Veech: Ifthatbook,theMakingoftheAtomBomb,thefirstfivechaptersarethebestthingthat'severbeenwrittenonthedevelopmentofphysicsinthatage.Thepeoplethatwereinvolvedinthat,KrebswasalsoabigfriendofNielsBohr.

Dave: Really?

Dr.Veech: Yes.

Dave: Ididn'trealizethephysicsguyswhereasconnectedwiththebiochemistryguysbackthenbecauseourbodiesarebiophysical,right?

Dr.Veech: Absolutely.Krebs,Bohrasyouknowinthequantummechanics,andhetalkedtoHisencher,theGermanswantedtomakeanuclearbomb.Hesaid,"Itwouldbeimmoralforphysicstobeturnedtosuchpurposes."Withinthreedays,hewasonaboatgoingtoSweden.ThentheBritishputhimonabomb-madeofabomberandflewhimtoEnglandwhereKrebsmethimintheauctiontocameloose.Krebsthought,theythought"Hereisthisbrainandwehavejustdestroyedit."

Dave: Ohno.


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Dr.Veech: Buthedidn't.Hecamebackandtheywerefriendsreallyfortherestoftheirlives.BothofthemreceivedaGermanPourleMéritenow.KrebsandBohrweretheonlyonesthatopposedtakingGermanyandturningitintoapasture.TheAmericanswantedtosay,"Listen,theseterribleNazisneedtobedestroyedandalltheirindustrygoes."KrebswhosefatherwaskilledbytheGermansbecausehewasaJew;ontheotherhand,hismother,hisstepmotherlivedforfiveyearsinGermany,washiddenbyaGermancitizen.Hedidn'tfeelthis,notallGermanswereravingNazis.HeandBohraretheonesthatpreventedGermanyfrombeingessentiallyagricultarized,destroyalltheirscience,destroyalltheirindustry.Hehadalotofplaquefromthatbutitwasclearlythemoralthingtodo.Hewas,afterWorldWarII,whatLincolnwastothecivilwar.YoucouldhavedestroyedalloftheSouthernersbutthebettercoursewouldbetoreconcile.Itwasn'tjusthisscience,itwashismorals.

Dave: Hewashumanitarianaswell.Wow.

Dr.Veech: Yes.

Dave: ThesearethingsIdidnotknow.I'mfascinatedtolearnthis.You'vealsodonesomeworkwithGeneralPetraeusaroundtraumaticbraininjury.Youhaveaprettyamazinghistoryhere.Tellmeaboutthat.

Dr.Veech: Well,mysonisaphysicianattheVA.HewenttoameetingwiththeVAtohearabouttraumaticbraininjurybecauseatthetime,about60%ofourcasualtieswereduetoIEDs.Hegavemethenotesfromthemeeting.Itwasnonsense.Itwasjustgarbage.Itwasawholebunchofpeoplestandingaroundtryingtogetmoneyfromthearmyandtheyhadnothingtodoexceptgettingmoney.ThisannoyedmebecausePetraeus,heisaPhDfromPrinceton.Hewentandsatthroughinthemiddleofthatandmore.Hesatthroughthiswholemeetingofnonsense.Isaid...It'sjustintolerable.Iwroteapaperonwhatthecauseis,howyou'rediagnosedandhowyou'retreated.Isentittohim.

He,atthattime,hadleftthearmyandwasheadofCIA.Igotaletter,averykindletterbackfromhimbecausePetraeuswasshotinthechestatafortinKentucky.ThesurgeonthatoperatedonhimwastrainedbyGeorgeCahill.IgotaletterbackfromthesaiddirectorofCIA,thestamponitsaid"Love",whichIthoughtwasveryamusing,alovestampfromthedirectoroftheCIA.I'msorryheleftbecausehewasa...Anotherfriendofmine,Dr.Newport.

Dave: MaryNewport?

Dr.Veech: Yes.

Dave: Shehasbeenaguestonthisshowtoo.Tellmeabouthere.

Dr.Veech: Well,wewereattheCosmosClubandIsawGeneralPetraeusinanothertablesoItookDr.Newportoverandintroducedhim.Hesaid,"Well,wemadealotofprogresswithtraumaticbraininjury."Isaid,"General,youhavemadenoprogresswhatsoever."IhadmytiecliponwhichwasanOxfordtieclipandlookedatthatandhesaid,"Whereisthatfrom?"Isaid,"That'sOxford."Hesaid,"Well,noteveryonecangotoPrinceton."


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Dave: Whatagreatguy,that'shilarious.

Dr.Veech: Yeah.Hereallyisveryveryverybright.HeunderstoodwhatIwassaying.That'sareasonIwrote

thatpaper.DARPA,thewholereasonwegotmoneytodotheketonescamefromDARPA,theDefenseAdvancedResearchProjectsAdministration,NIHhaveneverneverhasgivenmoneyforthiskindofmetabolicresearch.DARPAwanteditbecausetheywantedtoimprovetheperformanceofthespecialforces.

Dave: Yeah.

Dr.Veech: IreadthisstuffandItold...IwantedtoseethemanthatwroteitandIsaid,"Well,IknowDr.Blitzy,Idon'tknowwhowrotethisbutwhoeverdidthis,it'sfullofcrap."Hestartedlaughing.Hesaid,"Well,Iwroteit."Isaid,"Well,nottotallyfullofcrap,justhalffull."Hesaid,"Allright,whatwouldyoudo?"Iwrotehimathree-pagethingandsaidwhatIwoulddo.Hegaveme10milliondollars.

Dave: Wow.

Dr.Veech: That'sagoodscientistbecausemostscientistgetbentoutofshapewhenyoutellthem...Fullof...loadof...Hedidn't.Welearnedinthat,mycolleagueDr.ClarkwhoisinOxfordfoundthatnotonlydidtheratsrunmoreefficientlyonatreadmillbuttheirmazeperformanceincreased.Wewereabletoimprovethementalcapacity,thementalfunction,themazeperformanceoftheserats.Now,shehasalsostudiedOlympicathletes.Theycangrowfaster,well,longer.Keytonesdon'tdoanythingforsprintperformance,ifyou'rerunning100-yarddash,it'snotgoingtodoanything.Ifyou'redoing40-40orbetter,it'sgoingtohelpyou.Thesameis...Well,sinceit'samitochondrialsubstrate,itdoesn'tworkforsprints,everybodyislikesosad.Butitwillworkforbicyclingorrowingorthoselongdistanceinterimsports.

Dave: TherearecertainlyalotoftriathleteswhousetheBulletproofCoffeeidea,whichisawayofgettingsomeketonesinbecauseyoufeeladifference.I'mnotanenduranceathlete,Idon'teventhinkenduranceathleticsisparticularlygoodforyou.I'mplanningtohita180ifI'mlucky,notmilesanhour,that'syears.I'mcarefulwithmymitochondriabutIdoseethatineveryday,thereisacertainamountofendurancethat'sinvolvedifyou'regoingtooperateatyourmaximumcapacity.Itseemslikeanoticeabledifferencetome.

Dr.Veech: Ifyoujustlookatthegeneralquestionofageing,whichiswhatyou'retalkingabout,thecardinaltheoryinthegenerationofageingisfreeradicaldamage.

Dave: Yeah.

Dr.Veech: Thishasbeenknown.Ijusttoldyouthatketonebodiesabolishlargepartofthefreeradicaldamage.

Dave: Yes.


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Dr.Veech: NotonlywillthatworkinageingbutthatwouldworkifyouhappenedtobenexttoFukishima.It'sthesameprocess.Italsolowersthecholesterol.Itdecreasesthebloodsugar.Itincreasesyourhistonedeo-sete-lites.Itdecreasestheenzymeflammatoryreactions.Manyofthehallmarksoftheageingprocessareaddressedbyketosis.

Dave: Thereissomethingalittlebitscaryaboutthatthough.Therearestudiesthatshowforthingslikeexercise,ifyoutakeantioxidants,specificallyVitaminC,VitaminE,thetraditionalorthomolecularandantioxidants,thatyoudon'tputonmuscle.Thedamage,theshortburstofpro-oxinactivitythatcomesfromexercisecausesaresponseinthecellswheretheygeneratemoreSODandmoreglutathioneandthingslikethat,thatifyousuppressthat,youdon'tgetthemusclegrowth,youdon'tgettherepair.Doketonesdothesamethingastheseothercompounds?

Dr.Veech: Well,first,letmeaddressthequestionoftakingantioxidants.TheingestionofantioxidantslikeVitaminC,ifyourememberLinusPaulingwasabigproponentwiththese.Krebswroteinseverallettersaboutthis.Finally,IsawthelastbookhewroteandhesaidtoDr.Pauling,"Pleasequitlyingaboutthatwhatyoudonotunderstand."

Dave: Really?Thisisfascinating.

Dr.Veech: Thereason,youcan'tchangetheredoxstatebyfeedingantioxidants.ThereisawholelotofpeoplethatateQ.Allyou'redoingisincreasingthetotalpoolofQ.YouwanttochangetheratioofQtooxidizedQ.TheredoxstateofascorbicacidiscontrolledbytheNADPsystem.Theonlywayyoucancontroltheredoxstate,theonlywayIknowwaswithketosis.Youmustworkwithglucagon,youmustreducetheNADPsystem.Alltheseotherreducingagentsarenonsense.

Dave: IhaveacoupleothercompoundsthatareshowntochangetheNAD+toNADHratioinafavorableway.Twoofthemareinmycoreproducts,it'supgradedageingwhichisoxoloacetateandtheotheroneisauniqueformofPQQ.Theseareinterestinginthatthey'remessingwithbasicallyratioswithintheKrebscyclebutthey'renotclassicalantioxidantslikeVitaminC.

Dr.Veech: Theproblem,ifIcansayso.

Dave: Yeah.I'mveryinterested.

Dr.Veech: Oxoloacetate,it'sadicarboxylate.It'shardtogetinsidethecell.

Dave: Okaydeliverysystem

Dr.Veech: ThereareveryfewdicarboxylatesthatIgetinthere.Thevirtueofketonesisthey'remonocarboxylates.

Dave: Theygoinreallyeasy.

Dr.Veech: Theygoinreallyeasy.NowinQ,Ijustalreadyaddressedthatissue,thatisbyincreasingthepoolofQ,you'dneedn'tchangetheratioofoxidizedtoreduceQ.You'dmerelyincreasethe


13

totalamountofQ.Now,thatforanantigenicpointofview,let'ssayyou'rekindincreasedthedeltitudeofATP,you'vegottooxidizetheQandreducetheNADcouple.Thatgivesyouagreater...That'salldoneintheSOTOpaper.I'msureyou'vereadorlookatitagain.

Dave: I'lllookatitagain.Idon'trememberthat.

Dr.Veech: It'sgotdoublepictures,itwasdonebymycolleague,Dr.Hezariah.Hispicturesaremuchbetterthanallmyblab.

Dave: Well,I'llputthosepicturesoratleastalinktothepaperinthetranscriptionofthisinterview.Canyouexplainforpeoplelistening,alotofthemaredrivingtheircarsrightnowandthey'renotbiochemist,whatisQinthewayyou'retalkingaboutithere?

Dr.Veech: Qis...Themitochondriaissimplyaredoxmotor.Itstartswiththelowestredoxstateco-factor,it'scalled,whichisavitamin.ItiscalledNAD.

Dave: Yes.

Dr.Veech: Theelectronsareaccepted...Allyouareisfuelcells.You'retakingelectronsfromthesubstrateyou'reeatingandcombiningthemwithwatertomakeenergy.That'swhatyoudo.Now,thefirststepinthattransformationofenergyisgoingfromNADtoQ.Thedistance,theredoxdistancebetweenthosetwocouplesiswhattheterm"theDeltaG"ofATP.Youwanttowidenthatdistance.Now,ifyou'reeatingfats,saylikeAtkinsDiet,youreduceNAD,whichisgood.You'rereducingthat,producingmoreNADHtoNADHratio,butyou'realsoreducingQ.Thatdoesn'tgiveyouanincreasedspan.Youdecreasethespanandtherefore,you'reenergyislessened.Themagicofketonesisitreducesthefirstonewhileitoxidizedthesecondone.Idon'tknowanythingelsethatdoesthat.

Dave: Inmyentire20yearsoftryingtogetmybrainbackandworkingonlosingweightandall,I'veneverfoundanythingmoreimportantthanketoneseither.I'vespenthundredsofthousandsofdollarsonmyownsystem.I'vefoundthingsthatmovetheneedlebutthisislikea2%,5%orlikenow,Iknowthenumber,a38%.

Dr.Veech: Althoughdon'tfeelbad,I'vewasted30yearsdoingthis.Don'tfeelbad.

Dave: Idon'tfeelbad,IfeelfortunatebecauseIusedtohaveallkindsofproblemsthatIhavelargelyresolved.Idon'tthinkIstartedoutbiologicallythatstrongbutI'mbetternowat43thanIwasat23.That'snotnormal.

Dr.Veech: Right.That'sright.

Dave: You'vedonesomethingelsethatIreallywantedtozoominon.SomethingthatI'venevertalkedaboutthisbefore,butthreeyearsago,Ididpaytohaveketoneesterssynthesized.Itwasshockinglyexpensive.Igotonetinylittlevileofit.Isaid,"Thisisreallyneat.Ihavenoideawhatit'sgoingtodotomyliver.I'mjustgoingtotakeit."TherewasnoconceivablewayIcouldthinkoftosellthatstuffbecauseIdidn'tknowIcouldmakeitaffordable.It'sareallyneatideabutit's


14

notdoable.Hereitisthreeyearslater,Ifindoutyou'vebeendoingallkindsofcoolstuffwithketoneesters.CanyoutalkaboutwhatisaketoneesterversusthewaythatIdrinkketonesnow?Whatisit?What'sgoingonwiththatstuff?

Dr.Veech: Well,asyou'dknow,ketonebodiesareanacid.Theyarebeta-hydroxybutyricacid.Ifyou'refastingduringtheday,youmake150gramsofketonbody.ThatmeansifIgaveittoyouastheacid,I'dbegivingyou150molesofacid.Well,that'salittlebittoomuch.

Dave: Yep.

Dr.Veech: IfIgaveittoyouasasodiumsalt,I'dbegivingyou150gramsofsodium.Nowyou'recardiologistwouldshootme.You'reallowedtohave3grams,I'mgoingtogiveyou150grams.Theonlythingyoucandoisgiveyouabeta-hydroxybutyratewithacompoundcalledone-threebutanedialofaproperisomericstructure,thearformandjointhetwotogetherwheretheyhydrolizeitinthebody.Youcangetbywithouteitheryouexcessacidloadorincreasesaltload.That'swhatwe'vedone.Now,thenextquestionishowtomakethatcheaply?

Dave: Thatwastheproblem.Stuffwaslike$30,000apound,thewayIwasmakingthat.

Dr.Veech: Iknowthat.Youcan'tgotothedrugcompanies,they'reusedtomakepills.Youreallymustgototheagriculturalproducers.ThisisafoodandsoyoumustproduceitnotonlycanyounotgotoKoreaorJapanorIndiatobuythepre-cursorsbecauseyoudon'tknowwhatyou'regetting.Ifyourememberthestoryoftryptophan?

Dave: Yes.

Dr.Veech: TheEosinophilia–myalgia,MITkilled47peoplewiththatstuff.Youreallycannotusethat.Ifyoustartwithglucoseincornorsugarcane,youknowwhatyou'restartingwithandyouknowwhatyou'regoingtogetout.Youalsohavethecapacitytosupply...Let'ssayyouwanttosupply5millionAlzheimer'spatients,youwouldbreakthegovernment.Youmustgetthepricedown.

Dave: Yep.

Dr.Veech: Waywaywaydone.Theonlywayyoucandothisiswithatank,carquantities.Thisisnotapharmaceutical.

Dave: That'sexactlymypointwiththebrainoctane.Iwanttoputthatstuffoutthere.AnythingIcandotogetitmoreaffordablebecauseit'sthemostimportantthingIknowbutyou'retellingmetheremaybeanotherwaytodothiswhichiswhyI'msuperexcited.

Dr.Veech: Yeah.

Dave: HowdoIgettankorcarsofketoneesters?Arewethatclose?

Dr.Veech: Yes.


15

Dave: Okay.

Dr.Veech: Weknowhowtodothat.Therearementhatknowhowtodoit.Theyarechemicalengineers,I'mnotachemicalengineerbuttheymaketank,carloadsofthisstuff.Rightnow,they'remakingethmo,whichisworthless.

Dave: Yeah,awasteofcorn.

Dr.Veech: That'sright.They'remakinghighfructosecornsyrup,whichjustmakespeopleobese.

Dave: Wecanturnthatsamecornthatwe'rebasicallydestroyingoursoiltomakecorn,wecouldtakethatcornandinsteadofturningitintodiabetes...

Dr.Veech: Youcouldmakeketoneesters.

Dave: Forpeoplelisteningtothisrightnow,ifyouunderstandtheimplicationswe'retalkingabout,youshouldbepissedoff.

Dr.Veech: Alittlebit.

Dave: Yeah.

Dr.Veech: Yes,butbusinessmenaremainlymotivatedbyprofit.They'realsoextremelycautious.Whenyoutellthemsomethingnew,theketonebody,theDeltaGofATP,theyhavenoideawhatyou'retalkingabout,absolutelynone.Theyjustdon'tknow.Eventually,thisisgoingtohavetobedonebecausethegovernmentcan'tafford...Itcost$80,000ayeartokeepAlzheimer'spatientindiagnose.Thegovernmentcan'taffordthat.Eventhegovernmentcan'taffordthis.We'regoingtohavetodothis.

Dave: TheinterviewwithMaryNewportonBulletproofradio,Ithinkshewasnumber47,ifIrememberit,we'reataround300,sothisisawhile,shewasjusttalkingstraightuphowsheworkedwithherhusband.Eitheryouhaveitoryougoonaketosisdiet,youincreaseketonesinthebodyhoweveryouneedtoandthenyoudon'thavethesymptomsofAlzheimer's.Mygrandmother,whoworkedontheManhattanProject,sheis94.IfIcangetketonesintoherbodyassheusesbrainoctanestuff,shewatchescalculusvideosonYoutubeforfun.That'sawesome.Whenshedoesn'thavethatstuff,sheisnotherself.Sheisattheretirementcommunity,itdoesn'tdowhatshewouldnormallydo.Ivaluethat.Ithinkit'simportant.

Dr.Veech: Absolutely.Newportisright.Thisguycouldn'tlivewithoutmany...Hecouldgoabout...Well,shehaswrittenaboutitinthepaper.

Dave: Yeah.

Dr.Veech: YouimprovebehaviorthesameistruewithParkinsons.Parkisons,it'seasiertoseebecauseaParkisonian,manyofthemhavejustterribletremors.


16

Dave: Right.

Dr.Veech: Well,thesetremorsgoaway.

Dave: That'swhereketonesturnoffthetremorsinParkinsons.TheyturnoffalotofthebraindeactivationinAlzheimer'syou'resaying?

Dr.Veech: Yes.Yes.

Dave: WhataboutALS?Ihaveagoodfriendthat...

Dr.Veech: Wewouldliketotreatthat.Theproblemwiththat,it'slikeParkinsons.It'safreeradicalcauseddisease.IfyoustarttreatinganALSpatient,andhegetsbetter,let'ssayyougethimoffhisoxygentube,youcan'tstop.WecouldmakeenoughketoneestertotreatMaryNewport'shusband,onepatient.Unlesswegetindustrialcollaboration,sothereisnowaywecanstartALSuntilI'vegotafirmsupplybecauseyoucan'tgobackandsay,"Well,Mr.Jones,youdidalotbetter.We'regoingtoputyourtraytubebackin."

Dave: Yeah,they'renotgoingtogoforthat.Oneofthethingsthatis...Therearecorrelationswithallthese,especiallyALSisneuro-toxinexposurethatismitochondrialpoison.Theseareenvironmentalthingsmadebymothernatureormadebyusbuttheyinhibitmitochondrialrespiration.Thenpeoplegetsick.Theyarethefatsolubletoxins,andtheymostlycomefromeitheralgaeortoxicmold.Iknowinmycase,alotofmysymptoms,Igrewupinabasementwith Stachybotryswhichinhibitsmitochondrialrespiration.Okay,Ididadocumentaryaboutthedangersofwaterdamagedbuildings.Iseecorrelationsallthetime.WithALSverspecifically,thealgaederivetoxins.Butifyoucanfixmitochondriabyusingketonesinsteadofusingglucose,youbypassthedamagepartofthem.

WhenIgooutofketosis,whenIstopusingbrainoctane,Idon'thaveatleast0.5inmyblood,mybraindoesn'tworkthewayitdoesnow.Everysingleday,IdoBulletproofcoffee,everysingleday,IdonottoomuchsugarbecauseIlosemyabilitytofunctionthewayIdonow.I'mnotgoingtogobacktothatbutIthinkIhavesomemaybepermanentdamagetomymitochondriafromtoxinexposure.IthinkourfriendswithALSaredealingwithsomethingsimilar.

Dr.Veech: Yeah.Forreasons,Isaid,wehaven'teven...

Dave: Youhaven'tevengoton...

Dr.Veech: Youcan't...Well,Imean,I'dlovetodoitbutuntilwehaveacoupleoftonsinthebackroom,Ican'tdoit.

Dave: Maybethereisawaytohelp.IfIcan,Iwill.Wecantalkaboutthataftertheshow.Thisisimportantto,notevenjustthecountries,thecountriesbutthewholeworld.Wehavesomanypeoplewhoareageing,thisisn'ttheproblemwecanignore.Idon'tthinkit'saproblemthatdrugcompaniescansolvebecauseiftheytryandsolveitwithdrugs,noonecanaffordit.It's


17

gottobeafood-basedthing.Itlookslikeyou'vegotsomethingprettyspecialhere.Let'stalkaboutitalittlebitmore.Whataboutketonesalts?There'scompaniesmakingketonesalts.Wetalkedalittlebitabouthowyoudon'thavetohavehugeamountsofsodiumbutyougetmagnesiumandpotassiumandthingslikethat.Whathappensifyoutryanduseketonesaltstomaintainketosis?

Dr.Veech: Well,youcan'tgivethatmuchmagnesiumandsoyouendup...

Dave: Disasterpants.

Dr.Veech: Yeah.Yougettoomuchsaltandyourcalciumandpotassiumwillkillyou.Youreallyhavetohavesodium.Theadvantageofketonesaltsiftheyhaveaverygoodtaste.Theproblemisyoucan'tgetadequatelevels,theKMtogetinthebrainis5millimolar.You'dbeluckytoget.1withtheketonesalts.Furthermore,theketonesaltsthatarebeingsoldareracemicmixtures.They'renot...Theonlyketonethat'seffectiveistheD-form.TheDLiscompletelydifferent,itmetabolizedinbeta-oxidation.It'sactuallyharmful.Youcan't...It'sdumbforconvenienceofmanufacturing.It'scheapertousetheracemicsalt.Well,fine,buttheeffectsarenotonlynottrue,butcouldbeharmful.

Dave: Forlistenersrightnow,inbiology,therearebasicallydifferentshapesofmolecules.Oneisamirrorimageofmolecule.Whenourbodiesmakestuff,theymakeoneimage.Whenwemakeitinachemistrylab,halfofthemarethenaturalimageandhalfofthemaremirrorimages.Ifyoutakethemixofthosetwo,ithasadifferenteffectthanifyouuseonlythenaturalone.Dr.Veechissayinghereisthatbasically,you'reusingamirrorimageoftheketonesaltthatwouldbehelpful.That'saproblem.Formanufacturerslikemewhomakesupplementsandfoods,itismuchmoreexpensivetofilteroutsoyou'llonlygetthenaturalonesandyouthrowawayorrecycletheonesthatareunnaturaleventhoughtheymightbeharmful,theymightnotbeharmfulbuttheygetintheway.

Dr.Veech: Yeah,well,whenyouholdupyourhands,you'regivingtheperfectillustration.Thoseareracemic,thoseareraceme.They'remirrorimagesofeachother.Thebodywilluseonebutnotusetheotherorifitusestheother,itwilluseitinapathwaywhichisdifferentthanthispathwayandyoumaygetunwantedconsequencesfromusingthispathwayversusthatpathway.Ingeneral,usingracemic,it'sanextremelyrarecompoundwhereracemitescanbeused,thebodyisdefinitelyverycandid.

Dave: You'rerecommendationthen,andIdon'tputwordsinyourmouth,sotelltheexactmethisexactrecommendationisthatpeopledon'tuseketonesalts?

Dr.Veech: Yes.No,don'tusethem.

Dave: Allright,that's...

Dr.Veech: Youcangetahighenoughlevelandtheydon'ttellyouwhattheyare.Theydon'ttellyouwhat'stheDortheL.Theysayjustsaybeta-hydroxybutyrate.Well,fine.Theanswerisno,thoseareon-saleandyoucanbuythem.Myrecommendationisdon'ttouchaboutthe10-footpole.


18

Dave: Okay.I'vecertainlytriedvariousones.IdofeelalittlebitofenergybutIalsofeelusuallyabitof

aheadacheandI'veseensomestudiesonliverfunctionthatwereconcerning.Isthatsomethingyoupayattentionto?

Dr.Veech: Yes,ofcourse.We'retestingitagainbutit'smyimpressionthatyoucouldactuallyprecipitateParkinsoniancrisisbygivingtheseracemicsalts.Inotherwords,you'reinterferingwiththemetabolismoftheD-form.You'reinterferingthepenetrationoftheDintoofthebrain.They'recompetingforthemonocarboxylatetransport.You'reinhibitingthatandyou'realsometabolizingtheisomericformthroughbeta-oxidationwhichifyougoback,reducesQ,whichisnotwhatIwanttodo.Iwantedtooxidize.

Dave: Wow.Okay,that'sprettyscary.Theketonesaltisallafront.IfacompanycameoutwithonethatwasonlytheD-form,whatwouldyousay?

Dr.Veech: Wow.Howhighcanitget?

Dave: You'resayingtherewilljustbetoomuchsaltandnotenoughketone?

Dr.Veech: Yeah.

Dave: Okay.

Dr.Veech: Right.

Dave: Ihearwhatyou'resayingthere.Youmightgetaslightbumpbutlet'stalkaboutsaltthenbecauseifyouareinketosisbecauseyou'reeating,sayliketheBulletproofdiet,whereyou'regoingtoketosismuchofthetimebutnotallthetime.Howmuchextrasaltdoyouactualreallyneed?

Dr.Veech: Well,youdon'tneedallthatmuch.Whatyoudoneedispotassiumcitrate.Youneedtosupplementthatbecausewhenyou'reketonic,youdecreasetheurinaryexcretionofuricacid.Ifyou'reinketosisforquiteawhile,youcanelevateyoururicacidandactuallyprecipitategout.Itwouldbeagoodideaifyou'reketoticeitherfromyourBulletprooforanyothermeans,thatyougotoavitaminshopandbuy50mgcapsulesofpotassiumcitrateandeatthosebecausethatwillallowthekidneytoexcretetheuricacid.

Dave: Howmuchpotassiumcitratefortheaveragepersonwouldyourecommend?

Dr.Veech: 50gmaybeonceortwiceaday.

Dave: Youmeanmilligramsright?

Dr.Veech: Isitmilligrams?Oh,allright.

Dave: Yeah.


19

Dr.Veech: Whereismybottle...

Dave: Theyonlysell99mgcapsulesofmostplaces

Dr.Veech: Isaid50mgbutthat...

Dave: Okay,cool.

Dr.Veech: Areyousure?Isthatright?Yeah,allright.Billsaysit'sright.

Dave: Okay,cool.

Dr.Veech: IgottoalittleslipupIslippedbothhands.

Dave: Thathappenstomealot.That'sanormalsciencething.Ithinkthat'swhytheHubbletelescope

didn'tworkthefirsttimebecausethatwasunitconversationsbutanyway...

Dr.Veech: Yeah,wellso,butthat'stheonlysaltthatIthinkyouneed.Noteveryoneneedsit,particularlymalesaremoresubjectedtogout,sofemalesmightnot.Butyouneed.Ifyou'regoingtogetketonic,youneedtoperiodicallywatchyoururicacid.

Dave: Yep.Youcandothatwithaurinaryteststrip.

Dr.Veech: Yeah,foruricacid,that'sright.

Dave: Now,what'syourfavoritetestforketonelevels?

Dr.Veech: Onlythebloodtestmatters.Urinetestsareworthless.

Dave: Whyaretheyworthless?Imean,they'renotnearlyasaccuratebutthey'rebetterthannothing,aren'tthey?

Dr.Veech: No.

Dave: No?Ilovehowbluntyouare.Okay.Whyaretheynotbetterthannothing?

Dr.Veech: Becausetheydon'ttellyouatallwhatthebloodlevelis.Theyjusttellyouhowmuchisintheurine.OneismadebyAbbott,it'scalledPrecisionExtra.

Dave: Yeah,Ihavethat,Accu-Track.

Dr.Veech: Nova,thereisaNova.Frankthinksit'sgoodbutIcalibratedthePrecisionExtraanditcalibratesprettygooddownto.2millimolarbutI...Hethinkstheotherisprettygood.Theotheradvantagetothesecondform,theNovaisit'scheaper.


20

Dave: Ihaven'ttriedthatonebutmyPrecisionExtraone,Iliterally...Ididthistest,andgrantednequals1andnotwell-controlledbutI'mabio-acc,whatI'mdoingisthemostimportantthing.

Dr.Veech: Yeah,soIthinkyoushouldtestthat,absolutely.

Dave: Idid.Iateapoundofsushiofwhitericefordinner,getoutofketosis,right.Nextmorning,emptystomach,fasted,fromdinnerbefore.Ihadputtwotablespoonsofbrainoctane,atablespoonofbutterandIblendedupmyBulletproofcoffee.Idrankitahalfhourlater,.6,right.

Dr.Veech: That'sverygood.

Dave: Thatwasenoughformetogo,"Okay.Myhungeristurnedoff."ThentheCCKandtheghrelinnumberschanged.That'snotnutritionalketosisthough,that'sonly.6;youcangoupto7.0,I'ma10%ofthat.Butthatmuchmattersforme.

Dr.Veech: Itdependswhatyou'retryingtotreat.

Dave: Whatarethedifferentlevels?Whatmatters?

Dr.Veech: Ifyou'retryingtotreatAlzheimer's,Iwouldgoto5.

Dave: Thehigherisbetter,okay.

Dr.Veech: Ifyou'retryingtoParkinsons,I'vegotasickguywith16yearsofParkinsons.Hegets...Histremorstoppedat.3.

Dave: Wowthatlow,.3,okay.That'srelativelyachievable.

Dr.Veech: It'samazing.

Dave: IfIcangetsomeoneto.3withtheexistingstuffonthemarket,I'mnotverygoodatwhatI'mdoing.

Dr.Veech: That'sright.Itwillruinyourbusinessbutthat'sallright.

Dave: I'mjustsayingit'sgood,.3issoeasy.

Dr.Veech: Heinfactusesaformula,whichifthat'soneofyou...

Dave: Thatjustmakesmetohearthat,thatpeoplearebenefitingthatway.

Dr.Veech: HeisonmaximumParkinsonsmed.Heisondopacarbodopa,anNAOinhibitor,MCOTinhibitor.Heishereifyouwanttotalktohim.

Dave: Ohmygod.That'sincredible.


21

Dr.Veech: Comeoverhere,Bill.Hehashad16yearsofParkinsons.Whenhecametothelab,hecalledmeayearorsoagoandsaidhewantedsomething.Isaid,"No,Ican'tdoanything.Ican'tdoanythingforyou.Wedon'thaveenoughstuff,goway."

Dave: Oh,no.HeyBill.

Dr.Veech: Hekeptcomingbackandafterhewenttothecornerofthelabandjumpedupanddownbecausehehadspasmandheshapedlikealeafand...

Dave: Wow.You're16yearsofParkinsons?

Dr.Veech: Yeah.Well,tellhimandthat...

Bill: Well,it'sbeensince2000.Canyouhearme?

Dave: Yeah,Icanhearyou.You'reusingalltheParkinsonsmedsandyou'reusingmildketosisormaybedeepketosis?

Bill: IwouldbeinDr.Veech'slabandI'dgostandinacorner,jumpupanddown,trytodoanythingtogetridofmydistonia.Ihadawholelotoftroubleconcentrating.Ihadtohavesomebodydrivemetohislab.Hegottiredofmejusthavingallthesesymptoms.Hehadreceivedane-mailfromDr.Siefred,isthatwho...?

Dr.Veech: Yeah,Siefred.

Bill: Hewassaying,"Youknow,ifyoutrythisBulletproofcoffeerecipewiththeKerrygoldbutterandthecreamandtheSteviaandthecoconutoil.

Dave: Yeah,thebrainoctaneoilprobablyorareyoudoingjustplaincoconutoil?

Bill: Well,Siefreddidtherecipewithcoconutoil.

Dave: Gotit.Basicallyit'sacoffee,thefattening,gotit.Okay.

Bill: Yeah,Itriedthat.Ikepttrackofallofmysymptoms.EveryhourandIwouldaskmyselfthequestion,"DidIhavethissymptominthepasthour?"Attheendofthefirstdayonthatcoffee,IlookedbackandIcrossedabout8differentsymptoms.Therewasonlyonethatitdidn'tprettymuchhelpedthoroughly.

Dave: Yeah.

Bill: Thatwasthedyskinesia,that'scausedbythemedicine.

Dave: Iguessyou'restillusingthattoday?

Bill: Yes.IhavestartedtakingmoreoftheMCTwithit.


22

Dave: Letmesendyousomeofthebrainoctanebecausewe'vegotastudythat'scomingout.Ithasn't

beenpublishedyetbutitappearstodoaboutthreetimestofivetimesmoreketoneproductionthanyou'dgetfromcoconutoilorMCTs.That'swhyIhadputitintheofficialBulletproofCoffeerecipe.ThenumbersshowtherebutI'llsendyouabottleofthatjusttotrybecauseI'mstokedtoseeanyonewhohashadParkinsonsfor16yearswhoisusingahigherfatketosisgeneratingthing.LetmeseeifIcangiveyoualittleboostthere.

Bill: That'sgreat.

Dave: Well,congratulationsonyoursuccess.That'samazing.Whatanincredibleoutcome.I'mblownaway.It'ssocool.Let'ssee.WhatelsewasIgoingtoaskyou?Okay,withouttheketoneesterformthatyou'reworkingonandtheonethatIfiguredthatwas$30,000apoundthewayIwastryingtomakeit.

Dr.Veech: Yeah.

Dave: That'swhyIhadonedoseofitbecauseI'mnotmadeoutofmoney,right?Whatcanpeopledotodaytoraisetheirketonelevels?Whatdoyourecommendifsomeonecomestoyouandsays,"IhaveametabolicproblemorjustIwanttobeanathlete.HowdoIgetmyketonesup?"

Dr.Veech: Well,I'dprobablytellthemwhatItoldBill,"Goaway.Idon'thave..."HecametothelabsoIhadto.Hewouldn'tgoaway.

Dave: Yeah.

Dr.Veech: Whatwereallyneedtodoiswhatyousaid,weneedtogetpro-do-xin.TheproblemwithrecommendingahighfatdietisthatcertainpatientswillgetincreasebloodcholesterolsorincreaseLDL.Thelastthingyouwanttodoisprecipitateamonocarbonfunctionsomeofthese,forinstance,atNHI,youtreatepilepticswithahighfatdiet.Theywon'tgiveahighfatdiettoanypatientover70-yearofage.Theywon'tdoitforfearofcardiaccomplications

Dave: Thatseemsabitridiculousgivensomeofthenewersciencecomingout.Imean,MarkHighmond,ClevelandClinic.Thereissomanybigthingscomingoutsaying,"Dependsonthekindoffat,dependsonwhatelseisinthefat.Isthatfatdamaged?"

Dr.Veech: IcansendyouthepaperfromJohnHopkinsfromFriedrich.That'stheMayoDietthatsaysthatyouelevatethecholesterol.Whenthecardiologistshearthat,youcanputallthepapersyouwantto,theydon'twanttohearyou.

Dave: Yeah,theydon'twanttohearyou.Thenewerpapersaresayingthatcholesterolisnotwhattheythoughtitwas.

Dr.Veech: Well,IcouldagreewiththatbutIwouldsimplysaythatyoudon'twanttowilly-nillywayspeople'sketonesbyfatwithoutkeepinganeyeontheirbloodlipids.


23

Dave: Andtheirinflammationtoo,right?

Dr.Veech: Yeah,that'sright.Thecurrentcountryrunsonstocknews.

Dave: Yep.

Dr.Veech: You'renotgoingtochangethat.Cholesterolisabadthingwhetheritactuallyisornot.

Dave: WhatIfoundisthatwhenpeoplegoonthespecificBulletproofdietwhichisasetofprotocols,it'snotaproduct-basedthing,it'salifestyle,thatthey'reincreasingspecifickindsoffatbutnotallfats.They'reavoidingcanola,they'reavoidingtheOmega6'sthatcausearachidonicacidandotherinflammatorythings.They'renotdeepfryinganythingthewayAtkinswouldhaveallowed.You'renotgettingdamagedfats.Whentheydothat,andtheyavoidcertainotherinflammatorycompoundsandfoods,mostlyprotectiveelementsinplantsthatarehardonus,thattheircholesterollevelsmaygoup,theymaystaythesame,theymaygodown,butverypredictablytriglyceridesplummetwhenyoudothis.You'renoteatingfructose,sotriglyceridesgodown.That'sprettyeasytounderstand.

ThemarkersthatIpaythemostattention,homocysteine,psoriaticproteinandLPPAL2whichisamarkerofdamageatthearteries.Thoseguysdrop.Iftheydon't,wehaveamethalationproblemthatyoucanaddresswithotherthings.Inamajorityofpeople,that'swhatIexpecttosee.Ifyou'redoingyourlabs,youhavenoideawhatyou'refastisdoingtoyou.Youhavenoideaifthedietisworking.Ifyoudoyourlabs,wheretheproblemisnow,ifinflammationismostimportant,wedroptheinflammation,everybodywins.Ifcholesterolismostimportant,ifitdidgoup,ifyou'reoneofthosepeoplewhereitdoesgoupandstayup,alotofpeoplegoesupanddrops,okay,thenwhatdoyoudo?Myinflammationjustdroppedandmycholesterolisup,whichoneismostimportant?

Inmyworld,inflammationismostimportant.IfIcan'tseeanydamagetomyarteries,thenI'mprobablynotgoingtohaveamitochondrialinfarction.Thenthereisadebatethis.It'sveryfairtosay,that'saframeworkofthethatIworkwith.

Dr.Veech: Yourproblemisyouknowtoomuchbiochemistryandthedoctorsdojustcertaintestsandtheydon'tthinkabouthomocysteineor...You'renotpreachingtothechoir.You'repreachingtoaband.

Dave: Okay.

Dr.Veech: Allofthethingsyoumentionedaboutinflammationandthepsoriaticproteinareofcourseextremelyimportantbutthosearen't...Amerch...

Dave: Yeah,they'renotmainstream.

Dr.Veech: Makesmoneysellingstatins.Theypushstatinsforever.

Dave: It'strue.WhatI'mlookingatisisbecausetheBulletproofdiethassoldacoupleof100,000


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copiesandit'sinfourlanguages,Ifeelverysolidinmyscience.Iliveinthisstuff.Mywife,mykids,mywholefamily,wealldothis.ItrackthenumbersandIbelieveit.Idon'twanttobeself-deceptivelybelievinganything.AnytimeIgetachancetotalkwithsomeonewhohasactuallyworkedwithKrebs,ifyoupokedholesinthattheory,I'lltellpeopleaboutthoseholesbecauseIbelieveit'sreallyimportant.Wecandothiswithoutdrugs.Wecanusedrugsselectively.Drugsarenotabadthing.Theycansavelives.Theyhavesavedlives.Theyhavealsotakenlives,justlikefoodpoisoninghastakenlives.Foodisn'tgoodorbadbecausesomepeoplediefromit.Idon'twantususingdrugswhenweshouldbeusingfood.Thatwasjustabio-hack.

Dr.Veech: Certainthingsyoucandoonlywith...Idon'tcallthemfood,Icallthemsubstrates.Therearecertainsubstratesthatareessential.It'snoteasy.Idon'tknowawayIcouldmakethosechangesinmitochondrialenergyproductionbyusingpharmacologicagents.Icanonlydoitbychangingsubstrates.

Dave: Well,inmyworld,assomeonewhohadIbelievemitochondrialdamage,alotofmetabolicdisregulationandinflammationandjustautoimmuneconditions,limedisease,fibromyalgia,chronicfatiguesyndrome,allthosethings,I'vehadmercurypoisoning.Tobesittingheretoday,IdoeverythingthatIcanfindinapaperthatsaysit'sgoingtoincreasemymitochondrialfunction.Idoinfraredlightstimulation,UVexposure,allsortsofweirdstuff,cryotherapy.Basically,IstackeverythinginmyfavorbecauseIplantolivealongtimeandIliketofeelgood.VeryfewpeopledothatandIhavetosay,thenumberonethingthat'smaybethebiggestdifferenceinmyenergyisgettingmyketonelevelsup.Notupto7,I'veonlydonethatafewtimes,butjustup.I'malsonottreatingoneofthediseasesthatyou'retreating,thatstuff.I'mjustlookingforit.Yougavemethenumber,thenumberis28%.Ithinkearlier,weweresaying38,butit'snot,it's28%.

Dr.Veech: Yeah.That'sright.

Dave: Ido.NowthatIhearthatnumber,Irememberlooking,somethingaboutnumberofelectrons,itgoeswaybackintotheearlydaysofwhenIwasreadingabout,somethingaboutthenumberof...Theamountofcaloriespergramoffatsversuscaloriespergramofcarbs.Whenyoueatagramofsomething,thereismoreenergyinfat.We'resayingisfromketonesspecifically,thereisadifferenteffectthat's28%.

Dr.Veech: Whenyoueatfat,it'strue,dieseloilhasmorecaloriespergramthansugar.

Dave: Yep.

Dr.Veech: However,whenyou'reburningfat,you'regoingthroughbeta-oxidation.OnereducingequivalentgoestoNADandonegoestoplavoprotein.You'vealreadylost1/3ofyourATPinthatstep.Gobacktoyourlennature,beta-oxidation,youdooneNADH,youdooneNADH,youdooneplavoprotein.Youdothattokeepfromblowingthemitochondriaup.

Dave: Physicallyblowingitup,right.

Dr.Veech: Well,justtoomuchenergy.


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Dave: Right.

Dr.Veech: You'rerunning,you'rerunningthevoltageacrossyourmitochondrialmembraneforfour

electronsisabout140to160millivolts.Ifyougotitupto180,youwouldhearabunchofpops,likepoppingacondenser,youcan'tputthatmuchvoltageacrossamito....It'sonlyalypoproteinmembrane.

Dave: Yeah.

Dr.Veech: Youcan'tputthatmuchvoltageacrossit.Itwillblowup.

Dave: It'slikeacar.Ifyou'rerunningnitrousoxideandyoudriveacar,you'regoingtoblowagasgetsomewhere.

Dr.Veech: That'sright.

Dave: Isthereariskofthis?ThisissomethingIhaveaskedmyselfwhenIgotosleepatnight.Ididn'tactuallyspendanytimeworryingI'vehackedthat.IthinkaboutstuffandifI'vemaximizedmymitochondrialfunctionsotheyburncleanlyandI'vebasicallymovedtheratiosothatI'mmakingthemostenergyIcan.OneperspectiveisthatI'mgoingtowearthemout.TheotheroneisandtheoneIfavor,butIdon'thavegreatdataonthis,isthatI'mlesslikelytogetcancerwhenmymitochondrialrunningatmaximumcapacity.I'llprobablylivelonger.AmImakingafundamentalerrorthere?

Dr.Veech: Ithinkso.

Dave: Okay.Iappreciateyourperspectiveonthatbecausesomeofthisisunknown.Idon'tknowanyonewhospent40or100yearsoftheirlifeinmildketosisprettymucheverysingleday.That'swhatI'mgoingtobedoing.I'vebeendoingitforthelast10years.I'mnotstopping.

Dr.Veech: FrankYosaHeisquiteinterestedinmakinghimselfketotic.Hecangive...

Dave: Whoisthis?Imusthavemissedonebeforethat.

Dr.Veech: FrankYosa.You'vespokentohimaboutalotofyoursystems.Hecangetketonelevelsallupto8,whichis...That'shighenough.

Dave: Hegotupto8andheisdoingthatjustwithfator...?Howishedoingthat?HeyFrank.

Dr.Veech: Here,Frank.

Frank: Myfamilyisvegan.Wedon'tneedtogointodebateonthat.

Dave: Iknow.Thereisnoneed.Thereisnoneedonadebateonthat.


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Frank: IusetheBulletproofC8inthemorning.IwasexperimentingwithdifferentamountsofMCT8withcoconutoil,seeinghowhighIcouldgoandseeingifdoingitafteranovernightfast.Iwasdowninthe1andthe2's,hewasfreakingout,"Howareyouabletodothat?"IfI'mtweakingit.Theotherday,Isentthemamessagesaying,"Hey,myketonemeterhassomethingniceitwantstosay.Hi."Wemaxeditout,8.Hegoes,"Goeatanapple."IatehalfofapeartobringitbackdownbutIhithightwice.Rightnow,I'mprobably5.5.it'sonavegandiet.Itcanbedone.It'snotaketogenicdieteither.It'sjust...

Dave: You'renotdoingalowcarb?Soyou'reeatingsomericeandsomesalt?

Frank: I'mabsolutelydoinglowcarbs.

Dave: Doinglotsofgreenvegetablesandlotsofbrainoctanebasically?

Frank: Yeah.I'mjustremovingbread,pasta,chips,justthosebasiconesthatareoftentimesastaple,justoffthetable.Thenjustalotofavocado,Macadamianuts,wallnuts,alotofnuts.Coconutflakesismyfavoritethingatnight.IfIreallyneedsomething,it'sgotthecrunch.I'mstilleatinghummus,blackbeans.

Dave: Wow.

Frank: Yeah.

Dave: You'regettingsomecarbs,okay.

Frank: IfIgetachipandIhavetodoahugehummusonit,yeah.Thehummusisstillinthereto...

Dave: Youmakethehummusyourselfwithbrainoctaneinitorno?

Frank: No,Ido.Myfirstexperimentwasjustthemorningandthencheckingmylevelsatdifferentintervalsafterward.Thennow,I'vestartedactuallyinjustasquirtofitatlunch,justasquirtofitatdinnertime.Iusedtobeconkedout.I'dputthekidstobedat8PMandyou'dlaydownwiththem.It'slikeI'moutandthenitmessesupmyentiresleep.ThenwiththeMCT,it'sbeenanoticeabledifferent,I'mnotconkedoutat9:00.

Dave: Therearemorethanafewvegansusingbrainoctane.Iwasarawveganforawhile.Bytheway,peopleliketothinkIliketohateonvegans.Idon't.I'vebeenavegan.Iwanttonotkillanimals.Ijustwanthealthysoilandallthatstuff.Yeah,ifyou'regoingtobeavegan,Ithinkhavingsomeketosisinvolved,likemassesofavocadosandmacadamias...AlotofwhatIwaseatingwhenIwasarawvegan,wasn'tfullyketosisbutIwaslike,"I'mgoingtodieifIdon'tgetfat,"becausemymetabolismwaswrecked.It'samazingthatyou'vehit8.You'rethehighestketoneveganthatI'vemetsofar.Congratulations.

Frank: TheonetrickthatIfoundwas...Becauseobviously,thereisaGIproblemwiththeMCT8,youcouldtakealittlebittoomuch.I'vebeenabletogetupto4tablespoonsatonetimewith1tablespoonofcoconut.Ifoundthatthemoment,exactly22minuteslater,Ifeelatwingeinmy


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stomach.Itake5macadamianutsanditgoesaway.

Dave: ThereasonthatIrecommendnotblendingjustbrainoctaneincoffeeisthatitcausesGIdistress.Ifyouputanotherfatwithit,itsolvestheproblem.Butteristheotherfat,yeah.

Frank: Ididthe4C8oil.Wecan'tdothebutterbecauseI'mavegan.

Dave: Yeah,that'sright.Right.

Frank: Ididthe4C8andonecoconutoil.Thatwasalittlebitofthelonger.Thenthemacadamianuts22minuteslater,themomentthatIstart...Becauseotherwise,Iwasrunningtothebathroomandwhocangettothebathroomfaster?

Dave: Fourtablespoonsofbrainoctaneisalot.

Frank: No,no,I'mnowdowntooneortwo;oneortwonow,yeah.Hemademegetcholesterollevels.Hekeptonyellingatmesaying,"Getyourcholesterolchecked."Itjustcameback105.

Dave: 105,that'salittletoolow.Doyouhaveanytestosteroneinit?

Frank: AvailLDLdown.

Dave: AvailLDLdown?Okay,cool.Thatwasn'ttotal.Iwaslike,"Man,you'regoingtodie,okay."

Frank: No,no,no,so.

Dave: Wow.Well,congratulations.You'redoingsomethingright.OnethingaboutthebrainoctaneversusMCT,MCTespeciallythe10,isverydisasterpantspromoting.Whenyougettojustthe8,youcantoleratealotmoreofthatandyougetmoreketonesperunit.Theincreasedboweltoleranceandtheincreasedketonelevelsequals,okay,that'swhyit'sinthere.Iwouldtellpeople,"It'sjustcoconutoil,"ifitworked.Right?

Frank: Yeah,theC8ismoreexpensivebutifyou'reactuallybreakingitdownperketone,it'sprobablycheaper.

Dave: Itischeaperperketone.

Frank: You'dhavetotaketwotothreetimesasmuchjustkick...Sothat'smypoint.

Dave: Yeah.IgetallpissedofffrompeoplewhoaresellinglauricacidasanMCTbecauseitdoesn'tactuallyraiseketonesthewayactuallybiologicalMCTsdo.That'sawholeotherdebateso...

Dr.Veech: Allright.I'djustliketosayonethingthatIwouldn'tlikealotofwhatFrank...Frankissmarterthantheaveragebrownbear.Healsotalkstomeonceeverydayortwo,andthreemonitorsoflevelforthegeneralpublic,whatheisdoingisprobablynottoberecommended.


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Dave: It'sontheouteredgeofexperimentation,yeah.

Dr.Veech: That'sright.Iwatchit.Idon'tthinkthereisanycurehimselfbutIwouldn'twantthattobeputoutasageneral...

Dave: No,asageneral...

Dr.Veech: Asaferthingisgettheketoneestersmade,thatshouldregulatethem.Youcaneatwhatyouwant.Hehasaveryextremediet.Healsoknowsalot.HefollowshisdietsoIwouldn'trecommendwhathe...Itworks,itworks.HehasshownmealotofthingsIdidn'tbelievecouldhappenbutIwouldn'twanttorecommendit.

Dave: Thereisaroleforbio-hackingwhere,"Okay,thisismybeliefsystem.Thesearemygoals."Differentpeoplehavedifferentgoals.Ifyou'regoalis,"Idon'twanttoeverkillanotheranimal,"yougottomakesurethatallthevegetablesthatyouatedidn'tkillanimalsintheirproduction,whichisaharderthingtodo.Okay,let'ssay,thenyoupursuethatgoalandyoulookatallthebiologicalandmetaboliceffects.Wemightlearnsomethingnewfromthat,andIsupportthat100%butIalsowonder,rightnow,probablybetweenaquarterandahalfmillionpeoplearegoingtohearthisconversationandIwouldbebotheredifalotofthemsaid,"I'mgoingtogoonacentralhighfatvegandietrightnowbecauseit'sawaytoraisemyketones."Therearemanywaystoraiseyourketones.I'mnotsurethatI'drecommendthatasthemostanti-ageinglong-termleastinflammatorymoststudiedwaytodoit.Buthereisanexampleofsomeonewhopulleditoff,right?That'scoo.

Dr.Veech: Remember,thefirstroleofadoctorisdonoharm.Ireallydon'twanttokillpatients.Itellmystudents,"Idon'tmindkillingtheadministrators,butIhaveaproblemkillingpatients."Ithinkthatalittle...Frankisabitextremeinwhatheisdoing.HecandoitbutIdon'tknowaboutanyoneelse.I'veneverseenanyoneelsedoit.Let'sputitthatway.

Dave: I'venotheardofsomeonehittingthoselevelsespeciallywithcarbspresentbutit'scool.Hehasgotsometools.Heisworkingonit.Now,we'recomingupontheendoftheinterview.IfeltlikeIcouldtalktoyouforanotherhourbut...ThereisaquestionIwanttoaskyou.YoumighthavesomeofthemostinterestinganswersofanyoneIhaveinterviewedbecauseI'veaskedeveryguestontheshowthis.Givenallthethingsyou'velearnedinyourlife,notjustsciencebutallthethingsyou'velearned,ifsomeonecameintoyourofficetomorrowandsaid,"Dr.Veech,IwanttoperformbetterateverythingIdoasahumanbeing.Iwanttokickmoreassatlife."Whatthethreemostimportantpiecesofadviceyouhaveforme?Whatwouldyousay?

Dr.Veech: Well,numberone,keepyourweightdown,don'tgetoverweight.Two,exerciseinmoderation.Ithinkthethirdthingistoenjoyyourself.Ithinkahealthyattitudeisaverydesirablethingnow.Ithinkinthelongrun,maybewe'llcomebackandwe'llwileandsay,"Youshouldperhapsbeketotic,"butwedon'thavethatevidenceyet.That'sforanotheredition.

Dave: Iloveitthatbeingketoticwasn'toneofyourtopthree.That'sreallycool.

Dr.Veech: No,no,no.Imean,it'sveryimportantbutithasnotbeenestablishedthatlongandhappylife


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resultsinketosis.Itmaybetruebutwehavenotshownthatyet.

Dave: Iwilldomybesttoshowannequals1exampleofthatbecauseIfeelsocrappywhenI'mnotinmildketosis,thatI'mnotwillingtogothere.

Dr.Veech: Yeah.Well,ofcourse,thestarvation,ourconstructionwasverypopular.Theman,Iforgethisname,buthewasinCalifornia,hedied...

Dave: Itwasn'tBillFalloon,heisstillalive,right?

Dr.Veech: No.Iforgethisname,buthediedabout72.Itdidn't...

Dave: Didn'twork.

Dr.Veech: Didn'twork.AsIsaid,ifyoulookatthesumeffectsofketoneesterandcholesterolandbloodsugaroninflammation,onenergy,oncerebralfunction,ingeneralstrength,you'retalkingaboutmanyofthehallmarksofthephenotypesoftheageing,particularlythefreeradical.

Dave: Thisisprofoundstuff.I'vehadanamazingtime,learnedacoupleofthingsIdidn'tknowaboutparticularlyaroundthesaltlevelsandketonesaltsandaroundtheradioactivefreeradicalprotectiveeffectsofketonesinthebody,particularlyaroundradiation.ThesearethingsthatIjustdidn'tknowabout.IfeellikeIreadallthepapersbutthereyougo.Youactuallydoreadallthepapersthen.Thanksforyourwork,Dr.Veech.Youhave47yearsoflookingatthisisremarkable.Istheresomethingnewontheriseafterketoneesters?What'snextforyou?

Dr.Veech: Rightnow,ourmainproblemistogetthemtoproduceaquantityatalowprice.

Dave: Well,Iwillsupportyouonthat.We'regoingtohaveaconversationafterwardsaboutthatandseeifthereissomethingIcandotomoveaneedleforyou.Thanksagainforyourwork.Ilookforwardtohavingyouontheshowagainmaybeayearorsowhenyou'vemadesomeprogress.

Dr.Veech: Thankyouverymuch.

Dave: Ifyouenjoyedtoday'sshow,youknowwhattodo.Sendittoafriend.GoontoiTunesandclicklikeorgiveitagoodrevieworwhateveritisyoudooniTunes,Iforgetthere.Betteryet,ifyouwantactuallyseewhatDr.Veechlookslikeandexperiencethevideoofthis,headonoverbulletproofexec.com/youtubeandwe'llhookyouupwithourYoutubechannelsoI'llletyouknoweverytimeoneofthesethingscomesoutonYoutube.Iappreciateyoulistening.Whileyou'reatit,pickupanextrabottleofbrainoctaneandsomeBulletproofcoffeebeans,putitinyourmorningcoffee,pourbrainoctaneonyoursushithewayIdo,ittastesprettygood.Justgetyourketonesupalittlebit.Youmightfeeldifferentifyoudoit,justsaying.Haveanawesomeday.


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Transcript of “299 with Dr Veech”

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Transcript of Transcript of “299 with Dr Veech”