Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights...
Transcript of Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights...
![Page 1: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/1.jpg)
© 2012 HORIBA, Ltd. All rights reserved.
Advanced Software Features for the LA-950
Ian [email protected]/us/particle
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© 2012 HORIBA, Ltd. All rights reserved.
What we’ll talk about
Measurement tools
Data analysis tools
Data verification tools
Q&A
![Page 3: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/3.jpg)
© 2012 HORIBA, Ltd. All rights reserved.
One-button Measurement
Use the Navigator or Method Expert to create Sequence (.seq) filesManual: NavigatorAuto: Method Expert
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LA-950 Method Expert
Unique guided method developmentOptimize parameters Choose the best refractive index Create “one button” SOPsWebinar TE004 for Method Expert
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Collecting and Calculating
The LA-950 hardware collects scattered light data
The LA-950 software calculates the particle size distribution using that scattered light data
Both must be optimized to maximize data quality
![Page 6: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/6.jpg)
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LA-950 Method Expert
![Page 7: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/7.jpg)
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Method Expert Hardware
There are four important tests…
CirculationConcentration
DispersionDuration
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There are two important tests…
Real RIImaginary RI
Method Expert Calculation
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Why is the test important?What does the test do?How will the results be displayed?What is the best value?
User selects up to 5 values for testing
LA-950 Method Expert
![Page 10: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/10.jpg)
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Method Expert guides user to prepare the LA-950 for each test
Results displayed in multiple formats: PSD, D50, R-parameter
LA-950 Method Expert
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LA-950 Method Expert
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LA-950 Method Expert
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Dry Measurement
Method Expert currently wet onlyUse “Auto Measurement” for dryWebinar TE016: Optimizing Dry
Powder Measurements
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Navigator
LA Navigator function creates Sequence programs to operate the LA-950Maximum flexibility
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Navigator
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Navigator
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Automatic Dilution
Concentration controlAdds dispersant, drains, repeat Is not possible without fill pump
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Automatic Dilution
![Page 19: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/19.jpg)
© 2012 HORIBA, Ltd. All rights reserved.
What we’ll talk about
Measurement tools
Data analysis tools
Data verification tools
Q&A
![Page 20: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/20.jpg)
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Refractive Index
Many, many resources on websiteWebinar TR009: Optimization of RI
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Manually Changing RI
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Manually Changing RI
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Manual Optimization
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Automated RI ComputationReal part studyNeed to fix imaginary partSet up to 5 real partsSoftware will compute all RI and display R parameter
variation with RI selection
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Automated RI Computation
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Automated RI Computation
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Automated RI Computation Imaginary part studyNeed to fix real partSet up to 5 imaginary partsSoftware will compute all RI and display R parameter
variation with RI selection
![Page 28: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/28.jpg)
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Automated RI Computation
Imaginary study
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Error Calculations
yi The measured scattered light at each channel (i) of the detector.y (xi) The calculated scattered light at each channel (i) of the detector based on the chosen refractive index kernel and
reported particle size distribution.i The standard deviation of the scattered light intensity at each channel (i) of the detector. A larger i indicates lower
reliability of the signal on a given detector.N The number of detectors used for the calculation
Figure 3
Emulsion Sample
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Multimodal Report
Hard to use full-distribution metrics to describe multimodal results
D10 D50 D90
Are these meaningful?
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Multimodal Report
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Multimodal Report
Deconvolute distribution into components
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Multimodal Report
Statistics for each distribution mode
Better understanding of entire distribution
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Intensity Graph
Diffraction analyzer measures light scattering pattern, algorithm transforms this into a particle size distribution
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LARGE PARTICLE: Low angle scatter Large signal
SMALL PARTICLE: High Angle Scatter Small Signal
Wide Pattern - Low intensity
Narrow Pattern - High intensity
Size affects intensity
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Intensity Graph
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Intensity Graph
One way to use the Intensity GraphTwo results, one good and one bad
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Intensity Graph
Not Passing
Passing
Low AngleLarge Particle
High AngleSmall Particle
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Blank Check
Need to explain difference in scatteringTry other tools, i.e. Blank Check
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Blank Check
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Custom Calculations
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What we’ll talk about
Measurement tools
Data analysis tools
Data verification tools
Q&A
![Page 43: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/43.jpg)
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Automate COV Calculation
Coefficient of Variation indicates precision of multiple measurements ISO 13320 and USP <429> make
recommendations using COV
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Automate COV Calculation
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Automate COV Calculation
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Result Verification
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© 2012 HORIBA, Ltd. All rights reserved.
What we’ll talk about
Measurement tools
Data analysis tools
Data verification tools
Q&A
![Page 48: Training Series - Advanced Software Features for the LA-950 · © 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com](https://reader035.fdocuments.us/reader035/viewer/2022062603/5f0c28a17e708231d434071a/html5/thumbnails/48.jpg)
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Danke
Gracias
Большое спасибо
GrazieاُشْكرΣας ευχαριστούμε
감사합니다Obrigado
Tacka dig
谢谢ขอบคุณครับ
ありがとうございました
ध यवादநன்ற
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