Total Wrist Reconstruction - MarketResearch · The total wrist replacement (TWR) sales market in...
Transcript of Total Wrist Reconstruction - MarketResearch · The total wrist replacement (TWR) sales market in...
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Total Wrist Reconstruction US Analysis and Market Forecasts
GDME1018CFR / Published March 2013
Executive Summary
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Total Wrist Reconstruction, Key Metrics in the US Market (2012) Prevalence of Symptomatic Wrist Arthritis 1.5million
2012 US Market Sales for Wrist Reconstruction ($m) $24.3m
2012 US Market Sales for Wrist Replacement ($m) $19.3m
2012 US Market Sales for Total Wrist Fusion ($m) $5.1m
Key Events (2011–2018) Impact
(2012) US Food and Drug Administration approval of Medartis' Arthrodesis System 2.0/2.3, 2.5 APTUS Wrist in January
↑↑
(2013) Expected commercial launch and approval of two products by Small Bone Innovations late 2013 in the US for total wrist fusion and partial wrist fusion currently in development
↑↑↑
(2014) Expected approval of Tornier Resurfacing Capitate Pyrocarbon Implant via 501(k) in the US in April 2014 and commercial launch in July 2014
↑↑↑
Competitive Assessment
Number of Devices in Marketing Phase 10
2018 US Market Sales for Wrist Reconstruction ($m) $33.8m
2018 US Market Sales for Wrist Replacement ($m) $28.2m
2018 US Market Sales for Total Wrist Fusion ($m) $5.6m
Source: GlobalData, primary research interviews with leading hand orthopedic surgeons in 10 markets (US, France, Germany, Italy, Spain, UK, Japan, Brazil, China, and India). Note: 5EU = France, Germany, Italy, Spain, and the UK; Asia-Pacific = Japan, India, and China.
Sales for Total Wrist Reconstruction
The total wrist replacement (TWR) sales market in 2012
is estimated to be $19.3m across the US market covered
in this report. The total wrist fusion (TWF) market is
estimated to be $5.1m in the US. Combined, the market
is $24.3m.
By the end of the forecast, the TWR sales will grow to
over $28.2m with a Compound Annual Growth Rate
(CAGR) of 6.23%. The TWF sales will grow to over
$5.6m with a CAGR of 1.69%.
The key drivers for the market in the forecast are:
The growing prevalence of symptomatic osteoarthritis
and post-traumatic arthritis due to the growing aging
segment of the population across the globe
The major unmet need for late stage arthritis in the
wrist and desire to be able to maintain full range of
motion amongst patients and regain productivity
The high prevalence of revision surgery for those
with TWR driving surgical volumes up
TWR and TWF Revenue in the US (2009–2018)
0
510152025
303540
2009 2010 2011 2012 2013 2014 2015 2016 2017 2018
Milli
ons
Year
TWR TWF
Source: GlobalData, primary research interviews and surveys with leading orthopaedic hand surgeons in 10 markets (US, France, Germany, Italy, Spain, UK, Japan, Brazil, China, and India).
Executive Summary
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As of 2012, the US comprised a majority of the global
market share for TWR. GlobalData estimates that the
market share will remain relatively stable for the forecast
period in the US. There is expected to be an increase in
procedural volumes of 47% in the US for TWR and 11%
for TWF over the forecast period. The questionable long-
term efficacy of TWRs will keep adoption rates low. But
ample opportunities exist as these products continue to
technologically advance and a focus is kept on improving
technique during implantation.
Unmet Needs Remain a Challenge
While TWR technology has developed greatly over the
last 40 years, there is still much room for technological
advancement. Physicians still overwhelmingly see wrist
fusion as a safer alternative to wrist replacement. One
reason for this is the extensive bone resection still
needed for total wrist replacements. Orthopedic surgeons
have called for devices with better materials and coatings
on implants for better biological fixation. As for wrist
fusion plates, the materials required are different since
bone fixation and ingrowth is not expected to be at the
same level as with the replacement devices.
Additionally, the majority of TWR clinical trials to date
have been only short-term studies. The clinical efficacy of
TWR has yet to be proven as failure rates have been
high beyond five years of implantation. With complication
rates also high, it remains a challenge for physicians to
justify implantation of wrist implants in young patients.
Finally, better surgical training is needed, as wrist surgery
is one of the most complex to perform. Physicians have
given feedback that refined instrumentation is a must
from manufacturers to obtain more successful
implantation.
Key Players in the TWR and TWF Market
The four primary players in the TWR market are Small
Bone Innovations, Biomet, Integra LifeSciences and
Zimmer. While there are a few other smaller players as
well, these four comprise of 77.8% of the market share.
Small Bone Innovations has become a niche player by
making key acquisitions in arthroplasty. In the total fusion
market, Depuy Synthes, a Johnson & Johnson company,
has dominated the plate market. The other most
commonly used plate in the market is by Acumed.
Medartis, with the launch of TWF plates in 2012, is one
company that is expected to gain market share based on
feedback from interviews by GlobalData of key opinion
leaders. This would lead to the other firms to potentially
lose some market share in the US and EU. The
opportunity though is great in the emerging markets as
there is a large untapped population with the surgical
need. GlobalData believes that innovation and
penetration of the developing nations can drive their
growth and increase market share. Most importantly,
emergence of long-term clinical data can fuel significant
growth.
TWR and TWF Market Future Outlook
The TWR market is expected to only have moderate
growth, while TWF will be steady. The market is based
on and will be driven by the rising prevalence of
osteoarthritis and the rising aging population. As positive
clinical trial data with long-term results come out,
GlobalData expects sharper growth for TWRs. Until then
the growth and adoption is expected to be slow. Currently
the CAGR for the forecast period in the US until 2018 is
6.23% for TWR and 1.69% for TWF.
Executive Summary
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What Do Physicians Think?
Physicians are optimistic about the future adoption of
TWR devices.
“I think it will increase a lot because patients are getting
older and older. Health conditions of patients are better
and they want to use their wrists. And they don’t want to
have the wrist fused. So the indication will increase.”
Key Opinion Leader, December 2012
“I think that total wrist arthroplasty was a challenging
procedure years ago. But now it is getting to be more and
more popular and products are safer and there are less
complications. There is a large panel of implants, total
wrist, hemi, interposition arthroplasty. So we can give a
good answer to wrist problems for any kind of post-
traumatic or any kind of arthritis.”
Key Opinion Leader, December 2012
“Well, I think wrist arthroplasty has gone up because … I
think it is all due to promotional activities by companies.
Holding courses, showing you how to use it, tell you how
great it is.”
Key Opinion Leader, December 2012
Physicians expect better long-term efficacy studies in
order to substantiate additional implantations.
“Well, I think you just have to use an implant that has a
reasonable track record which there aren’t any and that’s
the problem. I mean, there are no wrist implants that
have been around for many years with good long-term
follow up. So that is the issue: to get an implant where
you are fairly convinced about the design rationale.”
Key Opinion Leader, December 2012
“Well, the major issue is that we don’t have long-term
follow-up available. We don’t really know how long they
last. There has been no studies. There are studies
coming through that show a failure rate of 60% in five
years perhaps. It’s very, very high. Much higher than
knee replacements or hip replacements. I think the worry
is how long do they last? Do they wear out?”
Key Opinion Leader, December 2012
Physicians are interested in more innovation.
“If people start thinking outside the box, start using other
materials. You mentioned pyrocarbon: that would be a
very good material to think about in the wrist.”
Key Opinion Leader, December 2012
Physicians are concerned about training programs
and implantation for wrong indications
“Yeah, there are ongoing studies to see how the
replacements fare. That’s important. In regards to cost
structure, it requires manufacturers to look at the process
and regards to training for the surgeons not too many
people doing it. In Britain [there is] a system of
commissioning where only certain surgeons will be
allowed to do the procedures. That’s important.”
Key Opinion Leader, December 2012
“The surgeon has to know what he is doing and [have]
experience. So wrist replacement should not be done by
every single hand surgeon or orthopedic surgeon. It
should be done by just a few people. The experience
concentrates.”
Key Opinion Leader, December 2012
Table of Contents
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1 Table of Contents
1 Table of Contents ............................................................................................................... 5
1.1 List of Tables ............................................................................................................. 11
1.2 List of Figures ........................................................................................................... 13
2 Introduction ....................................................................................................................... 14
2.1 Catalyst ..................................................................................................................... 14
2.2 Related Reports ........................................................................................................ 15
2.3 Upcoming Related Reports ........................................................................................ 15
3 Disease Overview ............................................................................................................. 16
3.1 Anatomy and Physiology ........................................................................................... 16
3.2 Pathophysiology ........................................................................................................ 17
3.2.1 Overview............................................................................................................. 17
3.2.2 Osteoarthritis ...................................................................................................... 17
3.2.3 Rheumatoid Arthritis ............................................................................................ 17
3.2.4 Carpal Tunnel Syndrome .................................................................................... 18
3.2.5 Others ................................................................................................................. 18
3.3 Clinical Presentation .................................................................................................. 19
3.4 Clinical Outcomes ..................................................................................................... 20
3.4.1 Overview............................................................................................................. 20
3.4.2 Conservative Therapy ......................................................................................... 21
3.4.3 Arthroscopic Debridement ................................................................................... 21
3.4.4 Proximal Row Carpectomy .................................................................................. 21
3.4.5 Total Wrist Fusion ............................................................................................... 22
3.4.6 Total Wrist Replacement ..................................................................................... 24
3.4.7 Wrist Fusion Versus Total Wrist Replacement ..................................................... 26
3.5 Epidemiology ............................................................................................................ 28
3.6 Economic Impact ....................................................................................................... 30
3.6.1 Economic Impact of Treating Arthritis .................................................................. 30
Table of Contents
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3.6.2 Cost Effectiveness of Orthopedic Implants .......................................................... 31
4 Competitive Assessment ................................................................................................... 32
4.1 Total Wrist Implant .................................................................................................... 32
4.1.1 Overview of Historical Designs ............................................................................ 32
4.1.2 Current Designs .................................................................................................. 32
4.2 Total Wrist Fusion ..................................................................................................... 45
4.2.1 Overview of Historical Designs ............................................................................ 45
4.2.2 Current Designs .................................................................................................. 45
5 Unmet Needs.................................................................................................................... 54
5.1 Long-Term Clinical Data ............................................................................................ 54
5.2 Limited Product Offerings .......................................................................................... 55
5.3 Failure and Revision Rate ......................................................................................... 56
5.4 Minimal Bone Resection and Other Complications ..................................................... 56
5.5 Lack of Pipeline Products .......................................................................................... 58
5.6 Need for Better Physician Training ............................................................................ 58
6 Pipeline Products .............................................................................................................. 60
6.1 Overview ................................................................................................................... 60
7 Industry Overview ............................................................................................................. 61
7.1 US Procedure Volumes ............................................................................................. 61
7.2 Market Access........................................................................................................... 64
7.2.1 Regulation .......................................................................................................... 65
7.2.2 Adoption ............................................................................................................. 65
7.3 US Reimbursement Trends ....................................................................................... 66
7.4 Regulatory Issues/Recalls ......................................................................................... 68
7.5 Mergers & Acquisitions / Key Partnerships ................................................................ 69
8 Company Profiles ............................................................................................................. 71
8.1 Small Bone Innovation Inc. ........................................................................................ 71
8.1.1 Overview............................................................................................................. 71
Table of Contents
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8.1.2 Portfolio Assessment .......................................................................................... 71
8.1.3 SWOT Analysis ................................................................................................... 72
8.2 Depuy Synthes International ...................................................................................... 72
8.2.1 Overview............................................................................................................. 72
8.2.2 Portfolio Assessment .......................................................................................... 72
8.2.3 SWOT Analysis ................................................................................................... 73
8.3 Integra LifeSciences Inc. ........................................................................................... 74
8.3.1 Overview............................................................................................................. 74
8.3.2 Portfolio Assessment .......................................................................................... 74
8.3.3 SWOT Analysis ................................................................................................... 74
8.4 Biomet Orthopedics ................................................................................................... 75
8.4.1 Overview............................................................................................................. 75
8.4.2 Portfolio Assessment .......................................................................................... 75
8.4.3 SWOT Analysis ................................................................................................... 76
8.5 Medartis AG .............................................................................................................. 76
8.5.1 Overview............................................................................................................. 76
8.5.2 Portfolio Assessment .......................................................................................... 76
8.5.3 SWOT Analysis ................................................................................................... 77
8.6 Acumed..................................................................................................................... 77
8.6.1 Overview............................................................................................................. 77
8.6.2 Portfolio Assessment .......................................................................................... 77
8.6.3 SWOT Analysis ................................................................................................... 78
8.7 Tornier N.V................................................................................................................ 79
8.7.1 Overview............................................................................................................. 79
8.7.2 Portfolio Assessment .......................................................................................... 79
8.7.3 SWOT Analysis ................................................................................................... 80
8.8 Swemac Orthopaedics AB ......................................................................................... 80
8.8.1 Overview............................................................................................................. 80
Table of Contents
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8.8.2 Portfolio Assessment .......................................................................................... 80
8.8.3 SWOT Analysis ................................................................................................... 81
8.9 Zimmer Holdings Inc. ................................................................................................ 82
8.9.1 Overview............................................................................................................. 82
8.9.2 Portfolio Assessment .......................................................................................... 82
8.9.3 SWOT Analysis ................................................................................................... 83
8.10 Skeletal Dynamics ..................................................................................................... 84
8.10.1 Overview............................................................................................................. 84
8.10.2 Portfolio Assessment .......................................................................................... 84
8.10.3 SWOT Analysis ................................................................................................... 84
9 Market Drivers & Opportunities ......................................................................................... 85
9.1 Market Drivers ........................................................................................................... 85
9.1.1 Rise in Osteoarthritis ........................................................................................... 85
9.1.2 Aging .................................................................................................................. 85
9.1.3 Trauma ............................................................................................................... 85
9.1.4 Patient Demand and Awareness ......................................................................... 86
9.1.5 Availability of Long-Term Clinical Data ................................................................ 86
9.1.6 Further Technological Advancement ................................................................... 87
9.1.7 Corporate Promotions and Teaching Seminars ................................................... 87
9.2 Opportunities ............................................................................................................. 88
9.2.1 Expanding Aging and Arthritis Indication ............................................................. 88
9.2.2 Revision Surgery ................................................................................................. 88
9.2.3 Emerging Markets ............................................................................................... 89
9.2.4 Capitalizing on Market Fragmentation ................................................................. 89
10 Market Threats & Substitutes ............................................................................................ 90
10.1 Market Threats .......................................................................................................... 90
10.1.1 Slow Technological Advancement ....................................................................... 90
10.1.2 Physician Perception and Learning Curve ........................................................... 90
Table of Contents
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10.1.3 Complications ..................................................................................................... 91
10.1.4 Cost .................................................................................................................... 91
10.1.5 Lack of Long-Term Studies ................................................................................. 92
10.2 Substitutes ................................................................................................................ 92
10.2.1 Therapeutic Options and Fusion .......................................................................... 92
11 US Outlook & Forecast ..................................................................................................... 93
11.1 Market Overview ....................................................................................................... 93
11.2 US Market Analysis ................................................................................................... 93
12 Appendix .......................................................................................................................... 95
12.1 Abbreviations ............................................................................................................ 95
12.2 Bibliography .............................................................................................................. 96
12.3 Report Methodology ................................................................................................ 102
12.3.1 Overview........................................................................................................... 102
12.3.2 Coverage .......................................................................................................... 102
12.3.3 Secondary Research ......................................................................................... 102
12.3.4 Forecasting Methodology .................................................................................. 103
12.3.5 Primary Research – Key Opinion Leader Interviews .......................................... 104
12.3.6 Primary Research – Physician Survey ............................................................... 104
12.3.7 Expert Panel Validation ..................................................................................... 104
12.4 Physicians and Specialists Included in this Study .................................................... 105
12.4.1 Dr. Philippe Bellemère....................................................................................... 105
12.4.2 Dr. Vikas Gupta, MBBS, MS .............................................................................. 105
12.4.3 William H. Seitz, Jr., MD .................................................................................... 105
12.4.4 Robert M. Szabo, MD, MPH .............................................................................. 105
12.4.5 David Warwick, MD, BM, DIMC, FRCS (Orth) ................................................... 105
12.5 About the Authors ................................................................................................... 106
12.5.1 Analysts ............................................................................................................ 106
12.5.2 Global Head of Healthcare ................................................................................ 107
Table of Contents
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12.6 About MediPoint ...................................................................................................... 108
12.7 About GlobalData .................................................................................................... 108
12.8 Contact Us .............................................................................................................. 108
12.9 Disclaimer ............................................................................................................... 109
Table of Contents
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1.1 List of Tables
Table 1: Clinical Symptoms and Descriptions ..................................................................... 19
Table 2: Advantages and Disadvantages of Wrist Fusion and Total Wrist Replacement ...... 27
Table 3: Direct and Indirect Costs of Arthritis ...................................................................... 30
Table 4: Universal 2 Total Wrist Implant System (Integra LifeSciences Inc.)........................ 34
Table 5: SWOT Universal 2 Total Wrist Implant System ..................................................... 34
Table 6: ReMotion Total Wrist (Small Bone Innovations, Inc.) ............................................. 36
Table 7: SWOT ReMotion Total Wrist ................................................................................. 36
Table 8: Maestro Total Wrist System (Biomet Orthopedics) ................................................ 38
Table 9: SWOT Maestro Total Wrist System ....................................................................... 38
Table 10: Tornier Resurfacing Capitate Pyrocarbon Implant ................................................. 40
Table 11: SWOT:Tornier Resurfacing Capitate Pyrocarbon Wrist Implant ............................. 40
Table 12: Motec Wrist Joint Prosthesis (Swemac Orthopaedics AB) .................................... 42
Table 13: SWOT Motec Wrist Joint Prosthesis ..................................................................... 42
Table 14: MWP III Total Wrist Prosthesis (Zimmer Inc.) ........................................................ 44
Table 15: SWOT MWP III Total Wrist Prosthesis .................................................................. 44
Table 16: LCP Wrist Fusion Set (DePuy Synthes, Johnson & Johnson Co.) ........................... 47
Table 17: SWOT LCP Wrist Fusion Set ................................................................................ 47
Table 18: Integra Total Wrist Fusion System (Integra LifeSciences Inc.) ............................... 49
Table 19: SWOT Integra Total Wrist Fusion System ............................................................. 49
Table 20: Arthrodesis System 2.0/2.3, 2.5 APTUS Wrist (Medartis AG) .................................. 51
Table 21: SWOT Arthrodesis System 2.0/2.3, 2.5 APTUS Wrist ........................................... 51
Table 22: Arthrodesis System 2.0/2.3, 2.5 APTUS Wrist (Medartis AG) ................................ 53
Table 23: SWOT Implate Wrist Arthrodesis Nail.................................................................... 53
Table 24: Complications and Risks for TWR and TWF ......................................................... 57
Table 25: Product Components and Costs ........................................................................... 64
Table 26: Reimbursements Associated with TWR ................................................................ 67
Table 27: Medicare Payment Trend for Wrist Procedures,1992–2004 ................................... 67
Table of Contents
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Table 28: Company Profile – Small Bone Innovation Inc. ...................................................... 71
Table 29: SWOT Analysis – Small Bone Innovations Inc. ..................................................... 72
Table 30: Company Profile – Depuy Synthes International ................................................... 73
Table 31: SWOT Analysis – Depuy Synthes International ..................................................... 73
Table 32: Company Profile – Integra LifeSciences Inc. ......................................................... 74
Table 33: SWOT Analysis – Integra LifeSciences Inc. .......................................................... 74
Table 34: Company Profile – Biomet Orthopedics ................................................................. 75
Table 35: SWOT Analysis – Biomet Orthopedics .................................................................. 76
Table 36: Company Profile – Medartis AG ............................................................................ 76
Table 37: SWOT Analysis – Medartis AG ............................................................................. 77
Table 38: Company Profile – Acumed LLC ........................................................................... 78
Table 39: SWOT Analysis – Acumed LLC ............................................................................ 78
Table 40: Company Profile – Tornier N.V. ............................................................................ 79
Table 41: SWOT Analysis – Tornier N.V. .............................................................................. 80
Table 42: Company Profile – Swemac Orthopaedics AB....................................................... 81
Table 43: SWOT Analysis – Swemac Orthopaedics AB ........................................................ 81
Table 44: Company Profile – Zimmer Holdings Inc. .............................................................. 82
Table 45: SWOT Analysis – Zimmer Holdings, Inc. ............................................................... 83
Table 46: Company Profile – Skeletal Dynamics LLC ........................................................... 84
Table 47: SWOT Analysis – Skeletal Dynamics LLC............................................................. 84
Table 48: US Sales ($m) Forecast for TWF and TWR, 2009–2018 ....................................... 94
Table of Contents
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1.2 List of Figures
Figure 1: Anatomy of the Wrist ........................................................................................... 16
Figure 2: Treatment Paradigm for Wrist Arthritis ................................................................. 20
Figure 3: Wrist Arthrodesis with a Fusion Plate .................................................................. 23
Figure 4: Total Wrist Arthroplasty ....................................................................................... 25
Figure 5: Population with Wrist Arthritis in the US, 2008–2020 ........................................... 28
Figure 6: Disease Segments of Wrist Arthritis .................................................................... 29
Figure 7: Universal 2 Total Wrist Implant System (Integra LifeSciences Inc.) ...................... 33
Figure 8: ReMotion Total Wrist (Small Bone Innovations, Inc.) ........................................... 35
Figure 9: Maestro Total Wrist System (Biomet Orthopedics) ............................................... 37
Figure 10: Tornier Resurfacing Capitate Pyrocarbon Implant ................................................ 39
Figure 11: Motec Wrist Joint Prosthesis (Swemac Orthopaedics AB) ................................... 41
Figure 12: MWP III Total Wrist Prosthesis (Zimmer Inc.) ...................................................... 43
Figure 13: LCP Wrist Fusion Set (DePuy Synthes, Johnson & Johnson Co.) ........................ 46
Figure 14: Integra Total Wrist Fusion System (Integra LifeSciences Inc.) ............................. 48
Figure 15: Arthrodesis System 2.0/2.3, 2.5 APTUS Wrist (Medartis AG) ............................... 50
Figure 16: Implate Wrist Arthrodesis Nail (Skeletal Dynamics LLC) ...................................... 52
Figure 17: Importance of Safety of Arthrodesis and Arthroplasty Implants ............................ 57
Figure 18: US Arthrodesis and Arthroplasty Procedure Volumes (2009–2018) ..................... 63
Figure 19: Medicare Payment Trend for Wrist Procedures, 1992–2004 ................................ 68
Figure 20: US TWR and TWF Market, 2009–2018 ............................................................... 94
Introduction
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2 Introduction
For patients suffering from severe wrist pain from degenerative osteoarthritis, traumatic arthritis or
rheumatoid arthritis, and gout, total wrist replacement and total wrist fusion provide a surgical
alternative to living with excessive pain that is no longer placated by non-surgical treatment. The
most significant clinical benefit in these surgical options is the relief from pain. In deciding between
the two options, fusion has been a more conservative one, with much less risk of complications
than replacement. Though wrist fusion has been more traditionally used in the past, replacement
has been gaining momentum as a choice for patients who want to retain more motion and have
more functional use of their hand. Though new technology development has been slow in the past,
the increasing popularity amongst patients and doctors to provide an option for better range of
motion will drive technology to improve amongst the current players and new companies looking to
enter the market. GlobalData’s analysis shows that with the unmet needs being great, companies
will need to step up the development of wrist implants to gain the confidence of physicians and
patients and create new opportunities for long-term studies. As these issued are addressed, the
industry is likely to grow moderately in the years to come.
2.1 Catalyst
Total wrist replacement and total wrist fusion offer patients with a surgical approach to regain some
function in their degenerative wrist. For those patients who no longer have proper usage of their
hand, experience extreme pain and at times take narcotics for the pain, wrist fusion and wrist
replacement offer good options. According to GlobalData’s interviews, an estimated 16% of
individuals in the US have arthritis and 6.9% of those are in the arthritis-attributable activity
limitations category of which 7% have wrist arthritis. Of the global prevalence, we can estimate that
30% have arthritis severe enough to be considered for surgery. The patient candidates need to be
selected carefully by indication and other clinical factors.
Joint replacement for the wrist is a complicated surgery with a high learning curve for the surgeon,
yet still it is being adopted in the US more and more by orthopedic hand surgeons. Total wrist
replacement is being adopted in countries such as India, China and Brazil, and depends heavily on
the availability of implants, reimbursement schemes and surgical training. As the population ages
and patients demand better treatment options and better outcomes, there develops a need for
long-term studies. This report addresses the various unmet needs, presents the current technology
and the drivers for the future and market growth in the US. Adoption rates are examined as well as
the decision makers in penetrating the market.
Appendix
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12.6 About MediPoint
MediPoint is the flagship product for GlobalData’s Medical team. Each MediPoint report is built
from the ground-up by our team of healthcare analysts in the US and UK. Each report includes
input from experienced physicians and leading Key Opinion Leaders (KOL). Running throughout
each report in the series, “What Physicians Think” quotes provide a unique insight into how
healthcare professionals are reacting to events within the industry, and what their responses could
mean for industry strategists.
12.7 About GlobalData
GlobalData is a leading global provider of business intelligence in the Healthcare industry.
GlobalData provides its clients with up-to-date information and analysis on the latest developments
in drug research, disease analysis, and clinical research and development. Our integrated business
intelligence solutions include a range of interactive online databases, analytical tools, reports and
forecasts. Our analysis is supported by a 24/7 client support and analyst team. GlobalData has
offices in New York, Boston, London, India and Singapore.
Appendix
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12.9 Disclaimer
All Rights Reserved.
No part of this publication may be reproduced, stored in a retrieval system or transmitted in any
form by any means, electronic, mechanical, photocopying, recording or otherwise without the prior
permission of the publisher, GlobalData.