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Transcript of Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and...
![Page 1: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/1.jpg)
Topics in Human Pathophysiology
Fall 2009
Instructor: Theresa Martin (CSM)Gilead
Drug Safety and Public Health
![Page 3: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/3.jpg)
Levels of Body Organization
• Atoms• Molecules• Cells• Tissues• Organs• Organ Systems• Organism
![Page 4: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/4.jpg)
Figure 1.1
![Page 5: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/5.jpg)
Figure 3.1
![Page 6: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/6.jpg)
Cell Structure and Function
• Cells are the basic unit of life• Cells are composed of chemicals• Human cells have a membrane, cytoplasm,
and nucleus
![Page 7: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/7.jpg)
Figure 3.14
![Page 8: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/8.jpg)
Water a polar
molecule
![Page 9: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/9.jpg)
Properties of Water
• A great solvent • A great reactant• Good at holding temperature • High heat of vaporization
![Page 10: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/10.jpg)
Figure 2.9
![Page 11: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/11.jpg)
Figure 3.14
![Page 12: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/12.jpg)
The Cell Membrane
• Composed of phospholipid bilayer with embedded proteins that serve a variety of functions
• Semipermeable• Allows passive transport and also has active
transport (pumps)• Has important communication functions
![Page 13: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/13.jpg)
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Figure 02.04The Cell (Plasma) Membrane
![Page 14: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/14.jpg)
Diffusion
![Page 15: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/15.jpg)
Figure 3.8
![Page 16: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/16.jpg)
Figure 3.9a
![Page 17: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/17.jpg)
Figure 3.10
Bulk Transport
![Page 18: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/18.jpg)
Figure 21.2a
![Page 19: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/19.jpg)
Figure 3.11
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![Page 20: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/20.jpg)
Cytoplasm
• Contains cytosol and organelles• Organelles have specific functions• Enzymes catalyze most reactions
![Page 21: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/21.jpg)
Figure 3.14
![Page 22: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/22.jpg)
Figure 2.23
•Proteins in the cells have a variety of functions including structural proteins, and enzymes.
•Enzymes catalyze almost all cellular reactions “metabolism”
Enzymes
![Page 23: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/23.jpg)
Figure 3.14
![Page 24: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/24.jpg)
Cell Nucleus
• Contains genetic material - DNA• DNA has genes on it.• DNA is a double strand with two chains of
nucleotides linked up anti-parallel
![Page 25: Topics in Human Pathophysiology Fall 2009 Instructor: Theresa Martin (CSM) Gilead Drug Safety and Public Health.](https://reader030.fdocuments.us/reader030/viewer/2022032709/56649eb25503460f94bb9678/html5/thumbnails/25.jpg)
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