Topic 6 Pharmacokinetics and Drug Metabolism · Drug candidate pharmaceutics are critical: ADME...
Transcript of Topic 6 Pharmacokinetics and Drug Metabolism · Drug candidate pharmaceutics are critical: ADME...
Drug candidate pharmaceutics are critical:Drug Administration route-
1. Oral
2. Mucous membranes1. Rectal2. Oral (buccal)
3. Topical-transdermal4. Inhaled5. Injected
1. Intravenous2. Intramuscular3. Subcutaneous4. Intrathecal-spinal5. Intraperotoneal
Drug candidate pharmaceutics are critical:Formulations
1. Pills, capsules2. Liquid3. Patch4. Liposome/micelle
AbsorptionDrug Absorption, Metabolism and Excretionhttp://www.cc.nih.gov/training/training/principles/schedule.html
1. Acid-base properties
2. Hydrophobicity/Functional groups
3. Size
Drug molecule factors affecting absorption anddistribution
Lipinski’s rules for lousy drug absorption:1. MW>5002. H-bond donors>53. H-bond acceptors>104. log Partition coefficient > 5
i.e. octanol /water > 100,000:1
Absorption
A “good” drug
A “lousy” drug: insulin