Chapter 13 Gene Regulation in Eukaryotes Chapter 13 Gene Regulation in Eukaryotes.
Title Chapter 13 Gene regulation. CO 13 Fig. 13.1.
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Transcript of Title Chapter 13 Gene regulation. CO 13 Fig. 13.1.
Fig. 13.13
Regulation of transcription in eukaryotes
3 features:1.2.3
1.2.
3.
Basal transcriptionSome RE: Enhancers or
silencers
Fig. 13.16
Gene accessibility is controlled by changes in chromatin structure
Activators:• Histone acetyltransferase (acetyl group, ---COCH3)
• ATP-dependent chromatin remodeling enzymes: to loosen the compaction of chromatin
Fig. 13.17
Steroid hormones exert their effects by binding to a regulatory transcription factors and controlling the
transcription of near genes
Nuclear localization
signals
Glucocorticoid response element
Page 272
DNA methylation inhibits gene transcription
DNA methylase
CpG island: near promoter
1. Prevent an activator binding
2. Inhibit open conformation:
Fig. 13.19
13.4 Regulation of RNA processing and translation in eukaryotes
Alternative splicing of pre-mRNA: creats protein diversity.
Fig. 13.20
MicroRNAs inhibit mRNA by translastional repression or mRNA degradation
Micro RNA: miRNA
enzyme
RNA-induced silencing complex(RISC)
RNA interference (RNAi):