Tinnitus Diagnosis and Treatment Hossein Talebi; PhD of Audiology Assistant Professor of Audiology...
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Transcript of Tinnitus Diagnosis and Treatment Hossein Talebi; PhD of Audiology Assistant Professor of Audiology...
Tinnitus Diagnosis and Treatment
Hossein Talebi; PhD of AudiologyAssistant Professor of AudiologyIsfahan University of Medical Sciences
Introduction• Tinnitus is defined as sensations of hearing in
the absence of external sounds
The burden of tinnitus
Introduction• Prevalence increases with age• 80% of people don’t seek help• 6-8% of those affected are severe• 40% of patients experience depression• Can vary between barely perceptible noise to a
deafening roar• Very little is understood about its cause or cure
Sound features of tinnitusNOISE CRITERIA
POSSIBLE FEATURES
Onset Sudden, gradual
Pattern Pulsatile, intermittent, constant, fluctuating
Site Right or left ear, both ears, within head
Loudness Wide range, varying over time
Quality Pure tone, noise, polyphonic
Pitch Very high, high, medium, low
Tinnitus sufferers
• Ludwig van Beethoven• Vincent van Gogh• Charles Darwin• Neil Young• Eric Clapton• Ronald Regan
Types of Tinnitus
•Objective: caused by sounds generated somewhere in the body
•Subjective: perception of meaningless sounds without any physical sound being present
•Auditory hallucinations: perceptions of meaningful sounds such as music or speech
Causes
Effects of Tinnitus
•Concentration•Hearing•Insomnia•Psychological
Ear Anatomy
Ear Anatomy
Mechanism of Hearing
Mechanism of Hearing
Mechanism of Hearing
Pathophysiology• Poorly understood
• Range of theories from loss of outer hair cell function to increased spontaneous activity of central nerves
• Can be generated from any part of the auditory system from the ear to the Central Nervous System (CNS)
• This then may become modified by the CNS
Peripheral events lead to central neurological changes
Brain response to auditory deprivation•Patients with tinnitus exhibit enhanced auditory sensitivity
•This is caused by hyperactivity of the auditory central nervous system• In patients with tinnitus and hearing loss, the tinnitus pitch and the hearing loss frequency spectrum are usually matched
DECREASED SOUND INPUT INCREASED
SOUND SENSITIVITY
Tinnitus is a balance of sensory input and spontaneous activity
• The decreased input from the cochlea, due to outer hair cell damage, results in readjustments in the central auditory system resulting in abnormal neural activity including hyperactivity, bursting discharges and increases in neural synchrony.
TINNITUS
AUDITORY DEPRIVATION AND CENTRAL
GAIN
ALTERED SPONTANEOUS NEURONAL
ACTIVITY
Pathophysiology• When the perception of tinnitus is associated
with negative reinforcement, the autonomic nervous system is activated.
• Physiological and psychological reactions then lead to enhancement of the tinnitus signal
• Often compared with chronic pain
Pathophysiology
Psychological associations with tinnitus
A Team Approach• Thorough evaluation to rule out significant
pathology• Treatment of other ear disorders eg. infection• Explanation of test results• Explanation of tinnitus mechanisms • Treatment options• Treatment of severe psychological disorders• Follow-up
Differential Diagnosis•Idiopathic (most common)
•Outer ear disease– Wax, foreign body, infection
•Middle ear disease– Infection, perforated eardrum, ossicular
problems, tumour
Differential Diagnosis
•Inner ear disease– Presbyacusis (older age hearing loss)– Meniere’s disease– Acoustic neuroma– Noise exposure– Drugs
Evaluation of Tinnitus
•Thorough history Duration, nature, effects Non vs. pulsatile Noise exposure Other ear symptoms
•Ear examination Rule out outer/middle ear disease Tuning fork tests
Normal Ear vs. Diseased Ear
Evaluation of Tinnitus
•Audiological (hearing) Tests Audiogram, tympanogram Specialized hearing tests: SOAE, ECochG,
ABR
•MRI Associated symptoms Asymmetric hearing loss
Evaluation - Subjective Tinnitus
•Audiometry - assymetrical hearing loss, unilateral tinnitus - MRI r/o post fossa
•Complete questionnaire for perceived severity:THI
Measurement of Tinnitus
•Pitch, loudness, minimum masking level, residual inhibition/post masking
•Minimum masking level most clinical use•Pitch - match most prominent pure tone,
poor reliability, octave difference•Loudness - Adjust pure tone to tinnitus•Most < 7 dB SL, may be 2 dB
Measurement of Tinnitus
•Minimal masking level - number of decibels to cover tinnitus
•Residual inhibition - response of patients tinnitus post masking
ENT Referral
ENT Referral
Acoustic Neuroma
Treatment
•Aim to improve habituation rather than “cure” tinnitus
•Most people don’t seek treatment•Multitude of potential treatments•Problems with scientific evidence
Treatment• Basic advice• Hearing Aid• Tinnitus Masking Device• Tinnitus Instrument• Tinnitus Retraining Therapy• Psychological Treatment• Medication• Alternative Treatments
Basic Advice• Reassurance• The first step is to understand the problem• Avoid aggravating factors eg. noise, NSAIDs• Decreased intake of stimulants eg. caffeine and
nicotine• Relaxation• Avoiding silence• White noise eg. Detuned radio
Treatment• Basic advice• Hearing Aid• Tinnitus Masking Device• Tinnitus Instrument• Tinnitus Retraining Therapy• Psychological Treatment• Medication• Alternative Treatments
Hearing Aids• Essentially for poor hearing• Increases ambient noise• Decreases stress of poor hearing• Various shapes and sizes• Cost• Limitations• Up to 90% may benefit
Hearing Aids
Hearing aids are central to tinnitus management
• Reports of the use of hearing aids in the management of tinnitus go back over 60 years
• Because hearing loss is often associated with tinnitus, at least partial restoration of hearing should help to reduce the central gain in auditory perception that is a feature of tinnitus
• A recent scoping review of studies of hearing aids in tinnitus revealed that 17/18 publications showed improvements in tinnitus symptoms by fitting hearing aids
Treatment• Basic advice• Hearing Aid• Tinnitus Masking Device• Tinnitus Instrument• Tinnitus Retraining Therapy• Psychological Treatment• Medication• Alternative Treatments
Tinnitus Masking Device• Essentially counteracts tinnitus• Generate noise bands• Tinnitus Instruments
Combination of hearing aid and masker
Wide Band Noise Generators• Emit ‘white noise’• Elimination of silence• White noise boring: tendency to ignore• Gives the tinnitus sufferer something tangible to
work with• Reduce the starkness of the tinnitus signal
Treatment• Basic advice• Hearing Aid• Tinnitus Masking Device• Tinnitus Instrument• Tinnitus Retraining Therapy• Psychological Treatment• Medication• Alternative Treatments
Tinnitus Retraining Therapy• Based on evidence that a person can habituate to
acoustic noise in the environment
• Goal is to weaken or remove the functional connections between the auditory pathways
• Key elements: counseling and sound therapy
Normal Condition
Tinnitus Condition
Counseling alone
Sound Therapy alone
Counseling and Sound Therapy
Tinnitus Retraining Therapy• May take several months to take effect
• Minimum 12 months treatment
• Involves wearing ear noise generator, table top generator
Tinnitus Retraining Therapy
Treatment• Basic advice• Hearing Aid• Tinnitus Masking Device• Tinnitus Instrument• Tinnitus Retraining Therapy• Psychological Treatment• Medication• Alternative Treatments
Psychological Treatment• Relaxation therapy• Hypnosis• Cognitive Behavioural Therapy
Information, managing aggravating factors Applied relaxation Cognitive restructuring of thoughts and beliefs Sleep management advice Improvement in quality of life, not tinnitus itself
• Medication
Psychological and behavioural support
INTERVENTION DESCRIPTION
Counselling and education
• Delivered in person, to groups and via the internet• Variable results may depend on personal characteristics
Cognitive behavioural therapy
• Designed to modify maladaptive behavioural and emotional responses
• One-to-one and group settings, delivered by psychologists or psychiatrists, or via internet
• Statistically significant reductions in severity of tinnitus symptoms (P<0.05)
Relaxation therapy
• May help reduce tinnitus symptoms and depressive symptoms
Treatment• Basic advice• Hearing Aid• Tinnitus Masking Device• Tinnitus Instrument• Tinnitus Retraining Therapy• Psychological Treatment• Medication• Alternative Treatments
Medications
• No approved drugs (European Medicines Agency [EMA] or US Food and Drug Administration [FDA])
• Some psychopharmacological agents may help reduce the severity of psychological issues associated with tinnitus, and some may also lessen tinnitus symptoms
DRUG CLASS EXAMPLES OF DRUGS USED IN TINNITUS
Antidepressants tricyclics, selective serotonin reuptake inhibitors
Antipsychotics sulpiride
Mood stabilisers gabapentin, valproate
Sedatives/hypnotics
benzodiazepines
Treatment• Basic advice• Hearing Aid• Tinnitus Masking Device• Tinnitus Instrument• Tinnitus Retraining Therapy• Psychological Treatment• Medication• Alternative Treatments
Alternative Therapies•Vitamins
B1, B3, B6, B12, zinc, calcium, Mg
•Laser Therapy Germany Thought to increase ATP in cochlea
Alternative Therapies
•Hypnotherapy•Acupuncture•Ear canal magnets
Transcranial Magnetic Stimulation• Brain stimulation
▫ Identify active areas with PET▫ Apply magnetic stimulation (rTMS)▫ Evidence in small trials that there is some effect on
tinnitus▫ More detailed research awaited
• Questions▫ Can this be clinically useful or is it just an experimental technique?▫ Long term safety?
Conclusion Tinnitus is a common condition
Main role of ENT Surgeon is to exclude major illness and co-ordinate further treatment
Basic advice and counseling as well as empathic support is paramount
More severe cases may require psychological support, masking devices or Tinnitus Retraining Therapy
Thank you for Your Attention