London: The Biochemical Society 0 I995 Executive Editor: Keith Snell Staff Editor: Kim Benson

Thudichum Medal Lecture

The Acetylcholine Receptor: A Model for Allosteric Membrane Proteins 1.-P, CHANGEUX

Colworth Medal Lecture

Molecules Mediating Signals L. STEVENS

Royal

Ultraviolet in DNA

Irish Academy Medal Lecture

Radiation Damage

colloquia

653rd Meeting Sussex

I95

107

R. 1. H. DAVIES 407

colloquium: Plant Peroxidases, Structure and Molecular Biology

Structural determinants of the catalytic activities of peroxidases

The crystal structure of ascorbate and manganese peroxidases: the role of non-haem metal in the catalytic mechanism

Aromatic donor molecule binding sites of haem peroxidases

The functional role of the key residues in the active site of peroxidases

Gene structures of peroxidase isoenzymes in horseradish and Arabidopsis thaliana and their expression

Expression of horseradish peroxidase in transgenic tobacco

Homology modelling of horseradish peroxidase coupled to two-dimensional NMR spectral assignments

P. R. ORTIZ DE MONTELLANO, S.4. OZAKI, S. L. NEWMYER, V. P. MILLER AND C. HARTMANN

T. L. POULOS, W. R. PAITERSON AND

M. SUNDARAMCCIRTHY

N. C. VEITCH

G. SMULEVICH

K. FUJIYAMA, C. INTAPRUK AND A. SHINMYO

A. PELLEGRINEXHI, M. KIS, I. Dix, T. A. KAVANAGH AND

P. J. Dix

G. H. Low, P. Du AND A. T. SMITH

113

iia

131

140

145

147

150

Volume 23 Part 2 May 1995

n 0 3 r) 0 3 rr VI

I -1

Z P n -1

z

F m

5 m

Functions of electrostatic potentials and conserved distal and proximal His-Asp H-bonding networks in haem peroxidases

Radical cation cofactors in lignin peroxidase catalysis

Vanadium chloroperoxidases occur widely in nature

Characterization of a novel non-haem-containing extracellular peroxidase from Thermomonorpora fusca

K. G. WELINDER, 6. BJ0RNHoLM AND H. 6. DUNFORD 257

P. J. HARVEY AND L. P. CANDEIAS 262

E. G. M. VOLLENBROEK, L. H. SIMONS, J. W. P. M. VAN SCHIJNDEL, P. BARNETT, M. BALZAR, H. DEKKER, C. VAN DER LINDEN AND R. WEVER

A. S. BALL AND C. TRIGO

267

272

colloquium: Lipids in Immune Function and Inflammatory Disorders

Chairman’s Introductory Remarks

n - 3 Polyunsaturated fatty acids in the regulation of human cytokine synthesis

Modulatory influence of unsaturated fatty acids on the biology of tumour necrosis factor-a

Suppression of autoimmune disease by a, - 3 fatty acids

Fatty acid modulation of cell responsiveness

Arachidonic acid in the reticuloendothelial network

Fatty acids, dietary lipids and lymphocyte functions

K. W. J. WAHLE

S. ENDRES, T. EISENHUT AND B. SINHA

277

277

R. F. GRIMBLE AND P. S. TAPPIA 282

D. R. ROBINSON, C. T. KNOELL, M. URAKAZE, R. HUANG, 287 H. TAKI, E. SUGIYAMA, L.-L. Xu, E. T. H. YEH, W. OLESIAK, M. Guo, R. B. COLVIN AND P. E. AURON

D. ROTONDO 29 I

H. A. LEAVER, J. R. WILLIAMS, I. M. DAWN AND 297 P.-L. YAP

P. C. CALMR 302

~~~

colloquium: Regulation of Carbohydrate Metabolism in Muscle and Liver

Regulation of glucose metabolism in cardiac muscle

Mechanisms underlying suppression of glucose oxidation in insulin-resistant states

The mitochondria1 carnitine palmitoyltransferase system: its broadening role in fuel homoeostasis and new insights into its molecular features

Amylin regulation of carbohydrate metabolism

Adult glucose and lipid metabolism may be programmed during fetal life

Paracrine/autocrine control of the islet and the amylin family

L. HUE, C. DEPRE, V. LEFEBVRE, M. H. RIDER AND

K. VEITCH

M. C. SUGDEN AND M. J. HOLNESS

31 I

314

J. D. MCGARRY 32 I

A. YOUNG, R. PITTNER, B. GEDULIN, W. VINE AND

T. RINK

M. DESAI, N. J. CROWTHER, S. E. OZANNE, A. LKAS AND C. N. HALES

D. M. SMITH AND S. R. B L ~

325

331

336

colloquium: The Control of Flux: 21 Years On

n 0 J ft

The control of flux

Molecular biology for flux control

Control analysis of energy metabolism in mitochondria

Probing the properties of enzymes in vivo using NMR

Two paradigms of metabolic engineering applied to amino acid biosynthesis

Recent developments beyond Metabolic Control Analysis

H. KACSER, J. A. BURNS AND D. A. FELL

P. R. JENSEN, J. L. SNOEP, D. MOLENAAR, W. C. VAN HEESWIJK, B. N. KHOLODENKO, A. A. VAN DER GUGTEN A ~ D H. V. WESTERHOFF

M. D. BRAND AND A. KESSELER

34 I

367

37 I

K. BRINDLE, 5. FULTON, J. SHELEON AND S. WILLIAMS 376

T. W. SIMPSON, G. E. C O L ~ N AND G. STEPHANOPOULOS 38 I

H. KACSER 387

colloquium: Molecular Liaisons

Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in V,,,,,., stability and membrane association

Models of human disease through gene targeting

M.D. HOUSLAY, G. SCOTLAND, L. POOLEY, S. SPENCE, I. WILKINSON, F. MCCALLUM, P. JULIEN, N. G. RENA, A. M. MICHIE, S. ERDOGAN, L. ZENG, J. C. O'CONNELL, E. S. TOBIAS AND I . MACPHEE

393

R. C. MOORE AND D. W. MELTON 398

Transforming growth factor-8 and the protection from cardiovascular injury hypothesis

J. C. METCALFE AND D. J. GRAINGER 403

colloquium: Environmental Biochemistry

Drug metabolizing enzymes of mussels as bioindicators of chemical pollution

The glutathione S-transferase multigene family: a paradigm for xenobiotic interactions

Peroxisome proliferation in response to xenobiotics

Might environmental factors contribute to neurodegenerative diseases?

Detection of micro-organisms in the environment

D. SHEEHAN, J. MC~NTOSH, A. POWER AND

P. J. FITZPATRICK

T. J. MANTLE

J. W. DEPIERRE, A.-K. SOHLENIUS, Y. CAI, A. MESSING ERIKSSON. K. ANDERSSON AND c. SUNDbERG

K. F. TIPTON

R. POWELL, M. MULL-ARKEY, D. O'BRIEN AND

J. 0. MC~NERNEY

419

423

425

429

435

(D

I

0" 3 r ) 0 3 r ) v)

I

Plant peroxidases, structure and molecular biology

Magnetic circular dichroism studies on Vaccinium myrtillus cationic peroxidases

lonically-bound and covalently-bound wall peroxidases differ in their substrate specificity

N. S. MELO, P. S. FEVEREIRO AND E. LARSEN I495

G. J. MCDOUGALL AND I. M. MORRISON 150s

A structural model of the alternative oxidase of plant A. L. MOORE, A. L. UMBACH AND J. N. SIEMW 151s mitochondria

Progress in the characterization of catalase-peroxidase from Mycobacterium tuberculosis

j. M. NAGY, A. E. G. CASS AND K. A. BROWN 152s

Electron transfer between cytochrome c peroxidase and ferrocene

S. J. SADEGHI AND A. E. G. CASS I535

Purification and partial characterization of 'extensin peroxidase' M. D. BROWNLEADER

N. AHMED, M. CHAPLIN, M. TREVAN, P. M. DEY AND 1545

Photosynthesis

reversible addition of 2-nitrobenzyl groups

Studies on photocleavable nitrobenzyl-bovine serum albumin conjugates

CO flash photolysis of cytochrome bd from Azobacter vinelandii

The modulation of Protein A-lgG(Fc) binding by the S. THOMPSON, M.-C. FAWCETT, J. A. SPOORS AND 155s C. H. SELF

C. H. SELF, M.-C. FAWCETT, J, A. SPOORS, L. B. PULMAN AND S. THOMEON

S. JUNEMANN, P. R. RICH AND J. M. WRIGGLESWORTH

156s

I575

Glvcobiolonv of inflammation

Appearance of lymphocytes positive for E-selectin ligands during inflammatory reactions in vivo

The L-selectin counter-receptor in porcine lymph nodes

Endothelial selectin expression and leukocyte trafficking in cutaneous DNFB-induced delayed hypersensitivity

The kinetics of E-selectin expression and leukocyte traffic in BCG/PPD delayed hypersensitivity in the pig

Adhesion of eosinophils to E- & P-selectin

Oligosaccharides of IgG in rheumatoid arthritis

The influence of cytokines on the glycosylation pattern of a- I -acid glycoprotein secreted by the HepG2 cell line

Tissue specific expression of the human a( 1-3) fucosyltransferase gene family

Chemical modification of a( 1-3) fucosyltransferase defines residues of caalytic importance

Activation of complement by DMSO and ethanol and i t s inhibition by soluble complement receptor type I

S. T. WOOLLEY, A. WHYTE, S. T. LICENCE, M. K. ROBINSON, D. 0. HASKARD AND R. M. BINNS

A. WHYTE, P. WOODING, N. NAYEEM, S. R. WATSON, S. D. ROSEN AND R. M. BINNS

A. WHYTE, S. T. LICENCE, S. T. WOOLLEY, A. A. HARRISON, D. 0. HASKARD AND R. M. BINNS

A. A. HARRISON, A. WHYTE, S. T. LICENCE, S. T. WOOLLEY, R. M. BINNS AND D. 0. HASKARD

R. PRIEST, S. NAWAZ, P. M. GREEN AND M. I. BIRD

A. J. MACGILLIVRAY, M. IWOBI, L. FERNANDES AND

G. PAPASAWAS

H. G. ELLIOTT, M. A. ELLIOTT, J. WATSON AND

K. D. SMITH

A. WINDER, N. SMITHERS, S. WITHAM, A. SYMONS AND M. EDBROOKE

C. BRITEN, C. HOOD AND M. BIRD

A. J. LAVER, M. HIBBS AND R. A. G. SMITH

158s

159s

160s

161s

162s

163s

164s

165s

I665

167s

An improved multiwell immunoassay using digoxigenin- labelled lectins to study the glycosylation of purified glycoproteins

M. T. GOODARZI, M. RAFIQ AND G. TURNER 168s

Molecular mechanisms of signalling by tyrosine kinases

lnositol I ,2,3-trisphosphate is a product of InsP, dephosphorylation in WRK- I rat mammary epithelial cells and exhibits transient concentration changes the cell cycle

Contrasting mechanisms of intracellular calcium ([Ca2+Ii) elevation by angiotensin II (All) and platelet derived growth factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs)

AIF,- inhibits influx of Ca2+ into vascular smooth muscle cells

Correlation of heparin binding with responsiveness in human vascular smooth muscle cells

Differential mitogenic effects of PDGF isoforms and heparin on human vascular smooth muscle cells

Signalling at the epidermal growth factor receptor: role of glycosyl-phosphatidylinositol hydrolysis

Cyclic AMP modulates adipogenesis in 3T3-F442A cells

Critical role for the phosphorylation of tyrosines 674 and 675 in signalling by the Trk tyrosine kinase

Developmental protein expression in thermally stressed Pisum sativum plants

lmmunochemical characterization of mitochondria1 proteins isolated from Pisum sativum, subjected t o thermal stress and age development

The role of phosphatidylinositol 3-kinase activity in insulin-stimulated mitogenesis in 3T3-L I adipocytes

Purification of an insulin-stimulated acetyl-CoA carboxylase kinase from rat epididymal adipose tissue

Inhibition of Xenopus laevis poly (ADP-ribose) polymerase in oocytes

Cytokine-induced E-selectin expression by human umbilical vein endothelial cells (HUVEC). A role for protein tyrosine kinases?

Effect of phorbol esters on phosphatidylinositol 3-kinase activity in adipocytes

Differential modulation of apical and basolateral endocytosis in Caco-2 cells

lntracellular mediators of insulin-like growth factor I during otic vesicle development

C. J. BARKER, J. WRIGHT, C. J. KIRK AND R. H. MICHELL 1695

G. F. CLUNN, M. SCHACHTER AND A. D. HUGHES

A. D. HUGHES AND M. SCHACHTER

J. 8. REFSON, M. SCHACHTER, M. K. PATEL, P. CHAN, J. H. N. WOLFE AND P. SEVER

J. 8. REFSON, M. ~ H A C H T E R , M. K. PATEL, J. H. N. WOLFE AND P. SEVER

D. R. JONES, R. CLEMENTE AND I. VARELA-NIETO

8. J. YARWOOD, N. G. ANDERSON AND E. KILGOUR

M. GUITON, F. J. GUNN-MOORE AND J. M. TAVARE

C. K. WOOD, J. R. PRATT AND A. L. MOORE

J. R. PRATT, C. K. WOODANDA. L. MOORE

R. J. HAIGH, P. R. SHEPHERD, B. T. NAVE AND K. SIDDLE

K. J. HEESOM, 8. K. MOULE AND R. M. DENTON

S. AOUFOUCHI AND 8. SHALL

M. J. MAY, C. P. D. WHEELER-JONES AND J. D. PEARSON

B. T. NAVE, P. R. SHEPHERD AND K. S~DDLE

W. SHURETY AND J. P. Luzio

Y. LEON, C. SANZ AND I. VARELA-NIETO

170s

1715

1725

I735

174s

I755

I765

177s

I785

I795

180s

1815

182s

1835

184s

185s

Construction and expression of a functional chimeric receptor from PDGFr-B and c-erbB-2

Effects of myristoylated pseudosubstrate protein kinase C peptide inhibitors on insulin secretion

Comparative phosphorylation kinetics of the human insulin receptor protein-tyrosine domain and an enzymatically competent deletion construct - the tail could wag the dog

Calcium oscillations and waves during IgE receptor crosslin king

Possible role for PI3 kinase but not ~ 7 0 ~ ~ ~ in regulation of lipogenesis by insulin and growth hormone in sheep adipose tissue

Micro-injection of p2 I ras into Xenopus oocytes, o r incubation of oocyte S- I00 with ATP, induces the activation of elF-4a kinase(s)

A basic residue C-terminal to tyrosine compromises its viability as a tyrosine kinase target

P2 I -ras is involved in regulation of voltage-dependent calcium channels in cultured rat dorsal root ganglion cells

Stimulation of platelets with platelet-activating factor induces changes in the subcellular distribution and activity of the tyrosine kinase pp6OC-"'

V-Ras activates phosphatidylinositol 3-kinase

Role of c-lyn in the functional effects of GM-CSF on human neutrophils

Differential effects of wortmannin on growth hormone dependent signalling pathways in 3T3-F442A cells

Phosphatidic acid phosphohydrolase in guinea-pig airway smooth muscle

Phospholipase D regulation involves extracellular calcium as a conditional requirement for subsequent stimulation by protein kinase C

PKC-dependent activation of the type II adenylate cyclase in airway smooth muscle limits the bradykinin- stimulated ERK-2 pathway

Involvement of PI 3-kinase in stimulation of glucose transport and recruitment of transferrin receptors in 3T3-L I adipocytes

Insulin activates glycogen synthase by a novel PI 3-kina~e/p70"~ dependent pathway in 3T3-L I adipocytes

Thrombin and histamine phosphorylate the 42 kDa mitogen-activated protein kinase in HUVEC

I. J. UINGS, G. D. SPACEY AND R. W. BONSER 186s

T. E. HARRIS, S. J. PERSAUD, T. SAERMARK AND

P. M. JONES

P. G. QUIRK, N. E. KEANE, B. A. LEVINE, L. WEI AND

L. ELLIS

187s

188s

B. HAYES, A. CROFTS AND K. RAY 189s

R. G. VERNON AND S. LINDSAY-WA~ 190s

S. J. MORLEY AND V. M. PAIN 191s

N. E. KEANE, P. G. QUIRK, B. A. LEVINE, A. CHAVANIEU, 192s B. CALAS, Y. GAO, L. WEI AND L. ELLIS

E. M. FITZGERALD AND A. C. DOLPHIN 193s

C. T. MURPHY AND J. WESTWICK 194s

T. KODAKI, R. W~XHOLSKI AND P. J. PARKER 195s

N. T. THOMPSON, R. W. RANDALL AND L. G. GARLAND 196s

N. G. ANDERSON AND E. KILGOUR 197s

D. G. TOLAN, N. J. PYNE AND S. PYNE 198s

S. PYNE AND N. J. PYNE 199s

N. J. PYNE, P. STEVENS, N. MOUGHAL AND S. PYNE 200s

P. R. SHEPHERD, B. T. NAVE AND K. SIDDLE 201s

P. R. SHEPHERD, B. T. NAVE AND K. SIDDLE 202s

C. P. D. WHEELER-JONES AND J. D. PEARSON 203s

Phosphatase inhibitors potentiate the release of vasoactive mediators from human endothelium

Effects of myristoylated pseudosubstrate inhibitor of PKC in intact human platelets

Studies with wortmannin indicate that insulin stimulation of lipogenesis involves multiple signalling pathways

Cloning of a chicken gene homologous to the rabbit mono-ADP-ribosyltransferase gene

The regulation of phospholipase C (PLC) and phospholipase D (PLD) by G protein receptor- activated tyrosine kinases in aT3- I cells

Characterization of a novel '22kDa' phosphoprotein which may be important in insulin action

The effect of tyrosin kinase inhibition on phorbol 12.13-dibutyrate- and ionomycin-induced LH and GH release

C. P. D. WHEELER-JONES, R. A. HOULISTON, A. J. MORGAN AND J. D. PEARSON

C. P. D. WHEELER-JONES, S. SAVED AND

S. J. PEFSAUD

S. K. MOULE, N. J. EDGELL, G. I. WELSH, T. A. DIGGLE, C. G. PROUD AND R. M. DENTON

204s

205s

2065

T. DAVIS AND S. SHALL 207s

R. MITCHELL, W. B. WOLBEFS, P. SIM AND

M. FENNELL 208s

T. A. DIGGLE AN[

M. S. JOHNSON, J. R. MITCHELL

R. M. DENTON 209s

~OBLE, W. B. WOLBEFS AND 210s

Biochemical immunology group

antigen 19-9 and carbohydrate antigen I25 in carcinoma of the lung

Serum levels of neuron-specific enolase, carbohydrate G. OKTAY, G. GUNER, C. KARLIKAYA AND

A. AKKKLU

A. GUNER, G. OKTAY, M. KERMAN AND G. GUNER

21 I S

Immunoglobulins and a- I -proteinase inhibitor in 212s human intervertebral disc material

Iron, desferrioxamine, and ATP interactions in proliferating lymphocytes and B-cell lines

Apoptosis in T and B lymphocyte's life cycles

G. 0. LATUNDE-DADA AND S. P. YOUNG 213s

C. G. H. BELL 214s

Heat shock protein (Hsp)65-70: dominant self-antigen candidate in the selection of yd lymphocytes?

B-cell repertoire selection: fine specificity of antibodies elicited by bacterial polysaccharide dextrans and by V-region reactive ligands

C. G. H. BELL

C. G. H. BELL

2155

2165

Hormone Prow

High concentrations of B-adrenergic agonists inhibit DNA binding of glucocorticoids in human lung in vitro

Measurement of insulin secretion from single pancreatic assay

Characterization of a variant of ovine growth hormone (oGH I158A) produced by site-directed mutagenesis

Preparation and characterization of recombinant DNA-derived ovine growth hormone variants in which the C-terminal disulphide bridge is modified

The mitogen-activated protein kinase cascade in rat islets of Langerhans

cells using a reverse haemolytic plaque

I. M. ADCOCK, M. J. PETERS, C. R. BROWN, D. A. STEVENS AND P. J. BARNES

H. RATCLIFF AND P. M. JONES

217s

218s

A. LIOUPIS, 0. C. WALLIS AND M. WALLIS 219s

R. E. GILES, 0. C. WALLIS AND M. WALLIS 220s

S. J. PEFSAUD, C. P. D. WHEELER-JONES AND P. M. JONES 221s

n 0 3

3 (3 VI

0 I 8 3 3 i5' R i5'

C 3

.II

3t

Membrane group

Effects of ion concentration gradients on glycine transport and accumulation

L. C. WARREN AND K. P. WHEELER 222s

Molecular and cellular pharmacology group

The involvement of inositol lipids and phosphates in signalling in the fission yeast Schizosocchorornyces pornbe

Antioxidant status in hypertension and effects of angiotensin converting enzyme inhibition

J. A. STUART, P. j. HUGHES, C. J. KIRK, j. DAVEY AND

R. H. MITCHELL 223s

H. J. F. WHY, H. ANSELL, V. B. PATEL, W. S. WASSIF, j. REEVES, T. SIDDIQ, P. J. RICHARDSON AND

V. R. PREEDY

224s

Naphthoquinone-induced DNA damage in the absence of oxidative stress

W. A. MORGAN 225s

Neurochemical group

Nerve growth factor regulation of a late response gene - neuropeptide Y

Alanine reverses the inhibitory effect of phenylalanine and i ts metabolites on Na*,K+-ATPase in synaptic plasma membanes from cerebral cortex of rats

formation from labeled substrates by rat cerebral cortex

Inhibition of citrate oxidation in vim by 2-hydroxybutyrate and 4-hydroxybutyrate in cerebral cortex of young rats

N. HOLLIDAY, D. BALBI, A. PANCE AND J. M. ALLEN

A. T. S. WYSE, M. WAJNER, A. BRUSQUE AND

C. M. D. WANNMACHER

226s

227s

2-Hydroxybutyrate and 4-hydroxybutyrate inhibit CO, C. S. DUTRA-FILHO, M. WAJNER, C. M. D. WANNMACHER, E. GASSEN, R. H. CANDIAGO, A. M. WILHELMS AND H. F. C. DE MALFUSSI

C. S. DUTRA-FILHO, M. WAJNER, C. M. D. WANNMACHER, E. GASSEN, R. H. CANDIAGO, A. M. WILHELMS AND H. F. C. DE MALFUSI

220s

229s

Free radicals and oxidative stress - environment, drunr and food additives

Mechanisms of free-radical scavenging by the nutritional antioxidant B-carotene

Effect of superoxide dismutase on nitric oxide production by RAW264 macrophages

E.p.r. studies on reduced rat liver mitochondria incubated with nitric oxide

Nitric oxide production, alveolar macrophages and type II alveolar epithelial cells in response to LPS in vivo and in v i m

Changes in the catalytic properties of benzylamine oxidase

Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs

Muscle damage revisited: does tamoxifen protect by membrane stabilization or radical scavenging rather then via the E2-receptor?

Modification of aromatic amino acids by reactive nitrogen species

S. A. EVERETT, S. C. KUNDU, S. MADDIXAND R. L. WILWN

S. P. FRICKER, E. SLADE AND N. A. POWELL

230s

231s

M. P. LINHARES AND R. CAMMACK 232s

X. LI, K. DONALDSON AND W. MACNEE 233s

I. J. SILVA, M. S. AZEVEDO AND C. F. MANSO 234s

I. RAHMAN, X. Y. LI, K. D~NALDSON AND W. MACNEE 235s

P. D. R. BAR, R. W. KOOT AND G. H. J. AMELINK 2365

A. VAN DER VLIET, J. P. EISERICH, 6. HALLIWELL AND

c. E. CROSS 2375

Interactions of diesel engine emissions with extracellular biological fluids

Role of oxidants in TNF-a-mediated cytotoxicity

Fructation induced cross-linking of /?-lactoglobulin and lysozyme

Molecular mechanisms of chromium toxicity: oxidation of hemoglobin

The role of thiols in oxidation of low-density lipoprotein by macrophages

The use of LDL-resembling particle (LDL-r) as a model for the investigation of the effect of oxidation on the behaviour of LDL

A study of the effects of complexation of heme by hemopexin upon its reactions with organic peroxides

Effect of a very low fat diet on lipid peroxidation indices

Effect of a high fat meal on lipid peroxidation products

Dietary linoleic acid in alcohol-induced liver cirrhosis

Detection of intermediates formed on reaction of hyaluronic acid and related materials with the hydroxyl radical

The action of iron on amino acid and protein peroxides

The pro-oxidant activity of aminoguanidine and protein glycation

Structural modulation of lipid peroxidation by the proteins within membranes: model protein studies with liposomes

The interaction of carotenoids with reactive oxy-species

Release of the antioxidant, ferulic acid, from plant material by specific esterases

Evaluation of the antioxidant properties of food extracts

Influence of the SOD-mimetic complex Cu-PuPy on cellular redox systems, adenylates, and cell survival

Mechanism of inhibition of microsomal lipid peroxidation by estrogens: possible interactions with the cytochrome P450-dependent monooxygenase system

Antioxidants and the prevention of cataract

J. P. EISERICH, A. VAN DER VLIET, B. HALLIWELL AND

c. E. CROSS

V. B. O'DONNELL AND A. Azzi

J. LIGGINS AND A. J. FURTH

M. C. ALPOIM, C. F. GERALDES, C. R. OLIVEIRA AND

M. C. LIMA

J. L. WOOD AND A. GRAHAM

K. R. BRUCKDORFER AND C. ETELAIE

G. S. TIMMINS, M. J. DAVIES AND U. MULLER-EBERHARD

C. H. BOLTON, J, F. DWIGHT, T. M. LEVY, V. J. PARFITT AND M. HARTOG

C. H. BOLTON, K. STEER, V. J. PARFITT, M. I. HOPTON AND M. HARTOG

J. M. BAILEY, G. FISKUM, A. N. MAKHEJA AND

J. Y. VANDERHOEK

C. L. HAWKINS AND M. J. DAVIES

S. GEBICKI, G. BARTOSZ AND J. M. GEBICKI

J. V. HUNT, A. G. Mcbv AND J. T. SKAMARAUSW

A. RIEDL, M. ANDERTON. Z. SHAMSI, P. GOLDFARB AND

A. WISEMAN

T. G. TRUSCOT, D. MCGARVEY, C. LAMBERT, T. HILL, J. TINKLER, P. CONN, F. BOHM, E. J. LAND AND

W. SCHALCH

C. B. FAULDS AND G. WILLIAMSON

G. W. PLUMB, S. J. CHAMBERS, N. LAMBERT, S. WANIGATUNGA, G. R. FENWICK AND

G. WILLIAMSON

A. NAGELE

M. B. RUIZ-LARREA, A. LEAL, R. MARTINEZ, C. MARTIN AND M. LACORT

2385

2395

240s

241s

2425

2435

244s

245s

246s

2475

2485

249s

250s

251s

2s2s

253s

254s

255s

256s

W. R. MCLAUCHLAN, J. SANDERSON AND G. WILLIAMSON 257s

3 r )

3 r ) ul I

Free-radical mediated toxicity in whole rat brain reaggregate cultures is prevented by a-tocopherol

Damage to DNA and RNA by tumour promoter- derived alkoxyl radicals: an EPR spin trapping study

Investigations of a series of novel cationic photosensitisers and their potential use in photodynamic therapy

Detection of protein radicals formed by the photodynamic action of porphyrin sensitizers

Amplification of oxidative stress by decarboxylation: a new strategy in anti-tumour drug design

Oxidative stress in the plant tissue culture environment

ATP: a hitherto unrecognised, iron-specific membrane antioxidant

Differential inhibition of DNA synthesis by paracetamol in the rat testis and GI tract

Molecular liaisons

R. M. Fox, J. DAVENPORT JONES AND C. K. ATTERWILL

C. HAZLEWCOD AND M. J. DAVIES

S. M. BURROW, S. GUINOT, M. WAINWRIGHT, 1.1. WARING AND D. A. PHOENIX

J. A. SILVESTER, G. S. TIMMINS AND M. J. DAVIES

L. P. CANDEIAS, L. K. FOLKES AND P. WARDMAN

L. ROBERTSON, W. J. MAGILL, E. E. BENKIN, D. H. BREMNER AND T. E. J. BUULTJENS

T. HALLINAN, D. KUNDU AND J. GOR

C. LISTER AND A. MCLEAN

258s

2595

260s

261s

262s

2635

264s

265s

Cloning and over-expression of the structural gene encoding isocitrate dehydrogenase from Klebsiella pneumoniae

Functional characterisation of an ovine oxytocin signal transduction pathway in oxytocin receptor cDNA transfected Cos 7 cells

Analysis of a novel A-kinase anchoring protein 100, (AKAP 100)

Exogenous CD59 incorporated into U937 cells through i t s glycosyl phosphatidylinositol anchor becomes associated with signalling molecules in a time dependent manner

The human A3 adenosine receptor gene

Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells

C. A. INCHE, D. J. PLATT, H. KACSER, S. A. COWAN C. F. A. BRYCE AND E. M. T. EL-MANSI

2665

P. R. RILEY, H. j. STEWART, R. E. ABAYASEKARA AND

A. P. F. FLINT 267s

S. MCCARTNEY, B. M. LITTLE AND J. D. SCOTT 2685

C. W. VAN DEN BERG, T. CINEK, M. B. HALLETT, V. HOREJSI AND B. P. MORGAN

269s

E. MURRISON, S. J. GOODSON, C. A. HARRIS AND

M. R. EDBROOKE

R. E. ABAYASEKARA, M.-J. SEARLE AND A. P. F. FLINT

270s

27 I S

b ids in immune function and indammatow disorders

The effect of dietary lipid manipulation on macrophage cell surface molecule expression

Dietary lipid modulation of cell mediated immunity in the rat

Systemic sclerosis, plasma antioxidants and lipids

Synthesis of ph~sphatidyl[~H]butanol molecular species by phospholipase D in HL60 granulocytes

Substrate selectivity of phospholipase D in HL60 granulocytes: effects of fatty acid supplementation

E. J. SHERRINGTON, P. SANDERSON AND P. C. CALDER 272s

P. SANDERSON, P. YAWB AND P. C. CALDER 273s

T. D. BUNCE, C. M. BLACK AND K. R. BRUCKCORFER

Y. M. M. HEUNG AND A. D. PSTLE

274s

275s

Y. M. M. HEUNG AND A. D. PSTLE 276s

Effects of high levels of dietary oils on autoimmune responses

Apo C subclasses from non-insulin-dependent diabetic patients - a quantitative comparison with control subjects

The effect of dietary lipid manipulation on the production of murine T-cell derived cytokines

The effects of dietary lipid manipulation upon the production of reactive oxygen species by murine peritoneal macrophages

Spontaneous hyperlipoproteinaemia in the Arabian dromedary

The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation

A role for phosphoinositide 3-kinase in RANTES induced chemotaxis of T lymphocytes

Comparison of the lipolysis of chylomicron remnants derived from corn oil or olive oil by hepatic lipase in vitro

Depolarising levels of KCI inhibit endothelin- I -mediated release of arachidonic acid in rat C6 glioma cells

The effect of cytokines on tissue factor expression in HL-60 and U937 cell lines

H. A. C. ATKINSON AND J. MAISEY

S. VENKATESAN, H. IMRIE, S. READ AND D. HALLIDAY

P. YAWS AND P. C. CALDER

P. C. CALDER

M. P. T. GILLET, M. S. LAKHANI AND G. NATION

A. WILKIN, D. SANSOM, R. PARRY, J. WESTWICK AND

S. WARD

L. TURNER, S. G. WARD AND J. WESTWICK

K. M. BOTHAM, P. A. MAYES, M. AVELLA, A. CANTAFORA AND E. BRAVO

D. J. DUNICAN, R. GRIFFITHS, L. A. J. O’NEILL AND

D. C. WILLIAMS

J. C. FREEBURN, W. S. GILMORE AND J. J. STRAIN

277s

2785

279s

2805

2815

282s

2835

2848

2855

286s

The control of flux: 21 years on

A series of cases in which metabolic channelling can decrease the pool size at constant net flux in a simple dynamic channel

Top-down regulation analyses of palmitoyl-CoA oxidation and ketogenesis in isolated rat liver mitochondria

A mathematical model t o describe quinone pool kinetics and analyse control of respiration in plant mitochondria

lsoprenoid synthesis in peppermint (Mentha x giperita): development of a model system for measuring flux of intermediates through the mevalonic acid pathway in plants

In situ regulation of methylglyoxal metabolism

Regulation of oxidative and glycogenolytic ATP turnover in exercising rat skeletal muscle

Trans-sarcolemmal Pi fluxes in perfused rat heart: a quantitative analysis

Error and bias in control coefficients calculated from elasticities

P. MENDES, D. B. KELL AND H. V. WESTERHOFF 2875

R. A. MAKINS, L. F. DRYNAN, V. A. ZAMMIT AND

P. A. QUANT

2885

K. KRAB, C. W. M. VAN DEN BERGEN AND A. L. MWRE 289s

D. MCCASKILL AND R. CROTEAU 2905

C. A. CORDEIRO AND A. P. FREIRE

A. L. SANDERSON, G. J. KEMP, C. H. THOMPSON AND

G. K. RADDA

G. J. KEMP, K. E. POLGREEN, J. A. C. HOPKINS, K. CLARKE 2935 AND G. K. RADDA

S. THOMAS AND D. A. FELL

291s

292s

294s

n 0 3 rs 0 3 rs # I

C 3

0 3

3 r ) cn

P

I

Cytochrome c oxidase control by ApH and A Y gradients: effects of fatty acids

P. NICHOLLS. M. SHARPE AND C. TARBA 295s

Object-oriented metabolic programming 1. H. WOODS 296s

Design of experiments to measure elasticity coefficients 297s D. A. FELL

Stimulation of free radical reactions: a multi-compartment Monte Carlo approach

J. P. MONIZ-BARRETO AND D. A. FELL 2985

Lipid group

Lipid analysis in human intervertebral disc material G. OKTAY, A. GUNER, G. GUNER, M. KERMAN AND

U. PABUCCUOLU

A. ADJABI, N. BELATAR, H. AMANI AND S. AQUABED

299s

Study of phospholipids in mucilage (Gum) of sunflower, rapeseed and soja: analytical approach

Effect of phospholipid extracts from brain and egg on activated partial prothrombin time

Desaturation and esterification of palmitic and stearic acids in cultured hepatocytes

N-3 polyunsaturated fatty acids (PUFA) modulate the expression of functionally associated molecules on human monocytes

Molecular enzymology group

300s

A. ADJABI, S. AMOKRANE, N. BELATTAR AND

Y. BOUGUERN

j. S. BRUCE, S. RICHARDS, G. LEGRAND AND A. M. SALTER 302s

3015

D. A. HUGHES, A. C. PINDER, Z. PIPER AND E. K. LUND 303s

Cloning and expression of human intestinal sucrase- isomaltase

C. E. C. MCOLENAAR AND H. Y. NAIM

Analysis of the putative cleavage site in human lactase-phlorizin hydrolase

R. JACOB AND H. Y. NAIM

304s

305s

Peptidase content of the bile canalicular membrane

Substrate dependence of the mitochondria1 energy status in the isolated working rat heart

Localisation and characterisation of carbonic anhydrase isozymes (CA I, CA II, CA 111 and CA IV) in an umbilical vein endothelial cell line (EA-hy926)

Characterization of a human ductal pancreatic Capan-I clone (IMEH): carbonic anhydrases II and IV (CA II and CA IV) expression and targetting

Evaluation of alkaline phosphatase isoenzymes in sera of hemodialysis and periton dialysis patients by agarose gel electrophoresis

Small RNAs in the nucleus and cytoplasm

K. A. ZUZEL, J. G. GRAHAM, J. HRYSZKO, D. BILLINGTON AND A. J. TURNER

C. A. KEON, N. TUKHIYA, Y. KASHIWAYA, K. SATO, K. CLARKE, G. K. RADDA AND R. L. VEECH

I. MAHIEU, A. SAGGAR-MALIK, E. HOLLANDE AND

N. CARTER

3065

307s

308s

I. MAHAIEU, N. CARTER AND E. HOLLANDE 309s

G. OKTAY, M. FADILOLU. B. ONVURAL, T. CAMSARI AND 3 IOS A. CELIK

Effects of expression of the Epstein-Barr virus small RNA EBER- I in heterologous cells on protein synthesis and cell growth

Analysis of the double-stranded RNA binding properties of the La antigen

Interaction of the dsRNA-dependent protein kinase PKR with Epstein-Barr virus W RNAs

K. G. LAING, V. MATYS AND M. j. CLEMENS 31 I S

M. C. JAMES, G. j. M. PRUIJN. W. J. VAN VENRCOIJ AND

M. J. CLEMENS

E. ELIA, A. SCHOFIELD AND M. j. CLEMENS

3 12s

3135

Genomic organization of plant U I 4 snoRNA genes D. J. LEADER, J. F. SANDERS, A. TURNBULL-ROSS, R. WAUGH AND J. W. S. BROWN

T. OHLMANN, M. RAU, S. MORLEY AND V. M. PAIN

314s

Effect of cleavage of the p220 subunit of eukaryotic translation initiation factor elF-4F on protein synthesis in vitro

Features of the translational regulation of the mammalian growth-related protein P23

315s

A. V. BOROVJAGIN, P. RUSSELL, M. J. CLEMENS, M. A. GREAGG AND U.-A. BOMMER

316s

Regulation of carbohydrate metabolism in muscle and liver

Profiles of sorbitol dehydrogenase and Na+/K+-ATPase activity in a rat brain capillary cell line in various glucose concentrations may suggest an endothelium- protective mechanism

Restoration o f hepatic metabolism by cold reperfusion

Glycogen metabolism in G8 mouse muscle cells

Characterization of membrane bound carbonic anhydrase IV (CA IV) located on the external surface o f lung pulmonary endothelial cells

Hepatic glucokinase activity in animals fed glucose at birth

Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis and gluconeogenesis

Measurement of glycogenin utilization for glycogen synthesis in type II diabetic cells by use of a specific immunoassay for apo-glycogenin

Inhibition of nitric oxide synthase by L-arginine metabolites

C. N. B. ECHETA AND K. R. F. E L L I O ~ 317s

S. J. MITCHELL, T. A. CHURCHILL AND B. J. FULLER

Y. S. ANDERSON, C. A. WOOD AND G. K. RADDA

I. MAHIEU, A. BENJAMIN, R. STEPHENS, D. WALTERS AND

N. CARTER

318s

319s

320s

H. LYALL, D. TOSH AND A. BURCHELL 321s

R. A. HORTON, R. G. KNOWLES AND M. A. TITHERA~CE 322s

J. M. BAILEY, E. P. LILLEHOJ, A. N. SIDAWY, B. JONES AND 323s J . L. COHEN

I. DAS AND N. S. KHAN 3248

Nucleic acids and molecular biology group

Inhibition of Pax 5 activity by expression of i t s DNA binding domain

Duodenal expression of NF-E2 in mouse models of altered iron metabolism

The effect of various stretch and electrical stimulation regimes on proto-oncogene induction in skeletal muscle

Growth hormone induction and somatostatin suppression of hepatic proto-oncogenes and IGF- I in the rat

lmmunolocalization of proto-oncogene expression in mechanically stimulated skeletal muscle

Upregulation of calreticulin expression in HeLa cells by calcium-stress

The cytotoxicity of anthramycin to mutants o f Schizosoccharornyces pornbe deficient in D N A damage responses

G. Z. HASTINGS AND B. ADAMS 325s

K. B. RAJA, B. GERARD, A. MCKIE, C. BEAUMONT, R. J. SIMPSON, B. GRANDCHAMP AND T. J. PETERS

N. J. DAWES, D. M. LEE, V. M. Cox, H. NGA AND

D. F. GOLDSPINK

326s

327s

J. PENMAN, S. LIU, P. BELCHETZ AND D. F. GOLDSPINK 3285

D. M. LEE, N. J. DAWES, V. M. Cox, J. E. HESKETH AND 329s D. F. GOLDSPINK

D. H. LLEWELLYN. F. N. SHEIKH, J. M. KENDALL AND

A. K. CAMPBELL

F. HAW, D. E. THURSTON, A. M. CARR AND R. W. JONES 331s

330s

I; P 3

3 ~

v)

I 8 3 111

5 C 111

The role of zinc in the structure and function of the transcription factor BSAP (PAX-5 gene product)

J. M. GCODING AND B. ADAMS 3325

Protein and DeDtide science grow

Haem and non-haem iron in pig tissues and vitro

Production of soluble surface glycoprotein GP70, of

G. 0. LATUNDE-DADA

J. M. ALLEN, M. ALI AND M. 0. MCCLURE

333s availability studies

the Mason-Pfizer monkey virus in COS cells is dependent on the presence of regions of the transmembrane domain

334s

Regulation in metabolism group

methionine synthase by protein kinase A

In vivo hepatic energy perturbations during alanine infusion using )IP-NMR spectroscopy

In vitro phosphorylation of vitamin B,, dependent S. H. KENYON, T. AST AND W. A. GIBBONS 335s

K. K. CHANGANI, M. L. BARNARD, J. D. BELL, S. C. R. WILLIAMS, S. R. BLOOM AND R. A. ILES

336s

Insulin insensitivity in the ischaemic heart J. C. A. HOPKINS, K. CLARKE AND G. K. RADDA

K. LAZOUW, D. POUNTNEY AND R. J. SIMPSON

337s

338s Inhibition of duodenal mucosal ferricyanide reductase

~

Miscellaneous

Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of pp42 mitogen-activated protein kinase C and protein kinase A in EAhy926 cells

A. MCLEES, A. GRAHAM, K. MALARKEY, G. W. GOULD AND R. PLEVIN

339s

Lignin peroxidase catalysis: reaction with veratryl alcohol and a polymeric dye, Poly R

The permissive effect of serum on the inhibition of mitogen-activated protein kinase by forskolin in vascular smooth muscle cells

P. J. HARVEY, L. P. CANDEIAS, P. J. KING, J. M. PALMER AND R. WEVER

D. M. AIDULIS, K. MALARKEY, A. MCLEES, G. W. GOULD 34 I S AND R. PLEVIN

340s

Spectra and reactivity of the radical cations of lignin peroxidase co-factors and model compounds

L. P. CANDEIAS AND P. HARVEY 342s

Irish Area Section Meeting on Environmental Biochemistry, University College Cork

Ca2+ transport in erythrocytes from a hibernating and non-hibernating species

Regulated nuclear entry of a yeast transcription factor

The cloning and expression of the a subunit of equine glycoprotein hormones

Rheological and syneretic properties of acid gels fortified with whey proteins

Adenomatous polyposis coli gene mutations in Irish pedigrees with familial adenomatous polyposis

I -Methyl-4-phenylpyridinium and catechol-0- methyltransferase

A comparison of the regulation of de novo cholesterol synthesis by LDL and LP(a)

E. R. HORWITZ AND J. C. ELLORY 345s

D. NEILL, M. MCNAMARA AND G. BUTLER

M. OBRIEN AND D. R. HEACON

346s

347s

G. CURTIN, R. MEHRA, T. GUINEE, B. OKENNEDY, B. CONNOLLY AND D. SHEEHAN

M. J. OSULLNAN, T. MULCAHY, C. B. 0. SUILLEABHAIN, W. 0. KIRWAN, C. T. DOYLE AND T. V. MCCARTHY

J. M. BYRNE AND K. TIPTON

3485

349s

350s

S. M. GILLIGAN AND P. B. COLLINS 351s

Mutation screening of dihydropyridine receptor y subunit cDNA from malignant hyperthermia susceptible patients

The complementary actions of proline specific enzymes of guinea-pig brain

Seasonal variations in the levels of antioxidant enzymes in Mytilus edulis

The detection of bovine herpesvirus I in routine diagnostic submissions using PCR

Investigation of glucocorticoid modulation of apolipoprotein mRNA transcription

Use of proton NMR spectroscopy in the toxicological evaluation of new anti-mycobacterial agents

Regulation of Ca2+ release from the ryanodine receptor of sarcoplasmic reticulum

Gene expression in bovine mammary tissue at different stages of the oestrus cycle

Differential reactivity of native and recombinant xGST in various assay systems

Perturbations in the cytosolic free calcium ion concentration in isolated cells exposed to certain organic atmospheric pollutants

Use of HPLC for the determination of serum 7a-hydroxycholesterol in cholestyramine-treated rats

Comparative immunoblot analysis of the guanine nucleotide binding protein Gqa in control and Alzheimer's disease brains

Evidence from affinity precipitation that glutamate analogues are bound in a folded conformation to glutamate dehydrogenase

Resolution of lactate dehydrogenase isoforms by affinity precipitation

Purification of a-acetolactate synthase from Leuconostoc lactis NCW I

Response of root surface phosphatase activity of Molinia caerulea (L.) Moench, the purple moor grass, t o edaphic environments

Effect of probenecid and pyridoxal-5-phosphate on the aggregation of rat blood platelets

Thermal denaturation as a predictor of stability on long-term storage of a protein

Soluble protein changes in pollution-adapted Gammarus duebeni

Identification of novel ligands for the peripheral-type benzodiazepine receptor

P. J. LYNCH, F. J. COUCH, R. G. GREGG, P. A. POWERS, K. HCGAN AND T. V. MCCARTHY

352s

L. GILMARTIN 353s

354s A. POWER AND D. SHEEHAN

S. MOORE, M. GUNN AND D. WALLS

M. M. MACMAHON AND W. M. C. LOVE

355s

356s

R. OCONNOR, R. O'KENNEDY AND P. JAMES

G. H. OSULLIVAN AND J. J. A. HEFFRON

357s

3585

N. A. SEELY, J. SREENAN, D. MORRIS AND D. R. HEADON 3595

F. MANNING, A. CONWAY AND S. DOYLE

J. MC~NTOSH AND J. J. A. HEFFRON

L. D~WLING AND R. DEVERY

C. SHANAHAN, M. DEASY, R. RAVID AND C. ONEILL

M. ODONNELL, M. MAHER AND T. GRIFFIN

J. A. IRWIN AND K. F. TIPTON

N. M. CARROLL, D. SHEEHAN AND T. M. CWAN

K. A. SALIM, D. GORDON, S. SHAW AND C. A. SMITH

N. EL-NAGEH AND M. G. HARRINGTON

C. TWOMEY, S. DOONAN AND A. GIARTOSIO

L. JERVIS AND M. B. JONES

D. M. ZISTERER AND D. C. WILLIAMS

360s

361s

3625

3638

3645

3655

366s

367s

3685

369s

370s

371s

I)

3

3 rt v)

0

0 I

I 8 3 3

F S =I

=I u)

Haplotype analysis of the RYRl gene in malignant hyperthermia and central core disease

Aggregation characteristics of platelets in stored concentrates of human blood

Purification of glutathione S-transferases from Yarrowia lipolytica

Oxidative stress and human ageing

Relationship between early diet and subsequent cognitive performance during adolescence

Studies on the GTP binding ability of the human Rabrlp, expressed in E. coli

The significance of adenine phosphoribosyl- transferase for DNA repair processes in Friend cells

Cloning of electron-transferring flavoprotein from Megasphaera elsdenii

Construction of a recombinant HRab I A Baculovirus

The effects of mutating aspartate-95 and aspartate- I27 on the thermodynamic properties of Desulfovibrio vulgaris flavodoxin

Structural investigation of a glutathione binding site using computational analysis

Can PCR be used t o normalise a cDNA library?

Cloning of the gene for flavodoxin from the anaerobic bacterium Megasphaera elsdenii

Validation of a HPLC method for measurement of collagen crosslinks in urine - potential biomarkers for osteoporosis

Purification of collagen crosslinks; potential biomarken for bone disorders

Potassium ferrate as a DNA chemical sequencing reagent and probe of secondary structure

Cysteine plays a role in catalysis in glutathione S-transferase I - I Purification and properties of salmon liver biliverdin reductase

Co-purification from human blood plasma of activated factor XI1 with albumin with dye-ligand and metal- chelate chromatography

Expression of gelatinolytic activity by oesophageal and colon carcinoma cell lines

The relationship between volume-sensitive taurine efflux and the anion-exchanger in lactating mammary tissue

K. A. QUANE, K. E. KEATING, J. M. S. HEALY, J. J. A. HEFFRON, M. LEHANE, R. KRIVOSIC-HORBER, L. HEYTENS AND T. V. MCCARTHY

M.-L. NOLAN AND M. G. HARRINGTON

V. FOLEY AND D. SHEEHAN

C. M. KING AND Y. A. BARNETT

L. C. GREENE, A. LUCAS, M. B. E. LIVINGSTONE P. S. E. G. HARLAND AND B. A. BAKER

F. OBRIEN AND M. W. MCCAFFREY

A. A. NELSON, K. JOYCE, P. G. MCKENNA AND

Y. A. BARNETT

H. M. ONEILL, G. BUTLER AND S. G. MAYHEW

F. J. DRUMMOND AND M. W. MCCAFFREY

D. P. OCONNELL, G. VOORWW AND S. G. MAYHEW

T. R. BARRY, P. WATERS, S. NAN AND

D. SHEEHAN

C. POPE, P. V. NESTOR, C. MORRISON AND F. GANNON

S. M. GECGHEGAN, G. BUTLER AND S. G. MAYHEW

U. M. CASSERLY, B. J. MCGUINNESS, M. J. POWER AND

P. F. FOTTRELL

B. J. MCGUINNESS, U. M. CASSERLY, M. J. POWER AND

P. F. FOTRELL

C. STEVENSON AND R. J. H. DAVIES

R. M. MCCARTNEY AND D. SHEEHAN

G. ELLIOTT AND T. J. MANTLE

B. J. MION AND B. F. MASTERSON

P. DELLA PORTA, N. M. RYAN AND J. K. COLLINS

D. 8. SHENNAN, S. A. MCNEILLIE AND M. J. CLIFF

372s

373s

374s

375s

3763

377s

378s

379s

380s

381s

382s

383s

384s

3856

386s

3875

3885

3895

390s

3915

392s

The dependance of the detection limit of reagent- T. O'CONNOR, M. M. KANE AND 1. P. GOSLING 393s limited immunoassay on antibody affinity

The relative protein disulphide isomerase (PDI) C. C. CHEW, T. MAGALLON, N. MARTINAT, F. LECOMPTE, T. COMBARNOUS AND J. P. GOSLING

394s activities of gonadotrophins, thioredoxin and PDI

n 0 3

3 r ) M

ri 1