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commonfund.nih.gov/earlyindependence

https://commonfund.nih.gov/earlyindependence

New Paradigms • 4D Nucleome (4DN)• Extracellular RNA Communication (exRNA)• Molecular Transducers of Physical Activity Consortium (MoTrPAC)

The Common Fund (in the NIH Office of the Director) Current Programs:

Data/Tools/Methods • Big Data to Knowledge (BD2K)• Gabriella Miller Kids First• Genotype-Tissue Expression (GTEx)• Glycoscience• Human BioMolecular Atlas Program

(HuBMAP)• Illuminating the Druggable Genome

(IDG)• Knockout Mouse Phenotyping (KOMP)• Library of Integrated Network-Based

Cellular Signatures (LINCS)

• Metabolomics• Regenerative Medicine Program (RMP)• Science of Behavior Change (SOBS)• Somatic Cell Genome Editing (SCGE)• Stimulating Peripheral Activity to

Relieve Conditions (SPARC)• Transformative High Resolution Cryo-

Electron Microscopy (CryoEM)

New Types of Clinical Partnerships • Acute to Chronic Pain Signatures (A2CPS)• Global Health• HCS Research Collaboratory• Undiagnosed Diseases Network (UDN)

Transformative Workforce Support • Enhancing the Diversity of the NIH-Funded Workforce (DPC/BUILD)• High-Risk, High-Reward Research Program

• Pioneer Award• New Innovator Award• Transformative Research Award• Early Independence Award

• Strengthening the Biomedical Research Workforce (BEST)

commonfund.nih.gov Slide 3

https://commonfund.nih.gov


The Common Fund (in the NIH Office of the Director)Current Programs:

Data/Tools/Methods

New Paradigms

New Types of Clinical Partnerships

Transformative Workforce Support

• Big Data to Knowledge (BD2K)• Gabriella Miller Kids First• Genotype-Tissue Expression (GTEx)• Glycoscience• Human BioMolecular Atlas Program







• 4D Nucleome (4DN)• Extracellular RNA Communication (exRNA)• Molecular Transducers of Physical Activity Consortium (MoTrPAC)

• Acute to Chronic Pain Signatures (A2CPS)• Global Health• HCS Research Collaboratory• Undiagnosed Diseases Network (UDN)

• Enhancing the Diversity of the NIH-Funded Workforce (DPC/BUILD)• High-Risk, High-Reward Research Program




New Paradigms • 4D Nucleome (4DN)• Extracellular RNA Communication (exRNA)• Molecular Transducers of Physical Activity Consortium (MoTrPAC)

The Common Fund (in the NIH Office of the Director) Current Programs:

Data/Tools/Methods • Big Data to Knowledge (BD2K)• Gabriella Miller Kids First• Genotype-Tissue Expression (GTEx)• Glycoscience• Human BioMolecular Atlas Program







New Types of Clinical Partnerships • Acute to Chronic Pain Signatures (A2CPS)• Global Health• HCS Research Collaboratory• Undiagnosed Diseases Network (UDN)

Transformative Workforce Support • Enhancing the Diversity of the NIH-Funded Workforce (DPC/BUILD)• High-Risk, High-Reward Research Program





High-Risk, High-Reward Research Program

Annual funding opportunities




High-risk, high-impact ideas




No preliminary data or detailed experimental plan required




Any topic relevant to NIH mission




Any topic relevant to NIH mission, including: behavioral, social, biomedical, applied, and formal sciences,

and basic, translational, or clinical research




Encourages applications from investigators with diverse backgrounds

and from the full spectrum of eligible institutions



High-Risk, High-Reward Research Program Chair James M. Anderson, MD, PhD OD Program Leader Ravi Basavappa, PhDOSC/DPCPSI/OD Members Kristin Abraham, PhDNIDDK Vernon Anderson, PhDNIGMS Hugh Auchincloss, MDNIAID David Balshaw, PhDNIEHS Abraham P. Bautista, PhD NIAAA Eugene Carstea, PhDCSR Robert H Carter, MDNIAMS Jennifer Collins, MRNIEHS

Christine Colvis, PhDNCATS Judith A. Cooper, PhD NIDCD Milton Corn, MD, FACP, FACMI NLM Cindy D. Davis, PhDOffice of Dietary Supplements/DPCPSI/OD Emmeline Edwards, PhD NCCIH Zeynep Erim, PhDNIBIB Rene Etcheberrigaray, MDNIA Valerie Florance, PhDNLM Gabriel HidalgoNIDCR Christine Hunter, PhD, ABPPOBSSR/DPCPSI/OD Raymond Jacobson, PhDCSR

Flora Katz, PhDFIC Karen Kellton OSC/DPCPSI/OD Anthony Kirilusha, PhDNIAMS Susan Koester, PhDNIMH Rajiv Kumar, PhDCSR James Li, PhDCSR Roger Little, PhDNIDA James Mack, PhDCSR Judy A. Mietz, PhD NCI Becky Miller, PhD OSC/DPCPSI/OD Brett Miller, PhDNICHD Daniel Miller, PhDNINDS

Michael Morse OSC/DPCPSI/OD Ellie Murcia, MEdOSC/DPCPSI/OD Srikanth Ranganathan, PhDCSR Diana (Dede) Rutberg, MBANIDCR Suzanne Ryan, PhDCSR John Satterlee, PhD NIDA Carol Shreffler, PhDNIEHS Lillian Shum, PhDNIDCR Darren Sledjeski, PhDNIDCR Heidi J. Sofia, PhD NHGRI Michael A. Steinmetz, PhD NEI

Nathaniel Stinson, Jr., PhD, MD NIMHD Edmund Talley, PhDNINDS Stephanie Johnson Webb, PhD NHLBI Tasmeen Weik, DrPH, MPHCSR Elizabeth L. Wilder, PhD OSC/DPCPSI/OD




Enables outstanding early career scientists to move rapidly into independent research positions by skipping the traditional postdoc • Started in 2011• Complete terminal research degree or clinical training

between June 1, 2019 and September 30, 2021• No previous postdoc experience >12 months• In non-independent position at time of application• Requires independent position from host institution• Limit of 2 applications per institution• Commit 9.6 months each year to research for first 2 years• No preliminary data required• Awards up to $250,000 per year for 5 years

commonfund.nih.gov


Application – DP5

Application Limit 2 applications per institution

Research Strategy Essay 12 pages: • Scientific challenge and significance• Innovativeness of approach• Investigator’s qualifications• Plans for development

Facilities & Other Resources Institutional support detailed

Budget Information Modular budget

Letters of Collaboration Should be included

Research Effort 80% for first 2 years

Letters of Reference 3-5 required

commonfund.nih.gov


Facilities & Other Resources (Institution)

• Important section that should not be overlooked• Tailor to candidate and avoid overuse of boilerplate language• Provide context for reviewers• Use the following headings:

• Candidate selection process – process and criteria to select candidate

• Position details – description of the position

• Institutional resources commitment – description of the lab space, officespace, facilities, supplies, equipment, administrative staff, support staff,additional funds, etc. provided by the institution

• Institutional career development – plans to ensure independence,mentorship, integration into community, resources, other opportunities

commonfund.nih.gov


Specific Aims

• Distillation of proposal into one page• Use the following headings:

• Research Objectives – describe research project and overallapproach

• Institutional Support – how will institutional support allowyou to accomplish your research objectives

• Early Independence Rationale – what qualifications,experience, and skills do you have that will allow you toaccomplish your research objectives

commonfund.nih.gov


Research Stra tegy Essay

Use following headings (12-page limit): 1. Rationale for omitting postdoc2. Evidence of transition to independent position3. Career development plan4. Evidence of leadership5. Host institution interactions6. Research challenge7. Approach8. Innovation9. Relationship to previous work10.Timeline

commonfund.nih.gov


Research Stra tegy Essay

Points to consider: • Convince reviewers that you-

1. Are ready for independent research2. Have the resources and support needed to succeed3. Have a significant research topic and innovative approach to addressing it

• Make reviewers feel confident that you are ready and prepared to begin your independentresearch career

• Given the review process, be sure that what you write can be easily appreciated by people welloutside the field (watch out for jargon) and provide context

• Though no preliminary data are required, convince reviewers that you have thought deeply aboutthe project – identify risky aspects, how they will be mitigated, alternate approaches

• Convince reviewers that the research will be performed in a robust and rigorous manner –validate new approaches, provide estimates of numbers of human or animal subjects (if used) andwhy, include that sex will be considered as a biological variable (if appropriate)

commonfund.nih.gov


Funding Opportunity Announcements

Standard (RFA RM20-014) – any topic of relevance to the NIH mission is welcome

COVID-19 – related (RFA RM20-021) – must be relevant to SARS-CoV-2 prevention, preparation, or response • Includes behavioral/social science research, research on health

disparities, novel therapeutics, and any other related topics.

Both have the same receipt date (September 4, 2020) and will use the same review process with the same study section.

commonfund.nih.gov


NIH Director’s Early Independence Award (DP5) Review Procedures

2020-2021

Suzanne Ryan, Ph.D Scientific Review Officer

Center for Scientific Review National Institutes of Health

Review Stages

Receipt of applications:September 4, 2020

Stage 1 Review by Subject Matter Experts:October-December, 2020

Editorial Board consideration:January-February, 2021

Discussion and final score by Editorial Board:March, 2021

Recommendation by Council of Councils, NIH:May, 2021

General Review Considerations The Principal Investigator is a t a v ery early stage of

research career and will devote “almost exclusive effort”.

Award will enable the Principal Investigator to start a productive independe nt research career and have a significant impact on the field.

Promise of the investigator Biosketch and Letters of Reference are critical sources

for evaluating the prospects and promise of the investigator.

Institutional support and commitment: Specific details from the “facilities and other resources”

section Letters of support

Significance, innovation and approach of the science

Scoring and Critiques

Overall impact score (1-9, 1 being the best).

Five criteria (1 to 9 scale): Significance Investigator Innovation Approach Environment

Stage 1 Review

All applications will be reviewed in one Special Emphasis Panel.

All CSR IRGs (Integrated Review Groups) will participate in assigning expert reviewers to applications based onappropriate biomedical and biobehavioral science areas.

Each application is assigned to 3 “mail” reviewers who are“Subject Matter Experts” to provide full written critiques and scores.

Focus is on the science.

Editorial Board Review

Board includes senior scientists with broad expertise.

Each Editor is assigned ~12-15 applications after Stage 1 review is completed.

Editors review applications and Stage 1 critiques, and assign an overall impact score to each application, using the 1-9 scale.

Board meets in March in Washington, DC to discussapproximately top 50% of applications.

3-4 assigned reviewers present the application; all members discuss and score application.

Editorial Board scores represent the final scores forthe application.

Board Considerations

Is the Principal Investigator an exceptional individualwith the scientific creativity and intellectualsophistication to launch and accelerate anindependent research career?

Has the host institution committed to providing thePrincipal Investigator scientific freedom, ampleresources, collaborating faculties, and protected timeto develop an independent research program?

Who are the top outstanding applicants with the bestresearch prospect for exerting a sustained impact tothe field?

After the Review

Discussed applicants receive scores within 3-5 business days. ERA Commons will show whether or not application was discussed/scored.

All applicants receive summary statements within 30 days. Discussed applications receive a resume/summary of the Editorial Board

discussion and critiques from the Stage 1 reviewers.

Non-discussed applications receive the critiques from the Stage 1 reviewers.

Tips for Applicants

Be very specific in the institutional support provided.

Letters of reference should not sound generic. Advise letter writersto comment on what makes you unique.

How will your research advance science? Clearly articulate thesignificance of your science to scientists who may not be from yourfield.

Set reasonable specific aims that can be accomplished within theproject resources. Discuss long term goals or next steps.

Resources Early Independence Award Web site

http://commonfund.nih.gov/earlyindependence/index.aspx

Request for Application (RFA): Non-COVID-19-related research proposals should apply to

funding opportunity announcement RFA-RM-20-014.

COVID-19-related research proposals should apply to funding opportunity announcement RFA-RM-20-021.

Review Contacts: Suzanne Ryan, PhD ([email protected])

http://commonfund.nih.gov/earlyindependence/index.aspx

https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-014.html

https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-021.html

mailto:[email protected]



Institutions





Eligibility





Application & Submission





Budget





Letters of Reference





Letters of Support





Review



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