This type of genetic disorder requires both parents to “donate” a defective gene.
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Transcript of This type of genetic disorder requires both parents to “donate” a defective gene.
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This type of genetic disorder requires both parents to “donate” a defective gene
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Autosomal recessive (2 little letters: aa, bb, ff) found on 1 of the first 22 chromosomes
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What is it called when an offspring is heterozygous for a recessive genetic disorder?
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A carrier (Dd, Hh, Aa)
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There are no carriers for these fatal diseases. If you have one copy of this gene then you HAVE the disease
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Autosomal Dominant
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Give an example of 1 autosomal dominant disease
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1- Huntington’s Chorea - like Parkinson’s
where physical and mental abilities deteriorate2 - Marfan’s syndrome – Lincoln was thought to have this (very tall – usually die of heart problems)
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the most common genetic disorder among black people. Red blood cells are abnormally shaped
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Sickle cell anemia
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This genetic disorder is seen in all races of people and animals where pigment (color) is missing
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Albinism
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X-linked genetic disorders are carried on the X chromosome
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Sex linked genetic disorder
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With sex linked genetic disorders, why is it that boys are mostly affected?
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Girls have XX so if 1 X is damaged, the other chromosome dominatesBUT
boys have XY so if the X is damaged, the Y cannot compensate
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Who is the carrier for sex linked disorders?
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Women are carriers of the disease – They DO NOT have it, but with each pregnancy they have a 50-50 chance of passing it on to their sons – those sons are NOT carriers
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Give 1 example of a sex linked disorder
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hemophilia (The Royal Disease of Europe), color blindness, Duchenne’s Muscular Dystrophy and Adrenoleukodystrophy (ALD)
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the most commonly inherited genetic disorder among Caucasian people. It produces a great deal of phlegm build up.
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Cystic fibrosis
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The universal blood donor
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Type O
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Aside from taking blood, where else can your blood type be found?
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Bodily fluids such as saliva, semen and vaginal secretions
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What are the 4 different blood types?
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A = IA IA or IAiB = IBIB or IBi
AB = IAIB
O = ii
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The universal blood recipient
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Type AB
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These genetic disorders are most common among people of Eastern European origin – both parents must be carriers
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Jewish genetic disorders such as:Tay-Sachs, Niemann-Pick, Canavan’s Disorder, Bloom’s Disease,
Familial Dysautonomia and Fanconi Anemia
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A diagram that shows the occurrence or appearance of a particular gene or organism from 1 generation to the next
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Pedigree chart
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Name common pedigree symbols
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Interpret the following pedigree chart:
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1 – autosomal dominant disease because the chart shows no carriers
2- in generation II, three out of the 5 siblings have the disease
3 – out of the generation II sibling that got married (2) who have the disease, they passed the disease to 50% of their
offspring
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Interpret this chart:
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Sex linked trait (for color blindness) because most of the females are carriers and most of the males get the disorder
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Cross an male with type AB blood with a female who is heterozygous type A
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Female: IAiMale: IAIB
Result:2 type A offspring: IAIA, Iai
1 type AB: IAIB
1 type B: IBi