A2 Physiology People are Awesome 2013 People are Awesome 2013.
This is With Host... Your Vasculitides Awesome Associations.
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Transcript of This is With Host... Your Vasculitides Awesome Associations.
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This
is
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With
Host...
Your
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Vasculitides
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Awesome Associations
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RA Rx
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Rheum with a View II
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Vasculitides RA RxRheum with
a View IIAwesome
Associations
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300300
400400
500500
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Involvement of the ophthalmic artery causing sudden
irreversible blindness is 1 sign of this large-sized vasculitis
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What is giant cell or temporal arteritis?
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Coin lesions+ pulmonary hemorrhage
+ RPGN +saddle-nose deformity
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What is Wegener’s granulomatosis?
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A.k.a. Kussmaul-Meier disease, this medium-sized vessel
vasculitis is common in Hep B and can show a classic “string of
beads” angiographic picture
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What is polyarteritis nodosa?
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Papable purpura, arthritis and abdominal pain make up the classic triad of this vasculitis
marked by IgA-immune complex deposition
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What is Henoch-Schonlein purpura?
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This vasculitis may be associated with uveitis and
erythema nodosum, but most typically known for recurrent oral and genital ulcers, and a
(+) pathergy reaction
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What is Behcet’s syndrome?
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Most common gynecologic
maligancy in dermatomyositis
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What is ovarian cancer?
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Painless yellow-brown lesions in palms/soles in
reactive arthritis
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What is keratoderma blennorrhagica?
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Valvular abnormality in ankylosing spondylitis
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What is aortic regurgitation?
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Lung condition in scleroderma with diffuse cutaneous involvement
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What is pulmonary fibrosis?
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Hematologic lab value typically >5x normal in
Adult-onset Still’s disease
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What is ferritin?
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A folic acid analogue used to treat moderately active RA, it
confers clinical improvement and possible survival benefit
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What is methotrexate?
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This anti-malarial drug has been shown to reduce inflammation and joint erosions but may also
cause rare ophthalmologic toxicity
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What is hydroxychloroquine?
(Plaquenil)
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An FDA-approved therapy for RA, this sulfonamide is now a
mainstay of outpatient treatment for inflammatory bowel disease
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What is sulfasalazine?
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A chimeric monoclonal antibody against TNF-ά, it
requires a pre-treatment PPD to rule out latent TB
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What is infliximab?(Remicade)
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A recombinant DNA drug, it is produced by combining IgG1 and human TNF receptor—the so-called “master regulator” of inflammation in autoimmune
diseases
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What is etanercept?(Enbrel)
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View Q1
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What is rheumatoid arthritis?
(Boutonniere deformity)
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What is gout?
(Ear tophus)
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What is dermatomyositis?(shawl sign)
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View Q4
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What is psoriatic arthritis?
(Dactylitis, DIP involvement, nail pitting)
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View Q5
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What is scleroderma?
(sclerodactily)
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HIV
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Buzz wordsin ID
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STDs
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Drugs for Bugs
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200
400
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800
1000
HIV STDsDrugs for
BugsBuzz words
in ID
200
400
600
800
1000
200
400
200
400
600600
800800
10001000
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The risk for this fungal infection increases when the CD4 count
drops below 200 cells/mm3
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What is Pneumocystis jiroveci pneumonia?
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Multiple brain lesions or
encephalitis in patients with severe HIV
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What is Toxoplasmosis?
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This HIV drug will make you live your dreams--and nightmares!
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What is efavirenz?
(Sustiva)
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HIV drug class most commonly associated with fat redistribution syndrome
or lipodystrophy
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What are protease inhibitors?
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The First and Only Once-Daily Single Tablet HIV Treatment
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What is Atripla?(efavirenz/emtricitabine/tenofovir)
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Hot tub folliculitis
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What is Pseudomonas aeruginosa
infection?
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Gardener+ painless nodule on the wrist + palpable axillary lymph node
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What is Sporotrichosis?
(Sporothrix schenckii)
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Hog farmer from Arkansas+ periorbital edema
+ joint and muscle pains+ eosinophilia
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What is Trichinosis?
(Trichinella spiralis)
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Post-renal transplant patient+ gram positive rod meningitis
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What is Listeriosis?(Listeria moncytogenes)
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Seawater exposure+ hemorrhagic bullae/ necrotizing fasciitis
+ septic shock
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What is Vibrio vulnificus infection?
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Painless penile ulcer with clear base but indurated edges
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What is syphilis?(Treponema pallidum)
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Painful vesicles in the groin and genital area
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What is Herpes simplex type 2 infection?
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This tender genital ulcer will make you “cry”!
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What is chancroid?(Haemophilus ducreyi)
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Small painless vesicle that can cause painful and suppurative
lymphadenopathy
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What is Lymphogranuloma venerum?
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Beefy red painless ulcer associated with pseudo-buboes,
subcutaneous swelling but not lymph nodes
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What is granuloma inguinale?(Calymmatobacterium
granulomatis)
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Treponema pallidum
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What is Penicillin?
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Sporothrix schenkii
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What is Itraconazole?
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Borrelia burgdorferi
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What is Doxycycline?(Tetracyclines)
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Bordetella pertussis
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What is Erythromycin?
(Macrolides)
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Chloroquine-resistantPlasmodium falciparum
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What is Mefloquin?
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Medical Milestones
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1 German and 2 French scientists shared the recently awarded Nobel prize for Medicine for discovering these two viruses causing global
disease and death
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What are HPV and HIV?
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Thank you for playing