Thirteen-Week Feeding Study OPPTS 870.3100

8/12/2019 Thirteen-Week Feeding Study OPPTS 870.3100

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DuPont-10997

Study Title

Thirteen-Week Feeding Study with

Transgenic Maize Grain T!1"07# in $ats

%o&u'e 1 o( )

*a+oratory Pro,ect D. DuPont-10997

TESTGUIDELINES: /S P2 3ea&th ((ects Test Guide&ines

4PPTS 570)100 1995#

4!D Guide&ine (or Testing o( !he'ica&s

Section 6. 3ea&th ((ects 8o 605 1997#

AUTHOR: Susan 2 Macenzie %MD PhD D2:T

STUDYCOMPLETEDON: Fe+ruary ) ;00)


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Thirteen-Week Feeding Study with Transgenic Maize Grain T!1"07# in $ats DuPont-10997

STATEMENT OF NO DATA CONFIDENTIALITY CLAIMS

Tit&e. Thirteen-Week Feeding Study with Transgenic Maize Grain T!1"07# in $ats

8o c&ai' o( con(identia&ity is 'ade (or any in(or'ation contained in this study on the +asis o( its (a&&ing

within the sco


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GOOD LABORATORY PRACTICE COMPLIANCE STATEMENT

This study was conducted in co'


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QUALITY ASSURANCE STATEMENT

3aske&& Sa'


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CERTIFICATION

We the undersigned dec&are that this re


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TABLE OF CONTENTS

Page

STATEMENT OF NO DATA CONFIDENTIALITY CLAIMS .............................................. 2

GOOD LABORATORY PRACTICE COMPLIANCE STATEMENT ................................... 3

QUALITY ASSURANCE STATEMENT ................................................................................... 4

CERTIFICATION ......................................................................................................................... 5LIST OF TABLES ....................................................................................................................... 12

LIST OF FIGURES ..................................................................................................................... 17

LIST OF APPENDICES ............................................................................................................. 24

STUDY INFORMATION ........................................................................................................... 25

STUDY PERSONNEL .................................................................................................................28

ABSTRACT .................................................................................................................................. 29OBJECTIVE ................................................................................................................................ 30

TESTING FACILITY ................................................................................................................. 30

MATERIALS AND METHODS ................................................................................................ 31

2 Test Guide&ines )1

: Test Su+stance )1

! Test S


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8 !&inica& Patho&ogy =a&uations )"

.1 Hematology and Coagulation ......................................................................................... 36

.2 Clinical Chemistry ......................................................................................................... 37

.3 Urinalysis ....................................................................................................................... 37

4 2nato'ic Patho&ogy =a&uations )7

P Statistica& 2na&yses )9

RESULTS AND DISCUSSION .................................................................................................. 40

DIET ANALYSES

(APPENDICES M-O) .................................................................................................................. 40

IN-LIFE TOXICOLOGY ........................................................................................................... 40

2 Mean :ody Weights and :ody Weight Gain

Ta+&es 1-6 Figures 1-; 2


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2 !ause o( Death

2


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T2:* 16

P$!8T S/$%%2* 4F FM2* $2TS 51

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17(CONTINUED)

SUMMARY OF FUNCTIONAL OBSERVATION BATTERY FINDINGS FOR MALE

RATS.............................................................................................................................................85

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8!D8!S 4F M!$4S!4P! 4:S$%2T48S 8 FM2* $2TS

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FIGURES .................................................................................................................................... 284FG/$ 1

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FG/$ )

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FG/$ "

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FG/$ ?

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LIST OF TABLES

Page




CERTIFICATION ......................................................................................................................... 5

LIST OF TABLES ....................................................................................................................... 12

LIST OF FIGURES ..................................................................................................................... 17



STUDY PERSONNEL .................................................................................................................28

ABSTRACT .................................................................................................................................. 29

OBJECTIVE ................................................................................................................................ 30




: Test Su+stance )1

! Test S


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.1 Hematology and Coagulation ......................................................................................... 36

.2 Clinical Chemistry ......................................................................................................... 37

.3 Urinalysis ....................................................................................................................... 374 2nato'ic Patho&ogy =a&uations )7

P Statistica& 2na&yses )9


DIET ANALYSES

(APPENDICES M-O) .................................................................................................................. 40





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: 4rgan Weight Data

Ta+&es )1-); 2


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T2:* 17


17(CONTINUED)


RATS.............................................................................................................................................85

T2:* 15



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FIGURES .................................................................................................................................... 284FG/$ 1

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FG/$ )

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FG/$ "

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FG/$ ?

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CERTIFICATION ......................................................................................................................... 5

LIST OF TABLES ....................................................................................................................... 12

LIST OF FIGURES ..................................................................................................................... 17



STUDY PERSONNEL .................................................................................................................28

ABSTRACT .................................................................................................................................. 29

OBJECTIVE ................................................................................................................................ 30




: Test Su+stance )1

! Test S


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DIET ANALYSES

(APPENDICES M-O) .................................................................................................................. 40





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D Microsco


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P$!8T S/$%%2* 4F FM2* $2TS 51

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T2:* 17


17(CONTINUED)


RATS.............................................................................................................................................85

T2:* 15


18(CONTINUED)

SUMMARY OF FUNCTIONAL OBSERVATION BATTERY FINDINGS FOR FEMALE

RATS.............................................................................................................................................87

T2:* 19


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T2:* ;6


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848-84P*2ST! *S48S ;66

FIGURES .................................................................................................................................... 284FG/$ 1

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FG/$ ;

M28 :4DA WG3TS 4F FM2* $2TS ;57

FG/$ )

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FG/$ 9


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LIST OF APPENDICES

Page

2PP8D 2 8D%D/2* :4DA WG3TS;51

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VOLUME 3................................................................................................................................................................ 498

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STUDY INFORMATION

Sub!"#$% T%!%&: T'"#(%#)$ M")*% G'")# +TC,-7/

Synony'sB!odes. T!1"07

3-;")6?

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STUDY INFORMATION +C0#!)#u%&/

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STUDY INFORMATION +C0#!)#u%&/

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STUDY PERSONNEL

Study Director. Susan 2 Macenzie %MD PhD D2:T

Manage'ent. Scott *o=e&ess PhD

Pri'ary Technician. $o+ert Wa&ker Cr

8euroto>ico&ogist.

Manage'ent. =e My&chreest PhD

!&inica& Patho&ogist. 8ancy =erds D%M

Manage'ent.

Patho&ogist. Cohn F 3ansen D%M PhD

Manage'ent.

Peer $e=iew Patho&ogist. G Tracy Mako=ec D%M

Statistica& 2na&ysis. Cohn W Green PhD

Manage'ent. Canice * !onne&& MS :2 !3

$e


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ABSTRACT

Fi=e grouBgrou


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MATERIALS AND METHODS

.AT%! Gu)&%4)#%

study design was adaic Su+stances 4PPTS# 3ea&th ((ects Test Guide&ines 4PPTS 570)100 90-Day 4ra&

To>icity in $odents 2/G-1995#

L 4rganisation (or cono'ic !oo


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) n=iron'enta& !onditions

2ni'a& roo's were 'aintained on a 1;-hour &ightBdark cyc&e (&uorescent &ight# and at ate'


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4n the +ases o( acce


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The sin and


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.LO68!8"43040()$"4 E"4u"!)0#

4


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1"-17 hours# and urine was co&&ected (ro' each ani'a& :&ood sa'a'ined 'icroscoa'ination !oagu&ation ti'es were deter'ined on a Sys'e>N!2-1000 !oagu&ation 2na&yzer

The (o&&owing he'ato&ogy and coagu&ation a'ination

'ean cor


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; !&inica& !he'istry

Seru' c&inica& che'istry


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$e


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.PS!"!)!)$"4 A#"4%

Grou


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RESULTS AND DISCUSSION

D)%! A#"4%

2ins


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s'a&& were not statistica&&y signi(icant and were not considered +io&ogica&&y signi(icant Fina&

'ean +ody weight and o=era&& 'ean +ody weight gain in (e'a&e rats (ed ))I ))P?? were 95I

and 9?I res


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grou< o=er the course o( the study and o=era&& 'ean (ood e((iciency in grou


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N%u'0b%8")0'"4 E"4u"!)0#

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ra


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.BC0"(u4"!)0#

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.BO'("# W%)(8! D"!"

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CONCLUSIONS

/nder the conditions o( this study e>


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REFERENCES

1 *e=ene 3 19?0# $o+ust test (or eua&ity o( =ariances Contributions to Probability

and StatisticsC 4&kin ed# a'


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TABLES


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T2:*S

P*282T4$A 84TS

Study Design

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N&,

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- 7" -



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Thirteen Week Feeding Study with Transgenic Maize Grain T!1"07# in $ats DuPont 10997

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ee Wee eed g S udy w a sge c a e G a ! "07# a s u o 0997

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g y g #

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g y g #

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- 79 -


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Treat'ent Grou


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Treat'ent Grou


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2ssess'ent

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T2:* 15

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nor'a& 1; 1; 1; 1; 1; 1; 1; 1; 1; 1;

increased reaction ,u'


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15!48T8/D#

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:2S*8 W 1)

Grou< % % % % % %

3aske&& 8u'+er 3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0 3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

8u'+er e>a'ined. 1; 1; 1; 1; 1; 1; 1; 1; 1; 1;

8 M4T4$ 2!T%TA M48T4$.

P/P**2$A $SP48S


88/295

T2:* 19


D/$2T48 4F M4%M8T F4$ M2* $2TS sec#

2SSSSM8T

P$4D G$4/P

32S**

8/M:$ S/!!SS% 10-M8/T 8T$%2*S

:2S*8 , 2 1 = - TOTAL

3-;")6? )?;;9# ;70"5# ;11?9# 1""10?# 111116# 7;109# 1150)6"#

3-;")67 ));"9# ;"?)"# 196?7# 1;010?# ??5"# 6??6# 1016)19#

% 3-;")65 );?)"# ;")"?# 1665?# 1)?107# 10;97# 9010"# 10"0)95#

% 3-;")69 )56)5# ;976?# ;167)# 1;;10;# "956# ))?"# 1105))9#

3-;")"0 )"1)7# ;9;)5# ;;6)6# 15971# 111115# 7?11"# 1;6;;95#

1)-W

3-;")6? )9;)"# ;956;# ;7)6?# ;?0";# ;?7?0# ;1791# 170?;66#

3-;")67 )"97)# ;91??# ;19115# 17010"# 1?511)# @ 11710;# @ 1);"65;# J

% 3-;")65 )59)7# )106)# ;7;57# ;;??7# ;0;10)# 1"11;;# 1"69;9"#

% 3-;")69 61")?# )60""# )0967# ;9;?6# ;59?"# ;)6117# 1579)06#

3-;")"0 )79?;# ;9557# ;7)")# ;;0110# ;)190# ;0;116# 1?0)601#

Data arranged as. Mean Standard De=iation#

@ Statistica&&y signi(icant di((erence (or Grou< co'


89/295

T2:* ;0


D/$2T48 4F M4%M8T F4$ FM2* $2TS sec#

2SSSSM8T

P$4D G$4/P

32S**

8/M:$ S/!!SS% 10-M8/T 8T$%2*S

:2S*8 , 2 1 = - TOTAL

3-;")6? ))76;# ;6)"?# 19;"7# 1505)# 1679?# 10)9)# 1;01)17#

% 3-;")67 ))6"7# ;"6"5# ;;?"?# ;0770# 17159# 56100# 1;77)0;#

% 3-;")65 )))66# ;69?0# ;156"# 19?51# 1);1;;# 10790# 1;)6);"#

% 3-;")69 );;?)# ;6)?6# ;;7?"# 1"79"# 10;97# 5696# 11)?)7"#

3-;")"0 )?;?;# ;9150# ;;"";# 19?9?# 1?;10)# 16611?# 1)50605#

1)-W

3-;")6? )97)6# ;99"0# ;"?60# ;1069# ;0170# ;1;95# 1"7";5?#

% 3-;")67 )5??;# );0"7# ;5769# ;617;# ;0"56# 159100# 1?;7)1?#

% 3-;")65 60766# )155?# ;"559# ;6057# ;6797# ;0155# 1?7061;#

% 3-;")69 6;"67# )6"?"# ;7;?0# ;)671# ;6??7# ;;;""# 1766;6;#

3-;")"0 616?5# );7??# ;7959# ;)77?# ;;6101# ;;95"# 1710)?7#


There were no statistica&&y signi(icant di((erences +etween Grou< and Grou< % at < U 00"

- 59 -



90/295

T2:* ;1


8/M:$ 4F M4%M8TS F4$ M2* $2TS

2SSSSM8T

P$4D G$4/P

32S**

8/M:$ S/!!SS% 10-M8/T 8T$%2*S

:2S*8 , 2 1 = - TOTAL

3-;")6? 1)610# 16016# 1;);0# 9"""# ?7"5# 67"7# ?0?171#

3-;")67 1)?1"# 16011# 1;6;"# 79"?# "1?1# 6)"?# "7)1")#

% 3-;")65 16"1?# 160)0# 111"7# 90?5# 76?5# ?)?6# ?;6;)"#

% 3-;")69 1;99# 1)016# 115;)# 7067# 66")# ;?6"# "15160#

3-;")"0 1)65# 1)?11# 1;919# 1;06;# 70?6# 69?;# ?)51?;#

1)-W

3-;")6? 1)"1)# 1)79# 1)616# 1);1?# 1;?15# 117)7# 751?6#

3-;")67 16"16# 16;19# 109"0# 95"?# 9;"6# 7)""# ?"9199#

% 3-;")65 16;16# 1"?17# 1616)# 1)7)7# 11)"6# 9;?9# 750170#

% 3-;")69 1)117# 1))16# 1)91)# 1;71)# 1;"17# 107);# 7?1";#

3-;")"0 1;919# 1)1;5# 1)119# 1106?# 11560# 110"7# 7;91""#


There were no statistica&&y signi(icant di((erences +etween Grou


91/295

T2:* ;;


8/M:$ 4F M4%M8TS F4$ FM2* $2TS

2SSSSM8T

P$4D G$4/P

32S**

8/M:$ S/!!SS% 10-M8/T 8T$%2*S

:2S*8 , 2 1 = - TOTAL

3-;")6? 16715# 16;;0# 1)0;0# 1;)67# 100")# 5;??# 7;6151#

% 3-;")67 1661"# 16016# 1)"1)# 1;0;9# 10"6)# ?1?1# 7061;6#

% 3-;")65 1)91)# 1601?# 1)91"# 116;9# 51?)# 77"7# ?591)6#

% 3-;")69 1)05# 1;?19# 1;517# 9;61# ?"""# """;# "9"1;7#

3-;")"0 1)7;;# 1)61"# 1;5;;# 11666# 101";# 5??"# 7001"?#

1)-W

3-;")6? 1)917# 1"715# 1"";6# 1)";0# 1;9))# 1;)65# 5)510)#

% 3-;")67 1))16# 1601)# J 16"1"# 1)61"# 1;1)6# 10"66# 77576#

% 3-;")65 16;1)# 165;0# 1)7;6# 16;;0# 1)7;9# 1;66?# 5)0110#

% 3-;")69 1)01)# 1)0;1# 1));;# 1)0;;# 1;61"# 115;?# 7?676#

3-;")"0 1;;;6# 1)61?# 1;9;5# 1)0)1# 111)?# 1;7);# 7")105#


J Statistica&&y signi(icant di((erences (or Grou< % co'


92/295


T2:* ;)

S/MM2$A 4F 3M2T4*4GA %2*/S F4$ M2* $2TS

Grou< Grou< Grou< % Grou< % Grou<

3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

$:! >10?B*#

W 1) 5"? 560 56) 5)1 5;6

06)1;# 06"1;# 0671;# 0661;# 09)1;#3G: gBd*#

W 1) 1"9 1"" 1"5 1"6 1""

0"1;# 071;# 0"11# 091;# 1)1;#

3!T I#

W 1) 6?1 6"1 6"" 66? 669

1?1;# ;01;# 1"11# ;;1;# )11;#

M!% (

W 1) "60 ")7 "6? ")7 "69

191;# 191;# 1"11# 161;# 6;1;#

M!3 10XB*#



93/295


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S/MM2$A 4F 3M2T4*4GA %2*/S F4$ M2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

2*AM >10XB*#

W 1) 5;9 95? 90) 796 9;0

1711;# ;901;# ;"511# ;601;# 16)1;#2M48 >10XB*#

W 1) 0;0 0;6 0;? 0;1 0;5

0071;# 0091;# 0;711# 0091;# 0051;#

24S >10XB*#

W 1) 017 016 01? 01" 016

0091;# 00"1;# 00?11# 00?1;# 0071;#

2:2S >10XB*#

W 1) 005 009 010 007 007

0061;# 00)1;# 00511# 0061;# 00)1;#

2*/! >10XB*#

W 1) 00? 005 005 00? 00?

00)1;# 0061;# 00611# 00)1;# 00)1;#

Data arranged as. Mean

Standard de=iation 8u'+er o( =a&ues inc&uded in ca&cu&ation#



94/295


T2:* ;6

S/MM2$A 4F 3M2T4*4GA %2*/S F4$ FM2* $2TS

Grou< Grou< % Grou< % Grou< % Grou<

3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

$:! >10?B*#

W 1) 517 56?@ 560 517 516

0;?1;# 0)"1;# 0611;# 0)61;# 0))1;#3G: gBd*#

W 1) 1"9 1?) 1?; 1"5 1?0

061;# 061;# 0?1;# 0?1;# 0?1;#

3!T I#

W 1) 6"6 6?5@ 6"5 6"6 6""

101;# 1"1;# 1"1;# 1?1;# 1"1;#

M!% (

W 1) ""? "") "6? ""? ""9

1)1;# 191;# 1?1;# 161;# 1?1;#

M!3 10XB*#



95/295


;6!48T8/D#

S/MM2$A 4F 3M2T4*4GA %2*/S F4$ FM2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

2*AM >10XB*#

W 1) 77; 5;? 505 5;; 76)

1)11;# 1?71;# ;191;# 1511;# 1951;#2M48 >10XB*#

W 1) 015 015 0;) 019 015

01;1;# 00?1;# 0111;# 0091;# 0091;#

24S >10XB*#

W 1) 011 01?Y 01?Y 01) 01)

00)1;# 0071;# 0071;# 0071;# 00?1;#

2:2S >10XB*#

W 1) 00? 005 00" 00? 007

00)1;# 00)1;# 00;1;# 00)1;# 00)1;#

2*/! >10XB*#

W 1) 00? 00? 007 007 00?

0011;# 00;1;# 0061;# 00)1;# 00)1;#



@ Statistica&&y signi(icant di((erence (ro' Grou< at < U 00" +y *inear !ontrasts test

Y Statistica&&y signi(icant di((erence (ro' Grou< at < U 00" +y Dunns Ty


96/295


T2:* ;"

S/MM2$A 4F !42G/*2T48 %2*/S F4$ M2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

PT seconds#

W 1) 1?1 1"5 1"? 1"? 1"5

101;# 071;# 0?1;# 071;# 091;#2PTT seconds#

W 1) ;;; ;;? ;1; ;19 ;;;

;71;# ;11;# 1"1;# ))1;# 191;#





97/295


T2:* ;7

S/MM2$A 4F !*8!2* !3MST$A%2*/S F4$ M2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

2ST /B*#

W 1) 59 59 5? 101 9;

;11;# 171;# 1;1;# ;71;# ;71;#2*T /B*#

W 1) )7 6" 6) ?0 66

?1;# 1?1;# 71;# );1;# 91;#

SD3 /B*#

W 1) 1?" 196 179 ;61 156

")1;# ;610# )?1;# 16)1;# ";1;#

2*P /B*#

W 1) 91 11;@ 91 110 95

191;# ;"1;# 161;# ;11;# 1"1;#

:* 'gBd*#

W 1) 005 009 010 010 010

00)1;# 00)1;# 0061;# 00;1;# 00)1;#

:/8 'gBd*#

W 1) 17 17 1? 17 17

;1;# ;1;# ;1;# ;1;# ;1;#

!$2 'gBd*#

W 1) 06" 06) 06; 06? 06;00"1;# 00"1;# 00?1;# 00)1;# 00"1;#

!34* 'gBd*#



98/295


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S/MM2$A 4F !*8!2* !3MST$A%2*/S F4$ M2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

2*: gBd*#

W 1) 6) 6; 6) 6; 6)

0;1;# 0;1;# 0;1;# 0)1;# 0;1;#G*4: gBd*#

W 1) ;7 ;5 ;5 ;5 ;7

0;1;# 0;1;# 0;1;# 0)1;# 0;1;#

!2*! 'gBd*#

W 1) 10? 107 107 107 105

061;# 0)1;# 0"1;# 0)1;# 0)1;#

P3S 'gBd*#

W 1) 76 7? 7; 75 75

0"1;# 091;# 061;# 051;# 071;#

82 ''o&B*#

W 1) 169? 169; 169) 1697 1690

151;# 1?1;# ;;1;# 1"1;# ;"1;#

''o&B*#

W 1) "95 "9" "55 "95 ?1"

06;1;# 0611;# 06)1;# 0"11;# 0"61;#

!* ''o&B*#

W 1) 10;? 10;7 10;5 10;? 10))1?1;# ;?1;# 151;# ;)1;# 191;#



99/295

g y g #

T2:* ;5

S/MM2$A 4F !*8!2* !3MST$A%2*/S F4$ FM2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

2ST /B*#

W 1) 50 51 5) 59 55

91;# 101;# ;)1;# 161;# 91;#2*T /B*#

W 1) )7 )5 6; )5 )9

?1;# 71;# 191;# 51;# 51;#

SD3 /B*#

W 1) 166 1)9 1)7 1)1 1?"

);1;# )01;# ";1;# ;)1;# ;"1;#

2*P /B*#

W 1) "9 ?1 ?" ?; "7

;11;# 1)1;# ;?1;# 1)1;# 191;#

:* 'gBd*#

W 1) 01" 016 01" 01) 016

00;1;# 00)1;# 00;1;# 00)1;# 00)1;#

:/8 'gBd*#

W 1) 17 17 15 17 1?

;1;# ;1;# )1;# )1;# 11;#

!$2 'gBd*#

W 1) 0"6 0") 0"6 0"; 0"60061;# 0071;# 00?1;# 00"1;# 00"1;#

!34* 'gBd*#



100/295

g y g #

;5!48T8/D#

S/MM2$A 4F !*8!2* !3MST$A%2*/S F4$ FM2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

2*: gBd*#

W 1) ") "1 "; "1 ";

061;# 061;# 0"1;# 0)1;# 0)1;#G*4: gBd*#

W 1) ;7 ;5 ;5 ;5 ;7

0;1;# 0;1;# 0)1;# 0;1;# 0;1;#

!2*! 'gBd*#

W 1) 11) 11; 11) 11) 11)

0?1;# 061;# 0"1;# 061;# 061;#

P3S 'gBd*#

W 1) ?? ?" ?7 ?? ?)

0?1;# 0?1;# 051;# 091;# 161;#

82 ''o&B*#

W 1) 1"1" 1"16 1"07 1"05 1";0

;;1;# ;;1;# 171;# 191;# );1;#

''o&B*#

W 1) "?) "5? "75 "7; "79

0)11;# 0)91;# 0);1;# 0)11;# 06;1;#

!* ''o&B*#

W 1) 106; 10"6 1065 10"? 10??;61;# ;11;# 151;# 171;# ;;1;#



101/295

g y g #

T2:* ;9

S/MM2$A 4F /$82*ASS %2*/S F4$ M2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

%4* '*#

W 1) 75 ?? "? ?; 59

?)1;# 651;# 6?1;# ?61;# 701;#/4SM '4s'#

W 1) 1?"0 1"5) 1561 19)9 1)90

10";1;# 7?01;# 106;1;# 16;;1;# 5961;#


102/295

g y g #

T2:* )0

S/MM2$A 4F /$82*ASS %2*/S F4$ FM2* $2TS


3-;")6? 3-;")67 3-;")65 3-;")69 3-;")"0

%4* '*#

W 1) ;9 67 )6 ;) 66

)01;# "?11# )61;# ;01;# ")1;#/4SM '4s'#

W 1) ;00) 1?70 156; 1??9 ;0)1

106"11# 110911# 1;?711# 71;11# 1;9;1;#


103/295

T2:* )1

M28 F82* :4DA 28D 4$G28 WG3TS F4$ M2* $2TS

ORGAN @EIGH1S "#G)': I III V VII IXH$&=, N'(;,) H25346 H25347 H25348 H25349 H25350

ADRENAL GLANDS 006! 0056 0062 0067 0055

00!!"!2# 00!!"!2# 00!3"!2# 00!!"!!# 00!3"!2#

BRAIN 2099 2096 2!0! 2!0! 2!2!0!37"!2# 0!60"!2# 0088"!2# 0073"!2# 0098"!2#

EPIDIDYMIDES !502 !474 !5!4 !49! !4!80!72"!2# 0!67"!2# 0262"!2# 0!96"!2# 03!0"!2#

INAL BODY @EIGH1520!!667 49!09999 49948334 50379!67 5099!6665983947"!2# 3682877"!2# 28647!3"!2# 3535252"!2# 4354493"!2#

HEAR1 !684 !706 !636 !673 !6350232"!2# 0263"!2# 0!46"!2# 0!4!"!2# 0!39"!2#

KIDNEYS 3538 3702 3747 3689 35!60325"!2# 0503"!2# 0325"!2# 0303"!!# 0387"!2#

LIVER !4482 !3565 !3848 !476! !4234223!"!2# !69!"!2# !285"!2# !972"!2# !899"!2#

SPLEEN 0777 0792 08!3 0729 08220093"!2# 0!55"!2# 0!30"!2# 0098"!2# 0200"!2#

1ES1ES 33!3 3294 3297 3226 326!0234"!2# 0524"!2# 0563"!2# 0448"!2# 0878"!2#

1HYMUS 0444 0389 0375 0366 03520!33"!2# 0!32"!2# 0!08"!2# 0084"!2# 0096"!2#

- 10) -



104/295

)1!48T8/D#

M28 F82* :4DA 28D 4$G28 WG3TS F4$ M2* $2TS

ORGAN @EIGH1 RELA1IVE 1O BRAING)': I III V VII IXH$&=, N'(;,) H25346 H25347 H25348 H25349 H25350

ADRENAL GLANDS

BRAIN < !00 2909 2659 2929 3!65 25830499"!2# 0422"!2# 0589"!2# 0588"!!# 0528"!2#

EPIDIDYMIDES BRAIN < !00 7!645 70458 7!895 70932 66490

7392"!2# 7!74"!2# !0937"!2# 8822"!2# !3073"!2#

HEAR1 BRAIN < !00 80459 8!!89 77797 798!8 77290

!!95!"!2# 8739"!2# 5449"!2# 8!2!"!2# 8468"!2#

KIDNEYS BRAIN < !00 !68996 !7606! !78420 !75!55 !65879

!6834"!2# !4278"!2# !4984"!2# !5978"!!# !7590"!2#

LIVER BRAIN < !00 693824 646443 65872! 703876 67!098

!278!!"!2# 55530"!2# 49902"!2# !0!370"!2# 84!56"!2#

SPLEEN BRAIN < !00 37099 37555 38685 3472! 3877!

45!9"!2# 5!!7"!2# 5836"!2# 470!"!2# 9337"!2#

1ES1ES BRAIN < !00 !58408 !58!84 !56934 !53527 !53!60

!4699"!2# 28273"!2# 26590"!2# 2!058"!2# 40406"!2#

1HYMUS BRAIN < !00 2!332 !8502 !7847 !740! !6673

689!"!2# 5954"!2# 50!8"!2# 3786"!2# 490!"!2#

- 106 -



105/295

)1!48T8/D#

M28 F82* :4DA 28D 4$G28 WG3TS F4$ M2* $2TS

ORGAN @EIGH1 RELA1IVE 1O BODY @EIGH1

G)': I III V VII IXH$&=, N'(;,) H25346 H25347 H25348 H25349 H25350

ADRENAL GLANDS

INAL BODY < !00 00!2 00!! 00!2 00!3 00!!0002"!2# 0002"!2# 0002"!2# 0002"!!# 0002"!2#

BRAIN INAL BODY < !00 0408 0428 042! 04!9 04!8

0048"!2# 003!"!2# 0020"!2# 0032"!2# 0034"!2#

EPIDIDYMIDES INAL BODY < !00 0292 030! 0303 0298 0278

004!"!2# 0038"!2# 0046"!2# 0045"!2# 0058"!2#

HEAR1 INAL BODY < !00 0325 0347 0328 0332 0322

0038"!2# 0043"!2# 0024"!2# 0022"!2# 0028"!2#

KIDNEYS INAL BODY < !00 0685 0753< 0750< 0734 0689

0073"!2# 0076"!2# 0052"!2# 0040"!!# 0043"!2#

LIVER INAL BODY < !00 2776 2759 2769 2922 2782

0!58"!2# 0238"!2# 0!36"!2# 0232"!2# 0!62"!2#

SPLEEN INAL BODY < !00 0!5! 0!60 0!63 0!45 0!6!

0023"!2# 0023"!2# 0025"!2# 0020"!2# 0038"!2#

1ES1ES INAL BODY < !00 064! 0674 066! 0646 064!

0053"!2# 0!!7"!2# 0!!2"!2# 0!!6"!2# 0!69"!2#

1HYMUS INAL BODY < !00 0085 0078 0075 0073 0069

0023"!2# 0023"!2# 002!"!2# 00!5"!2# 00!9"!2#

< S%$%*&%*$ &*.**$.% *,),., )( G)' I $% 005 '&*. .,-$ ANOVA $. *.,$) .%)$&%&

- 10" -



106/295

T2:* );

M28 F82* :4DA 28D 4$G28 WG3TS F4$ FM2* $2TS

ORGAN @EIGH1 "#

G)': II IV VI VIII XH$&=, N'(;,) H25346 H25347 H25348 H25349 H25350

ADRENAL GLANDS 0083 0073 0072 008! 007!

00!4"!2# 00!!"!2# 00!3"!2# 0023"!2# 00!4"!2#

BRAIN 2034 !986 !985 !97! !9470085"!2# 0!0!"!2# 0065"!2# 0!05"!2# 0077"!2#

INAL BODY @EIGH129425000 28250000 28905834 29!65000 290283332970927"!2# 2538!62"!2# !782264"!2# 3395362"!2# 3367375"!2#

HEAR1 !092 !!02 !!05 !!85 !0920!3!"!2# 0!26"!2# 009!"!2# 0!22"!2# 0!42"!2#

KIDNEYS 2257 2!89 2098 2296 22250!79"!2# 0209"!2# 0!63"!2# 034!"!2# 0207"!2#

LIVER 834! 7852 7986 8425 79980623"!2# 0729"!2# 0807"!2# !220"!2# 0886"!2#

OVARIES 0!44 0!47 0!40 0!66 0!370027"!2# 0024"!2# 0035"!2# 0062"!2# 0042"!2#

SPLEEN 059! 0585 0577 0562 05540078"!2# 0078"!2# 0!2!"!2# 0!!4"!2# 0!05"!2#

1HYMUS 03!0 028! 03!9 0324 03!8

008!"!2# 006!"!2# 0036"!2# 0!!0"!2# 0099"!2#

U1ERUS 0756 0707 069! 0673 08!90248"!2# 0227"!2# 0!97"!2# 0209"!2# 0280"!2#

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ORGAN @EIGH1 RELA1IVE 1O BRAING)': II IV VI VIII XH$&=, N'(;,) H25346 H25347 H25348 H25349 H25350

ADRENAL GLANDS

BRAIN < !00 4066 365! 3622 4092 36280620"!2# 04!3"!2# 0558"!2# !!45"!2# 0660"!2#

HEAR1 BRAIN < !00 53645 55548 55689 60!99 56!84

547!"!2# 6!67"!2# 4687"!2# 6349"!2# 7848"!2#

KIDNEYS BRAIN < !00 !!0936 !!0!78 !05677 !!6669 !!4475

67!6"!2# 8383"!2# 6579"!2# !8476"!2# !2!26"!2#

LIVER BRAIN < !00 4!0!59 395638 402279 429022 4!0765

253!3"!2# 34347"!2# 3727!"!2# 72769"!2# 433!3"!2#

OVARIES BRAIN < !00 7055 7359 7052 84!8 7003

!254"!2# !004"!2# !632"!2# 3!77"!2# !990"!2#

SPLEEN BRAIN < !00 29008 29397 29000 285!3 28478

3!59"!2# 3!02"!2# 5585"!2# 5946"!2# 543!"!2#

1HYMUS BRAIN < !00 !5296 !4!35 !6!!! !6445 !626!

4053"!2# 3097"!2# !964"!2# 5740"!2# 4793"!2#

U1ERUS BRAIN < !00 37369 35734 349!! 34079 42060

!2857"!2# !!544"!2# !0425"!2# !0096"!2# !4!93"!2#

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ORGAN @EIGH1 RELA1IVE 1O INAL BODY @EIGH1

G)': II IV VI VIII XH$&=, N'(;,) H25346 H25347 H25348 H25349 H25350

ADRENAL GLANDS

INAL BODY < !00 0028 0026 0025 0027 00250005"!2# 0005"!2# 0004"!2# 0006"!2# 0005"!2#

BRAIN INAL BODY < !00 0696 0709 0689 0683 0679

0062"!2# 0077"!2# 0047"!2# 0075"!2# 0080"!2#

HEAR1 INAL BODY < !00 037! 0390 0383 0407 0377

00!9"!2# 0028"!2# 003!"!2# 0025"!2# 0029"!2#

KIDNEYS INAL BODY < !00 077! 0780 0727 0786 0772

0063"!2# 0!0!"!2# 0055"!2# 0049"!2# 0080"!2#

LIVER INAL BODY < !00 2846 2786 2764 2883 2762

0!73"!2# 0208"!2# 024!"!2# 0!32"!2# 0!67"!2#

OVARIES INAL BODY < !00 0049 0052 0048 0056 0047

0008"!2# 00!0"!2# 00!!"!2# 00!8"!2# 00!0"!2#

SPLEEN INAL BODY < !00 0202 0209 0!99 0!9! 0!90

0028"!2# 0038"!2# 0036"!2# 0024"!2# 0025"!2#

1HYMUS INAL BODY < !00 0!06 0099 0!!! 0!09 0!08

0027"!2# 0020"!2# 00!5"!2# 0025"!2# 0026"!2#

U1ERUS INAL BODY < !00 0259 0252 0240 023! 0286

0090"!2# 0083"!2# 0072"!2# 0068"!2# 0!02"!2#

1,), ,), . &%$%*&%*$ &*.**$.% *,),.,& $% 005 ;,%,,. G)' II $. IV

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F LIVER F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F KIDNEYS F "!2# F "!2# F "!2# F "!2# F "!2# F

F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !! F !2 F !2 F !! F !2 F F DEORMI1Y MISSING RIGH1 F F F F ! F F F DILA1A1ION LE1 PELVIS F ! F F F F F F F F F F F F F LUNGS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F HEAR1 F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F SKELE1AL MUS>LE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F SPLEEN F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F AOR1A F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F BRAIN F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F SPINAL >ORD F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F S1OMA>H F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !! F !2 F !2 F !2 F !2 F F DIS>OLORA1ION BLA>K E@ GLANDULAR 5MM DIA F ! F F F F F F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&',

1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F DUODENUM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F EUNUM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F ILEUM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F PAN>REAS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F >E>UM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F >OLON F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F RE>1UM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F MESEN1ERI> LYMPH NODE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F SALIVARY GLANDS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F MANDIBULAR LYMPH NODE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F 1HYMUS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F ADRENAL GLANDS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !! F !2 F

F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F ADRENAL GLANDS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F DEORMI1Y MISSING RIGH1 F F F F ! F F F F F F F F F F S>IA1I> NERVE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F PI1UI1ARY GLAND F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F 1HYROID GLAND F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F PARA1HYROID GLANDS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F 1RA>HEA F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F ESOPHAGUS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F PHARYNXLARYNX F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F EYE"S# @I1H OP1I> NERVE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F SKIN F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F PROS1A1E F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F SEMINAL VESI>LES F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !! F !2 F

F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F SEMINAL VESI>LES F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F DEORMI1Y MISSING RIGH1 F F F F ! F F F F F F F F F F URINARY BLADDER F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F 1ES1ES F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !! F !! F !0 F !0 F F SMALL SO1 RIGH1 F F F F ! F F F SMALL BILA1ERAL F F ! F ! F F ! F F SMALL RIGH1 F F F F ! F F F LARGE LE1 F F F F F ! F F F F F F F F F EPIDIDYMIDES F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !! F !! F F SMALL BILA1ERAL F F F F F ! F F SMALL RIGH1 F F F F ! F F F F F F F F F -----------------------------------------------------------------------------------------------

*'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F EMURKNEE OIN1 F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F S1ERNUM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F NOSE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F F F----------------------------------F F F ,($,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FII FIV FVI FVIII FX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F LIVER F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F KIDNEYS F "!2# F "!2# F "!2# F "!2# F "!2# F

F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F LUNGS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F HEAR1 F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F SKELE1AL MUS>LE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F SPLEEN F "!2# F "!2# F "!2# F "!2# F "!2# F

F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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----------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "N'(,)*# F

F F----------------------------------F F F ,($,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FII FIV FVI FVIII FX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F AOR1A F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F BRAIN F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F SPINAL >ORD F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F S1OMA>H F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F DUODENUM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F EUNUM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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F F----------------------------------F F F ,($,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FII FIV FVI FVIII FX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F ILEUM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F PAN>REAS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F >E>UM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F >OLON F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F RE>1UM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F MESEN1ERI> LYMPH NODE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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F F----------------------------------F F F ,($,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FII FIV FVI FVIII FX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F SALIVARY GLANDS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F MANDIBULAR LYMPH NODE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F 1HYMUS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F ADRENAL GLANDS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F S>IA1I> NERVE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F PI1UI1ARY GLAND F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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F F----------------------------------F F F ,($,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FII FIV FVI FVIII FX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F 1HYROID GLAND F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F PARA1HYROID GLANDS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F 1RA>HEA F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F ESOPHAGUS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F PHARYNXLARYNX F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F EYE"S# @I1H OP1I> NERVE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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F F----------------------------------F F F ,($,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FII FIV FVI FVIII FX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F SKIN F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !! F !2 F !! F !2 F !2 F F ALOPE>IA VEN1RAL F ! F F F F F F MASS 1AN IRM LE1 AXILLA F F F ! F F F F F F F F F F F MAMMARY GLAND "EMALE# F "!2# F "!2# F "!2# F "!2# F "!2# F

F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F OVARIES F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F U1ERUS F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F VAGINA F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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F F----------------------------------F F F ,($,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FII FIV FVI FVIII FX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F---------------------------------------------------------------------------------------------F F F F F F F F F URINARY BLADDER F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F EMURKNEE OIN1 F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F

F F F F F F F F S1ERNUM F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F F NOSE F "!2# F "!2# F "!2# F "!2# F "!2# F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F !2 F !2 F !2 F F F F F F F F ----------------------------------------------------------------------------------------------- *'),& *. $),.%,&,& *& %, .'(;,) $.*($& )&& ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, *.*. &,**, $& .% *,.%**,

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---------------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "NUMERI># F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F--------------------------------------------------------------------------------------------------F F F F F F F F

F DIGES1IVE SYS1EM F F F F F F F F F F F F F F F F F F F F F LIVER F "!2# F "!2# F F F F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F 3 F ! F F F F F INLAMMA1ION SUBA>U1E>HRONI> O>AL F 9 F !! F F F F F F F F F F F ---------------------------------------------------------------------------------------------------- *'), *. $),.%,&,& *& .'(;,) $.*($& (*)&*$ ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, ,&*. &,**, $& .% *,.%**,

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---------------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "NUMERI># F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F--------------------------------------------------------------------------------------------------F F F F F F F F F DIGES1IVE SYS1EM F F F F F F F F F F F F F

F F F F F F F F PAN>REAS F "!2# F "!2# F F F F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F 9 F !! F F F F F A1ROPHY F 2 F ! F F F F F AL1ERA1ION BASOPHILI> O>AL F ! F F F F F F F F F F F F ---------------------------------------------------------------------------------------------------- *'), *. $),.%,&,& *& .'(;,) $.*($& (*)&*$ ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, ,&*. &,**, $& .% *,.%**,

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F F F F F F F F ESOPHAGUS F "!2# F "!2# F F F F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F F F F F F F F F F F ---------------------------------------------------------------------------------------------------- *'), *. $),.%,&,& *& .'(;,) $.*($& (*)&*$ ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, ,&*. &,**, $& .% *,.%**,

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F F F F F F F F S1OMA>H F "!2# F "!2# F F F F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F F F F F F F F F F F ---------------------------------------------------------------------------------------------------- *'), *. $),.%,&,& *& .'(;,) $.*($& (*)&*$ ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, ,&*. &,**, $& .% *,.%**,

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F F F F F F F F DUODENUM F "!2# F "!2# F F F F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F F F F F F F F F F F ---------------------------------------------------------------------------------------------------- *'), *. $),.%,&,& *& .'(;,) $.*($& (*)&*$ ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, ,&*. &,**, $& .% *,.%**,

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---------------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "NUMERI># F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F F F F F F F F F F F F F F F F F--------------------------------------------------------------------------------------------------F F F F F F F F F DIGES1IVE SYS1EM F F F F F F

F F F F F F F F F F F F F F F EUNUM F "!2# F "!2# F F F F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F F F F F F F F F F F ---------------------------------------------------------------------------------------------------- *'), *. $),.%,&,& *& .'(;,) $.*($& (*)&*$ ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, ,&*. &,**, $& .% *,.%**,

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F F F F F F F F F F F F F F F ILEUM F "!2# F "!2# F F F F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F F F F F F F F F F F ---------------------------------------------------------------------------------------------------- *'), *. $),.%,&,& *& .'(;,) $.*($& (*)&*$ ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, ,&*. &,**, $& .% *,.%**,

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F F F F F F F F F F F F F F F >E>UM F "!2# F "!2# F F F F F F F F F F F F NO ABNORMALI1Y DE1E>1ED F !2 F !2 F F F F F F F F F F F ---------------------------------------------------------------------------------------------------- *'), *. $),.%,&,& *& .'(;,) $.*($& (*)&*$ ,$(*., ) %*& %*&&', 1, $;&,., $ .'(;,) *.*$%,& %, ,&*. &,**, $& .% *,.%**,

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---------------------------------------------------------------------------------------------------- F F LESION IN>IDEN>E "NUMERI># F F F----------------------------------F F F M$,& F F -------------------------------------------------F F LESIONS F 1REA1MEN1 FI FIII FV FVII FIX F F F FH25346FH25347FH25348FH25349FH25350F F

Thirteen-Week Feeding Study OPPTS 870.3100

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Transcript of Thirteen-Week Feeding Study OPPTS 870.3100