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8/6/2019 Thiazolo[4,5- d ]pyrimidine evaluations: synthesis and antibacterial

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Fubk`# @$0 Ebfxrfufc# U$ _$0 Uzhbar# @$ O$ Uqdxbjuau kg 5,P8 ,"~,ebckrk~bjdqc!,xbafykc,? ,qc\,?,P"uzouxaxzxjh fyjxahadkdj xbafykcahadkdj!,fladkljxbqc\,7,orklkvzadfykcad,8,kdju fufdxa,ad fllfxkrq fmjdx$ Oakkrmfd$ Ljh$ Ebjl$ ?>>= # 6: #5>21 5>17$

Of`fwkca# L$0 Da`~kzr# L$0 _fbalayfhjb# L$ Dj} feejuu xkxbafykckP8#:,h \~qralahadj hjrawfxawju$ I$ Bjxjrkeqecae Ebjl$ ?>>7 #85 # 65?=65?1$

Of`fwkca# L$0 _fbalayfhjb# L$0 Ubara# F$0 Jubmba# B$0 Dae`~kzr# L$Gfeacj uqdxbjuau kg ?,fdacadk,~qralahkP8#:, j \P6#5#8\ xbafhafyadju$

Bjxjrkeqecju ?>>2 #=: # 6=8: 6=82$Of`fwkca# L$0 Ofmbjryfhjb# M$0 Wfujmbagfr# L$0 Ubara# F$0 ^krhjca#

^$ Akhadj efxfcqyjh uqdxbjuau fdh fdxaofexjrafc jwfczfxakd kg dj}hjrawfxawju kg xbajdkP?#5,h\~qralahadj$ I$ Ebjl$ _ju$ ?>>1 # 1#7:5 7::$

Of`fwkca# L$0 Ofmbjryfhjb# M$0 Wfujmbagfr# L$0 Ubara# F$0 ^krhjc#L$0 Lfubrjmba# L$0 ^krhjca# ^$0 Frfmba# L$ Lkcjezcfr akhadj ~rk,lkxjh uqdxbjuau kg dj} ~qrfykckP5#8,h\~qralahadj hjrawfxawjufu ~kxjdxafc fdxaofexjrafc fmjdxu$ Jzr$ I$ Ljh$ Ebjl$ ?>6>f #8: #78=7:>$

Of`fwkca# L$0 _fbalayfhjb# L$0 Ubara# F$0 F`ofryfhjb# L$0 Lkzufwa#U$ B$0 Fxf~kzr,Lfubbfh# B$0 Xfqfrfda,Dfifrfd# Y$ Uqdxbjuau fdhfdxaefdejr jwfczfxakd kg dj} hjrawfxawju kg 5,~bjdqc,6#:,halj,xbqc,6B,P6#?#8\xrafykckP8 #5 96#?\ ~qralahkP8#:, j \P6#5#8\k fhafy,adj$ I$ Ebjl$ _ju$ ?>6>o #58# 8>58>7$

Of`fwkca# L$0 _fbalayfhjb# L$0 Ubara# F$0 F`ofryfhjb# L$0 Lkzufwa#U$ B$0 Xfqfrfda,Dfifrfd# Y$0 Fxf~kzr,Lfubbfh# B$0 Da`~kzr# L$Uqdxbjuau kg dj} hjrawfxawju kg 5,frqc,6#:,haljxbqc,6 B ,P6#?#8\xrafykckP8 #5 96#?\~qralahkP8#:, j \P6#5#8\k fhafyadju fu ~kxjdxafcfdxa~rkcagjrfxawj fmjdxu$ I$ Bjxjrkeqecae Ebjl$ ?>66f #82 # 62562=$

Of`fwkca# L$0 _fbalayfhjb# L$0 Ubara# F$0 Jubmba# B$0 ^krhjca# ^$0^krhjc# L$0 Da`~kzr# L$ Uqdxbjuau fdh fdxaofexjrafc jwfczfxakdu kg dj} ~qrahfyadkP8#5,j\P6#5#8\k fhafyadju$ I$ Bjxjrkeqecae Ebjl$ ?>66o #82 # 6816:?$

Obfxxfebfrqf# ^$0 Cjkdfrh# X$ I$0 _kq# @$ J ~ckradm VUF_ kg xba,fykcj fdh xbafhafykcj hjrawfxawju fu ~kxjdx fdh ujcjexawj bzlfdfhjdkuadj F5 rjej~xkr fdxfmkdauxu zuadm GF fdh MGF xjebdavzju$

Oakkrmfd$ Ljh$ Ebjl$ ?>>: #65 # 66:1 667:$Ecfr`# G$ _$0 Ybfdm# X$0 ]fdm# R$0 ]fdm# _$0 Ybfdm# R$0 Efl~# U$ B$0

Ojzxjc# O$ F$0 Ubfl# B$ C$0 Mz# M$ Q$ ^bjdk q xbafykcj hjrawf,xawju fu ~kxjdx fdh ujcjexawj fejxqc,EkF efrok qcfuj ? adbaoaxkru9lkhzcfxakd kg aukyqlj ujcjexawaxq oq adekr~krfxakd kg ~bjdqc radmuzouxaxzjdxu$ Oakkrm$ Ljh$ Ebjl$ Cjxx$ ?>>= #6= # 6176617:$

Jc _fhq# J$ F$ F ekdwjdajdx fdh gfeacj uqdxbjuau kg dj} xbafykcjhjrawfxawju$ bku~bkrzu Uzcgzr Uacaekd ?>>2 #625 # 67:1 67=6$

Jc,Uzoofmb# A$0 Fckofah# F$ L$ ?#8,Hauzouxaxzxjh xbafykcju AA$ F dkwjcecfuu kg fdxaxzlkr fmjdxu# uqdxbjuau fdh oakckmaefc jwfczfxakdu$

Jzr$ I$ Ljh$ Ebjl$ 6117 #56 # 6>6=6>?6$Izdm# Q$ @$0 @al# @$ U$0 Mjk# M$ Y$0 Mrkuu# F$ U$0 Ljclfd# D$0

Ifekoukd# @$ F$0 @al# E$ Q$ Uxrzexzrj,fexawaxq rjcfxakduba~u kg xbafykcj fdh xbafhafykcj hjrawfxawju fu ~kxjdx fdh ujcjexawj bzlfdfhjdkuadj F5 rjej~xkr fdxfmkdauxu$ Oakkrmfd$ Ljh$ Ebjl$ ?>>8 #6? # 7657?5$

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8/6/2019 Thiazolo[4,5- d ]pyrimidine evaluations: synthesis and antibacterial

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XbafykckP8#:, h \~qralahadju 8=

@ada# M$ H$0 Fdhjrukd# I$ H$0 Ufdmbwa# Q$ U$0 Cj}au# F$ G$0 Uljj#H$ G$0 _jwfd`fr# M$ _$0 _koadu# _$ @$0 Ekxxfl# B$ O$ Uqdxbjuaufdh fdxawarfc fexawaxq kg ejrxfad mzfdkuadj fdfckmu ad xbjxbafykckP8#:,h \~qralahadj radm uquxjl$ I$ Ljh$ Ebjl$ 6116 #58 #5>>75>6>$

@aujcqkw# F$ U$0 ^afxfdaxu`a# J$0 Ujljdkwf# L$0 Ujljdkw# W$ W$ D ,"Frqc!,8,"fykcqcjxbqc!xbafykcj,:,efrok flahju9 dkwjc ~kxjdx

adbaoaxkru kg WJMG rjej~xkru A fdh AA$ Oakkrm$ Ljh$ Ebjl$ Cjxx$ ?>>7 #67 # 7>?7>7$

Cjoufe`# F$ H$0 Orfduxjxxjr# O$ I$0 Bfe`# L$ H$0 Rafk# ]$0 ^jxjrukd#L$ C$0 Dfuujr# D$0 Lfbjr# L$ ^$0 Fk# B$0 Obfxxfebfrqf# F$0@fdufmfrf# L$0 jx fc$ Ahjdxa efxakd fdh uqdxbjuau kg ?#=,hafladk,xbafykckP:#8,h \~qralahadj hjrawfxawju fu X_^W6 fdxfmkdauxu$

Oakkrm$ Ljh$ Ebjl$ Cjxx$ ?>>1 #61 # 8>87$Caz# I$0 ^fxeb# _$ I$0 Uebzojrx# E$0 ^cfqjr# L$ _$ Uadmcj,uxj~ uqdxbj,

uju kg ?,fladk,=,ebckrkxbafykckP:#8, h \~qralahadju9 adxjrljha,fxju gkr oawfcjdx xbafykck~qralahadju$ I$ Krm$ Ebjl$ ?>>: # => #6>618 6>61=$

Ljx}fccq# L$ F$0 Fohjc,cfxag# J$0 Fljr# G$ F$0 @fz~~# M$ Wjrufxacj?,fladk,8,uzouxaxzxjh,6#5,xbafykcju9 uqdxbjuau fdh rjfexakdu$ I$Uzcgzr Ebjl$ ?>>8 #?: # 752:$

Dfmfbfrf# @$0 Fdhjrukd# I$ H$0 @ada# M$ H$0 Hfccjq# D$ @$0 Cfrukd#U$ O$0 Uljj# H$ G$0 Iad# F$0 Ubfrlf# O$ U$0 Ikccjq# ]$ O$XbafykckP8#:,h\~qralahadj dzecjkuahju$ Xbj uqdxbjuau kg ejr,xfad 5, , h ,raokgzrfdkuqc xbafykckP8#:,h \~qralahadju fu ~kxjdxafcallzdkxbjrf~jzxae fmjdxu$ I$ Ljh$ Ebjl$ 611> #55 # 8>=86:$

^f}fd# @$ U$0 Uf}bdjq# U$ D$ kxjdx fdxa,ad fllfxkrq 5,xbafykcj,8,":!,fejxae feahu kg 6#?,ojdyaukxbafykcj$ Oakkrm$ Ljh$ Ebjl$ Cjxx$ 611= #= # ?8?=?85>$

_jjwju# H$ U$0 ]baxj# C$ K$ ^radea~cju kg Ljxbkhu kg Fuufqadm Fdxaoakxae ad ^bfrlfejzxaefc Laerkoakckmq 0 5rh Jhaxakd$Ocfe`}jcc9 K gkrh# 6125# ~~$ 68> 67?$

_zuuk# G$0 Mzeeakdj# U$0 _kljk# M$0 Ofrrjxxf# E$ Z$0 zeea# U$0 Efrzuk#F$0 Flaek,_k fu# L$0 Ezxzca# W$ ^qrfykckxbafykck~qralahadjhjrawfxawju fu f dkwjc ecfuu kg fdxa,ad fllfxkrq kr fdxa,dkeaej~xawj fmjdxu9 uqdxbjuau# uxrzexzrfc ebfrfexjrayfxakd fdh

~bfrlfekckmaefc jwfczfxakd$ Jzr$ I$ Ljh$ Ebjl$ 6115 # ?2 #575 5=7$

Uarefr# I$ E$0 Uzxk# L$ I$0 Uekxx# L$ J$0 Hkdm# L$ @$0 Macojrxujd#_$ O$ Adbaoaxkru kg bzlfd ~zradj dzecjkuahj ~bku~bkrqcfuj$Uqdxbjuau# ~zradj dzecjkuahj ~bku~bkrqcfuj adbaoaxakd# fdhX,ejcc eqxkxk aeaxq kg ?#:,hafladkxbafykckP:#8, h \~qralahad,=,"7 B !,kdj fdh ?#:,hafladkxbafykckP8#:, h \~qralahad,="7 B !,kdj$

X}k xbakaukuxjrju kg 2,fladkmzfdadj$ I$ Ljh$ Ebjl$ 6127 #?1 #62>8 62>7$

Wfd Xacozrm# J$ ]$0 Wfd hjr @cjad# $ F$0 Hj Mrkkxj# L$0 Ojz`jru# L$ ]$0]yjrlfd# F$ $ Uzouxaxzxjh 8,~bjdqc,?,"~bjdqcefrok flahk!,6,#5,xbafykcj hjrawfxawju fu fdxfmkdauxu gkr xbj fhjdkuadj F6 rjej~,xkr$ Oakkrm$ Ljh$ Ebjl$ Cjxx$ ?>>6 #66 # ?>6=?>61$

Waeada# ^$0 Mjrkda`f`a# F$0 Adejrxa# L$0 Ozukdjrf# O$0 ^kda# M$0Eforfu# F$ E$0 Ekccf# C$ ^$ Uqdxbjuau fdh oakckmaefc jwfczfxakdkg ojdykPh \aukxbafykcj# ojdykxbafykcj fdh xbafykcj Uebagg ofuju$

Oakkrm$ Ljh$ Ebjl$ ?>>5 #66 # 8=2: 8=21$]fcj`# ]$ HaebckrkxbafykckP8#:, h \~qralahadju$ Y$ Ebjl$ 6125 # ?5 #

6=1625 "Ebjl$ Fouxr$ 6125 #11 # ?6?82:g!$]fcj`# ]$0 ^fccfu# L$0 Mkjxyuebjc# @$0 @keblfdd# ]$0 ]jrdjr# _$ H$

XbafykckP8#:,h\~qralahadju$ Mjr$ "Jfux! 6128 # HH ?>25::"Ebjl$ Fouxr$ 6128 #6>6 # 61617:j!$

]koam# H$ Xbafykcj hjrawfxawju9 uqdxbjuau kg xbafykckP8#:,h \~qrala,hadj hjrawfxawju$ Cajoamu Fdd$ Ebjl$ 6121 # 8>1866 " Ebjl$

Fouxr$ 6121 #66> # ?6?=7=w!$Ra# D$0 Ok# Q$0 Hkbjrxq# J$ L$0 Gkxueb# E$0 Mf}f# D$ _$0 Bfd# D$0

Bzdmfxj# _$ ]$0 @cakdu`q# C$0 Caz# V$0 Xflar# _$0 jx fc$ Uqdxbjuaufdh jwfczfxakd kg xbafykcj efrok flahju fu wfdacckah rjej~,xkr 6 "X_^W6! fdxfmkdauxu$ Oakkrm$ Ljh$ Ebjl$ Cjxx$ ?>>: #6: #:?66 :?6=$

Yaxkzda# M$ X$0 Hjlarfqf`# F$ K$0 @f~cfdea`ca# Y$ F$# Qachay# X$ L$Uqdxbjuau kg uklj ?,P"ojdyfykc,?,qc!xbakfejxqcfladk\xbafykcjhjrawfxawju fdh xbjar fdxalaerkoafc fexawaxq fdh xk aeaxq$ Jzr$ I$

Ljh$ Ebjl$ ?>>8 #51 # ?7=?=?$

_jejawjh Lfq 68# ?>660 feej~xjh Lfq ?=# ?>66

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