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Arunkumar RengarajPhd research Scholar (2014 March -)
Under the Guidance of Prof.Yun Suk Huh
Department of Biological EnginneringInha university
Teaching Experience
Since June, 2012: Working as an Assistant Professor in Dept. of Biotechnology, Prathyusha Institute of Technology and
Management, Tiruvallur, Chennai, India -602 025.Industry Experience
Aug 2011 to May 2012: Worked as an Executive in Research and Development at Tex Biosciences (Pvt.) Ltd sister
company of Hospira pharma ceuticals , Chennai.
Qualification
From 2009 to 2011 - M.Tech. (Biotechnology) @ Bannari Amman Institute of Technology affiliated to Anna University,
Coimbatore, TN, India. [First class with CGPA 8].
From 2005 to 2009 - B.Tech. (Biotechnology) @ P.S.R Engineering College affiliated to Anna University, Sivakasi, TN,
India. [First class with 75 %].
Paper Published
Papers under correction
Dendrimer~5-FU conjugate for targeting E6& E7 oncoproteins in cervical cancer: a combined experimental/ in silico approach†
Arunkumar Rengaraj,aѱ Subbiah Balaji,bѱ Giribabu Krishnamoorthy,a Yuvaraj Haldorai,c Dhanusha Yesudhas,d Nam-Soo Heo,a
Soonjo Kwon,e Sangdun Choi,d Young-Kyu Han,c N. Hema Shenpagamb* and Yun Suk Huha*
Writing for nanoscale
Porous, 2D covalent organic framework/Fe3O4 nanocomposite for strontium ion recovery from sea water
Arunkumar Rengaraj,a ǂ Yuvaraj Haldorai,bǂ Pillaiyar Puthiaraj,c Seung Kyu Hwang,a Taegong Ryu,d Junho Shin,d Young-Kyu Han,b
Yun Suk Huha*
(MIL-125)~PEG~FA for thernostatics and anticancer drug delivery for Breast cancer
Under process
Polymethylene blue mediated heparin sesnor
Looking for CV
CVD grown graphene-Au mediated LSPR sensor
Looking for graphene
Polymer for Anticancer drug delivery
Cancer is one of the devastating disease to human society with the mortality rate of 8.2million peoples per year.
So there is a huge need of interdisciplinary research, hope nanotechnology is a key to cure to this diseases.
Nanomaterials are the particles which have unique property due to its nano-size and I am obsessed with its unique ability to
interact with the biological molecules without causing damage to the cellular system.
Nano-polymers are one of its kind which has so many interesting characters like less toxicity, high surface area, drug holding
property and binding with the cellular macro-moles.
These polymers (POP, dendrimers) can be synthesize using organic and inorganic monomers as binding blocks via different
chemical reactions.
In this research 20-200nm organic polymers were synthesized and characterized using FE-TEM, SEM, XPS, XRD, Zeta poten-
tial analysis, UV spectroscopic and Fluorescence spectroscopy analysis.
MTT assay was used to check the toxicity of this material and Laser confocal imaging, Bio-TEM analysis is used to localize the
nanoparticle within the cell.
These nanoparticles were loaded with the cancer drugs such as Doxorubicin and 5-Flurouracil via chemical bonding, hydropho-
bic-hydrophilic interaction. Molecular docking was used to analysis the interaction of polymer-drug conjugate with the target
protein present in the cancer cells. Hematological analysis, histochemical analysis of tissue sections were used to check the
safety of this nanoparticles over therapeutic application on cancer.
Drug delivery
Dendrimer~5-FU conjugate for targeting E6& E7 oncoproteins in cer-vical cancer: a combined experimental/ in silico approach†
(MIL-125)~PEG~FA for thernostatics and anticancer drug delivery for Breast cancer
Electrochemical sensor for the detection of Biomolecules
In this modern life, biosensors are very important tool for detection and treatment of particular disease.
Because they are cheap, stable and sensitive to particular analyst.
In my research I am having more concern over the detection of macromolecules using electrochemical sensor.
Detection of macromolecules like cholesterol and heparin are very complex because of their structure ,charge and molecular weight .
Here we are utilizing metal oxide, polymers to detect these analyst based on electrochemical reaction (oxidation or reduction) and charge interaction.
We are utilizing different type of analyt to check the selectivity of these molecules towards particular analyst.
The sensitivity of the detection is measured using chronoamperometry and DPV
The stability of the sensor was checked for wide range of cycles and duration
Biosensor
Polymethylene blue mediated heparin sensor