Therapeutic Plasma Exchange copy
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Transcript of Therapeutic Plasma Exchange copy
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Dr. Nippun Prinja
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Plasmapheresis Plasma exchange
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TPE Healthy Donors Plasma Exchange
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Crystalloids Colloids Plasma Protein Fraction FFP
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Removal Of Antibodies Removal Of Immune Complexes Hyperviscosity Syndromes Removal Of toxins Replacement Of Deficient Plasma
Components
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1=standard& acceptable 2=generally accepted 3=case studies 4=lacking efficacy P=phase 3 pharma trials
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Manual-by use of plastic bag Automated-by cell separator machines
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Reaction to replacement fluids Vasovagal reactions Pyrogenic reactions Hypocalcemia Haemolytic transfusion reactions.
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THERAPEUTIC LEUCAPHERESIS THERAPEUTIC THROMBOPHERESIS THERAPEUTIC ERYTHROPHERESIS
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MANUAL APHERESIS MACHINE
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INTERMITTENT FLOW CENTRIFUGATION. CONTINUOUS FLOW CENTRIFUGATION.
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Haemonetics Density=redcells>white
cells>platelets>plasma Seprated components from bowl through
outlet port into seprated bag Centrifuge stops and pump get reversed Components not required returned to
individual 6-8 cycles are done till desired quality &
quantity
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COMTEC,AMICUS. Blood is withdrawn,processed and returned
to the individual simultaneously. Earlier two venous access,now one. Advantage of speed,small extra corporeal
volume. Isovolumeic status of donor is maintained
minimizing fluid loss.
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ICU Well trained staff First aid kit Written consent Adverse effects/reaction Availability of physician if complication