Therapeutic Clinical Trials Accrual

* TJUH Accruals Only, does not contain JCN accrual data.

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100

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2003 2004 2005 2006

Industrial/Pharmaceutical Trials

National Cooperative group Trials

Investigator Iniitiated Trials

TJUH Clinical Trials 2006 (to date) Therapeutic Accrual by Enrolling MD

4Shari Rudoler M.D.#154John Wagner M.D.#144Joanne Filicko M.D.#138Rajnish Mago M.D.#128Bijoyesh Mookerjee M.D.#119Neal Flomenberg M.D.#109Adam Dicker M.D.,Ph.D.#9

10Rita Axelrod M.D.#810Richard Valicenti M.D.#718Pramila Anne M.D.#618Edith Mitchell M.D.#519Takami Sato M.D.#434Maria Werner-Wasik M.D.#335Mitchell Machtay M.D.#242Walter Curran M.D.#1

TJUH Clinical Trials2006 (to date) IIT Accrual by Trial

Analysis of Donor Cells Engrafted in Recipients of AllogeneicHematopoietic Stem Cell Transplantation

18Non-T#5

A Phase 1 Study of the Combination of VELCADE andChemoradiation for the Treatment of Patients

29Therap#4

Comparison of Two Forms of Immobilization of the Head forFractioned Sterotactic Radiotherapy

39Therap#3

A Research Database for Allogeneic and AutologousHematopoietic Progentior Cell Transplantation

53Non-T#2

Guanylyl Cyclase C in Blood and Colorectal Cancer63Non-T#1

Trial TitleAccrualType

TJUH Clinical Trials2006 (to date) IIT Accrual by Trial

Protocol for a Research Sample Repository for AllogeneicUnrelated Hematopoietic Stem Cell Transplantation11Non-T#9

A Pilot Study Investigating Active Breathing Control (ABC) toReduce Radiation Dose to Normal Structures in Breast CancerPatients15Therap#8

Utility of Guanylyl Cyclase C as a Biomarker for Staging PatientsWith Colorectal Cancer15Non-T#7

Molecular Staging of Esophageal Cancer using Guanylyl CyclaseC and Cdx217Non-T#6

Trial TitleAccrua

lType

TJUH Clinical Trials2006 (to date) Therapeutic Accrual by Trial

A Phase I/II Study of LLME Treated Non-Myeloablative AllogeneicHematopoietic Stem Cell Transplantation for Patients withHematological Malignancies

10IIT#5

M-Vax: A feasibility and bio-equivalence study using a DNP-modified autologous melanoma tumor cell vaccine as therapy inpts. with stage III or IV

11Ind#4

A Pilot Study Investigating Active Breathing Control (ABC) toReduce Radiation Dose to Normal Structures in Breast CancerPatients

15IIT#3

A Phase 1, Open-Label, Dose-Escalation, Safety Study of theCombination of VELCADE and Chemoradiation for the Treatment ofPatients with Cancer

29IIT#2

A Randomized Trial Comparing Two Forms of Immobilization of theHead for Fractioned Sterotactic Radiotherapy

39IIT#1

Trial TitleAccru

alType

TJUH Clinical Trials2006 (to date) Therapeutic Accrual by Trial

A Clinical Trial of Chemotherapy and Bevacizumab with and withoutPanitumumab in the First-line Treatment of Subjects with MetastaticColorectal Cancer

7Ind#10

A Pilot Study of the Efficacy and Tolerability of Bupropion ExtendedRelease (Wellbutrin XL) for the Treatment of Major DepressiveDisorder in Women with Breast Cancer

8Ind#9

Immunoembolization of Hepatic Artery with Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)8IIT#8

A Randomized Phase III Study of Conventional Whole BreastIrradiation (WBI) versus Partial Breast Irradiation (PBI) for Womenwith Stage 0, I, II Breast Cancer

9RTOG#7

A Phase 1, Open-Label, Dose-Escalation, Safety Study of theCombination of EPO906 and Radiation Therapy (IND#67,253)10IIT#6

Trial TitleAccru

alType

TJUH Clinical Trials2006 (to date) Non-Therapeutic Accrual by Trial

Prospective, Longitudinal, Multi-Center, Descriptive Registry ofPatients Receiving Therapy Other than Surgical Resection Alone forNewly Diagnosed Head and Neck Carcinoma.

16Ind#5

Molecular Staging of Esophageal Cancer using Guanylyl Cyclase Cand Cdx217IIT#4

Analysis of Donor Cells Engrafted in Recipients of AllogeneicHematopoietic Stem Cell Transplantation

18IIT#3

A Research Database for Allogeneic and Autologous HematopoieticProgentior Cell Transplantation

53IIT#2

Guanylyl Cyclase C in Blood and Colorectal Cancer63IIT#1Trial TitleAccrualType

TJUH Clinical Trials2006 (to date) Non-Therapeutic Accrual by Trial

Analysis of Donor Cells in Allogeneic Hematopoietic Stem CellTransplantation10IIT#9

Protocol for a Research Sample Repository for Allogeneic UnrelatedHematopoietic Stem Cell Transplantation

11IIT#8

Bio-Behavioral Pathways in Oral Lesions14Coop#7

Utility of Guanylyl Cyclase C as a Biomarker for Staging Patients WithColorectal Cancer: GCC Staging of Lymph Nodes Havested DuringColorectal Cancer Surgery: Evaluating Patients For Time toRecurrence""

15IIT#6

Trial TitleAccrua

lType

JCN Clinical TrialsAccrual by Year: Therapeutic vs Not-Therapeutic

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120

2004 2005 2006

NTT

JCN Clinical Trials2006 (to date) Accrual by Institution

0 5 1 0 1 5 2 0 2 5

Mercy Fitzgerald Hospital

Albert Einstein Medical Center

Riddle Hospital

Pocono Medical Center

Ephrata Hospital

Northeast Radiation Oncology Center

Frankford Hospital

Hematology & Oncology Assoc of NE PA

JCN Clinical Trials2006 (to date) Accrual by Trial

A Randomized Study of Intermittent Capecitabine incombination with Oxaliplatin (XELOX Q3W) and Bevacizumabversus Intermittent Capecitabine in Combination with Oxaliplatin(XELOX Q2W) and Bevacizumab

4Ind#5

RTOG #P-0126- A Phase III Randomized Study of High Dose 3D-CRT in Patients Treated for Localized Prostate Cancer7RTOG#4

A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxiplatin (mFOLFOX6) Every Two Weekswith Bevacizumab to the Same Regimen Without Bevacizumabfor the Treatment of Patients with Resected Stages II and IIICarcinoma of

11NSABP#3

(CIRB) A Phase III, Adjuvant Trial Comparing ThreeChemotherapy Regimens in Women with Node-Positive BreastCancer11NSABP#2

A Randomized Phase III Study of Conventional Whole BreastIrradiation (WBI) versus Partial Breast Irradiation (PBI) forWomen with Stage 0, I, II Breast Cancer

15RTOG#1

Trial TitleAccrualType

JCN Clinical Trials2006 (to date) Accrual by Trial

A Phase III Randomized, Double-Blind Study of AdjuvantST1571 (Gleevec) Versus Placebo in Patients Following theResection of Primary Gastrointestinal Stromal Tumor

3ECOG#10

A Phase III Randomized Study of Hypofractionated 3D-CRT/IMRT Versus Conventionally Fractionated 3D-CRT/IMRTin Patients with Favorable-Risk Prostate Cancer

3RTOG#9

A Clinical Trial Comparing Six Cycles of 5-Fluorouracil,Epirubicin, and Cyclophosphamide (FEC) to Four Cycles ofAdriamycin and Cyclophosphamide in Patients with Node-Negative Breast Cancer

3NSABP#8

Sequencing Topoisomerase Inhibitors for Extensive StageSmall Cell Lung Cancer (SCLC): Topotecan Sequenced withEtoposide/Cisplatin, and Irinotecan/Cisplatin with Etoposide

3ECOG#7

A Randomized Phase III Trial of Concurrent AcceleratedRadiation and Cisplatin Versus Concurrent AcceleratedRadiation, Cisplatin, and Cetuximab (C225) For Stage III andIV Head and Neck Carcinomas

4RTOG#6

Trial TitleAccrualType