The Upper Airway, Asthma and Sleep Disorders in Children A ... AAAAI-OSA inflammation... ·...
Transcript of The Upper Airway, Asthma and Sleep Disorders in Children A ... AAAAI-OSA inflammation... ·...
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The Upper Airway, Asthma and Sleep Disorders in Children
A. Kaditis, MD
Pediatric Pulmonology Unit, Sleep Disorders Laboratory
First Department of Pediatrics
University of Athens School of Medicine
and Aghia Sophia Children’s Hospital
Athens, Greece
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Upper Airway, Asthma, Sleep Disorders
SnoringRecurrent Wheezing
Sleep Quality
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Upper Airway, Asthma, Sleep Disorders
Pathophysiology of Obstructive Sleep-Disordered Breathing and its
effects on Sleep Quality
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Obstructive Sleep-Disordered Breathing
Spectrum of abnormal respiratory patterns during sleep characterized by snoring and increased respiratory effort
� Primary snoring� Upper airway resistance syndrome� Obstructive hypoventilation� Obstructive sleep apnea (OSA)
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A Mechanical Model for Obstructive Sleep-Disordered Breathing
Upper Airway Resistance
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Katz et al.Genioglossus activity during sleep in normal control subjects and children with OSA. AJRCCM 2004;170:553
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Upper Airway Dysfunction and Adenotonsillar Hypertrophy
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Conditions affecting Upper Airway Resistance and Pharyngeal Collapsibility
� Septal deviation
� Nasal polyps� Hypertrophied turbinates
� Obesity� Craniofacial abnormalities
� Neuromuscular disorders
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OSA symptoms
� Snoring� Reported apneas during sleep� Difficulty breathing during sleep� Restless sleep� Frequent arousals� Daytime sleepiness� Hyperactivity� Decreased cognitive functioning� Learning problems
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Allergic Rhinitis and Obstructive Sleep-Disordered Breathing
� McColley et al. High Prevalence of Allergic Sensitization in Children with OSA. Chest 1997;111:170
� Kalra et al. Atopy as a Risk Factor for Habitual Snoring at Age 1 Year. Chest 2006;129:942-6
� 13.7 ± 2.6 months� Independent Risk Factor for habitual snoring
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Upper Airway, Asthma, Sleep Disorders
Effects of Recurrent Wheezing on Sleep Quality
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Daytime tiredness
Daytime sleepiness
Restless sleep
Difficulty falling asleep
OutcomesOR (95% CI)
<0.015.1(2.2-12.1)
<0.013.8(1.8-8.0)
<0.015.0 (2.2-11.1)
<0.052.0 (1.0-4.0)
pWheezing adjusted for
snoring
Desager et al. Sleep Disturbance and Daytime Symptoms in Wheezing School-Aged Children. J Sleep Res 2005;14:77
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Upper Airway, Asthma, Sleep Disorders
Epidemiologic Association between Snoring and Recurrent Wheezing
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History of asthma
Cough
Persistent wheeze
Occasional wheeze
Risk factors adjusted for race, obesity
<0.053.83(1.39-10.55)
<0.058.83(2.29-34.05)
<0.057.45 (2.03-27.39)
<0.053.29(1.24-8.94)
pAHI>10
OR (95% CI)
Redline et al. Risk Factors for SDB in Children.AJRCCM 199;159:1527
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0.0131.73(1.12-2.67)
History of wheezing
0.5650.88 (0.58-1.35)
PassiveSmoking
0.0411.65 (1.02-2.66)
Obesity
0.0201.67 (1.08-2.58)
Gender
0.1250.95 (0.90-1.01)
Age
pvalue
Dependent variable: snoring
OR (95% CI)
Risk factors
Kaditis et al. Associations of Tonsillar Hypertrophy and Snoring with History of Wheezing in Childhood. Pediatr Pulmonol 2010;45:275
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0.0012.23(1.37-3.63)
History of wheezing
0.8510.96 (0.60-1.53)
PassiveSmoking
0.2190.69 (0.38-1.25)
Obesity
0.9061.03 (0.64-1.65)
Gender
0.3210.97 (0.90-1.04)
Age
pvalue
Dependent variable: tonsillar hypertrophy
OR (95% CI)
Risk factors
Kaditis et al. Associations of Tonsillar Hypertrophy and Snoring with History of Wheezing in Childhood. Pediatr Pulmonol 2010;45:275
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Wheezing is significantly associated with snoring
In children with tonsillar hypertrophy[OR = 2.76 (1.10-6.93); p=0.031],
But not in children without tonsillar hypertrophy[OR = 1.49 (0.92-2.43); p=0.107].
Tonsillar hypertrophy partially explains the association of snoring with wheezing
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Upper Airway, Asthma, Sleep Disorders
Pathogenetic links between Obstructive Sleep-Disordered
Breathing and Recurrent Wheezing
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Shibata et al. Increased Leukotriene E4 in the EBC of Children with Mild Asthma. Chest 2006;130:1718
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Caballero Balanza et al. Leukotriene B4 and 8-Isoprostane in EBC of Children with Episodic and Persistent Asthma. J Investig Allergol CIin Immunol 2010;20:237
LTB48-
Isoprostane
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Goldbart et al. Inflammatory Mediators in EBC of Children with OSAS. Chest 2006;130:143
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Biltagi et al. Correlation of 8-isoprostane, IL-6, and cardiac functions in childhood with OSA. Acta Paediatr 2006;97:1397
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Kaditis et al. CysLT-Rs in Tonsillar Tissue of Children with OSA. Chest 2008;134:324-31
OSA Recurrent tonsillitis
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Goldbart et al. Leukotriene Modifier Therapy for Mild SDB. AJRCCM 2005; 172: 364
OSA Recurrent tonsillitis
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Dayyat et al. Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive
sleep apnea. Chest 2009;135:1142
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Conclusions
� Obstructive sleep-disordered breathing and recurrent wheezing/asthma: Both result in sleep-disturbance
� Obstructive sleep-disordered breathing is associated with allergic rhinitis and frequently coexists with recurrent wheezing/asthma
� Airway inflammation related to leukotrienes and oxidative stress: Probably participate in the pathogenesis of both snoring and recurrent wheezing