The Treatment of Infection Without Antibiotics AANP Annual Conference August 2003 Jared L. Zeff, ND.

The Treatment of Infection The Treatment of Infection Without AntibioticsWithout Antibiotics

AANP Annual ConferenceAANP Annual Conference

August 2003August 2003

Jared L. Zeff, NDJared L. Zeff, ND

Goal: to present a system of effective Goal: to present a system of effective treatment for antibiotic-resistant infectionstreatment for antibiotic-resistant infections

Overview:Overview:

1. The scope of the problem1. The scope of the problem

2. Contrasting approaches to treatment2. Contrasting approaches to treatment

3. Principles of a naturopathic approach3. Principles of a naturopathic approach

4. Case illustrations 4. Case illustrations

Primary cause of death: 1900Primary cause of death: 1900

Infectious pneumoniaInfectious pneumonia

1929: Sir Alexander Fleming discovers penicillin.1929: Sir Alexander Fleming discovers penicillin.Penicillin is effective against Streptococcus Penicillin is effective against Streptococcus pneumoniae.pneumoniae.

1930’s: Howard Florey and Ernst Chain extract and 1930’s: Howard Florey and Ernst Chain extract and purify penicillin.purify penicillin.

1941: British policeman is first person treated with 1941: British policeman is first person treated with penicillin, dies: insufficient quantity.penicillin, dies: insufficient quantity.

1943: Selman Waksman discovers streptomycin.1943: Selman Waksman discovers streptomycin.Streptomycin is effective against Mycobacterium Streptomycin is effective against Mycobacterium tuberculosis.tuberculosis.

1940’s: penicillin available to armed forces.1940’s: penicillin available to armed forces.

1950’s: penicillin available to general public. 1950’s: penicillin available to general public.

More antibiotics are developed.More antibiotics are developed.

The age of miracle medicine has arrived!The age of miracle medicine has arrived!

By the end of the 20By the end of the 20thth century we will see the century we will see the “virtual elimination of infectious disease as a “virtual elimination of infectious disease as a significant factor in societal life.” significant factor in societal life.”

Sir F. MacFarlane Burnett, MD, Sir F. MacFarlane Burnett, MD, 19621962

Australian Nobel laureateAustralian Nobel laureate

“…“…it [is] time to close the book on infectious it [is] time to close the book on infectious diseases.”diseases.”

U.S. Surgeon General William StewartU.S. Surgeon General William Stewart

19691969

Causes of Death Causes of Death (2000)(2000)

1.1. Heart DiseaseHeart Disease 710,760710,760

2.2. CancerCancer 553,091553,091

3.3. StrokeStroke 167,661167,661

4.4. Chronic Lung DiseaseChronic Lung Disease 122,009122,009

5.5. AccidentsAccidents 97,900 97,900

Causes of Death Causes of Death (2000)(2000)

6.6. DiabetesDiabetes 69,301 69,3017.7. Influenza and PneumoniaInfluenza and Pneumonia 65,313 65,3138.8. Alzheimer’s diseaseAlzheimer’s disease 49,558 49,5589.9. Kidney diseaseKidney disease 37,251 37,25110.10. SepticemiaSepticemia 31,224 31,224

National Center for Health Statistics, CDC, 2002National Center for Health Statistics, CDC, 2002

Causes of DeathCauses of Death

2,000,000 nosocomial infections 2,000,000 nosocomial infections annually which kill 90,000 each year.annually which kill 90,000 each year.

William Jarvis, MD Director: CDC William Jarvis, MD Director: CDC

March 11, 1998March 11, 1998

Causes of Death Causes of Death

5. Accidents5. Accidents 97,90097,900

*6. Nosocomial infections*6. Nosocomial infections 90,00090,000

7. Diabetes7. Diabetes 67,30167,301

Causes of DeathCauses of Death

1.1. Heart DiseaseHeart Disease 710,760710,760

2.2. CancerCancer 553,091553,091

3.3. *Infection*Infection 150,000 – 200,000 150,000 – 200,000 (?)(?)

4.4. StrokeStroke 167,661167,661

5.5. Chronic Lung DiseaseChronic Lung Disease 122,009122,009

Antibiotic ResistanceAntibiotic Resistance

19451945 14% of Staph. a. penicillin resistant14% of Staph. a. penicillin resistant




WhyWhy1. bacteria reproduce every 20 minutes:1. bacteria reproduce every 20 minutes:

rapid mutation potentialrapid mutation potential2. significant antibiotic exposure:2. significant antibiotic exposure:

common and inappropriate usecommon and inappropriate useenvironmental presence: animal husbandryenvironmental presence: animal husbandry

3. hospitals concentrate the worst pathogens3. hospitals concentrate the worst pathogens4. reduction in hospital hygiene (fewer staff)4. reduction in hospital hygiene (fewer staff)


Streptococcus pneumoniaeStreptococcus pneumoniae(pneumococcus)(pneumococcus)

7,000,000 cases of otitis media7,000,000 cases of otitis media 100,000 – 135,000 hospitalizations/pneumonia100,000 – 135,000 hospitalizations/pneumonia 50,000 cases of septicemia50,000 cases of septicemia 3,000 cases of meningitis3,000 cases of meningitis

““Between 10% and 40% of pneumococcus infections are drug Between 10% and 40% of pneumococcus infections are drug resistant”resistant”

CDC, July 2002CDC, July 2002


200,000 nocosomial Staph. Aureus infections 200,000 nocosomial Staph. Aureus infections annually;annually;

80,000 are antibiotic resistant.80,000 are antibiotic resistant.CDC Fact Book, 2002CDC Fact Book, 2002


The newest problem:The newest problem:

““CAMRSA”CAMRSA”

Community Acquired Multiple Resistant Community Acquired Multiple Resistant

Staphlococcus aureusStaphlococcus aureus


The ProblemThe Problem

1. Antibiotic resistant infection is a significant 1. Antibiotic resistant infection is a significant and growing cause of morbidity and mortality;and growing cause of morbidity and mortality;

2. The medical profession is increasingly 2. The medical profession is increasingly concerned;concerned;

3. Vancomycin resistance has occurred: no new 3. Vancomycin resistance has occurred: no new antibiotics are available.antibiotics are available.

Standard Medical AssumptionsStandard Medical Assumptions“Diagnosis and Treatment of Disease”

1. Diseases exist as discrete entities

2. Disease entities can be identified (diagnosis)

3. Disease entities can be eliminated through treatment

4. Evidence-based application of drugs or surgery constitutes appropriate and effective treatment

Standard Medical AssumptionsStandard Medical Assumptionsabout infectionabout infection

1. Infection is caused by pathogens1. Infection is caused by pathogens (bacteria, virus, parasite)(bacteria, virus, parasite)2. Pathogens overwhelm the immune system2. Pathogens overwhelm the immune system

a. excessive virulencea. excessive virulenceb. weakened immunity/host resistanceb. weakened immunity/host resistance

3. Antibiotics will reduce the pathogenic presence:3. Antibiotics will reduce the pathogenic presence:eliminating the infection, oreliminating the infection, or until the immune system can take over.until the immune system can take over.

4. Antibiotics are the only effective treatment for 4. Antibiotics are the only effective treatment for infectioninfection

A Naturopathic PerspectiveA Naturopathic Perspective“The Restoration of Health”

1. The universe is ordered, intelligent, wise, and benign

2. Health is the constant and natural state of being

3. Ill health is an adaptive response to disturbance in the organism

4. Removal of disturbing factors will result in the potential return of normal health

5. Intervention should involve the least force necessary to stimulate the self-healing mechanisms

Disease as ProcessDisease as Process

Normal Health

Disturbing DischargeFactors Process

Disturbance of Function

Reaction(fever, inflammation, etc.)

Chronic Reaction

Degeneration

Standard Medical Approach:Standard Medical Approach:directed against the reactiondirected against the reaction

Normal Health

Pathogens Discharge Process


Reaction*(fever, inflammation, etc.)

Chronic Reaction

Degeneration

Classical Naturopathic Approach:Classical Naturopathic Approach:reduce the disturbing factors, stimulate the reduce the disturbing factors, stimulate the visvis

Normal Health

Disturbing DischargeFactors Process


Reaction(fever, inflammation, etc.)

Chronic Reaction

Degeneration

General Medical ConceptGeneral Medical ConceptInfection is an interplay of several forcesInfection is an interplay of several forces

Virulence of pathogenVirulence of pathogen

Susceptibility factorsSusceptibility factors

Host resistance factorsHost resistance factors

Immune competenceImmune competence

Standard Medical ApproachStandard Medical Approach

(reduce) Virulence of pathogen(reduce) Virulence of pathogen

Susceptibility factorsSusceptibility factors

Host resistance factorsHost resistance factors

Immune competenceImmune competence

Naturopathic ModelNaturopathic Model


(reduce) Susceptibility factors(reduce) Susceptibility factors

(strengthen) Host resistance factors(strengthen) Host resistance factors

(strengthen) Immune competence(strengthen) Immune competence

Reducing susceptibility factorsReducing susceptibility factorsDeterminants of healthDeterminants of health

What disturbs health?What disturbs health?

1. Spiritual life1. Spiritual lifeself-assessment/relationship to the larger universeself-assessment/relationship to the larger universe

basic sense of safety, etcbasic sense of safety, etc

2. Diet and digestion - toxemia2. Diet and digestion - toxemia3. Emotional stresses and traumas3. Emotional stresses and traumas4. Rest and exercise patterns4. Rest and exercise patterns

Reducing susceptibility factorsReducing susceptibility factors

6. Physical Stresses, Traumas, and Exposures7. Physical Strengths and Weaknesses8 Illnesses, Illness Sequelae, and Addictions9. Medical Interventions:

surgeriessuppressionsdrug effects



(reduce) Susceptibility factors(reduce) Susceptibility factors

(strengthen) Host resistance factors(strengthen) Host resistance factors

(strengthen) Immune competence(strengthen) Immune competence

Clinical ModelsClinical Models

Standard Medical ModelStandard Medical Model

1. Diagnose infection1. Diagnose infection2. Identify pathogen (culture)2. Identify pathogen (culture)3. Apply appropriate antibiotic3. Apply appropriate antibiotic(4. Support vital functions)(4. Support vital functions)

i.e.: Attack pathogen (antibiotics)i.e.: Attack pathogen (antibiotics)

With antibiotic failure: no viable treatment!With antibiotic failure: no viable treatment!

Clinical Models Clinical Models


1. Reduce causes (disturbing factors)1. Reduce causes (disturbing factors) 2. Create a healthy regimen2. Create a healthy regimen 3. Stimulate self-healing mechanisms3. Stimulate self-healing mechanisms 4. Support affected systems4. Support affected systems 5. Correct structure5. Correct structure

i.e.: reduce susceptibility factors, strengthen host i.e.: reduce susceptibility factors, strengthen host resistance, and strengthen immune competenceresistance, and strengthen immune competence

A case of OsteomyelitisA case of Osteomyelitis

Female, Age 40Female, Age 40

May 11, 1999: Mandibular advancement surgeryMay 11, 1999: Mandibular advancement surgeryjaw surgically cut and held by plate.jaw surgically cut and held by plate.

September 1: plate removed; appeared healedSeptember 1: plate removed; appeared healed2 weeks later: xray shows infection/non-union 2 weeks later: xray shows infection/non-union

mouth wired shut, antibioticsmouth wired shut, antibioticsOctober: systemic infection: IV antibiotics in hospitalOctober: systemic infection: IV antibiotics in hospitalNovember: oral antibiotics, pain medicationsNovember: oral antibiotics, pain medications


January 4, 2000: chief complaintsJanuary 4, 2000: chief complaints

1. Antibiotic-resistant osteomyelitis1. Antibiotic-resistant osteomyelitis

2. Constant pain2. Constant pain

3. Anxiety regarding healing3. Anxiety regarding healing

4. Anxiety regarding weight loss4. Anxiety regarding weight loss

5. Non-union of bone5. Non-union of bone


Some significant aspects of historySome significant aspects of history

Many teeth problemsMany teeth problems

Difficulty with stomach and digestionDifficulty with stomach and digestion

Neck and back tensionNeck and back tension

hands go numbhands go numb

Excessive fatigueExcessive fatigue

Gonorrhea age 22, tx with antibiotics (suppression)Gonorrhea age 22, tx with antibiotics (suppression)


Current Diet:Current Diet:

liquid only: wired jaw: 8 monthsliquid only: wired jaw: 8 months

blended soup, “boost” (caloric blended soup, “boost” (caloric drink),drink),

fruit juice, fruit smoothiesfruit juice, fruit smoothies

weight: 116, began at 141.weight: 116, began at 141.


Psycho/spiritual factorsPsycho/spiritual factors

Sister died of measles encephalitis when patient Sister died of measles encephalitis when patient was 8 was 8

Father died of MI when patient was 13Father died of MI when patient was 13


Pulse: Pulse:

digestive stress, acute disturbance, deficiencydigestive stress, acute disturbance, deficiency

BP: 110/70BP: 110/70

Sugar: 67Sugar: 67

Stomach reflex: 3+Stomach reflex: 3+

Arroyo: 2+ (adrenal fatigue)Arroyo: 2+ (adrenal fatigue)


Assessment:Assessment:1. Severe digestive dysfunction1. Severe digestive dysfunction

2. Adrenal fatigue2. Adrenal fatigue

3. Osteomyelitis with non-union3. Osteomyelitis with non-union

4. Significant childhood traumas4. Significant childhood traumas

5. Suppressed gonorrhea5. Suppressed gonorrhea

6. Acute pain and anxiety6. Acute pain and anxiety


Acute TreatmentAcute Treatment

Address pain and anxiety:Address pain and anxiety:

1. Arnica 10M: single dose1. Arnica 10M: single dose

2. Acupuncture: St 4,6, LI4, CV12, Liv 3, Gb 412. Acupuncture: St 4,6, LI4, CV12, Liv 3, Gb 41

(note: patient reports immediate reduction in pain, more (note: patient reports immediate reduction in pain, more calm and relaxed)calm and relaxed)

A Case of OsteomyelitisA Case of OsteomyelitisTreatment RegimenTreatment Regimen

1. Dietary change to reduce maldigestive toxemia: 1. Dietary change to reduce maldigestive toxemia: ““FIT” (Carroll method): Fruit IntoleranceFIT” (Carroll method): Fruit Intolerance

2. Daily Constitutional Hydrotherapy2. Daily Constitutional Hydrotherapy3. Medorrhinum 200c: one dose3. Medorrhinum 200c: one dose4. Gentiana/Scutellaria: gtt 15 tincture cc4. Gentiana/Scutellaria: gtt 15 tincture cc5. “Reishi Bupleurum”: (Gaia) gtt 40, tid5. “Reishi Bupleurum”: (Gaia) gtt 40, tid6. Avena/Glycerrhiza: tincture gtt 40 tid6. Avena/Glycerrhiza: tincture gtt 40 tid7. Calc. Phos. 3x: #5, tid7. Calc. Phos. 3x: #5, tid8. Daily exercise8. Daily exercise

(note: patient leaves office feeling better: reduced pain, more relaxed, sense of hope.)(note: patient leaves office feeling better: reduced pain, more relaxed, sense of hope.)

A Case of OsteomyelitisA Case of Osteomyelitis

January 9: (Day 5)January 9: (Day 5) “ “doing much better, reduced swelling and pain.” doing much better, reduced swelling and pain.”

reduced pain medsreduced pain medscontinue regimen continue regimen add acupuncture treatment:add acupuncture treatment:

Liv 3, GB 41, St 36, 30, 25, 6, 4, Lu 2, LI 4, CV 12 Liv 3, GB 41, St 36, 30, 25, 6, 4, Lu 2, LI 4, CV 12

January 11: (day 7)January 11: (day 7)““doing better: no more pain meds needed”doing better: no more pain meds needed”

continue regimencontinue regimenacupuncture as aboveacupuncture as above


January 16: (Day 12)January 16: (Day 12)significant pain reductionsignificant pain reductionsignificant reduction in swellingsignificant reduction in swellingsignificant increase in jaw openingsignificant increase in jaw opening

d/c immune tonicd/c immune tonicd/c avena/glycerrhizad/c avena/glycerrhizaacupuncture: acupuncture: Lv 3, CV 12, LI 4 Lv 3, CV 12, LI 4

St 36, 30, 25, 6St 36, 30, 25, 6


January 23: (Day 19)January 23: (Day 19)much bettermuch betteracupuncture as aboveacupuncture as above

January 30: (Day 26)January 30: (Day 26)antibiotics cut in half by MDantibiotics cut in half by MDjaw opens more, feels betterjaw opens more, feels betterenergy level significantly better: 75%energy level significantly better: 75%

February: vacation to VeniceFebruary: vacation to Venice


March 3: (2 months) March 3: (2 months) doing well physically; jaw has knit (!)doing well physically; jaw has knit (!)

March 23: March 23: doing quite welldoing quite well*reports a bit of jaw pain and swelling after *reports a bit of jaw pain and swelling after

dietary violation (ate some fruit)dietary violation (ate some fruit)

May 3: doing well; reports jaw mal-alignmentMay 3: doing well; reports jaw mal-alignmentmouth opens to 27 mm (needs 28 to remove wires)mouth opens to 27 mm (needs 28 to remove wires)needs neck manipulation: performedneeds neck manipulation: performed


May 10: May 10: continuing improvement: continuing improvement: date set to remove wiringdate set to remove wiringrepeat manipulationrepeat manipulation

May 24: May 24: feeling goodfeeling good

June 19: June 19: MD reports well healed; MD reports well healed; feeling generally better than before surgeryfeeling generally better than before surgery

Principles of TreatmentPrinciples of Treatment(A Therapeutic Hierarchy)(A Therapeutic Hierarchy)

1. Address acute symptoms1. Address acute symptoms2. Reduce disturbing factors2. Reduce disturbing factors3. Create a healthy regimen3. Create a healthy regimen4. Stimulate self-healing mechanisms4. Stimulate self-healing mechanisms5. Support affected systems5. Support affected systems6. Correct structure6. Correct structure7. Treat pathology7. Treat pathology8. Suppress pathology8. Suppress pathology


Mechanisms of TreatmentMechanisms of Treatment

1. Address acute symptoms: do not suppress!1. Address acute symptoms: do not suppress!

a. Relieve paina. Relieve pain

hydrotherapy, homeopathy, acupuncture,hydrotherapy, homeopathy, acupuncture,

manipulationmanipulation

b. Relieve anxietyb. Relieve anxiety

homeopathy, botanicals, confidence of doctorhomeopathy, botanicals, confidence of doctor



2. Reduce causes2. Reduce causesa. toxemia: a. toxemia:

dietary changes: no fruitdietary changes: no fruitdigestiondigestion

hydrotherapyhydrotherapybotanical stomach tonicbotanical stomach tonic

b. “suppression”: medorrhinum 200c single b. “suppression”: medorrhinum 200c single dose dose



3. Create a healthy regimen3. Create a healthy regimena. appropriate dietary changesa. appropriate dietary changesb. appropriate rest and exercise b. appropriate rest and exercise c. stress reductionc. stress reductiond. spiritual exercised. spiritual exercisee. “air, water, sunshine”e. “air, water, sunshine”



4. Stimulate self-healing mechanisms4. Stimulate self-healing mechanisms

a. constitutional hydrotherapya. constitutional hydrotherapy

daily treatmentdaily treatment

b. homeopathy – as indicatedb. homeopathy – as indicated

c. acupuncture – once or twice a weekc. acupuncture – once or twice a week



5. Support affected systems5. Support affected systemsa. digestion: hydrotherapy, stomach tonica. digestion: hydrotherapy, stomach tonicb. immune system: hydrotherapy, immune b. immune system: hydrotherapy, immune

tonictonicc. nervous system: nerve tonic, homeopathicsc. nervous system: nerve tonic, homeopathicsd. adrenal system: adrenal tonicd. adrenal system: adrenal tonice. bone system: calc phos. 3xe. bone system: calc phos. 3x



6. Correct structural integrity6. Correct structural integrity

manipulationmanipulation

non-force: ease neck stiffness non-force: ease neck stiffness

force - wait until bone healing can force - wait until bone healing can support thissupport this



7. Treat pathology7. Treat pathology

often not necessaryoften not necessary

8. Suppress pathology:8. Suppress pathology:

done for eight month with no effect.done for eight month with no effect.


SummarySummary

1. Address acute complaints: (pain and fear)1. Address acute complaints: (pain and fear)immediate reliefimmediate reliefpromise of continued improvement (hope)promise of continued improvement (hope)

2. Gradual and obvious improvement noted from first 2. Gradual and obvious improvement noted from first intervention (infection, non-union)intervention (infection, non-union)

3. Case resolved:3. Case resolved:75% improvement within four weeks75% improvement within four weeks total resolution within five monthstotal resolution within five monthspatient health fundamentally improvedpatient health fundamentally improved

General PrinciplesGeneral Principles

II. Stimulate and support immune function

Stimulate and Support Immune Function

1. Hydrotherapy1. Hydrotherapy

a. constitutional hydrotherapya. constitutional hydrotherapy

b. specific hydrotherapy to affected partsb. specific hydrotherapy to affected parts

c. sine current to affected partsc. sine current to affected parts


2. Homeopathya. etiologic remedy

miasm, suppression, injury,emotional trauma, etc.

b. constitutional remedyc. systemic remedies (drainage)d. specific or acute remedies


3. Botanicals

a. botanicals to support or repair damaged

or weakened systems

b. botanicals to stimulate immune function

c. botanicals with antibiotic properties*c. botanicals with antibiotic properties*


4. Acupuncture

5. Specific nutrients to support immune function

6. UV light and other specific therapies

7. Prayer and spiritual medicine

Botanical SupportBotanical Support

1. Antibiotic activity1. Antibiotic activityAnti-bacterialAnti-bacterialAnti-viralAnti-viralAnti-parasiticAnti-parasitic

2. Immune tonic activity2. Immune tonic activity

Antibiotic ResistanceAntibiotic Resistancemost common antibiotic resistant bacteriamost common antibiotic resistant bacteria

EnterococcusEnterococcus septicemia, surgical,septicemia, surgical,UTIUTI

Haemophilus infl.Haemophilus infl. meningitis, otitis,meningitis, otitis,pneumonia, etc.pneumonia, etc.

Myco. tub.Myco. tub. TuberculosisTuberculosis

Neisseria gonorrheaNeisseria gonorrhea gonorrheagonorrhea


Streptococcus pneu.Streptococcus pneu. Meningitis, pneumonia,Meningitis, pneumonia,

otitisotitis

Klebsiella pneu.Klebsiella pneu. Septicemia,pneumonia,Septicemia,pneumonia,

UTI, post-surg. InfectionUTI, post-surg. Infection

E. coli.E. coli. Severe diarrheaSevere diarrhea

SalmonellaSalmonella severe diarrheasevere diarrhea


Plasmodium spp.Plasmodium spp. malariamalaria

Pseudomonas aer.Pseudomonas aer. septicemia, UTI, septicemia, UTI, pneumoniapneumonia

Shigella dysen.Shigella dysen. diarrheadiarrhea

Staph. aur.Staph. aur. septicemia,pneumonia,septicemia,pneumonia,post-surgical infectionpost-surgical infection

Botanical SupportBotanical Support Antibiotic Activity Antibiotic Activity

Anti-Staphylococcus aureusAnti-Staphylococcus aureus

Allium sat.Allium sat.Anthemis nob.Anthemis nob.Arctium lappaArctium lappaArctostaphylosArctostaphylosAstragalus memb.Astragalus memb.



Eucalyptus glob.Eucalyptus glob.Eupatorium perf.Eupatorium perf.HoneyHoneyHydrastis can.Hydrastis can.Hypericum perf.Hypericum perf.Hyssopus off.Hyssopus off.

..



LomatiumLomatium

PeoniaPeonia

PlantaigoPlantaigo

Salvia off.Salvia off.

Trifolium prae.Trifolium prae.

Usnea barbUsnea barb


Anti-StreptococcusAnti-Streptococcus

Allium sat.Allium sat.

HoneyHoney

HydrastisHydrastis

PlantaigoPlantaigo

LomatiumLomatium

Salvia spp.Salvia spp.


Anti-PseudomonasAnti-Pseudomonas


HydrastisHydrastis

LomatiumLomatium

SalviaSalvia

UsneaUsnea


Anti E.coliAnti E.coli


Eupatorium perf.Eupatorium perf.

HydrastisHydrastis

HypericumHypericum

LomatiumLomatium


Anti-E. coliAnti-E. coli

PeoniaPeonia

UsneaUsnea

Uva UrsiUva Ursi


Anti Myco. TuberculosisAnti Myco. Tuberculosis


Usnea barb.Usnea barb.


Hydrastis can.Hydrastis can.

Staph. aureus Strep. spp.Staph. aureus Strep. spp.

Pseudomonas SyphilisPseudomonas Syphilis

Gonorrhea Vibrio choleraGonorrhea Vibrio cholera

Botanical SupportBotanical Support Anti-viral Activity Anti-viral Activity

Allium sativaAllium sativaGlycerrhizaGlycerrhizaHypericumHypericumHyssopusHyssopus

Tabebuia impet.Tabebuia impet.(“Taheebo”, “Pau’Darco”)(“Taheebo”, “Pau’Darco”)

Melissa offMelissa offCamellia sinensisCamellia sinensis

Lentinus, GanodermaLentinus, Ganoderma(“Shitake”, “Reishi”)(“Shitake”, “Reishi”)

Botanical SupportBotanical Support Anti-parasitic Activity Anti-parasitic Activity

Artemesia annuaArtemesia annua

Cinchona off.Cinchona off.

Gentiana luteaGentiana lutea

Inula helen.Inula helen.

Spigelia anth.Spigelia anth.

(etc.)(etc.)

Botanical ReferencesBotanical References

1. 1. Plant Medicine in PracticePlant Medicine in Practice, Mitchell, Wm. A.,ND, , Mitchell, Wm. A.,ND, Churchill Livingstone, 2003Churchill Livingstone, 2003

2. 2. Herbal Medicine From the Heart of the EarthHerbal Medicine From the Heart of the Earth,, Tilgner, Sharol, ND, Wise Acres Press, Inc., 1999Tilgner, Sharol, ND, Wise Acres Press, Inc., 1999

3. 3. The Book of Herbal WisdomThe Book of Herbal Wisdom, Wood, Matthew, , Wood, Matthew, Matthew, North Atlantic Books, 1997Matthew, North Atlantic Books, 1997

4. 4. Herbal AntibioticsHerbal Antibiotics, Buhner, Stephen Harrod, Storey , Buhner, Stephen Harrod, Storey Publications, Vt. 1998Publications, Vt. 1998

Botanical SupportBotanical Support Immune tonification Immune tonification

Echinacea: large doses work best; Bastyr used 10-30 Echinacea: large doses work best; Bastyr used 10-30 drop dosesdrop doses

Baptesia: 1-5 drops dosesBaptesia: 1-5 drops dosesPhytolacca: 1 – 10 drop dosesPhytolacca: 1 – 10 drop dosesLomatium: 1/10 – 2 drops dosesLomatium: 1/10 – 2 drops dosesLigusticum: 5 – 20 drop dosesLigusticum: 5 – 20 drop dosesAstragalus: 5 – 30 drops dosesAstragalus: 5 – 30 drops dosesEtc.Etc.

A Case of Chronic ProstatitisA Case of Chronic Prostatitis

Male, age 48Male, age 48

Prostatitis began 1992Prostatitis began 1992

7 episodes of kidney stones7 episodes of kidney stones

88thth “episode”: pain is different “episode”: pain is different

dx: acute prostatitisdx: acute prostatitis

put on antibiotic regimen: no changeput on antibiotic regimen: no change

put on anti-inflammatoriesput on anti-inflammatories


6 months later: no change6 months later: no change

put on new antibioticsput on new antibiotics

5 subsequent antibiotic regimens: no change.5 subsequent antibiotic regimens: no change.

constant pain, intermittent spasmsconstant pain, intermittent spasms

better: Imiprimine (symptomatic)better: Imiprimine (symptomatic)

fatigue and depression due to painfatigue and depression due to pain

needs to nap dailyneeds to nap daily


Chlamydia: ’96: tx with antibioticsChlamydia: ’96: tx with antibioticsGonorrhea age 22, tx with antibioticsGonorrhea age 22, tx with antibioticsarthritis in back, anklesarthritis in back, anklesmedicated for hypertensionmedicated for hypertension

BP: 90/60BP: 90/60Stomach reflex: 3+Stomach reflex: 3+Pulse: weak, smallPulse: weak, small


Acute TreatmentAcute Treatment

1. Thuja 30 c: single dose1. Thuja 30 c: single dose

2. Acupuncture: Liv 3, Ki 3, St 30, Li 4, CV 1.2. Acupuncture: Liv 3, Ki 3, St 30, Li 4, CV 1.

(note: patient leaves office without pain.)(note: patient leaves office without pain.)


TreatmentTreatment

1. discontinue anti-hypertensives1. discontinue anti-hypertensives2. remove dietary intolerances (potato)2. remove dietary intolerances (potato)3. daily constitutional hydrotherapy3. daily constitutional hydrotherapy4. Medorrhinum 1M: single dose (note: instant relief 4. Medorrhinum 1M: single dose (note: instant relief

of neck and back tension, headache pain; eases of neck and back tension, headache pain; eases pelvic tension)pelvic tension)


TreatmentTreatment

5. stomach tonic: Gentiana/Scutellaria5. stomach tonic: Gentiana/Scutellaria

6. adrenal support: 6. adrenal support: Glycerrhiza/EluthrococcusGlycerrhiza/Eluthrococcus7. Immune tonic/antibiotic formula:7. Immune tonic/antibiotic formula:

Hydrastis, Phytolacca, Baptesia, Urtica, Hydrastis, Phytolacca, Baptesia, Urtica, Taraxicum: A:, gtt. 60, t.i.d.Taraxicum: A:, gtt. 60, t.i.d.

8. Thuja 30c: prn for prostate pain.8. Thuja 30c: prn for prostate pain.


Treatment ResultsTreatment Results

1. pain of prostate intermittent, low level, gradually 1. pain of prostate intermittent, low level, gradually decreases: improves with thuja 30cdecreases: improves with thuja 30c

2. energy gradually returns over four months,2. energy gradually returns over four months, no more fatigueno more fatigue

A Case of Nosocomial Staph InfectionA Case of Nosocomial Staph Infection

Female, 81Female, 81

Hospitalized for surgery, Hospitalized for surgery, contracts Staph infection, contracts Staph infection, on antibiotics for 8 weeks without on antibiotics for 8 weeks without improvement,improvement,developing CHF symptomsdeveloping CHF symptoms


TreatmentTreatment

1. daily constitutional hydrotherapy1. daily constitutional hydrotherapy

2. diet of soup2. diet of soup

3. colonic hydrotherapy3. colonic hydrotherapy

4. Hydrastis tincture4. Hydrastis tincture


Treatment resultsTreatment results

Mother urinates (!)Mother urinates (!)

Mother improves daily.Mother improves daily.

CHF symptoms recede.CHF symptoms recede.

Infection is cleared in three weeks.Infection is cleared in three weeks.

Mother currently working in garden.Mother currently working in garden.

A Case of LymphedemaA Case of Lymphedemawith infectionwith infection

Female, age 49Female, age 49

Presents with very swollen, Presents with very swollen,

painful legs, red feet, painful legs, red feet,

inflammation beginning to spread up legs.inflammation beginning to spread up legs.


Patient has multiple pathologies, Patient has multiple pathologies,

multiple surgeries to legs and feet as childmultiple surgeries to legs and feet as child

She is very afraid. She is very afraid.

Oral antibiotics have not worked.Oral antibiotics have not worked.

Multiple pain drugs including methadoneMultiple pain drugs including methadone

One med causing kidney inflammationOne med causing kidney inflammation


TreatmentTreatment

1. Homeopathic Staphisagria 1M: significant child abuse1. Homeopathic Staphisagria 1M: significant child abuse2. Constitutional hydrotherapy with sine to feet.2. Constitutional hydrotherapy with sine to feet.3. Acupuncture to legs and feet3. Acupuncture to legs and feet4. Homeopathic Belladonna and Phytolacca4. Homeopathic Belladonna and Phytolacca5. Botanical immune tonic 5. Botanical immune tonic 6. Botanical lymphagogues and diuretics6. Botanical lymphagogues and diuretics7. Diet based upon “FIT” (no milk products)7. Diet based upon “FIT” (no milk products)8. Discontinue offending medication8. Discontinue offending medication9. Stomach, kidney, and adrenal support: botanical9. Stomach, kidney, and adrenal support: botanical


Effects of TreatmentEffects of Treatment

1. Immediate pain relief: walks without pain1. Immediate pain relief: walks without pain

2. Feels significantly less anxiety2. Feels significantly less anxiety


Effects of TreatmentEffects of Treatment

1. Rapid reduction of redness over two weeks1. Rapid reduction of redness over two weeks

2. Gradual reduction of swelling over one month2. Gradual reduction of swelling over one month

3. Significant reduction of pain medications over 3. Significant reduction of pain medications over one monthone month

4. Total resolution of edema and leg pain after 4. Total resolution of edema and leg pain after two monthstwo months

Treatment of InfectionTreatment of Infection

Principles of TreatmentPrinciples of Treatment1. assess whole patient1. assess whole patient

a) spirituala) spiritualb) psycho-emotionalb) psycho-emotionalc) physicalc) physical

current - all systemscurrent - all systemshistorical – illnesses, historical – illnesses,

suppressions, interventionssuppressions, interventions


““Therapeutic Hierarchy”Therapeutic Hierarchy”a. identify and remove causes, with special a. identify and remove causes, with special attention attention to toxemia, determinants of healthto toxemia, determinants of healthb. create a healthy regimenb. create a healthy regimenc. stimulate the self healing mechanismsc. stimulate the self healing mechanismsd. support weakened/damaged systemsd. support weakened/damaged systemse. correct structural integritye. correct structural integrityf. address pathology if necessarayf. address pathology if necessarayg. suppress pathology to preserve life or functiong. suppress pathology to preserve life or function


Principles appliedPrinciples applied

90 minute first visit:90 minute first visit:

A. chief complaint detailsA. chief complaint detailslet the patient tell their storylet the patient tell their storyget as much detail as you can get as much detail as you can

B. dietary historyB. dietary history

1. daily dietary details1. daily dietary details

2. presence of common intolerant foods2. presence of common intolerant foods

3. reactions to foods3. reactions to foods

4. cravings and aversions4. cravings and aversions

Dietary historyDietary history

1. Adequacy: calories, nutrients1. Adequacy: calories, nutrients

2. Balance: excesses2. Balance: excesses

3. Reactivity:3. Reactivity:

Intolerance vs. allergy vs. sensitivityIntolerance vs. allergy vs. sensitivity

4. Supplementary needs4. Supplementary needs

C. Review of systemsC. Review of systems

1. Patient has filled out a comprehensive form 1. Patient has filled out a comprehensive form

2. I inquire regarding all marked areas2. I inquire regarding all marked areas

3. I ask whether I’ve missed anything 3. I ask whether I’ve missed anything

Past medical historyPast medical history

1. 1. InfancyInfancy

1-5, 5-10, 10-15, etc.1-5, 5-10, 10-15, etc.

2. 2. Suppressions, significant events, Suppressions, significant events, illnesses, illnesses, injuries, medications, surgeriesinjuries, medications, surgeries

Social historySocial history

1. How’s life?1. How’s life?

2. Relationships2. Relationships

3. Childhood3. Childhood

4. Work and exposures4. Work and exposures

5. Spiritual life5. Spiritual life


Physical examinationPhysical examination

1. standard exam1. standard exam2. functional exam2. functional exam

pulsepulse, tongue, reflexes, etc., tongue, reflexes, etc.

Goal: Goal: a. assessment of functiona. assessment of functionb. discovery or verification of pathologyb. discovery or verification of pathology

ToxemiaToxemia

Fundamental Concept:Fundamental Concept:

maldigestive processes foster a dysbiotic maldigestive processes foster a dysbiotic intestinal population which generate toxic intestinal population which generate toxic products through inappropriate degradation of products through inappropriate degradation of poorly digested foods. These toxins enter the poorly digested foods. These toxins enter the blood and become the basis for chronic blood and become the basis for chronic inflammatory processes, autoimmune processes, inflammatory processes, autoimmune processes, etc. This process promotes infection.etc. This process promotes infection.

ToxemiaToxemia

For example: as early as 1879, Baumann For example: as early as 1879, Baumann demonstrated that Tyrosine is metabolized by demonstrated that Tyrosine is metabolized by gut bacterial to generate phenols and p-cresol. gut bacterial to generate phenols and p-cresol. (Baumann, E. (1879). (Baumann, E. (1879). Ber. Dtsch. Chem. Ges.Ber. Dtsch. Chem. Ges. 1212, 1450.), 1450.)

Phenols and p-cresol are implicated in Phenols and p-cresol are implicated in tumor formation in mice. Certain phenols are tumor formation in mice. Certain phenols are demonstrated convulsant agents in humans.demonstrated convulsant agents in humans.

ToxemiaToxemia

1924, Harke and Koessler demonstrated the generation 1924, Harke and Koessler demonstrated the generation of histamine by gut bacterial action on dietary amino of histamine by gut bacterial action on dietary amino acids. (Urbach, K.F. (1949). acids. (Urbach, K.F. (1949). Proc. Soc. Exp. Biol.Proc. Soc. Exp. Biol. (NY), (NY), 7070, 146.), 146.)

Perry demonstrated the generation of the body burden Perry demonstrated the generation of the body burden of tyramine is entirely by gut flora. (Perry, T. L., et. of tyramine is entirely by gut flora. (Perry, T. L., et. al. (1966). al. (1966). Clin Chem. ActaClin Chem. Acta 1414, 116., 116.

Both histamine and tyramine are implicated in Both histamine and tyramine are implicated in hypertension, suggesting that essential hypertension hypertension, suggesting that essential hypertension may be the result of “toxemia”.may be the result of “toxemia”.

SuppressionSuppression

Spiritual Aspect of Treating InfectionSpiritual Aspect of Treating Infection

1. “Tell me about your spiritual life”.1. “Tell me about your spiritual life”.

2. Discuss the patient’s fears and concerns.2. Discuss the patient’s fears and concerns.

3. Discuss patients beliefs about healing3. Discuss patients beliefs about healing

ReviewReview

I. Treat the person, not the infection

1. evaluate/improve the general state of health2. evaluate/improve the diet and digestion, with

special attention to intestinal toxemia:a. recommend appropriate dietary changesb. improve digestive functionc. facilitate toxin elimination

3. evaluate and treat to normalize all major systems and functions

4. Stimulate and support immune function5. evaluate the psycho-spiritual patient: treat as

indicated

““How to treat infection How to treat infection without antibiotics”without antibiotics”

Thank you!Thank you!

Jared L. Zeff, NDJared L. Zeff, [email protected]@AOL.com

360-823-8121360-823-8121

The Treatment of Infection Without Antibiotics AANP Annual Conference August 2003 Jared L. Zeff, ND.

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