The T-Cell ReceptorMHC Restriction

TCR Structure & Function

Genetic Generation of TCR Diversity

Thymus T-cell "Education" and Immunological Tolerance

Folder title: Receptor

November 15, 2006 TCRTitle

Comparison of T-Cell Receptors (TCR)and Antibodies: Differences

TCR

Remains Membrane-bound.

Present in small amounts.

Recognizes binary complex:

Antigen and MHC Protein

Associated with CD3, CD4, & CD8 AccessoryMolecules

Is MHC Restricted

Antibody

Can be membrane bound;

Secreted in large amounts.

Recognizes Antigen alone:

Soluble or particulate

No accessory molecules

involved

Not MHC Restricted

TCRvsAb1

Comparison of T-Cell Receptors (TCR)and Antibodies: Similarities

TCR and Ab

Rearrange V, J, and (Sometimes) D Germ-line Genes, link these, and join them to C-region Gen

es, during somatic cell differentiation.

(V, J, D and C region germ-line genes are different for TCR vs Ab)

Have Complementarity Determining Regions (CDR's) that are hypervariable

Recognize an enormous variety of antigenic determinants

TCRvsAb2

See Figure 8-15,

Kuby, 6th Edition

p. 207

Self-MHC Restriction of TCRKuby, 6th Edition, Fig 9-1, p. 224

MHCRestr

Figure 10-5. Top. Kuby, 6th Edition, p. 249

Figure 10-5. Bottom. Kuby, 6th Edition, p. 249

See Figure 9-3, Right Side, Kuby, 6th Edition, p. 226

costimu

(costimulates)

(inhibits)

Generation of Alpha and Beta Subunits of TCR from Germ-line DNAFigure 11-6, Kuby 3rd Edition

See Table 9-3, Kuby, 6th Edition, p. 229

Allo-Reactivity of T-Cells: orWhy Do T-cells Frustrate Transplant Surgeons?

AlloKill

Figure 11-1

Kuby, 3rd Edition