The (short) story of brucellosis in western Kenya
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Transcript of The (short) story of brucellosis in western Kenya
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The (short) story of brucellosis in western Kenya
Will de Glanvillewww.zoonotic-diseases.org
Centre for Immunity, Infection and Evolution, University of EdinburghandInternational Livestock Research Institute, Nairobi
Workshop: An Integrated Approach to Controlling Brucellosis in Africa, Addis Ababa, 29-31 January 2013
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A lateral flow assay was used as primary screening test for brucellosis in sympatric animals and people.
- Rapid and simple
- Good performance
- Animal and human tests
- A bit expensive
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2116 people in 416 homesteads
LFA : 0.71% (95% C.I. 0.38 – 1.17)
RBT : 0.06% (95% C.I. 0.0014 – 0.32)
No relationship between animal and human sero-status at the household level
We found:
893 cattle in 230 homesteads
LFA : 0.31% (95% C.I. 0.06 – 0.89)
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Further surveillance based on central point sampling
Seroprevalence based on RBT < 0.5%
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But, brucellosis apparently a common diagnosis in district and sub-district hospitals in study area....
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So, we went to investigate.
Rose Bengal
Brucella Agglutination Test
Lateral Flow Assay
+ve
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A population of 827 brucellosis suspects
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A population of 827 brucellosis suspects
BAT: 19.7%
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A population of 827 brucellosis suspects
RBT: 0.6%
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5% of reactive BAT confirmed on LFA
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So, brucellosis appears to be rare and over-diagnosed using current diagnostic approaches in western Kenya.
Limits use of people as ‘sentinels’ for zoonotic disease in animals.
.....‘one-health’