The separation of pharmacy and medicine in Europe Edict of Salerno, 1241 Edict of Salerno, 1241...
-
Upload
alexina-berry -
Category
Documents
-
view
478 -
download
5
Transcript of The separation of pharmacy and medicine in Europe Edict of Salerno, 1241 Edict of Salerno, 1241...
The separation of pharmacy and medicine in EuropeThe separation of pharmacy and medicine in Europe Edict of Salerno, 1241Edict of Salerno, 1241
Frederick II (1194-1250)Frederick II (1194-1250)Holy Roman EmperorHoly Roman EmperorKing of Sicily, Germany, and King of Sicily, Germany, and JerusalemJerusalem
Frederick II issued a number of rules aimed at Frederick II issued a number of rules aimed at protecting the patient such asprotecting the patient such as
Supervision of both professions bySupervision of both professions by governmental agenciesgovernmental agencies
Fixed pices (tariff) for drugs, preparationsFixed pices (tariff) for drugs, preparations and servicesand services
Prohibition of shared practice settings for Prohibition of shared practice settings for physicians and pharmacistsphysicians and pharmacists
Dept. of Experimental and Clinical Pharmacology (Tim Tracy)
Dept. of Pharmaceutics (Ron Siegel)
Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth
(Randy Seifert)
Dept. of Pharmaceutical Care & Health Systems (Steve Schondelmeyer)
MedicineMedicine
Public Health Public Health
PharmacyPharmacy
DentistryDentistry
NursingNursing
Vet. MedicineVet. Medicine
(2009)
Students in the Pharm.D. programStudents in the Pharm.D. program648 professional students648 professional students1.100 applicants competed for 167 spots1.100 applicants competed for 167 spots
Graduate studentsGraduate students104 students in 4 graduate programs104 students in 4 graduate programsFew, if any, Pharm.D.s enroll in grad. Few, if any, Pharm.D.s enroll in grad. programs!programs!
College of Pharmacy (CoP) student numbersCollege of Pharmacy (CoP) student numbers
FacultyFaculty97 voting faculty97 voting faculty
Research fundingResearch fundingFederal Federal $6,647,293$6,647,293State State $2,385,739 $2,385,739Other $3,144,520Other $3,144,520
Development Development $3,449,113$3,449,113(UMF year-end gift activity report for FY ’08)(UMF year-end gift activity report for FY ’08)
College of Pharmacy (CoP) numbers: College of Pharmacy (CoP) numbers: faculty and financesfaculty and finances
Dept. of Experimental and Clinical Pharmacology (Tim Tracy)
Dept. of Pharmaceutics (Ron Siegel)
Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth
(Randy Seifert)
Dept. of Pharmaceutical Care & Health Systems (Steve Schondelmeyer)
MedicineMedicine
Public Health Public Health
PharmacyPharmacy
DentistryDentistry
NursingNursing
Vet. MedicineVet. Medicine
(2008)
What does a Linguist do in Pharmacy?What does a Linguist do in Pharmacy?
Serguei Pakhomov Assistant Professor CoP, PCHS
Education: M.A. and Ph.D. in English/LinguisticsPetrozavodsk Pedagogical University, Russia - 1992U of M 1994, 1999
Assessing linguistic manifestations of cognitive Assessing linguistic manifestations of cognitive impairment resulting from neurodegenerative impairment resulting from neurodegenerative disorders as well as exposure to medicationsdisorders as well as exposure to medications
Using natural language processing and machine Using natural language processing and machine learning in analyzing unstructured text of clinical learning in analyzing unstructured text of clinical notesnotes
… …results in inexpensive and scalable methods results in inexpensive and scalable methods for risk factor and quality assessment at the point for risk factor and quality assessment at the point of care of care
Dept. of Experimental and Clinical Pharmacology (Tim Tracy)
Dept. of Pharmaceutics (Ron Siegel)
Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth (Randy Seifert)
Dept. of Pharmaceutical Care & Health Systems (Steve Schondelmeyer)
MedicineMedicine
Public Health Public Health
PharmacyPharmacy
DentistryDentistry
NursingNursing
Vet. MedicineVet. Medicine
(2008)
Agency for Healthcare Research and Quality (AHRQ)new FOAP, AR-08-270
Title: Utilizing Health Information Technology (IT) to Improve Health Care Quality (R18)
Real world demonstration projects that evaluate factors associated with successful health IT implementation and ultimately improve health care outcomes.
……such as “Medication Therapy Management (MTM) in a rural such as “Medication Therapy Management (MTM) in a rural setting using ITV or similar telemedical approaches - comparison setting using ITV or similar telemedical approaches - comparison with conventional in-person counseling”with conventional in-person counseling”
Collaborative funding opportunities for PharmacyCollaborative funding opportunities for Pharmacy(Twin Cities/Duluth) and Public Health (Twin Cities/Duluth) and Public Health
Duluth Pier Duluth Pier LighthouseLighthouse
Dept. of Experimental and Clinical Pharmacology (Tim Tracy)
Dept. of Pharmaceutics (Ron Siegel)
Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth (Randy Seifert)
Dept. of Pharmaceutical Care & Health Systems (Steve Schondelmeyer)
MedicineMedicine
Public Health Public Health
PharmacyPharmacy
DentistryDentistry
NursingNursing
Vet. MedicineVet. Medicine
(2008)
Developing probes to seek out DNA damage by carcinogensDeveloping probes to seek out DNA damage by carcinogens
Shana SturlaAssistant ProfessorCoP, Med. Chem. B.S., UC Berkeley, 1996Ph.D., MIT, 2001
Luminescent jack-o'-lantern mushrooms Luminescent jack-o'-lantern mushrooms contain DNA alkylating acylfulvenes contain DNA alkylating acylfulvenes
BULKY BINDING. BULKY BINDING. Acylfulvenes form adducts with DNA.Acylfulvenes form adducts with DNA.
Gong, J.; Sturla, S. J. A Synthetic Nucleoside Probe that Gong, J.; Sturla, S. J. A Synthetic Nucleoside Probe that Discerns a DNA Adduct from Unmodified DNA. J Amer Discerns a DNA Adduct from Unmodified DNA. J Amer Chem Soc, 2007, 129, 4882-4883 Chem Soc, 2007, 129, 4882-4883
Institute for Therapeutics Discovery & Development
ITDD High Throughput Screening Instrumentation
Plate Management/Automation• Thermo/CRS Dimension 4 robotic system
Resea
rch
Targe
t Id
Lead
Opt
im
HTS
Pharm
acol
Toxico
lPha
se 1
Phase
2Pha
se 3
Tamiasyn in TraumaTriptolide in Cancer
Treg in Diabetes-TransplantGM-Endostatin in Cancer
Pro-Triptolide in Cancer
DRUG DEVELOPMENT PIPELINE OF THE AHC-UMN
Aquavan in Pain
Gamendazol in ContraceptToxoflavin in Contraception
TX-67 in Alzheimer’sTH-2-237 in Alzheimer’s
Iminosugars in Contracept
Cardenolides in ContraceptKinase Inhib in Contracept
LDH-C in ContraceptionDMRTI in Contraception
Vaccine AdjuvantsAC in Contraception
GMPManuf
Dept. of Experimental and Clinical Pharmacology (Tim Tracy)
Dept. of Pharmaceutics (Ron Siegel)
Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth (Randy Seifert)
Dept. of Pharmaceutical Care & Health Systems (Steve Schondelmeyer)
MedicineMedicine
Public Health Public Health
PharmacyPharmacy
DentistryDentistry
NursingNursing
Vet. MedicineVet. Medicine
(2008)
Drug/Device combination products will change the face of healthcare.
Why Establish a Center for the Integration of Drugs and Devices (CIDD)?
“The future is combining devices and drugs.” -- Ralph Larson, Chairman & CEO of J&J
BRAIN CANCERBRAIN CANCER
100,000 Patients in USA – 20,000 Children
Median Survival: 12 months
GLIOBLASTOMA
BLOOD BLOOD
Cancer Drug Cancer Drug + Inhibitor
0
1
2
3
TU
MO
R S
IZE
[m
m3]
Efflux Pump
Pump InhibitorDrug
Drug
Overcoming Barriers in Treating Brain DiseasesOvercoming Barriers in Treating Brain DiseasesCoP Brain Barriers Research Center, since 8/2008CoP Brain Barriers Research Center, since 8/2008
William ElmquistWilliam Elmquist(director)(director)
Les DrewesLes Drewes
Anika Hartz Anika Hartz
Bjoern BauerBjoern Bauer
Grant AndersonGrant Anderson
Stephen HainesStephen Haines
2 Schools, 2 Campuses Pharmacy/Medicine, Twin Cities/Duluth2 Schools, 2 Campuses Pharmacy/Medicine, Twin Cities/Duluth
Haim EinatHaim Einat
John OhlfestJohn Ohlfest
Matthew AndrewsMatthew Andrews
Bob CormierBob Cormier
Ken DornfeldKen Dornfeld
Joe ProhaskaJoe Prohaska
Cornelius LamCornelius Lam
Dept. of Experimental and Clinical Pharmacology (Tim Tracy)
Dept. of Pharmaceutics (Ron Siegel)
Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth (Randy Seifert)
Dept. of Pharmaceutical Care & Health Systems (Steve Schondelmeyer)
MedicineMedicine
Public Health Public Health
PharmacyPharmacy
DentistryDentistry
NursingNursing
Vet. MedicineVet. Medicine
(2008)
ECP Research Focus Areas (Disease States)
Hematology/Oncology Infectious Disease Cardiovascular Disease Epilepsy Critical Care Renal Transplantation
CoP Center for Forecasting Drug Response
• Pharmacometrics– Clinical Trial Simulation– Trial Design– Limited Sampling
Methodologies– Population
Pharmacokinetics– Pharmacokinetic-
Pharmacodynamic Analyses 0
1
2
3
4
5
24 28 32 36 40 44 48
10 mg/kg Q6H15 mg/kg Q8H
TIME