1

Supporting information

Chloroform as carbon monoxide source in Palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a] pyridines

P. R. Nitha,a,b Manu M. Joseph,a Greeshma Gopalan,a,b K. K. Maiti,*a,b K. V. Radhakrishnan,*a,b Parthasarathi Das*c

a.National Institute for Interdisciplinary Science and Technology (CSIR)

Thiruvananhapuram-19 (India)b.Academy of Scientific and Innovative Research (AcSIR) Thiruvananthapuram-19

(India)c.Department of Applied Chemistry, Indian Institute of Technology (ISM)

Dhanbad- 826004

* Corresponding Author: Parthasarathi Das

E-mail: partha@iitism.ac.in

Table of contents

1. Biological Data of compounds 3j, 3m, 3p, 3r, 3q and 3c....................... 2

2. Copies of 1H and 13C NMR spectra of compounds 3a-3u........................5

Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry.This journal is © The Royal Society of Chemistry 2018

2

Cytotoxicity evaluation of compounds at different concentrations on Hela and

WI-38 cell lines

3j

3m

3

3p

3r

4

3q

3c

5

1H and 13C NMR of 3a (CDCl3)

N

N N

O

3a

N

N N

O

3a

6

1H and 13C NMRof 3b (CDCl3)

N

N N

O

3b

N

N N

O

3b

7

1H and 13C NMRof 3c (CDCl3)

N

N N

O

O

3c

N

N N

O

O

3c

8

1H and 13C NMRof 3d (CDCl3)

N

N N

N

O

OO

3d

N

N N

N

O

OO

3d

9

1H and 13C NMRof 3e (CDCl3)

N

N N

N

O

3e

N

N N

N

O

3e

10

1H and 13C NMRof 3f (CDCl3)

N

N O

HN 8

3f

N

N O

HN 8

3f

11

1H and 13C NMRof 3g (CDCl3)

N

N HN

O

3g

N

N HN

O

3g

12

1H and 13C NMRof 3h (CDCl3)

N

N

O

NH

3h

N

N

O

NH

3h

13

1H and 13C NMRof 3i (CDCl3)

N

N

HN

O

3i

N

N

HN

O

3i

14

1H and 13C NMRof 3j (CDCl3)

N

N

HN

NH

O

3j

N

N

HN

NH

O

3j

15

1H and 13C NMRof 3k (CDCl3)

N

N NH

O

3k

N

N NH

O

3k

16

1H and 13C NMRof 3l (CDCl3)

N

N NH

O

OMe

3l

N

N NH

O

OMe

3l

17

1H and 13C NMRof 3m (CDCl3)

N

N

HN

O

HO3m

N

N

HN

O

HO3m

18

1H and 13C NMRof 3n (CDCl3)

N

N

O

HNOH

3n

N

N

O

HNOH

3n

19

1H and 13C NMRof 3o (CDCl3)

N

N NH

O

OMe

3o

N

N NH

O

OMe

3o

20

1H and 13C NMRof 3p (CDCl3)

N

N N

O

F

3p

N

N N

O

F3p

21

1H and 13C NMRof 3q (CDCl3)

N

N N

O

OMeMeOOMe 3q

N

N N

O

OMeMeOOMe

3q

22

1H and 13C NMRof 3r (CDCl3)

N

N N

O

CN

3r

N

N N

O

CN

3r

23

.

1H and 13C NMRof 3s (CDCl3)

N

N N

O

3s

N

N N

O

3s

24

1H and 13C NMRof 3t (CDCl3)

N

N

O

N

3t

N

N

O

N

3t

25

1H and 13C NMRof 3u (CDCl3)

N

N

O

N

3u

N

N

O

N

3u