Meta-Analysis for Clinical Researchers An Introduction to Systematic Reviews & Meta-analysis.
The Role of Systematic review and Meta analysis in Scientific research- Pubrica.com
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Transcript of The Role of Systematic review and Meta analysis in Scientific research- Pubrica.com
META ANALYSIS &SYSTEMATIC REVIEW
Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing Copyright © 2019 pubrica. All rights reserved
META ANALYSIS
Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing Copyright © 2019 pubrica. All rights reserved
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Copyright © 2019 pubrica. All rights reserved
Writing Meta Analysis
Pubrica has extensive experience in conducting meta-analysisa quantitative, formal, epidemiological study design used tosystematically assess the results of previous research to deriveconclusions about that body of research.
As a general principle, generating, summarizing, and understandingthe best available evidence are essential for establishing thebenefits and safety of interventions.
A well designed and implemented meta-analysis study can be agreat benefit to society.
While meta-analysis has the potential to be a powerful tool inevaluating health care treatments and interventions, there aremany potential pitfalls and problems that are yet to be resolved.
A poorly performed meta-analysis can perpetuate biases from ill-conceived studies or lead to false conclusions.
Introduction
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Contd..
This, in turn, can cause consumers and caregivers, who frequently accessresults of meta-analysis through websites and popular press, to formincorrect conclusions and can result in inappropriate medical decisions.
While the idea behind combining studies to improve precision and poweris straightforward, the actual implementation of the process is difficult.
Those who act or react based on meta-analysis should understand thevarious biases that could be incorporated into a review.
Examples of some potential pitfalls in meta-analysis include publicationbias, pipeline bias, and English language bias.
In addition, combining studies that are not similar in study design,population, methods of analysis or outcome definitions can lead to biasesas well,which may result in spurious conclusions being drawn.
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Moreover, a useful guide to improve reporting of systematic reviews and meta-analysis is the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analysis) statement that replaced the QUOROM (Quality of Reporting of Meta-analysis) statemen.
We include all relevant studies, because loss of studies can lead to bias in the study.
Typically, published papers and abstracts are identified by a computerized literaturesearch of electronic databases that can include PubMed(www.ncbi.nlm.nih.gov./entrez/query.fcgi), ScienceDirect (www.sciencedirect.com),Scirus (www.scirus.com/srsapp ), ISI Web of Knowledge(https://www.isiwebofknowledge.com), Google Scholar (https://scholar.google.com)and CENTRAL (Cochrane Central Register of Controlled Trials,https://www.mrw.interscience.wiley.com/cochrane/ochrane_clcentral_articles_fs.htm).
Guidelines for Reporting:
Detailed Literature Search:
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Heterogeneity is inherent in meta-analysis, not a problem to be solved.
It includes clinical components (eg,diversity in patient populations orinterventions) and statisticalcomponents (eg, random differences).
Heterogeneity
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StatisticalAnalysis
SYSTEMATIC REVIEW
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SystematicReview
Identifying a well-defined focused clinically relevant question,
Developing a detailed review protocol with strict inclusion and exclusion criteria,
Systematic literature search of multiple databases and unpublished data, inconsultation with a medical librarian,
Meticulous study identification and
Systematic data abstraction, by at least two sets of investigators independently,
Risk of bias assessment, and
Thoughtful quantitative synthesis through meta-analysis where relevant.
Performing a rigorous systematic review is multi-step process, which includes
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Formulate the research questionSearch for studiesSelection of studiesData collectionMethodology quality assessmentResults are analysed and presentedFindings are interpreted.
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GeneralStructure
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