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![Page 1: The Role of Post- Chemoradiotherapy Neck Dissection: Evidence for a Change in Paradigm Tung T. Trang, M.D. Director of Head and Neck Oncology Department.](https://reader036.fdocuments.us/reader036/viewer/2022062315/56649c755503460f949283e0/html5/thumbnails/1.jpg)
The Role of Post- Chemoradiotherapy Neck Dissection: Evidence for a
Change in ParadigmTung T. Trang, M.D.
Director of Head and Neck OncologyDepartment of Otolaryngology –Head and Neck
SurgeryMetroHealth Medical Center
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Format
• History and Basics of Neck Dissection
• The old paradigm, neck dissection in:– Radiotherapy alone– Chemo-radiotherapy
• Evidence for a change in paradigm
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George W. Crile
• First neck dissection
• 1906
• Saint Michael’s Hosp.
• Cleveland, OH
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Bulky Neck Metastases
TTT TTT
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Levels of Neck Dissection
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Radical Neck Dissection
Myers et.al. TTT
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Modified Radical Neck Dissection
Myers et.al. TTT
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Selective (Bocca) Neck Dissection
Myers et.al. TTT
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Format
• History and Basics of Neck Dissection
• The old paradigm, neck dissection in:– Radiotherapy alone– Chemo-radiotherapy
• Evidence for a change in paradigm
![Page 12: The Role of Post- Chemoradiotherapy Neck Dissection: Evidence for a Change in Paradigm Tung T. Trang, M.D. Director of Head and Neck Oncology Department.](https://reader036.fdocuments.us/reader036/viewer/2022062315/56649c755503460f949283e0/html5/thumbnails/12.jpg)
Neck Dissection Following Definitive Radiation Therapy
• Mendenhall and Parsons et. al. - University of Florida
• Radiation only for head and neck cancers
• N0 and N1 neck disease had excellent control after radiation only without neck dissection
Mendenhall et. al. 1986
Parson et. al. 1989
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Neck Dissection Following Definitive Radiation Therapy
• Factors that prognosticated worse neck control
– > 3cm neck nodes– Fixed nodes– Multiple nodes
Mendenhall et. al. 1986
Parson et. al. 1989
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Neck Dissection Following Definitive Radiation Therapy
• For N2 or greater
• 49% failure rate due to uncontrolled neck disease without planned neck dissection.
• 25% failure rate due to uncontrolled neck disease with planned neck dissection.
Mendenhall et. al. 1986
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Important Points From the Era of Radiation Only
• 1. N0 and N1 neck disease was sterilized with just radiation alone without neck dissection (or chemotherapy).
• 2. In patients with N2(+) disease, the addition of neck dissection significantly decreased the incidence of uncontrolled neck disease.
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Format
• History and Basics of Neck Dissection
• The old paradigm, neck dissection in:– Radiotherapy alone– Chemo-radiotherapy
• Evidence for a change in paradigm
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Laryngeal Cancer
Laryngectomy and Post-op XRT
Induction chemo then XRTSurgery as salvage
~66% 5-year survival
2/3 able to preserve Larynx without surgery
Induction Chemotherapy
Wolf et. Al. VA Laryng. Ca Study
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Neck Management in Induction Chemotherapy
37 patients with N2 or N3 disease
18 Complete Responders
19 Partial Responders
6 died of uncontrolled neck disease
Nosurgery
NeckDissection
@12 weeks
13 died of uncontrolled neck disease
Wolf et. al. 1992
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Conclusions From VA Study
• Partial responders were more likely to have residual neck disease and need addition of neck dissection
• 12 weeks was (too?) long to wait for neck dissection after treatment as 13/19 died of disease despite neck dissection.
• 6/18 complete responders still died of neck disease…Neck dissection may still be needed in complete responders.
Wolf et. al. 1992
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Paradigm of Planned Neck Dissection
109 patients with N2+ disease had concurrent chemoradiation
Complete Responders n=65
Partial Respondersn=44
Neck Dissection n=32
No Neck Dissection n=33
Neck Dissection n=44
McHam et. al. 2003
Residual Diseasen=8(25%)
Residual Diseasen=17(39%)
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Planned Neck Dissection for N2(+) Disease
• Conclusions from this study:– Having a complete clinical response could not
predict a complete pathological response.– No difference in survival between neck
dissected and un-dissected patients.– Recommend planned neck dissection
because dying of uncontrolled neck disease is very morbid.
McHam et. al. 2003
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Uncontrolled Neck Disease
• Chronic draining wound
• Uncontrolled Pain• Bleeding• Malodor• Social Isolation
TTT
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Format
• History and Basics of Neck Dissection
• The old paradigm, neck dissection in:– Radiotherapy alone– Chemo-radiotherapy
• Evidence for a change in paradigm
![Page 24: The Role of Post- Chemoradiotherapy Neck Dissection: Evidence for a Change in Paradigm Tung T. Trang, M.D. Director of Head and Neck Oncology Department.](https://reader036.fdocuments.us/reader036/viewer/2022062315/56649c755503460f949283e0/html5/thumbnails/24.jpg)
Role of PET scans: Yao et al 2005 (Iowa)
70 hemi-necks with N2 (+) disease
Concurrent ChemoradiationWith complete response at primary
42 hemi-necks(-) CT neck mass(-) PET
O B S E R V E
42 NED
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Yao et al 2005 (Iowa)70 hemi-necks with N2 (+) disease
Concurrent ChemoradiationWith complete response at primary
42 hemi-necks(-) CT neck mass(-) PET
O B S E R V E
21 hemi-necks(+) CT neck mass(-) PET
42 NED 21 NED
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Yao et al 2005 (Iowa)70 hemi-necks with N2 (+) disease
Concurrent ChemoradiationWith complete response at primary
42 hemi-necks(-) CT neck mass(-) PET
O B S E R V E
21 hemi-necks(+) CT neck mass(-) PET
7 hemi –necks(-) CT neck mass(+) PET
3 persistentdisease
4 NED42 NED 21 NED
Neck Dissection
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Yao et al 2005 (Iowa)
• Median f/u 26 months
• PET @ 12 weeks
• NPV 100%• SUV > 3.0 were positive
• PPV only 43%
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Nayak et al 2007 (Pittsburgh)43 patients with N2 (+) disease
Concurrent ChemoradiationWith complete response at primary
33 patients(-) PET
O B S E R V E
32 NED 1 persistentdisease
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Nayak et al 2007 (Pittsburgh)43 patients with N2 (+) disease
Concurrent ChemoradiationWith complete response at primary
33 patients(-) PET
O B S E R V E
10 patients(+) PET
7 persistentdisease
3 NED32 NED 1 persistentdisease
Neck Dissection
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Nayak et al 2007 (Pittsburgh)
• Median f/u 18.1 months• PET @ 8 weeks
• NPV 97%• SUV > 3.0 were positive• PPV only 70%
• Other recent unpublished data agree with high NPV of PET in this setting.
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Porceddu et al 2011
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Porceddu et al 201150 Patients with residual adenopathy
PET scan
41 Patients PET (-)
OBSERVATION ONLY
41 Patients NED
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Porceddu et al 201150 Patients with residual adenopathy
PET scan
41 Patients PET (-) 9 Patients PET (+)
OBSERVATION ONLY
41 Patients NED
Neck Dissection
6 Patients Persistent Tumor
3 PatientsNED
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Porceddu et al 2011
• Conclusions– NPV of PET 100%– PET better than physical exam or CT scan for
follow-up after definitive Radiotherapy +/- Chemotherapy.
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Extent of Neck Dissections
• 69 patients with N2(+) disease• All had post treatment selective neck
dissections.• Only 1 patient recurred in the neck after
selective neck dissection.• Selective neck dissections are oncologically safe
in the post chemoradiation setting.• Selective neck dissection confers less morbidity
than (modified) radical neck dissection.
Stenson, 2000
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Conclusions
• The SUV of a hyper-metabolic focus is an important variable to report on PET readings and has prognostic value.
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Conclusions
• The SUV of a hyper-metabolic focus is an important variable to report on PET readings and has prognostic value.
• When negative, CT/PET done after definitive chemoradiation accurately predicts negative neck nodal status.
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Conclusions
• The SUV of a hyper-metabolic focus is an important variable to report on PET readings and has prognostic value.
• When negative, CT/PET done after definitive chemoradiation accurately predicts negative neck nodal status.
• We should consider routine use of CT/PET after definitive chemoradiation to guide therapy of neck nodes.
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Conclusions
• The SUV of a hyper-metabolic focus is an important variable to report on PET readings and has prognostic value.
• When negative, CT/PET done after definitive chemoradiation accurately predicts negative neck nodal status.
• We should consider routine use of CT/PET after definitive chemoradiation to guide therapy of neck nodes.
• Selective neck dissections may be enough to control disease in place of modified radical neck dissections.
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• Stenson et al. The Role of Cervical Lymphadenectomy After Aggressive Concomitant Chemoradiotherapy: The Feasibility of Selective Neck Dissection. Archives of Otolaryngology -- Head & Neck Surgery. 126(8):950-956, August 2000.
• Wolf GT, Fisher SG Effectiveness of salvage neck dissection for advanced regional metastases when induction chemotherapy and radiation are used for organ preservation. Laryngoscope 1992;102:934-939. Yao et al Int. J of Rad Onc, biol and phys. 63(4):991-9, 2005.
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