THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield...

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THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied Statistics
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Transcript of THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield...

Page 1: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

THE PURSUIT OF UNDERSTANDING:MODELLING DYNAMIC BEHAVIOUR IN

DISEASE, LIFE & LOVE

Brian DangerfieldProfessor of Systems Modelling

Centre for OR & Applied Statistics

Page 2: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

System Dynamics modelling is based upon: * Concept of Information Feedback

* Delays

* Mapping Tools– Stock-Flow Diagrams– Influence Diagrams

* Equations linking variables to one another in the system

Page 3: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 4: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Chou En-lai (1898-1976)

- asked for his assessment of the effects of the French Revolution

Page 5: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 6: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

•At what minute did most people enter the bar?

•At what minute did most people leave the bar?

•At what minute were most people in the bar?

•At what minute were fewest people in the bar?

Page 7: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 8: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

A stock-flow diagram

In the barEntering Leaving

Page 9: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

COCAINE PREVALENCE IN THE USA

Survey data suggested lifetime prevalence estimates were falling rapidly in the latter part of 1980’s.

Argument for more resources to support policies of interdiction & incarceration (rather than prevention).

But reported decline physically impossible (Homer);

-Survey collected biased data

Page 10: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Current &Past Users(lifetime

prevalence)

first timecocaine use

death fromall causes

Page 11: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Limits on Our Capacity for Processing Information

7 + 2

George Miller, Psychological Review63:2 (1956) pp. 81-97

Page 12: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

5 variables A, B, C, D, and E

A= f (B,C,D)

B= f (C, E)

C= f (B,A)

D= f (C, E)

E= f (B,C)

A

B C

E

D

Page 13: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 14: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 15: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 16: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Who are the most important people involved in securing

the safe passage of an aircraft from A to B?

Page 17: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 18: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 19: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

DYNAMICS OF AN EPIDEMIC

Page 20: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 21: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 22: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

MILESTONES IN THE EVOLUTION OF THE HIV/AIDS MODEL

Number of Year (quarter) of

Feature equations (approx) introduction

Project-based model 13 1987(2)

Variable infectivity 20 1989(1)

Heterogeneity & changing behaviour 47 1990(2)

Reporting delay & fitting model to data 70 1992(2)

Treatment effect & removals / additions 120 1997(4)

Health care sector 190 1998(4)

Introduction of HAART 300 1999(2)

Effects of regression in behaviour

after HAART (fitting to HIV data) 360 2001(3)

Page 23: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 24: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 25: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 26: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 27: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 28: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 29: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 30: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 31: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Estimated Numbers & Percent on HAART at end-1998

Homo/bisexual men only

Estimated Number Percent of total

of Patients

U.K. 10734 67%

France 17500 64%

Germany 10359 69%

Netherlands 2069 76%

Page 32: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 33: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 34: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 36: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

FASHION ITEM DYNAMICS

Page 37: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 38: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

TOURIST DEVELOPMENT IN ISLAND ECONOMIES

Page 39: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 40: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 41: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 42: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Need a balance between economic gain and environmental conservation.

For: jobs; tax revenue; foreign currency earnings

Against: environmental pollution; higher cost of living; migration from agriculture to tourist services

SUSTAINABLE DEVELOPMENT IN AN ISLAND TOURIST ECONOMY

Page 43: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Environmental deterioration might affect the numbers and/or mix of tourist visitors— no rail links - congested motorways— Reina Sofia airport congestion— obsolete tourist facilities; poor professional training

Issues:— water supply— waste collection and treatment— communications— health care— noise pollution— public safety

Page 44: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 45: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

DIFFUSION OF AN INNOVATION

Page 46: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Barriers to innovation:

–QWERTY Keyboard : Sholes vs Dvorak

–VHS video format vs Betamax

Sharp take-off innovations:

–CAT scanners

–Mobile phones

Page 47: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 48: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

“CLUBBED TO DEATH” (Student Direct Dec. 2002)

• Superclubs are suffering … Renaissance; Gatecrasher, Cream.

• How did things go so wrong?– Competition – more clubs and (now) bars.– Merchandising (In 2000, 5% of MoS

profits came from the clubs).– Big name DJ’s charged at least £10K per

set.– Higher door prices.

Page 49: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

visiting rateper club

spin-offmerchandising

(brand awareness)

average clubdoor price

new clubopenings DJ fees

new baropenings

numbers in clubper week

profits

-

+

+

-

++

+

+

- -

+ +

+1

2

34

5

6

+

Page 50: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 51: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

SARAWAK (EAST MALAYSIA)

• CORAS/CER Two year research project

• Economic model for the State Government

Model Purpose?

Page 52: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Map of Borneo

Page 53: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Sarawak Gross Domestic Product 1980 – 1999

(Constant Prices)

02,0004,0006,0008,000

10,00012,00014,000

1980 1983 1986 1989 1992 1995 1998

Years

GD

P R

M M

illio

ns

Page 54: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

DYNAMIC HYPOTHESIS: DYNAMIC HYPOTHESIS: high-level maphigh-level map

Primary & SecondaryEducation

HigherEducation

(Arts)

HigherEducation(Science)

VocationalEducation

(Sub-professional)

R & D Centres

(Exemplars)

Primary Industry

(Agric; Forestry;Mining; M/facturing)

Knowledge-basedIndustry & Services

High Value-added; Biotech; Medicine

SecondaryIndustry

(Transport; Storage;Retail; Finance &

Insurance)

BroadbandCabling (Kms)

Number of PC’s

State Incentives

FederalFunds

ICT Infrastructure

StateRevenue

SUPPLY

DEMAND

COMMSINFRASTRUCTUREF

DI

Closures?

Leakage

Overseas?

Skills/Tech Transfer Money

Capital Equipment Human Resources

Page 55: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Virtuous circles (positive loops): if ICT Resources (actual)>= ICT Resources (desired). Otherwise negative

loops come into play & positive loops shifted from growth to decay mode

K.Industries

ICT Resources(desired)

ICT Resources(actual)

Supply ofHigh-Tech Human

Capital

R&DCentres

+

+

++

+

-

-

+

++

+

Page 56: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 57: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 58: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 59: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.
Page 60: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

DYNAMICS OF A PARTNERSHIP

Page 61: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Sustainable Futures:

Endgames:

Page 62: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Sustainable Futures:

‘Golden Wedding’

0

Time

+

-

Page 63: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Sustainable Futures:

‘Amo et Odi ’

0

+

-

Time

Page 64: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Endgames:

‘We’re still good friends’

0

+

-

Time

Page 65: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Endgames:

‘Mutual loathing’

0

+

-

Time

Page 66: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

EU Divorce Rates in 2001 (per '000 population)

EU Divorce Rates in 2001 (per '000 population)

2.6 2.72

2.6 2.9

0.9 1 0.7 0.7

1.9

00.5

11.5

22.5

33.5

Page 67: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

UK Marriages

406000

286000

0

100000

200000

300000

400000

500000

1976 2001

Page 68: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

England & Wales Divorce Rates per '000 Married Population

0.00

5.00

10.00

15.00

1976 1981 1986 1991 1996 2001

Page 69: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

England & Wales Re-marriages of one or other partner (% of all marriages)

6

16

2327

0

5

10

15

20

25

30

1964 1974 1984 1994

Page 70: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Median duration of marriage at divorce (yr)

11.511.3

10.19.8

8.59

9.510

10.511

11.512

1963 1973 1983 1993

Page 71: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

Co-habitation (%) of single non-married women

8

31

05

1015

20253035

1979 1998

Page 72: THE PURSUIT OF UNDERSTANDING: MODELLING DYNAMIC BEHAVIOUR IN DISEASE, LIFE & LOVE Brian Dangerfield Professor of Systems Modelling Centre for OR & Applied.

• The UK picture??

• Fewer Sustainable Futures & more Endgames ??