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![Page 1: The Preventive Role of Nutrition for BRCA1/2 Mutation Carriers The Preventive Role of Nutrition for BRCA1/2 Mutation Carriers Sharon Bar-Gil, Ph.D., RH.](https://reader035.fdocuments.us/reader035/viewer/2022062409/56649d9c5503460f94a8460c/html5/thumbnails/1.jpg)
The Preventive Role of Nutrition The Preventive Role of Nutrition for for BRCA1/2 Mutation CarriersBRCA1/2 Mutation Carriers
Sharon Bar-Gil, Ph.D., RH (AHG)
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Functional Medicine Functional Medicine
• Goal: optimal function• Integrative • Science based • For prevention and treatment• Patient centered - focusing on the individual and
tailoring a unique plan to restore balance• Tools: nutrition, herbs, supplements and life style
modifications
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ObjectiveObjective
Understand the Role of Nutrition in Cancer Prevention.
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You’re not ill yet, Mrs. Smith,but you’ve got potential.”
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Nutrition is an Essential Tool in Your
“Cancer Prevention Tool Kit”.
• Nutritional interventions can:– Reduce & prevent further mutations– Support proper cell growth and death
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AgendaAgenda
• Nutrigenomics – nutrition can change gene expression
• Natural agents that can help regulate BRCA1/2 genes:– Fatty acids– Green tea – Turmeric
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What is Food? What is Food?
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Nutrigenomics – Nutrigenomics – You can turn genes “On” or You can turn genes “On” or
“Off” “Off”
• Nutrigenomics is the study of how foods interact with your genes and alter their expression.
• Genes do not function in isolation. • They interact with each other as well as
with their environment. • Nutrigenomics provides the ambitious goal
of optimizing an individual’s health via nutritional interventions. FASEB; Mutch et al. 19 (12): 1602. (2005)
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Nutrition Can Change Nutrition Can Change Gene ExpressionGene Expression
• Animals fed healthy or nutrients deficient diet.• Those on deficient diet developed colon cancer
within 1 year.• 2,000+ genes altered their expression toward a
cancer profile• Pattern of gene expression reverted toward a
healthy profile when nutrients added back to diet. Augenlicht LH: Nutritional genomics and proteomics in cancer prevention conference. J. Nutr. 133: 2410S–2416S, 2003
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AgendaAgenda
• Nutrigenomics – How Nutrition can change gene expression
• Natural agents that can help regulate BRCA1/2 genes:– Fatty acids– Green tea – Turmeric
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Fatty Acids Regulate BRCA1/2Fatty Acids Regulate BRCA1/2
• Fatty acids (such as fish oils) can regulate BRCA1/2 expression:– Omega 3 (EPA & DHA) fatty acids have been shown to
reduce pathological cell growth.– Omega 6 fatty acids have been found to induce tumor
proliferation.
• DHA supplementation significantly reduced the incidence of tumors (30%) and led to a 60% increase BRCA1 protein level.
• Bernard-Gallon et-al, British Journal of Nutrition (2002), 87, 281–289• MARIE-LISE JOURDAN, ET-AL ,ONCOLOGY REPORTS 17: 713-719, 2007
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Where Are They Found? Where Are They Found? • Omega 3 – cold water fish, flax seed, dark leafy
greens, nuts and seeds, olive oil, grass fed beef
• Omega 6 - Safflower oil, Sunflower oil, Corn oil Sesame oil, Soybean oil, Walnut oil, commercially raised beef
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Green Tea & Gene ExpressionGreen Tea & Gene Expression
• Helps DNA repair • Inhibits promoting genes (MMP-2, MMP-9)• Increases inhibitory genes • Induces apoptosis• Prevention dosage:
– 300-600 mg (>50% EGCG)= 2-4 caps. daily
• Katiyar, S.K., et al, 1992. Green Tea in Chemoprevention of Cancer. • Adhami, et al, J. Nutr, 2003• Tang et al. Int J Cancer, 2007• Lozano, et al, Febs J, 2006• Susan McCarthy, et-al, molecular Oncology, Volume 1, Issue 2, Pages 196-
204 (September 2007)
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Green Tea Extract Inhibits PC inGreen Tea Extract Inhibits PC inHuman Clinical TrialHuman Clinical Trial
• 60 volunteers with PC.• Consumed 200 mg * 3 per day or placebo
for 1 year• At 1 year: 1 tumor was diagnosed in the
green tea group (3%), while 9 cancers were found in the placebo (30%)
• S. Bettuzzi, et-al, Cancer Research 66, 1234-1240, January 2006
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Turmeric – Turmeric – Synergy with Chemotherapy Synergy with Chemotherapy
• Turmeric has many mechanisms through which it prevents/destroys cancer cells:– Inhibit the proliferation of tumor cells – Destroy mutated cancer cells
• M.D. Anderson Cancer Center (2008) : Mice injected with aggressive breast cancer cells. – Divided to 4 groups:
• No treatment = 95% metastasis• Taxol only = 75% metastasis• Curcumin only = 50% metastasis• Curcumin + Taxol = 22% metastasis
• Research dosage= 8 g’ daily• journal Clinical Cancer Research, October 15th, 2005• M.D. Anderson Cancer Center, Sept. 2008
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Prevention = The Concept Prevention = The Concept of Total Loadof Total Load
• Most of us are exposed to constant low level of toxins. • Such exposure is not well studied:
– Difficult to measure – Biochemical individuality = different risks– Multiple sources of exposures have synergistic effects
• The ability to inhibit or repair mutations depends, to a great extent, on lifestyle choices
• The concept of total load = – Decrease exposure – Increase protection
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Talk to Your Genes With FoodTalk to Your Genes With Food• Drink about 1 glass of red wine 3-5 days a week. • Limit sugar intake• Consume moderate amounts of fish, eggs, poultry
and/or wild meats up.• Limited consumption of red meat• Eat organically grown or wild foods.• Spice it Up: Use herbs & kitchen spices liberally
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Talk to Your Genes With Food Talk to Your Genes With Food
• Consume mostly food from plant sources, including fruits, vegetables, whole grains, beans, nuts, and seeds
• Aim for 2-3 fruits & 5+ vegetables daily• Eat minimally processed and mostly
seasonally fresh foods.• Eat a Rainbow: Choose deeply colored
produce and eat full rainbow of colors daily.
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You can be in control when it comes to actively maintaining
your nutritional status.
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Thank You Thank You
Sharon Bar-Gil Ph.D., R.H. (AHG)
www.sharonbargil.com
E-mail: [email protected]
Tel: 054-818-7275