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Nitric Oxide & HealthNitric Oxide & HealthNitric Oxide & HealthNitric Oxide & Health

The Wonderwork The Wonderwork ofof

Nitric Oxide Nitric Oxide

The Wonderwork The Wonderwork ofof

Nitric Oxide Nitric Oxide Presented by Presented by

Healthway C.T.M.L., Inc.Healthway C.T.M.L., Inc.

Nitric OxideNitric OxideNitric OxideNitric Oxide1998 Nobel Prize in 1998 Nobel Prize in Physiology/MedicinePhysiology/Medicine1998 Nobel Prize in 1998 Nobel Prize in Physiology/MedicinePhysiology/Medicine

Robert F. Furchgott

Dept. of

Pharmacology,

SUNY Health

Science Center

Louis J. Ignarro

Dept. of Molecular

And medical

Pharmacology

UCLA School of Medicine

Los Angeles

Ferid Murad

Dept. of Integrative Biology

Pharmacology and Physiology

University of Texas

Medical School

Houston

The 1998 Nobel Prize for Physiology or Medicine was awarded to 3 American scientists for their research on NO (Nitric Oxide). They discovered that NO, a gas, is responsible for transmitting important signals and regulating cellular functions in the human body.

The Winners of 1998 Nobel PrizeThe Winners of 1998 Nobel PrizeThe Winners of 1998 Nobel PrizeThe Winners of 1998 Nobel Prize

3 Nobel Prize Winners receiving their awards from the hands of His Majesty the King of Sweden.

3 Nobel Prize Winners receiving their awards from the hands of His Majesty the King of Sweden.

World Famous Scientist: World Famous Scientist: Alfred Nobel & NitroglycerineAlfred Nobel & Nitroglycerine

World Famous Scientist: World Famous Scientist: Alfred Nobel & NitroglycerineAlfred Nobel & Nitroglycerine

Alfred Nobel is the founder of Nobel Prize. He starts his experiments with nitroglycerine in 1860. He also invented dynamite in 1866 and later built up companies and laboratories in more than 20 countries all over the world. Ironically, when Nobel was taken ill with heart disease, his doctor prescribed nitroglycerin, but he refused to take it.

It has been known since last century that the explosive, nitroglycerin, has beneficial effects against chest pain. However, it would take 100 years until it was clarified that nitroglycerin acts by releasing NO gas.

The President of the American Heart Association, Dr. Valentin Fuster said, “The discovery of Nitric Oxide and its function is one of the most important in the history of cardiovascular medicine.”

Cardiovascular Disease &

Hardening of the Arteries

vessels will be protected from the development of plaque, affording protection from atherosclerosis.

Dr. John P. Cooke, Director of Vascular Medicine at Stanford University Medical School, states that- Even when blood cholesterol is high, if sufficient nitric oxide from arginine, is being produced, the

Nitric oxide

Dilated Artery

Cardiovascular Disease

NO Production in Human Body

There is a high incidence of cardiovascular disease among the old. The incidence is 15% for the people over age 40, and men have a high risk factor than women. The death rate for heart disease and stroke is around 49%. Cardiovascular disease ranks as world’s No.1 killer, claiming the lives of 15 million people.

According to statistics, stroke deaths occur more often during periods between 2:00 a.m.- 6:00 a.m. This may due to NO level is low at nights. Also, heart disease patients produce less nitric oxide than normal persons.

Healthy People Unhealthy People Cardiovascular disease patient

NO & Blood VesselsNO & Blood VesselsNO & Blood VesselsNO & Blood Vessels

Healthy people– Healthy immune system Unhealthy people– Weak immune system

According to the research, the cells of your body decline 2% per year in effectiveness starting at age 21! Therefore, you need to deposit an equal amount in your nutritional bank account to maintain your health.

Dr. Cooke said, “endothelium-made nitric oxide is your body’s strongest self defense against heart attacks and stroke…preventing and reversing hardening of the arteries.”

From 70’s, Dr. Ferid Murad started experiments with Nitroglycerin. Until 1997, he found out that nitroglycerin works by releasing nitric oxide. NO molecules from the endothelium travel into smooth muscle cells, set off a cascade of cellular reactions that cause the cell’s contractile filaments to slide. As a result, smooth muscle cells relax and blood vessel dilates.

擁 A healthy endothelium is the cardiovascular cure

Dr. Cooke points out, the person with healthy blood vessels, by eating an arginine rich diet, manufactures sufficient nitric oxide but- most of us have unhealthy blood vessels and unhealthy diets!

Furthermore, he states that high cholesterol, even in healthy young people, and diseased coronary arteries interferes with the production of nitric oxide by the body.

一 Ample Nitric Oxide production dissolves plaque

Nitric oxide, endogenously produced gas that acts as a signaling molecule in the body. Signal transmission by gas, produced by one cell, which penetrates membranes and regulates the function of other cells is a revolutionary breakthrough in the human organism. Scientists believe that insufficient nitric oxide production in human body leads to a variety of diseases.

Function in Cardiovascular System

Function in Nerve Transmission

Function in Immune System

Function in Respiratory & Endocrine System

NO Performance NO Performance NO Performance NO Performance

NO Function in Cardiovascular:

Relaxes blood vessels keeping them open, pliable, and elastic

Preventing platelets and white blood cells from sticking to the vessel wall

Preventing arterial spasms

Atherosclerosis

According to recent research, the average persons’ cholesterol level is raised up to 20%; and around 10% of children triglyceride level is higher than normal.

Scientist evidence shows by lowering 1% of cholesterol reduces 2% of incidence in Myocardial Infraction. Cholesterol-lowering also reduces the hardening of the arteries.

Atherosclerosis is the buildup of deposits of fatty substances on the insides of the artery walls. This causes thickening and hardening of the arteries, high blood pressure chest pain, heart attack, stroke, and sudden cardiac death.

Hypertension

Double NO in blood vessels,pliable blood vessels

High blood pressure is the most important risk factor for cardiovascular disease. Many people believe the effective treatment of hypertension is a key reason for the accelerated decline in the death rates for heart attack, heart disease, and stroke.

Normal Hypertension Coronary Artery Disease Cerebral Embolism

血液平衡疗法对原发性高血压，冠状动脉硬化性心脏病，动脉硬化脑梗塞，病人血浆一氧化氮的影响， 健康对照组， 血液平衡前对照， 一次血液平衡后， 二次血液平衡后，

三次血液平衡后。n=56,x±s**p<0.01 与对照组比较； ++p<0.01 与血液平衡前比较。

Cardiovascular System

Blood vessels bring oxygen and nutrients to the heart, brain, and various human body.

Especially, heart and brain consume most of oxygen that body produced, around 60%.

When the body is under heavy physiological stress or trauma, it requires more nitric oxide; otherwise may damage blood vessels and cause cardiovascular disease such as heart disease, stroke…..

Coronary Artery Disease Coronary artery disease generally refers to the buildup of cholesterol in the inside layers of the arteries. This will slowly narrow the flow of blood through the vessels, and the muscle it supplies will not get enough blood. The plaque weakens the wall. A crack may develop in the plaque and a blood clot may form~ this is the mechanism of most heart attacks.

Hardening of Arteries Hardening of arteries is a common disorder of the arteries. It often shows no symptoms until flow within a blood vessel has become seriously compromised. Typical symptoms include chest pain when a coronary artery is involved, or leg pain when a leg artery is involved.

Fat, cholesterol and other substances accumulate in the walls of arteries and form atheromas or plaques.

Blood Vessel Disease

Risk as:

1. contracted artery,

increase blood pressure;

2. increase stickiness of platelets,damage endothelium;

3. the hardening of arteries, blockage in coronary artery;

Nitric Oxide in Nerve System:

Nitric Oxide Nourishes Brian Cells.

Nitric Oxide enhanced nerve cells communication and long-term memory storage.

Brain researchers have begun to examine the role of NO in diseases such as Alzheimer’s and Parkinson’s. In patients suffering either of these disorders, there is frequently a significant reduction in the nitric oxide being produced in their brain.

Inhibiting the enzyme used to make NO caused constriction of the arteries supplying the brain.

NO and Brain

Cerebri

posterior

Cerebri

anterior

Cerebri

Media

Cerebral embolism

Cerebral hemorrhages

A stroke occurs when a blood vessel bring oxygen and nutrients to the brain bursts or is clogged by a blood clot or some other particle.

NO Function in Immune System:

NO reduces lung disorders & help HGH release Dr. Jonathan S. Stamler, professor of Medicine at Duke University Medical Center, once said, “NO does everything, everywhere.” NO involved in complex behavioral changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, function of blood cells, the immune system, even how digits and arms move.

Strengthen the body’s defense against infectionRetards tumor growth by enhancing immune functionAmple production of Nitric oxide in white blood cells to kill invading bacteria and parasites

NO & Body FunctionNO & Body FunctionNO & Body FunctionNO & Body Function

Individuals without sufficient nitric oxide production are likely to develop heart or blood vessel disease.

Scientists believe 一 The decrease of nitric oxide production in human body decreases the function and health of normal cells. Therefore, disease may follow…..

2. Stroke

For example:

1. Hypertension (high blood pressure)

3. Coronary artery disease

4. Heart failure

5. Diabetes Mellitus

6. Other diseases

Unhealthy

Healthy

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