The Power of Fasting or Why Less is More · 10/4/2019 · presentation Defence against...
Transcript of The Power of Fasting or Why Less is More · 10/4/2019 · presentation Defence against...
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The Power of Fasting orWhy Less is More
We will review:§Energy metabolism basics§Insulin§Growth and Reproduction Times of Plenty
Philip Myron MDCM, FRCPC October 4, 2019
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The Power of Fasting orWhy Less is More
§Hormesis Times of Scarcity§Autophagy§Bad Science Bad Outcomes§Bad Science Dietary Myths§Fasting A Powerful Tool and Corrective
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1980 ððð2014
• Quadrupling of number of adults with DM worldwide
• 108M in 1980è 422M in 2014• Burden growing faster in low and middle
income countries• Based on current trends global target of
holding levels to 2010 levels in 2025:< 1% males< 1% females
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3 Principle Macromolecules
• Carbohydrates• Fat• Protein
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Gluconeogenesis
• Takes place primarily in liver• Converts pyruvate, lactate, glycerol and amino
acids into glucose• Energy for this biochemical process from
oxidation of fat• Mammals cannot convert fat directly into
glucose
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Energy Regulating Hormones
Glucose Lowering• Insulin
Glucose Raising• Glucagon• Growth hormone• Epinephrine• Norepinephrine• T4, T3• Cortisol
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Hormesis
•What doesn’t kill you makes you stronger• The dose makes the poison
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Figure 1
Cell Metabolism 2014 19, 181-192DOI: (10.1016/j.cmet.2013.12.008) Copyright © 2014 Elsevier Inc. Terms and Conditions
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Yoshinori Ohsumi Recipient of 2016 Nobel Prize in Physiology or Medicine
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