The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for...

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The Pleura

Transcript of The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for...

Page 1: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

The Pleura

Page 2: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

The Pleura

A mesothelial surface lining the lungs and mediastinum

Mesothelial cells designed for fluid absorption

Hallmark of disease is the effusion

Page 3: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Pleural Effusion

Transudate (low protein) cardiac failure hypoproteinaemia

Exudate (high protein) pneumonia TB connective tissue

disease malignancy (primary

or metastatic)

Page 4: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Purulent Effusion

Full of acute inflammatory cells Empyema Can become chronic

Page 5: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Pneumothorax

Air in pleural space Trauma Rupture of bulla

Page 6: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Large bullae

Page 7: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Pleural Neoplasia

Primary benign (rare) malignant mesothelioma

Secondary common (adenocarcinomas - lung, GIT,

ovary)

Page 8: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Mesothelioma

Page 9: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Pleural biopsy - mesothelioma

Mixed spindle cell (mesenchymal) and epithelial differentiation

Page 10: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Metastases in Pleura

Page 11: The Pleura. A mesothelial surface lining the lungs and mediastinum Mesothelial cells designed for fluid absorption Hallmark of disease is the effusion.

Differential diagnosis of malignant effusions…..

Cytology, biopsy Difficult Immunohistochemistry for lineage

specific antigens may help Medicolegal importance